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  1. Book: Neurodegenerative diseases

    Galimberti, Daniela

    clinical aspects, molecular genetics and biomarkers

    2014  

    Author's details Daniela Galimberti ... ed
    Keywords Nervous system/Diseases ; Nervous system/Diseases/Molecular aspects ; Biochemical markers/Diagnostic use
    Subject code 616.8
    Language English
    Size XIX, 253 S. : Ill., 24 cm
    Publisher Springer
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018274153
    ISBN 978-1-4471-6379-4 ; 9781447163800 ; 1-4471-6379-6 ; 144716380X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 2097 available for loan (reading room) Lesesaal EG

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  2. Book: Biomarkers for early diagnosis of Alzheimer’s disease

    Galimberti, Daniela

    (Nova biomedical)

    2008  

    Author's details Daniela Galimberti ..., ed
    Series title Nova biomedical
    Keywords Alzheimer Disease / diagnosis ; Alzheimer Disease / metabolism ; Biological Markers / metabolism ; Early Diagnosis
    Language English
    Size VI, 307 S. : Ill., graph. Darst.
    Publisher Nova Biomed. Books
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT016014766
    ISBN 978-1-60456-991-9 ; 1-60456-991-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 846 order for loan Magazin

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  3. Article ; Online: Genetic risk factors and role of immune dysfunction in FTLD.

    Galimberti, Daniela

    Nature reviews. Neurology

    2019  Volume 15, Issue 5, Page(s) 250–251

    MeSH term(s) C9orf72 Protein ; Frontotemporal Dementia ; Frontotemporal Lobar Degeneration ; Genome-Wide Association Study ; Humans ; Risk Factors
    Chemical Substances C9orf72 Protein
    Language English
    Publishing date 2019-03-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-019-0173-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 88: Show issues

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  4. Article: Beyond dentistry: could prevention and screening for neurodegenerative diseases start in the dental office?

    Buccellato, Francesca R / Galimberti, Daniela / Tartaglia, Gianluca M

    Neural regeneration research

    2023  Volume 19, Issue 1, Page(s) 156–157

    Language English
    Publishing date 2023-07-24
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.375323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Frontotemporal dementia: from genetics to therapeutic approaches.

    Buccellato, Francesca R / D'Anca, Marianna / Tartaglia, Gianluca Martino / Del Fabbro, Massimo / Galimberti, Daniela

    Expert opinion on investigational drugs

    2024  

    Abstract: Introduction: Frontotemporal dementia (FTD) includes a group of neurodegenerative diseases characterized clinically by behavioral disturbances and by neurodegeneration of brain anterior temporal and frontal lobes, leading to atrophy. Apart from ... ...

    Abstract Introduction: Frontotemporal dementia (FTD) includes a group of neurodegenerative diseases characterized clinically by behavioral disturbances and by neurodegeneration of brain anterior temporal and frontal lobes, leading to atrophy. Apart from symptomatic treatments, there is, at present, no disease-modifying cure for FTD.
    Areas covered: Three main mutations are known as causes of familial FTD, and large consortia have studied carriers of mutations, also in preclinical Phases. As genetic cases are the only ones in which the pathology can be predicted in life, compounds developed so far are directed toward specific proteins or mutations. Herein, recently approved clinical trials will be summarized, including molecules, mechanisms of action and pharmacological testing.
    Expert opinion: These studies are paving the way for the future. They will clarify whether single mutations should be addressed rather than common proteins depositing in the brain to move from genetic to sporadic FTD.
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2024.2349286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The Gut Microbiome-Brain Crosstalk in Neurodegenerative Diseases.

    Ghezzi, Laura / Cantoni, Claudia / Rotondo, Emanuela / Galimberti, Daniela

    Biomedicines

    2022  Volume 10, Issue 7

    Abstract: The gut-brain axis (GBA) is a complex interactive network linking the gut to the brain. It involves the bidirectional communication between the gastrointestinal and the central nervous system, mediated by endocrinological, immunological, and neural ... ...

    Abstract The gut-brain axis (GBA) is a complex interactive network linking the gut to the brain. It involves the bidirectional communication between the gastrointestinal and the central nervous system, mediated by endocrinological, immunological, and neural signals. Perturbations of the GBA have been reported in many neurodegenerative diseases, suggesting a possible role in disease pathogenesis, making it a potential therapeutic target. The gut microbiome is a pivotal component of the GBA, and alterations in its composition have been linked to GBA dysfunction and CNS inflammation and degeneration. The gut microbiome might influence the homeostasis of the central nervous system homeostasis through the modulation of the immune system and, more directly, the production of molecules and metabolites. Small clinical and preclinical trials, in which microbial composition was manipulated using dietary changes, fecal microbiome transplantation, and probiotic supplements, have provided promising outcomes. However, results are not always consistent, and large-scale randomized control trials are lacking. Here, we give an overview of how the gut microbiome influences the GBA and could contribute to disease pathogenesis in neurodegenerative diseases.
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10071486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Circular RNAs: Emblematic Players of Neurogenesis and Neurodegeneration.

    D'Anca, Marianna / Buccellato, Francesca R / Fenoglio, Chiara / Galimberti, Daniela

    International journal of molecular sciences

    2022  Volume 23, Issue 8

    Abstract: In the fascinating landscape of non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are peeping out as a new promising and appreciated class of molecules with great potential as diagnostic and prognostic biomarkers. They come from circularization of ... ...

