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Article: Correction: Rossignol, D.A.; Frye, R.E. Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.

Rossignol, Daniel A / Frye, Richard E

2022 Volume 12, Issue 5

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2022-04-29
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12050721
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Article ; Online: A pig model of chronic hepatitis E displaying persistent viremia and a downregulation of innate immune responses in the liver.

León-Janampa, Nancy / Caballero-Posadas, Ignacio / Barc, Céline / Darrouzain, François / Moreau, Alain / Guinoiseau, Thibault / Gatault, Philippe / Fleurot, Isabelle / Riou, Mickaël / Pinard, Anne / Pezant, Jérémy / Rossignol, Christelle / Gaudy-Graffin, Catherine / Brand, Denys / Marlet, Julien

Hepatology communications

2023 Volume 7, Issue 11

Abstract: Background: Hepatitis E virus (HEV) is a zoonotic virus transmitted by pig meat and responsible ... for chronic hepatitis E in immunocompromised patients. It has proved challenging to reproduce this disease ... in its natural reservoir. We therefore aimed to develop a pig model of chronic hepatitis E to improve the characterization ...

Abstract	Background: Hepatitis E virus (HEV) is a zoonotic virus transmitted by pig meat and responsible for chronic hepatitis E in immunocompromised patients. It has proved challenging to reproduce this disease in its natural reservoir. We therefore aimed to develop a pig model of chronic hepatitis E to improve the characterization of this disease. Methods: Ten pigs were treated with a tacrolimus-based regimen and intravenously inoculated with HEV. Tacrolimus trough concentration, HEV viremia, viral diversity, innate immune responses, liver histology, clinical disease and biochemical markers were monitored for 11 weeks post-infection (p.i.). Results: HEV viremia persisted for 11 weeks p.i. HEV RNA was detected in the liver, small intestine, and colon at necropsy. Histological analysis revealed liver inflammation and fibrosis. Several mutations selected in the HEV genome were associated with compartmentalization in the feces and intestinal tissues, consistent with the hypothesis of extrahepatic replication in the digestive tract. Antiviral responses were characterized by a downregulation of IFN pathways in the liver, despite an upregulation of RIG-I and ISGs in the blood and liver. Conclusions: We developed a pig model of chronic hepatitis E that reproduced the major hallmarks of this disease. This model revealed a compartmentalization of HEV genomes in the digestive tract and a downregulation of innate immune responses in the liver. These original features highlight the relevance of our model for studies of the pathogenesis of chronic hepatitis E and for validating future treatments.
MeSH term(s)	Humans ; Swine ; Animals ; Hepatitis E ; Down-Regulation ; Viremia ; Tacrolimus ; Immunity, Innate/genetics
Chemical Substances	Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000274
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Book ; Online: A Personalized Medicine Approach to the Diagnosis and Management of Autism Spectrum Disorder

Frye, Richard E / Boles, Richard / Rose, Shannon / Rossignol, Daniel / Rossignol, Daniel

2022

Keywords	Medicine ; Neurosciences ; fecal metabolites ; ASD ; microbiome ; gastrointestinal symptoms ; Fisher Discriminant Analysis ; digital biomarkers ; wearables ; time series analysis ; autism ; social dyads ; socio-motor parameters ; network connectivity ; non-linear complex dynamics ; stochastic analysis ; autism spectrum disorders ; copy number variants ; females ; Array-Comparative Genomic Hybridization (Array-CGH) ; autism spectrum disorder ; Ehlers-Danlos syndrome ; hypermobility spectrum disorders ; autonomic disorder ; mast cell activation syndrome ; genetic testing ; chromosomal microarray analysis ; whole exome sequencing ; whole genome sequencing ; clinical utility ; polygenic risk scores ; Temple Grandin ; biomarker ; omics ; precision medicine ; proteomics ; transcriptomics ; epigenetics ; metabolomics ; patient stratification ; mitochondria ; oxidative stress ; prenatal environment ; immune dysfunction ; immunoglobulin G ; intravenous immunoglobulin ; energy metabolism ; fatty acid oxidation ; acyl-carnitines ; resveratrol ; integrative ; model ; concomitant ; condition ; disorder ; autism spectrum disorder (ASD) ; genomics ; personalized treatment strategy ; single nucleotide polymorphisms ; clinical decision support tool ; ADHD ; PANDAS ; OCD ; anxiety ; folate receptor alpha ; folates ; pregnancy ; brain development ; fetal development ; cobalamin ; glutathione ; methylation ; methylcobalamin ; redox metabolism ; locked-in network syndrome ; resting-state functional magnetic resonance imaging ; temporal lobe epilepsy ; amygdala ; brain ; COVID-19 ; children ; cytokines ; flavonoids ; inflammation ; luteolin ; mast cells ; microglia ; SARS-CoV-2 ; stress ; nutraceuticals ; survey ; vitamins ; minerals ; B12 ; folinic acid ; quality of life ; parents ; intervention ; systematic review ; medical claims ; logistic regression analysis ; retrospective analysis ; associated risk ; monoamine neurotransmitters ; neurotransmitter deficiency ; cerebral folate deficiency ; folate receptor alpha autoantibodies ; leucovorin ; α-amylase ; cortisol ; heart rate variability ; neuromodulation ; sleep anxiety ; transdermal electrical neuromodulation ; neurostimulation ; n/a
Language	English
Size	1 electronic resource (416 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030378931
ISBN	9783036532202 ; 303653220X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: A personalized medicine approach to the diagnosis and management of autism spectrum disorder

