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  1. Article: What’s in a colluvial deposit? Perspectives from archaeopedology

    Scherer, S / Deckers, K / Dietel, J / Fuchs, M / Henkner, J / Höpfer, B / Junge, A / Kandeler, E / Lehndorff, E / Leinweber, P / Lomax, J / Miera, J / Poll, C / Toffolo, M.B / Knopf, T / Scholten, T / Kühn, P

    Catena. 2021 Mar., v. 198

    2021  

    Abstract: Colluvial deposits are considered as sedimentary archives for the reconstruction of the sedimentation and climate history, past pedogenesis and phases of land use. However, the human contribution to the formation of colluvial deposits is mainly based on ... ...

    Abstract Colluvial deposits are considered as sedimentary archives for the reconstruction of the sedimentation and climate history, past pedogenesis and phases of land use. However, the human contribution to the formation of colluvial deposits is mainly based on assumptions derived from the local chronostratigraphy and archaeology. For this reason, there is often a substantial gap in the identification of specific land use practices that promoted prehistoric soil erosion and sedimentation processes.We use an archaeopedological multi-proxy approach on a multi-layered colluvial deposit (six colluvial horizons) at the prehistoric site of Fürstenberg (Southwest Germany) to gain detailed insights into the sedimentation history, past pedogenesis and land use practices since the Neolithic. Soil and geochemical analyses such as X-ray fluorescence (XRF), X-ray diffraction (XRD), pedogenic oxides, pH-value and calcium carbonate content support the chronostratigraphy based on ages from optically stimulated luminescence (OSL) and AMS ¹⁴C dating. Further, biogeochemical analyses of phytoliths, charcoal spectra, black carbon (BC), soil organic matter (SOM) composition by using pyrolysis-field ionization mass spectroscopy (Py-FIMS), urease activity, steroid biomarker and heavy metals (HM) are used as land use proxies.The OSL and ¹⁴C ages and the local archaeological record indicate six phases of colluvial deposition that occurred through five phases of land use comprising the Early to Younger Neolithic, the Urnfield to Hallstatt period, the Iron to Roman Age, the High Middle Ages, and the pre-modern period. The soil and geochemical proxies correlate with a phase of geomorphodynamic stability between the Early to Younger Neolithic and the Urnfield to Hallstatt period. The high abundance of grass morphotypes since the Neolithic and the increase of Juniperus since the Urnfield to Hallstatt period indicate a persistent anthropogenic impact on the vegetation. Considerable amounts of burned OM (up to 676 g BC kg⁻¹ SOC, also identified as thermally stabilized SOM compounds by Py-FIMS) in colluvial horizons provide information that fire clearing (e.g. slash-and-burn) was especially used to open and maintain the landscape until the Roman Age. The absence of phytolith species originating from cereals, the occurrence of Juniperus and the evidence from the analysis of urease activity and faecal biomarkers indicate that the slopes of the Fürstenberg were mainly used for livestock farming and wood procurement.Thus, the application of specific soil-biogeochemical proxies to colluvial deposits provide new information on the nature of past land use practices that caused the formation of colluvial deposits at that time. In general, archaeopedological multi-proxy analyses of colluvial deposits, integrating the local archaeological record, contributes to a refined understanding of how humans have shaped the landscape since the Neolithic.
    Keywords Juniperus ; X-radiation ; X-ray diffraction ; anthropogenic activities ; archaeology ; biomarkers ; calcium carbonate ; carbon ; catenas ; charcoal ; climate ; fluorescence ; grasses ; humans ; ionization ; land use ; landscapes ; livestock ; mass spectrometry ; morphs ; phytoliths ; soil ; soil erosion ; soil formation ; soil organic matter ; urease ; vegetation ; wood ; Germany
    Language English
    Dates of publication 2021-03
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 519608-5
    ISSN 1872-6887 ; 0008-7769 ; 0341-8162
    ISSN (online) 1872-6887 ; 0008-7769
    ISSN 0341-8162
    DOI 10.1016/j.catena.2020.105040
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Thiopeptide Defense by an Ant’s Bacterial Symbiont

    Chang, Preston T / Rao, Krithika / Longo, Lauren O / Lawton, Elisabeth S / Scherer, Georgia / Van Arnam, Ethan B

    Journal of natural products. 2020 Jan. 21, v. 83, no. 3

    2020  

    Abstract: ... previously identified in a biochemical screen but had no known ecological role. GE37468’s host-associated ...

