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Article ; Online: Can strength training or tai ji quan training reduce frailty in postmenopausal women treated with chemotherapy? A secondary data analysis of the GET FIT trial.

Winters-Stone, Kerri M / Stoyles, Sydnee A / Dieckmann, Nathan F / Eckstrom, Elizabeth / Luoh, Shiuh-Wen / Horak, Fay B / Roeland, Eric J / Li, Fuzhong

Journal of cancer survivorship : research and practice

2024

Abstract: Purpose: To determine whether strength training or tai ji quan can reduce frailty in older ... cancer survivors were randomized to supervised group exercise programs: tai ji quan, strength training ... compared to controls (OR [95%CI] 1.86 [1.09, 3.17]) but not for tai ji quan (1.44 [0.84, 2.50 ...

Abstract	Purpose: To determine whether strength training or tai ji quan can reduce frailty in older, postmenopausal women treated with chemotherapy for cancer. Methods: We conducted a secondary data analysis from a 3-arm, single-blind, randomized controlled trial where older (50-75 years), postmenopausal women cancer survivors were randomized to supervised group exercise programs: tai ji quan, strength training, or stretching control for 6 months. We assessed frailty using a 4-criteria model consisting of weakness, fatigue, inactivity, and slowness. Using logistic regression, we determined whether the frailty phenotype (pre-frailty or frailty) decreased post-intervention, how many and which frailty criteria decreased, and what characteristics identified women most likely to reduce frailty. Results: Data from 386 women who completed baseline and 6-month testing were used (mean age of 62.0 ± 6.4 years). The odds of reducing overall frailty over 6 months were significantly higher in the strength training group compared to controls (OR [95%CI] 1.86 [1.09, 3.17]) but not for tai ji quan (1.44 [0.84, 2.50]). Both strength training (OR 1.99 [1.10, 3.65]) and tai ji quan (OR 2.10 [1.16, 3.84]) led to significantly higher odds of reducing ≥ 1 frailty criterion compared to controls. Strength training led to a three-fold reduction in inactivity (p < 0.01) and tai ji quan to a two-fold reduction in fatigue (p = 0.08) versus control. Higher baseline BMI, comorbidity score, and frailty status characterized women were more likely to reduce frailty than other women. Conclusions: Strength training appears superior to tai ji quan and stretching with respect to reducing overall frailty phenotype among postmenopausal women treated with chemotherapy for cancer, but tai ji quan favorably reduced the number of frailty criteria. Trial registration: ClinicalTrials.gov identifier: GET FIT was registered as a clinical trial in clinicaltrials.gov: NCT01635413. Implications for cancer survivors: Supervised, group exercise training that emphasizes strength training and/or tai ji quan may help combat accelerated aging and reduce frailty after cancer treatment.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388888-X
ISSN	1932-2267 ; 1932-2259
ISSN (online)	1932-2267
ISSN	1932-2259
DOI	10.1007/s11764-024-01592-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Does venture capital Quan Zi affect stock mispricing: Evidence from Chinese listed companies.

Chen, Ping / Deng, Li

PloS one

2023 Volume 18, Issue 4, Page(s) e0281255

Abstract: Chinese traditional culture is characterized by "Quan Zi" culture with a "differential order ... pattern". As a special informal institutional arrangement, "Quan Zi" plays an important role ... in the capital market. This paper investigates how Venture Capital Quan Zi affects the stock mispricing of invested ...