Frye, Richard Eugene / Boles, Richard G. / Rose, Shannon / Rossignol, Daniel

2022

Author's details	edited by Richard Eugene Frye, Richard G. Boles, Shannon Rose, Daniel Rossignol
Language	English
Size	1 Online-Ressource (xi, 402 Seiten), Illustrationen, Diagramme
Publisher	MDPI
Publishing place	Basel
Publishing country	Switzerland
Document type	Book ; Online
Note	Printed edition of the special issue published in "Journal of personalized medicine" ; Open Access
HBZ-ID	HT021592982
ISBN	978-3-0365-3220-2 ; 9783036532219 ; 3-0365-3220-X ; 3036532218
DOI	10.3390/books978-3-0365-3220-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Human hepatitis B viral e antigen and its precursor P20 inhibit T lymphocyte proliferation.

Purvina, Maija / Hoste, Astrid / Rossignol, Jean-Michel / Lagaudrière-Gesbert, Cécile

Biochemical and biophysical research communications

2012 Volume 417, Issue 4, Page(s) 1310–1315

Abstract: The hepatitis B virus (HBV) Precore protein is processed through the secretory pathway directly as HBeAg or with the generation of an intermediate (P20). Precore gene has been shown to be implicated in viral persistence, but the functions of HBeAg and ... ...

Abstract	The hepatitis B virus (HBV) Precore protein is processed through the secretory pathway directly as HBeAg or with the generation of an intermediate (P20). Precore gene has been shown to be implicated in viral persistence, but the functions of HBeAg and its precursors have not been fully elucidated. We show that the secreted proteins HBeAg and P20 interact with T cell surface and alter Kit-225 and primary T cells proliferation, a process which may facilitate the establishment of HBV persistence. Our data indicate that the N-terminal end of Precore is important for these inhibitory effects and exclude that they are dependent on the association of HBeAg and P20 with two characterized cell surface ligands, the Interleukin-1 Receptor Accessory Protein and gC1qR (present study).
MeSH term(s)	Amino Acid Sequence ; Carrier Proteins/immunology ; Cell Proliferation ; Cells, Cultured ; Hepatitis B e Antigens/chemistry ; Hepatitis B e Antigens/genetics ; Hepatitis B e Antigens/immunology ; Hepatitis B virus/immunology ; Humans ; Interleukin-1 Receptor Accessory Protein/immunology ; Lymphocyte Activation ; Mitochondrial Proteins/immunology ; Molecular Sequence Data ; T-Lymphocytes/immunology ; T-Lymphocytes/virology
Chemical Substances	C1QBP protein, human ; Carrier Proteins ; Hepatitis B e Antigens ; Interleukin-1 Receptor Accessory Protein ; Mitochondrial Proteins
Language	English
Publishing date	2012-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2011.12.138
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Article ; Online: Mortalité maternelle et prise en charge par les services d’urgence en France 2016–2018.

Rossignol, Mathias / Verspyck, Éric / Jonard, Marie

Gynecologie, obstetrique, fertilite & senologie

2024 Volume 52, Issue 4, Page(s) 288–295

Abstract: In France, 272 maternal deaths occurred during the period 2016-2018, of which 131 were initially treated by healthcare professionals not specialized in obstetric. Fifty-six files were excluded because they did not concern emergency services or because ... ...