    Abstract Fungus-growing ants and their microbial symbionts have emerged as a model system for understanding antibiotic deployment in an ecological context. Here we establish that bacterial symbionts of the ant Trachymyrmex septentrionalis antagonize their most likely competitors, other strains of ant-associated bacteria, using the thiopeptide antibiotic GE37468. Genomic analysis suggests that these symbionts acquired the GE37468 gene cluster from soil bacteria. This antibiotic, with known activity against human pathogens, was previously identified in a biochemical screen but had no known ecological role. GE37468’s host-associated defense role in this insect niche intriguingly parallels the function of similar thiopeptides in the human microbiome.
    Keywords Trachymyrmex septentrionalis ; animal pathogens ; antibiotics ; genomics ; humans ; insects ; microbiome ; models ; multigene family ; soil bacteria ; symbionts
    Language English
    Dates of publication 2020-0121
    Size p. 725-729.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b00897
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: S‐(3‐Hydroxypropyl)mercaptursäure (HPMA) : Biomonitoring Methods in German language, 2010

    Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Scherer, Gerhard / Urban, Michael

    2010  

    Institution Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
    Keywords Analyse in biologischem Material ; Analysenmethoden ; Bestimmung im Urin ; Biomonitoring-Methoden ; Biomonitoring Methods ; Biomarker ; Hochleistungsflüssigkeitschromatographie ; LC-MS/MS ; Metabolite ; Tandem-massenspektrometrische Detektion
    Language German
    Document type Article
    Note Lieferung: 19
    DOI 10.4126/FRL01-006455294
    Database Repository for Life Sciences

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  4. Article: S‐(3‐Hydroxypropyl)mercapturic acid (HPMA) : Biomonitoring Methods, 2010

    Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe / Scherer, Gerhard / Urban, Michael

    2010  

    Institution Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe
    Keywords Biomonitoring-Methoden ; Biomonitoring Methods ; LC-MS/MS ; analytical method ; analysis in biological materials ; biomarker ; determination in urine ; high performance liquid chromatography ; occupational monitoring ; metabolites ; tandem mass spectrometric detection
    Language English
    Document type Article
    Note Volume: 12
    DOI 10.4126/FRL01-006455296
    Database Repository for Life Sciences

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  5. Article ; Online: Change is Coming: Plan S From the Early Career Scientist Perspective.

    Borges, Nuno M / Kabanova, Anna / Scherer, Florian

    HemaSphere

    2020  Volume 4, Issue 6, Page(s) e500

    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Editorial
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Biodiversity Loss from Freshwater Use for China’s Electricity Generation

    Jin, Yi / Behrens, Paul / Tukker, Arnold / Scherer, Laura

    Environmental science & technology. 2022 Feb. 18, v. 56, no. 5

    2022  

    Abstract: ... we analyze the spatiotemporal freshwater biodiversity impacts of China’s electric power system and the driving factors ... in 2013 (13.6 Gm³). Meanwhile, the freshwater consumption factor of China’s electricity generation ...

    Abstract Electricity generation has two major, under-investigated impacts on freshwater biodiversity due to its water use: the consumption of freshwater and thermal emissions to freshwater. Here, we analyze the spatiotemporal freshwater biodiversity impacts of China’s electric power system and the driving factors for these impacts. We show that between 2008 and 2017, the freshwater consumption of electricity generation peaked in 2013 (13.6 Gm³). Meanwhile, the freshwater consumption factor of China’s electricity generation decreased from 3.2 to 2.0 L/kWh. However, due to increasing thermal emissions, the biodiversity loss via freshwater use increased from 1.1 × 10⁸ in 2008 to 1.6 × 10⁸ PDF m³ year. The overall biodiversity loss per unit of electricity generation decreased from 3.2 × 10–⁵ to 2.5 × 10–⁵ PDF m³ year/kWh. Biodiversity loss from thermal pollution is 60% higher than that driven by water consumption. Electricity transmission results in the shifting of biodiversity impacts across regions. The results show that 15% of total biodiversity loss was embedded in transmission networks. In terms of electrical power system drivers of biodiversity loss, the total generation was the main driving factor of the increase in loss (rather than shifts in generation type, for example). Our results indicate the necessity of assessing the biodiversity impacts of electricity generation and incorporating them into energy system planning.
    Keywords biodiversity ; electric power ; electricity ; electricity generation ; freshwater ; technology ; thermal pollution
    Language English
    Dates of publication 2022-0218
    Size p. 3277-3287.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1520-5851
    DOI 10.1021/acs.est.1c07155
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: BERA und VEMPs war’s das schon, oder geht noch mehr?

    Hecker, Dietmar / Scherer, Hans / Schönfeld, Uwe / Bozzato, Alessandro / Schick, Bernhard / Metzler, Patrick

    Nervenheilkunde

    2022  Volume 41, Issue 11, Page(s) 745–757

    Abstract: Gegenstand und Ziel: Computerbasierte Diagnosegeräte sind im klinischen Alltag allgegenwärtig und erweitern über die Möglichkeit einer komplexen Datenverarbeitung (z. B. Künstlichen Intelligenz) immer mehr unser Leben. Ist die Tumorforschung schon seit ... ...

