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  1. Article ; Online: Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.

    Migliore, Lucia / Coppedè, Fabio

    Nature reviews. Neurology

    2022  Volume 18, Issue 11, Page(s) 643–660

    Abstract: With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve multiple susceptibility genes and environmental factors. The role of environmental factors is difficult to determine and, until a few ... ...

    Abstract With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve multiple susceptibility genes and environmental factors. The role of environmental factors is difficult to determine and, until a few years ago, the molecular mechanisms underlying gene-environment (G × E) interactions in AD were largely unknown. Here, we review evidence that has emerged over the past two decades to explain how environmental factors, such as diet, lifestyle, alcohol, smoking and pollutants, might interact with the human genome. In particular, we discuss how various environmental AD risk factors can induce epigenetic modifications of key AD-related genes and pathways and consider how epigenetic mechanisms could contribute to the effects of oxidative stress on AD onset. Studies on early-life exposures are helping to uncover critical time windows of sensitivity to epigenetic influences from environmental factors, thereby laying the foundations for future primary preventative approaches. We conclude that epigenetic modifications need to be considered when assessing G × E interactions in AD.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Gene-Environment Interaction ; Epigenesis, Genetic/genetics ; Life Style ; Oxidative Stress ; DNA Methylation
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-022-00714-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis.

    Stoccoro, Andrea / Smith, Adam R / Mosca, Lorena / Marocchi, Alessandro / Gerardi, Francesca / Lunetta, Christian / Lunnon, Katie / Migliore, Lucia / Coppedè, Fabio

    Epigenomics

    2024  Volume 16, Issue 4, Page(s) 203–214

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/genetics ; Mutation ; DNA Methylation ; DNA, Mitochondrial/genetics ; Mitochondria/genetics
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2023-0265
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  3. Article ; Online: DNA Methylation Biomarkers for Young Children with Idiopathic Autism Spectrum Disorder: A Systematic Review.

    Stoccoro, Andrea / Conti, Eugenia / Scaffei, Elena / Calderoni, Sara / Coppedè, Fabio / Migliore, Lucia / Battini, Roberta

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, the underlying pathological mechanisms of which are not yet completely understood. Although several genetic and genomic alterations have been linked to ASD, for the majority of ASD ...

    Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, the underlying pathological mechanisms of which are not yet completely understood. Although several genetic and genomic alterations have been linked to ASD, for the majority of ASD patients, the cause remains unknown, and the condition likely arises due to complex interactions between low-risk genes and environmental factors. There is increasing evidence that epigenetic mechanisms that are highly sensitive to environmental factors and influence gene function without altering the DNA sequence, particularly aberrant DNA methylation, are involved in ASD pathogenesis. This systematic review aimed to update the clinical application of DNA methylation investigations in children with idiopathic ASD, investigating its potential application in clinical settings. To this end, a literature search was performed on different scientific databases using a combination of terms related to the association between peripheral DNA methylation and young children with idiopathic ASD; this search led to the identification of 18 articles. In the selected studies, DNA methylation is investigated in peripheral blood or saliva samples, at both gene-specific and genome-wide levels. The results obtained suggest that peripheral DNA methylation could represent a promising methodology in ASD biomarker research, although further studies are needed to develop DNA-methylation-based clinical applications.
    MeSH term(s) Humans ; Child ; Child, Preschool ; DNA Methylation ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/genetics ; Epigenesis, Genetic ; Biomarkers ; Phenotype
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119138
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  4. Article: Gender Specific Differences in Disease Susceptibility: The Role of Epigenetics.

    Migliore, Lucia / Nicolì, Vanessa / Stoccoro, Andrea

    Biomedicines

    2021  Volume 9, Issue 6

    Abstract: Many complex traits or diseases, such as infectious and autoimmune diseases, cancer, xenobiotics exposure, neurodevelopmental and neurodegenerative diseases, as well as the outcome of vaccination, show a differential susceptibility between males and ... ...