Title translation	Maternal deaths and management by emergency departments in France 2016-2018.
Abstract	In France, 272 maternal deaths occurred during the period 2016-2018, of which 131 were initially treated by healthcare professionals not specialized in obstetric. Fifty-six files were excluded because they did not concern emergency services or because there was insufficient data to allow analysis. Seventy-five cases of maternal deaths initially treated by emergency services (in-hospital emergency department [ED] or emergency medical ambulance [SAMU]) were analyzed. Fifty-six cases were treated by the SAMU and 22 by an ED (both in 3 cases). The causes of death were 20 cardiovascular events, 18 pulmonary embolisms, 9 neurological failures and 8 hemorrhagic shocks. The event occurred during pregnancy in 48 cases (64%) and during per or postpartum period in 27 cases (36%). The motivations for consultation at the ED were mainly pain (n=9), respiratory distress (n=6) or faintness (n=3). The reasons for calling emergency dispatching service (SAMU) were cardiorespiratory arrest in 32 cases (57%) and neurological failure (coma or status epilepticus) in 6 cases (11%). Among the 56 patients treated outside the hospital, 17 died on scene and 39 were transported to a resuscitation room (n=13), a specialized department (n=13), an obstetrics department (n=8) and less often in the ED (n=2). This was considered appropriate in 35 out of 39 cases (90%). Concerning the 75 files analyzed (ED and SAMU), death was considered unavoidable in 37 cases (49%) and potentially avoidable in 29 cases (38%) (maybe=23, probably=6). Avoidability could not be established in 9 cases. Among the 29 potentially avoidable deaths (38%), one of the criteria of avoidability concerned emergency services in 14 cases (ED=9, SAMU/SMUR=5, 18% of the files studied). ED's cares were considered optimal in 11 cases (50%) and non-optimal in 11 cases (50%). SAMU's cares were considered optimal in 45 cases (80%).
MeSH term(s)	Pregnancy ; Female ; Humans ; Maternal Death/etiology ; Emergency Medical Services ; Emergency Service, Hospital ; Hospitals ; France/epidemiology
Language	French
Publishing date	2024-02-17
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2024.02.008
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Article: Sodium polystyrene is unsafe and should not be prescribed for the treatment of hyperkalaemia:

Rossignol, Patrick / Pitt, Bertram

Clinical kidney journal

2023 Volume 16, Issue 8, Page(s) 1221–1225

Abstract: Old-generation' potassium (K) binders [i.e. sodium (SPS) and calcium polystyrene sulfonate] are ...

Abstract	'Old-generation' potassium (K) binders [i.e. sodium (SPS) and calcium polystyrene sulfonate] are widely used, but with substantial heterogeneity across countries to treat hyperkalaemia (HK). However, there are no randomized data to support their chronic use to manage HK, nor have they been shown to have a renin-angiotensin-aldosterone system inhibitor (RAASi)-enabling effect. These compounds have poor tolerability and an unpredictable onset of action and magnitude of K lowering. Furthermore, SPS may induce fluid overload, owing to the fact that it exchanges K for sodium. Its use has also been associated with colonic necrosis, as emphasized by a black box warning from the US Food and Drug Administration. In contrast, two new K binders, patiromer and sodium zirconium cyclosilicate, have been shown to be safe and well tolerated for chronic management of HK, thereby enabling RAASi optimization, as acknowledged by the latest international cardiorenal guidelines. In view of the lack of reliable evidence regarding the efficacy and safety of the old-generation K binders compared with the placebo-controlled randomized and real-word evidence demonstrating the safety, efficacy and RAASi-enabling effect of the new K binders, clinicians should now use these new K binders to treat HK (
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfad090
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Article ; Online: Mortalité maternelle par accident vasculaire cérébral en France 2016–2018.

Lepercq, Jacques / Rossignol, Mathias / Jonard, Marie

Gynecologie, obstetrique, fertilite & senologie

2024 Volume 52, Issue 4, Page(s) 259–262

Abstract: ... whose main cause was stroke represent 7.4% of all maternal deaths, i.e. a maternal mortality ratio (MMR) of 0 ...

Title translation	Maternal mortality by stroke in France 2016-2018.
Abstract	Between 2016 and 2018, twenty maternal deaths were associated with a stroke. The 20 deaths whose main cause was stroke represent 7.4% of all maternal deaths, i.e. a maternal mortality ratio (MMR) of 0.9 per 100,000 live births (95%CI 0.6-1.3). Among the 20 stroke deaths, it was hemorrhagic in 17 cases (85%), ischemic in 2 cases, and due to thrombophlebitis in 1 case. Stroke occurred during pregnancy in 8 women (40%) - one case before 12 weeks, 3 cases between 28 and 32 weeks, and 4 cases between 34 and 40 weeks; in 3 cases the stroke occurred intrapartum, and for the other 9 cases (45%) the stroke occurred postpartum between Day 1 and Day 15. Care was assessed as non-optimal in 10/19 (56%) of cases but mortality as possibly avoidable in 24% of cases (4/17 cases with conclusion established by the CNEMM) and not established in two cases. The potentially improvable elements identified were a delay in carrying out initial brain imaging in three cases (one case antepartum, two cases postpartum) and insufficient hemodynamic monitoring in intensive care in one case.
MeSH term(s)	Pregnancy ; Female ; Humans ; Maternal Mortality ; Maternal Death/etiology ; Postpartum Period ; Stroke ; France/epidemiology
Language	French
Publishing date	2024-02-17
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2024.02.019
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Article: Overexpression and purification of the hepatitis B e antigen precursor.