Abstract	Chinese traditional culture is characterized by "Quan Zi" culture with a "differential order pattern". As a special informal institutional arrangement, "Quan Zi" plays an important role in the capital market. This paper investigates how Venture Capital Quan Zi affects the stock mispricing of invested companies. Using the syndicate investment data of China's venture capital institutions from 2009 to 2019, this study documents that Venture Capital Quan Zi significantly increases the positive deviations of stock prices of Quan Zi-backed firms but has no obvious influence on the negative deviations, showing an asymmetric effect on stock mispricing. In addition, this effect is dynamic. Stock mispricing significantly increased in the lock-up period and the following year, but then gradually weakened. Mechanism tests suggest that, on the one hand, Venture Capital Quan Zi increases a company's earnings manipulation, thus raising investors' expectations to push up stock prices. On the other hand, Venture Capital Quan Zi boosts the stock price through market reaction channels, increasing institutional investors' shareholdings, positive media coverage and stock liquidity. This paper has high theoretical and applied value to guide the orderly competition of capital and the supervision of institutional investors.
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281255
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Does venture capital Quan Zi affect stock mispricing

Ping Chen / Li Deng

PLoS ONE, Vol 18, Iss

Evidence from Chinese listed companies

2023 Volume 4

Abstract	Chinese traditional culture is characterized by "Quan Zi" culture with a "differential order pattern". As a special informal institutional arrangement, "Quan Zi" plays an important role in the capital market. This paper investigates how Venture Capital Quan Zi affects the stock mispricing of invested companies. Using the syndicate investment data of China’s venture capital institutions from 2009 to 2019, this study documents that Venture Capital Quan Zi significantly increases the positive deviations of stock prices of Quan Zi-backed firms but has no obvious influence on the negative deviations, showing an asymmetric effect on stock mispricing. In addition, this effect is dynamic. Stock mispricing significantly increased in the lock-up period and the following year, but then gradually weakened. Mechanism tests suggest that, on the one hand, Venture Capital Quan Zi increases a company’s earnings manipulation, thus raising investors’ expectations to push up stock prices. On the other hand, Venture Capital Quan Zi boosts the stock price through market reaction channels, increasing institutional investors’ shareholdings, positive media coverage and stock liquidity. This paper has high theoretical and applied value to guide the orderly competition of capital and the supervision of institutional investors.
Keywords	Medicine ; R ; Science ; Q
Subject code	332
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Does venture capital Quan Zi affect stock mispricing

Ping Chen / Li Deng

PLoS ONE, Vol 18, Iss 4, p e

Evidence from Chinese listed companies.

2023 Volume 0281255

Abstract	Chinese traditional culture is characterized by "Quan Zi" culture with a "differential order pattern". As a special informal institutional arrangement, "Quan Zi" plays an important role in the capital market. This paper investigates how Venture Capital Quan Zi affects the stock mispricing of invested companies. Using the syndicate investment data of China's venture capital institutions from 2009 to 2019, this study documents that Venture Capital Quan Zi significantly increases the positive deviations of stock prices of Quan Zi-backed firms but has no obvious influence on the negative deviations, showing an asymmetric effect on stock mispricing. In addition, this effect is dynamic. Stock mispricing significantly increased in the lock-up period and the following year, but then gradually weakened. Mechanism tests suggest that, on the one hand, Venture Capital Quan Zi increases a company's earnings manipulation, thus raising investors' expectations to push up stock prices. On the other hand, Venture Capital Quan Zi boosts the stock price through market reaction channels, increasing institutional investors' shareholdings, positive media coverage and stock liquidity. This paper has high theoretical and applied value to guide the orderly competition of capital and the supervision of institutional investors.
Keywords	Medicine ; R ; Science ; Q
Subject code	332
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Can strength training or tai ji quan training reduce frailty in postmenopausal women treated with chemotherapy? A secondary data analysis of the GET FIT trial.

Winters-Stone, Kerri M / Stoyles, Sydnee / Dieckmann, Nathan / Eckstrom, Elizabeth / Luoh, Shiuh-Wen / Horak, Fay / Roeland, Eric J / Li, Fuzhong

Research square

2023

Abstract: Purpose: To determine whether strength training or tai ji quan can reduce frailty in older ... cancer survivors were randomized to supervised group exercise programs: tai ji quan, strength training ... training group compared to controls (OR [95%CI]: 1.86 [1.09, 3.17]), but not for for tai ji quan (1.44 [0 ...