    Abstract Many complex traits or diseases, such as infectious and autoimmune diseases, cancer, xenobiotics exposure, neurodevelopmental and neurodegenerative diseases, as well as the outcome of vaccination, show a differential susceptibility between males and females. In general, the female immune system responds more efficiently to pathogens. However, this can lead to over-reactive immune responses, which may explain the higher presence of autoimmune diseases in women, but also potentially the more adverse effects of vaccination in females compared with in males. Many clinical and epidemiological studies reported, for the SARS-CoV-2 infection, a gender-biased differential response; however, the majority of reports dealt with a comparable morbidity, with males, however, showing higher COVID-19 adverse outcomes. Although gender differences in immune responses have been studied predominantly within the context of sex hormone effects, some other mechanisms have been invoked: cellular mosaicism, skewed X chromosome inactivation, genes escaping X chromosome inactivation, and miRNAs encoded on the X chromosome. The hormonal hypothesis as well as other mechanisms will be examined and discussed in the light of the most recent epigenetic findings in the field, as the concept that epigenetics is the unifying mechanism in explaining gender-specific differences is increasingly emerging.
    Language English
    Publishing date 2021-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9060652
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  5. Article ; Online: DNA Methylation Biomarkers for Young Children with Idiopathic Autism Spectrum Disorder

    Andrea Stoccoro / Eugenia Conti / Elena Scaffei / Sara Calderoni / Fabio Coppedè / Lucia Migliore / Roberta Battini

    International Journal of Molecular Sciences, Vol 24, Iss 9138, p

    A Systematic Review

    2023  Volume 9138

    Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, the underlying pathological mechanisms of which are not yet completely understood. Although several genetic and genomic alterations have been linked to ASD, for the majority of ASD ...

    Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, the underlying pathological mechanisms of which are not yet completely understood. Although several genetic and genomic alterations have been linked to ASD, for the majority of ASD patients, the cause remains unknown, and the condition likely arises due to complex interactions between low-risk genes and environmental factors. There is increasing evidence that epigenetic mechanisms that are highly sensitive to environmental factors and influence gene function without altering the DNA sequence, particularly aberrant DNA methylation, are involved in ASD pathogenesis. This systematic review aimed to update the clinical application of DNA methylation investigations in children with idiopathic ASD, investigating its potential application in clinical settings. To this end, a literature search was performed on different scientific databases using a combination of terms related to the association between peripheral DNA methylation and young children with idiopathic ASD; this search led to the identification of 18 articles. In the selected studies, DNA methylation is investigated in peripheral blood or saliva samples, at both gene-specific and genome-wide levels. The results obtained suggest that peripheral DNA methylation could represent a promising methodology in ASD biomarker research, although further studies are needed to develop DNA-methylation-based clinical applications.
    Keywords autism spectrum disorder ; epigenetics ; DNA methylation ; idiopathic ASD ; peripheral biomarkers ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Gender Specific Differences in Disease Susceptibility

    Lucia Migliore / Vanessa Nicolì / Andrea Stoccoro

    Biomedicines, Vol 9, Iss 652, p

    The Role of Epigenetics

    2021  Volume 652

    Abstract: Many complex traits or diseases, such as infectious and autoimmune diseases, cancer, xenobiotics exposure, neurodevelopmental and neurodegenerative diseases, as well as the outcome of vaccination, show a differential susceptibility between males and ... ...

    Abstract Many complex traits or diseases, such as infectious and autoimmune diseases, cancer, xenobiotics exposure, neurodevelopmental and neurodegenerative diseases, as well as the outcome of vaccination, show a differential susceptibility between males and females. In general, the female immune system responds more efficiently to pathogens. However, this can lead to over-reactive immune responses, which may explain the higher presence of autoimmune diseases in women, but also potentially the more adverse effects of vaccination in females compared with in males. Many clinical and epidemiological studies reported, for the SARS-CoV-2 infection, a gender-biased differential response; however, the majority of reports dealt with a comparable morbidity, with males, however, showing higher COVID-19 adverse outcomes. Although gender differences in immune responses have been studied predominantly within the context of sex hormone effects, some other mechanisms have been invoked: cellular mosaicism, skewed X chromosome inactivation, genes escaping X chromosome inactivation, and miRNAs encoded on the X chromosome. The hormonal hypothesis as well as other mechanisms will be examined and discussed in the light of the most recent epigenetic findings in the field, as the concept that epigenetics is the unifying mechanism in explaining gender-specific differences is increasingly emerging.
    Keywords epigenetics ; gender bias ; complex diseases ; infectious diseases ; vaccination outcomes ; skewed X inactivation ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Polymorphisms of genes required for methionine synthesis and DNA methylation influence mitochondrial DNA methylation.