Lainé, Sébastien / Salhi, Samia / Rossignol, Jean-Michel

Journal of virological methods

2002 Volume 103, Issue 1, Page(s) 67–74

Abstract: Circumstantial evidence suggests that the secreted hepatitis B virus (HBV) e antigen (HBeAg) and/or ...

Abstract	Circumstantial evidence suggests that the secreted hepatitis B virus (HBV) e antigen (HBeAg) and/or its 22 kDa precursor (P22) have an essential role in the establishment of persistent infection. In order to identify cellular proteins that could interact with P22, large amounts of this protein are required to perform pull-down assays. A plasmid was constructed encoding a recombinant P22 with a Histidine-tag at its N-terminal extremity (P22r). The initial attempts to overexpress P22r in a conventional Escherichia coli strain failed, most likely due to the presence of rare AGA/AGG codon clusters in the 3' part of the gene. To overcome this difficulty, P22r was overexpressed in the Epicurian coli BL21-codonplus (DE3)-RIL strain, which possesses extra copies of the ArgU gene that encodes the tRNA(AGA/AGG). In this strain, P22r was overexpressed successfully and then purified in milligram quantities by metal affinity chromatography on Ni2+-chelated His-Bind resin. The purified recombinant protein P22r was able to interact with a cellular protein (P32), which had previously been shown to co-immunoprecipitate with native P22, indicating that at least some of the P22r molecules were folded correctly.
MeSH term(s)	Base Sequence ; Chromatography, Affinity ; Codon/genetics ; Escherichia coli ; Gene Expression Regulation, Bacterial ; Genetic Vectors/genetics ; Hepatitis B e Antigens/biosynthesis ; Hepatitis B e Antigens/genetics ; Hepatitis B e Antigens/isolation & purification ; Humans ; Molecular Sequence Data ; Protein Folding ; Protein Precursors/biosynthesis ; Protein Precursors/genetics ; Protein Precursors/isolation & purification ; RNA, Bacterial/genetics ; Recombinant Fusion Proteins/metabolism
Chemical Substances	Codon ; Hepatitis B e Antigens ; Protein Precursors ; RNA, Bacterial ; Recombinant Fusion Proteins
Language	English
Publishing date	2002-04-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/s0166-0934(02)00019-8
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Zs.A 1565: Show issues

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Article ; Online: Interneuron odyssey: molecular mechanisms of tangential migration.

Toudji, Ikram / Toumi, Asmaa / Chamberland, Émile / Rossignol, Elsa

Frontiers in neural circuits

2023 Volume 17, Page(s) 1256455

Abstract: Cortical GABAergic interneurons are critical components of neural networks. They provide local and long-range inhibition and help coordinate network activities involved in various brain functions, including signal processing, learning, memory and ... ...

Abstract	Cortical GABAergic interneurons are critical components of neural networks. They provide local and long-range inhibition and help coordinate network activities involved in various brain functions, including signal processing, learning, memory and adaptative responses. Disruption of cortical GABAergic interneuron migration thus induces profound deficits in neural network organization and function, and results in a variety of neurodevelopmental and neuropsychiatric disorders including epilepsy, intellectual disability, autism spectrum disorders and schizophrenia. It is thus of paramount importance to elucidate the specific mechanisms that govern the migration of interneurons to clarify some of the underlying disease mechanisms. GABAergic interneurons destined to populate the cortex arise from multipotent ventral progenitor cells located in the ganglionic eminences and pre-optic area. Post-mitotic interneurons exit their place of origin in the ventral forebrain and migrate dorsally using defined migratory streams to reach the cortical plate, which they enter through radial migration before dispersing to settle in their final laminar allocation. While migrating, cortical interneurons constantly change their morphology through the dynamic remodeling of actomyosin and microtubule cytoskeleton as they detect and integrate extracellular guidance cues generated by neuronal and non-neuronal sources distributed along their migratory routes. These processes ensure proper distribution of GABAergic interneurons across cortical areas and lamina, supporting the development of adequate network connectivity and brain function. This short review summarizes current knowledge on the cellular and molecular mechanisms controlling cortical GABAergic interneuron migration, with a focus on tangential migration, and addresses potential avenues for cell-based interneuron progenitor transplants in the treatment of neurodevelopmental disorders and epilepsy.
MeSH term(s)	Cerebral Cortex/physiology ; Neurogenesis ; Interneurons/physiology ; Cell Movement/physiology
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2452968-0
ISSN	1662-5110 ; 1662-5110
ISSN (online)	1662-5110
ISSN	1662-5110
DOI	10.3389/fncir.2023.1256455
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