Abstract	Purpose: To determine whether strength training or tai ji quan can reduce frailty in older, postmenopausal women treated with chemotherapy for cancer. Methods: We conducted a secondary data analysis from a 3-arm, single-blind, randomized controlled trial where older (50+ years), postmenopausal women cancer survivors were randomized to supervised group exercise programs: tai ji quan, strength training, or stretching control for 6 months. We assessed frailty using a 4-criteria model consisting of weakness, fatigue, inactivity, and slowness. Using logistic regression, we determined whether the frailty phenotype (pre-frailty or frailty) decreased post-intervention, how many and which frailty criteria decreased, and what characteristics identified women most likely to reduce frailty. Results: Data from 386 women who completed baseline and 6-month testing were used (mean age of 62.0 ± 6.4 years). The odds of improving overall frailty phenotype over 6 months was significantly higher in the strength training group compared to controls (OR [95%CI]: 1.86 [1.09, 3.17]), but not for for tai ji quan (1.44 [0.84, 2.50]). Both strength training (OR 1.99 [1.10, 3.65]) and tai ji quan (OR 2.10 [1.16, 3.84]) led to significantly higher odds of reducing ≥1 frailty criterion compared to controls. Strength training led to a three-fold reduction in inactivity (p <0.01), and tai ji quan to a two-fold reduction in fatigue (p=0.08) versus control. Higher baseline BMI, comorbidity score, and frailty status characterized women more likely to reduce frailty than other women. Conclusions: Strength training appears superior to tai ji quan and stretching with respect to reducing overall frailty phenotype among postmenopausal women treated with chemotherapy for cancer, but tai ji quan favorably impacted the number of frailty criteria. Implications for cancer survivors: Supervised, group exercise training that emphasizes strength training and/or tai ji quan may help combat accelerated aging and reduce frailty after cancer treatment.
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3425168/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: GET FIT: A Randomized Clinical Trial of Tai Ji Quan Versus Strength Training for Fall Prevention After Chemotherapy in Older, Postmenopausal Women Cancer Survivors.

Winters-Stone, Kerri M / Horak, Fay / Dieckmann, Nathan F / Luoh, Shiuh-Wen / Eckstrom, Elizabeth / Stoyles, Sydnee A / Roeland, Eric J / Li, Fuzhong

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 41, Issue 18, Page(s) 3384–3396

Abstract: Purpose: To compare the efficacy of tai ji quan versus strength training to prevent falls after ... supervised group exercise programs (tai ji quan, strength training, or stretching control) twice weekly for 6 ... reduced incidence of fall-related injuries within the tai ji quan group over the first 6 months, dropping ...

Abstract	Purpose: To compare the efficacy of tai ji quan versus strength training to prevent falls after chemotherapy in older, postmenopaual women. Methods: We conducted a three-arm, single-blind, randomized controlled trial where older (50+ years), postmenopausal women cancer survivors participated in one of three supervised group exercise programs (tai ji quan, strength training, or stretching control) twice weekly for 6 months and were followed up 6 months after training stopped. The primary outcome was the incidence of falls. Secondary outcomes included fall-related injuries, leg strength (1 repetition maximum; kg), and balance (sensory organization [equilibrium score] and limits of stability [LOS; %] tests). Results: Four hundred sixty-two women were enrolled (mean age, 62 ± 6.3 years). Retention was 93%, and adherence averaged 72.9%. In primary analysis, there was no difference in the incidence of falls between groups after 6 months of training, nor during 6-month follow-up. A post hoc analysis detected a significantly reduced incidence of fall-related injuries within the tai ji quan group over the first 6 months, dropping from 4.3 falls per 100 person-months (95% CI, 2.9 to 5.6) at baseline to 2.4 falls per person-months (95% CI, 1.2 to 3.5). No significant changes occurred during 6-month follow-up. Over the intervention period, leg strength significantly improved in the strength group and balance (LOS) improved in the tai ji quan group, compared with controls ( Conclusion: We found no significant reduction in falls for tai ji quan or strength training relative to stretching control in postmenopausal women treated with chemotherapy.
MeSH term(s)	Humans ; Female ; Aged ; Middle Aged ; Resistance Training ; Cancer Survivors ; Tai Ji ; Single-Blind Method ; Postmenopause ; Neoplasms
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.01519
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Professor Zhao Quan-lin's experience in the diagnosis and treatment of type 2 diabetes mellitus with acute gout