    Abstract In the fascinating landscape of non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are peeping out as a new promising and appreciated class of molecules with great potential as diagnostic and prognostic biomarkers. They come from circularization of single-stranded RNA molecules covalently closed and generated through alternative mRNA splicing. Dismissed for many years, similar to aberrant splicing by-products, nowadays, their role has been regained. They are able to regulate the expression of linear mRNA transcripts at different levels acting as miRNA sponges, interacting with ribonucleoproteins or exerting a control on gene expression. On the other hand, being extremely conserved across phyla and stable, cell and tissue specific, mostly abundant than the linear RNAs, it is not surprising that they should have critical biological functions. Curiously, circRNAs are particularly expressed in brain and they build up during aging and age-related diseases. These extraordinary peculiarities make circRNAs potentially suitable as promising molecular biomarkers, especially of aging and neurodegenerative diseases. This review aims to explore new evidence on circRNAs, emphasizing their role in aging and pathogenesis of major neurodegenerative disorders, Alzheimer's disease, frontotemporal dementia, and Parkinson's diseases with a look toward their potential usefulness in biomarker searching.
    MeSH term(s) Biomarkers ; Humans ; MicroRNAs/genetics ; Neurodegenerative Diseases/genetics ; Neurogenesis/genetics ; RNA, Circular/genetics ; RNA, Messenger
    Chemical Substances Biomarkers ; MicroRNAs ; RNA, Circular ; RNA, Messenger
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23084134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Alterations of the miR-126-3p/POU2AF1/Spi-B Axis and JCPyV Reactivation in Multiple Sclerosis Patients Receiving Natalizumab.

    Mancuso, Roberta / Agostini, Simone / Hernis, Ambra / Caputo, Domenico / Galimberti, Daniela / Scarpini, Elio / Clerici, Mario

    Frontiers in neurology

    2022  Volume 13, Page(s) 819911

    Abstract: Natalizumab (NTZ) can reactivate human polyomavirus John Cunningham polyomavirus (JCPyV) latent infection and lead to progressive multifocal leukoencephalopathy (PML). NTZ modulates the expression of microRNA-126-3p (miR-126-3p) and its target genes, ...

    Abstract Natalizumab (NTZ) can reactivate human polyomavirus John Cunningham polyomavirus (JCPyV) latent infection and lead to progressive multifocal leukoencephalopathy (PML). NTZ modulates the expression of microRNA-126-3p (miR-126-3p) and its target genes,
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.819911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Unveiling the Antifouling Potential of Stabilized Poly(phosphorus ylides).

    Karagrigoriou, Dimitrios / Berking, Bela B / Wang, Qi / Sánchez-Cerrillo, Dulce M / Galimberti, Daria R / Wilson, Daniela A / Neumann, Kevin

    ACS macro letters

    2023  Volume 12, Issue 12, Page(s) 1608–1613

    Abstract: Zwitterionic polymers have emerged as highly attractive building blocks for antifouling coatings in biomedical applications. Notably, these polymers offer effective alternatives to the widely used poly(ethylene glycol) (PEG), which has raised concerns ... ...

    Abstract Zwitterionic polymers have emerged as highly attractive building blocks for antifouling coatings in biomedical applications. Notably, these polymers offer effective alternatives to the widely used poly(ethylene glycol) (PEG), which has raised concerns regarding its immunotoxicity and the development of PEG-specific antibodies. Polymeric ylides, a largely overlooked class of zwitterionic polymers, have been reported as effective antifouling scaffolds. However, the reported subclasses, poly(sulfur ylides) and
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ISSN 2161-1653
    ISSN (online) 2161-1653
    DOI 10.1021/acsmacrolett.3c00524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Circular RNAs

    Marianna D’Anca / Francesca R. Buccellato / Chiara Fenoglio / Daniela Galimberti

    International Journal of Molecular Sciences, Vol 23, Iss 4134, p

    Emblematic Players of Neurogenesis and Neurodegeneration

    2022  Volume 4134

    Abstract: In the fascinating landscape of non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are peeping out as a new promising and appreciated class of molecules with great potential as diagnostic and prognostic biomarkers. They come from circularization of ... ...

    Abstract In the fascinating landscape of non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are peeping out as a new promising and appreciated class of molecules with great potential as diagnostic and prognostic biomarkers. They come from circularization of single-stranded RNA molecules covalently closed and generated through alternative mRNA splicing. Dismissed for many years, similar to aberrant splicing by-products, nowadays, their role has been regained. They are able to regulate the expression of linear mRNA transcripts at different levels acting as miRNA sponges, interacting with ribonucleoproteins or exerting a control on gene expression. On the other hand, being extremely conserved across phyla and stable, cell and tissue specific, mostly abundant than the linear RNAs, it is not surprising that they should have critical biological functions. Curiously, circRNAs are particularly expressed in brain and they build up during aging and age-related diseases. These extraordinary peculiarities make circRNAs potentially suitable as promising molecular biomarkers, especially of aging and neurodegenerative diseases. This review aims to explore new evidence on circRNAs, emphasizing their role in aging and pathogenesis of major neurodegenerative disorders, Alzheimer’s disease, frontotemporal dementia, and Parkinson’s diseases with a look toward their potential usefulness in biomarker searching.
    Keywords circular RNAs ; Alzheimer’s disease ; frontotemporal dementia ; Parkinson’s disease ; aging ; neurogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 612
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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