    Stoccoro, Andrea / Tannorella, Pierpaola / Migliore, Lucia / Coppedè, Fabio

    Epigenomics

    2020  Volume 12, Issue 12, Page(s) 1003–1012

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase ; Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Case-Control Studies ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases ; DNA Methylation ; DNA Methyltransferase 3A ; DNA, Mitochondrial ; Female ; Ferredoxin-NADP Reductase ; Genotype ; Humans ; Male ; Methionine/biosynthesis ; Methylenetetrahydrofolate Reductase (NADPH2) ; Polymorphism, Single Nucleotide ; Replication Protein C ; DNA Methyltransferase 3B
    Chemical Substances DNA, Mitochondrial ; DNMT3A protein, human ; RFC1 protein, human ; Methionine (AE28F7PNPL) ; methionine synthase reductase (EC 1.18.1.-) ; Ferredoxin-NADP Reductase (EC 1.18.1.2) ; MTHFR protein, human (EC 1.5.1.20) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20) ; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (EC 2.1.1.13) ; MTR protein, human (EC 2.1.1.13.) ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNA Methyltransferase 3A (EC 2.1.1.37) ; DNMT1 protein, human (EC 2.1.1.37) ; Replication Protein C (EC 3.6.4.-)
    Language English
    Publishing date 2020-05-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2020-0041
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  8. Article: Plasma Homocysteine and Polymorphisms of Genes Involved in Folate Metabolism Correlate with

    Coppedè, Fabio / Stoccoro, Andrea / Tannorella, Pierpaola / Migliore, Lucia

    Metabolites

    2019  Volume 9, Issue 12

    Abstract: DNA methyltransferase 1 (DNMT1) is responsible for the maintenance of DNA methylation patterns during cell division. Several human diseases are characterized by ... ...

    Abstract DNA methyltransferase 1 (DNMT1) is responsible for the maintenance of DNA methylation patterns during cell division. Several human diseases are characterized by impaired
    Language English
    Publishing date 2019-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo9120298
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  9. Article: First Molecular Survey to Detect

    Galluzzo, Paola / Migliore, Sergio / Galuppo, Lucia / Condorelli, Lucia / Hussein, Hany A / Licitra, Francesca / Coltraro, Miriana / Sallemi, Sabrina / Antoci, Francesco / Cascone, Giuseppe / Puleio, Roberto / Loria, Guido Ruggero

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 8

    Abstract: Mycoplasmas are recognized as avian pathogens, which may cause both respiratory disease and synovial infections in poultry, resulting in severe economic losses. Our study aims to determine the occurrence ... ...

    Abstract Mycoplasmas are recognized as avian pathogens, which may cause both respiratory disease and synovial infections in poultry, resulting in severe economic losses. Our study aims to determine the occurrence of
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12080962
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  10. Article ; Online: Preliminary Study on the Host Response to Bivalent and Monovalent Autogenous Vaccines against

    Hussein, Hany A / Tolone, Marco / Condorelli, Lucia / Galluzzo, Paola / Puleio, Roberto / Vazzana, Irene / Scatassa, Maria Luisa / Marogna, Gavino / Barreca, Santino / Loria, Guido Ruggero / Galuppo, Lucia / Migliore, Sergio

    Veterinary sciences

    2022  Volume 9, Issue 12

    Abstract: In Italy, dairy sheep farming represents a vital agro-industry sector, but it is still challenged by contagious agalactia (CA), which is endemic there, and vaccination is the most economical and sustainable tool for control. This study aimed to evaluate ... ...

    Abstract In Italy, dairy sheep farming represents a vital agro-industry sector, but it is still challenged by contagious agalactia (CA), which is endemic there, and vaccination is the most economical and sustainable tool for control. This study aimed to evaluate the combined
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci9120651
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