Xin-Tong Li / Quan-Lin Zhao

Journal of Hainan Medical University, Vol 26, Iss 23, Pp 56-

2020 Volume 58

Abstract: Type 2 diabetes mellitus (T2DM) is a common clinical endocrine and metabolic disease characterized by elevated blood sugar and insulin resistance. The onset of T2DM will affect the metabolic balance of the body, and uric acid metabolism is one of them. ... ...

Abstract	Type 2 diabetes mellitus (T2DM) is a common clinical endocrine and metabolic disease characterized by elevated blood sugar and insulin resistance. The onset of T2DM will affect the metabolic balance of the body, and uric acid metabolism is one of them. Hyperuricemia (HUA) is very common in type 2 diabetes. Based on HUA, gout is a crystal-related disease caused by urate deposition, and its clinical manifestations are complex and varied. Professor zhao quanlin has rich experience in clinical experience, and he has made good use of traditional Chinese medicine system to treat type 2 diabetes mellitus with gout in the acute phase of clinical effect.
Keywords	type 2 diabetes mellitus ; acute phase of gout ; chinese medicine ; metabolic diseases ; experience ; Medicine ; R
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A cognitively enhanced online Tai Ji Quan training intervention for community-dwelling older adults with mild cognitive impairment: A feasibility trial.

Li, Fuzhong / Harmer, Peter / Fitzgerald, Kathleen / Winters-Stone, Kerri

BMC geriatrics

2022 Volume 22, Issue 1, Page(s) 76

Abstract: ... cognitive-enhancing Tai Ji Quan training intervention, delivered via remote videoconferencing, for older ... enhanced Tai Ji Quan (n = 23), standard Tai Ji Quan (n = 22), or stretching group (n = 24) and participated ... The cognitively enhanced Tai Ji Quan intervention was shown to be acceptable to participants as well as safe ...

Abstract	Background: This study examines the feasibility, acceptability, and safety of a newly developed cognitive-enhancing Tai Ji Quan training intervention, delivered via remote videoconferencing, for older adults with mild cognitive impairment (MCI). Methods: In a three-arm feasibility trial, community-dwelling older adults with MCI (N = 69; mean age = 74.6 years, 57% women) were randomized to a cognitively enhanced Tai Ji Quan (n = 23), standard Tai Ji Quan (n = 22), or stretching group (n = 24) and participated in a 60-minute online exercise session via Zoom, twice weekly for 16 weeks. Participants were recruited primarily in the state of Oregon through mass mailing and word of mouth. The primary outcomes were intervention feasibility (with respect to recruitment, online intervention delivery, fidelity and compliance, and attrition and retention rates), acceptability, and safety. We also assessed feasibility of online data collection and test-retest reliability and explored preliminary trends on secondary outcomes that included global cognitive function, dual-task cost, and domain-specific cognition function. Results: The study had an average recruitment rate of 55%. Feasibility was demonstrated by the overall successful online program implementation, with good fidelity, acceptable compliance (76%), and excellent retention (94%). The cognitively enhanced Tai Ji Quan intervention was shown to be acceptable to participants as well as safe, with no major intervention-related moderate/severe events. At week 16, the group receiving cognitively enhanced Tai Ji Quan training showed a positive trend in the cognitive function and dual-task outcome measures whereas the group receiving standard Tai Ji Quan training exhibited positive trends on global and domain-specific cognitive measures. Conclusions: Preliminary findings of this pilot study indicate the feasibility, acceptability, and safety of a tailored, cognitively enhanced Tai Ji Quan training intervention delivered remotely to home settings via videoconferencing for community-dwelling older adults with MCI. Trial registration: Clinicaltrials.gov identifier NCT04070703.
MeSH term(s)	Aged ; Cognitive Dysfunction/therapy ; Feasibility Studies ; Female ; Humans ; Independent Living ; Internet-Based Intervention ; Male ; Pilot Projects ; Reproducibility of Results ; Tai Ji/methods
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-021-02747-0
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Article ; Online: Clinical Effectiveness of Cognitively Enhanced Tai Ji Quan Training on Global Cognition and Dual-Task Performance During Walking in Older Adults With Mild Cognitive Impairment or Self-Reported Memory Concerns : A Randomized Controlled Trial.

Li, Fuzhong / Harmer, Peter / Eckstrom, Elizabeth / Fitzgerald, Kathleen / Winters-Stone, Kerri

Annals of internal medicine

2023 Volume 176, Issue 11, Page(s) 1498–1507

Abstract: ... To compare the effectiveness of cognitively enhanced tai ji quan versus standard tai ji quan or stretching ... Intervention: Cognitively enhanced tai ji quan (: Measurements: The co-primary endpoints were change ... enhanced tai ji quan outperformed standard tai ji quan and stretching with a greater improvement in MoCA ...

Abstract	Background: Mild cognitive impairment (MCI) negatively impacts cognition and dual-task abilities. A physical-cognitive integrated treatment approach could mitigate this risk for dementia. Objective: To compare the effectiveness of cognitively enhanced tai ji quan versus standard tai ji quan or stretching exercise in improving global cognition and reducing dual-task walking costs in older adults with MCI or self-reported memory concerns. Design: 3-group, randomized (1:1:1), superiority trial. (ClinicalTrials.gov: NCT04070703). Setting: Community residential homes. Participants: 318 older adults with self-reported memory decline or concern and a Clinical Dementia Rating (CDR) global score of 0.5 or lower at baseline. Intervention: Cognitively enhanced tai ji quan ( Measurements: The co-primary endpoints were change in Montreal Cognitive Assessment (MoCA; range, 0 to 30) and dual-task walking costs (difference between single- and dual-task gait speed, expressed in percentage) from baseline to 24 weeks. Secondary outcomes included CDR-Sum of Boxes (CDR-SB), Trail Making Test B, Digit Span Backward (DSB), and physical performance tests. Outcomes were assessed at 16, 24 (primary endpoint), and 48 weeks (6 months after intervention). Results: A total of 304 participants (96%) completed the 24-week assessment. Cognitively enhanced tai ji quan outperformed standard tai ji quan and stretching with a greater improvement in MoCA score (mean difference, 1.5 points [98.75% CI, 0.7 to 2.2 points] and 2.8 points [CI, 2.1 to 3.6 points], respectively) and in dual-task walking (mean difference, 9.9% [CI, 2.8% to 16.6%] and 22% [CI, 13% to 31%], respectively). The intervention effects persisted at 48-week follow-up. Limitation: There was no nonexercise control group; participants had subjective or mild cognitive impairment. Conclusion: Among community-dwelling older adults with MCI, cognitively enriched tai ji quan therapy was superior to standard tai ji quan and stretching exercise in improving global cognition and reducing dual-task gait interference, with outcomes sustained at 48 weeks. Primary funding source: National Institute on Aging.
MeSH term(s)	Humans ; Aged ; Self Report ; Tai Ji ; Task Performance and Analysis ; Treatment Outcome ; Cognitive Dysfunction/therapy ; Walking ; Cognition
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M23-1603
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Article ; Online: Tai Ji Quan

Fuzhong Li

Journal of Sport and Health Science, Vol 3, Iss 1, Pp 1-

From traditional applications to contemporary practice

2014 Volume 2

Keywords	Sports ; GV557-1198.995 ; Sports medicine ; RC1200-1245
Language	English
Publishing date	2014-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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