    Abstract Gegenstand und Ziel: Computerbasierte Diagnosegeräte sind im klinischen Alltag allgegenwärtig und erweitern über die Möglichkeit einer komplexen Datenverarbeitung (z. B. Künstlichen Intelligenz) immer mehr unser Leben. Ist die Tumorforschung schon seit vielen Jahren dabei, Bilddaten elektronisch zu erfassen und zu verarbeiten, so erfolgt die Befundung akustisch evozierter Potenziale noch visuell auf gemittelten Daten.
    Material und Methoden: In einer Publikation haben die Autoren erstmals ein Verfahren beschrieben 7, womit es möglich ist, Single sweeps bei vestibulär evozierten myogene Potenzialen (VEMPs) zu erfassen und detailliert zu verarbeiten. Weiterhin wurde 2018 ein Patent eingereicht, womit Brainstem Evoked Response Audiometrie (BERA)-Daten über maschinelles Lernen ausgewertet werden können.
    Ergebnisse: Der neuartige Single-sweep-Algorithmus kann bei VEMP-Messungen noch weitere Parameter über neuronale Grundaktivität und Latenzrauschen erfassen. Mittels Künstlicher Intelligenz (KI) können Amplitudenwachstumsfunktionen von BERA-Daten automatisiert erhoben werden.
    Schlussfolgerungen: Single sweeps haben das Potenzial, automatisiert neue Merkmale zu erfassen und intelligent zu verarbeiten.
    Keywords Mittelwertfunktion ; BERA ; VEMPs ; Single sweeps ; Algorithmus ; maschinelles Lernen ; Averaging technique ; ABR ; VEMPs ; single sweeps ; algorithm ; machine learning
    Language German
    Publishing date 2022-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223503-6
    ISSN 2567-5788 ; 0722-1541
    ISSN (online) 2567-5788
    ISSN 0722-1541
    DOI 10.1055/a-1893-6992
    Database Thieme publisher's database

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  8. Article ; Online: “It’s way more than just writing a prescription”

    Elizabeth C. Saunders / Sarah K. Moore / Olivia Walsh / Stephen A. Metcalf / Alan J. Budney / Patricia Cavazos-Rehg / Emily Scherer / Lisa A. Marsch

    Addiction Science & Clinical Practice, Vol 16, Iss 1, Pp 1-

    A qualitative study of preferences for integrated versus non-integrated treatment models among individuals with opioid use disorder

    2021  Volume 16

    Abstract: Abstract Background Increasingly, treatment for opioid use disorder (OUD) is offered in integrated treatment models addressing both substance use and other health conditions within the same system. This often includes offering medications for OUD in ... ...

    Abstract Abstract Background Increasingly, treatment for opioid use disorder (OUD) is offered in integrated treatment models addressing both substance use and other health conditions within the same system. This often includes offering medications for OUD in general medical settings. It remains uncertain whether integrated OUD treatment models are preferred to non-integrated models, where treatment is provided within a distinct treatment system. This study aimed to explore preferences for integrated versus non-integrated treatment models among people with OUD and examine what factors may influence preferences. Methods This qualitative study recruited participants (n = 40) through Craigslist advertisements and flyers posted in treatment programs across the United States. Participants were 18 years of age or older and scored a two or higher on the heroin or opioid pain reliever sections of the Tobacco, Alcohol, Prescription Medications, and Other Substances (TAPS) Tool. Each participant completed a demographic survey and a telephone interview. The interviews were coded and content analyzed. Results While some participants preferred receiving OUD treatment from an integrated model in a general medical setting, the majority preferred non-integrated models. Some participants preferred integrated models in theory but expressed concerns about stigma and a lack of psychosocial services. Tradeoffs between integrated and non-integrated models were centered around patient values (desire for anonymity and personalization, fear of consequences), the characteristics of the provider and setting (convenience, perceived treatment effectiveness, access to services), and the patient-provider relationship (disclosure, trust, comfort, stigma). Conclusions Among this sample of primarily White adults, preferences for non-integrated versus integrated OUD treatment were mixed. Perceived benefits of integrated models included convenience, potential for treatment personalization, and opportunity to extend established relationships with medical ...
    Keywords Patient preference ; Opioid use disorder ; Treatment model ; Integrated treatment ; Medicine (General) ; R5-920 ; Social pathology. Social and public welfare. Criminology ; HV1-9960
    Subject code 150
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: U.S. state correlations between oral health metrics and Alzheimer's disease mortality, prevalence and subjective cognitive decline prevalence.

    Scherer, Rana X / Scherer, Warren J

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 20962

    Abstract: Given the association between periodontal disease (PdD) and Alzheimer's disease (AD), we examined correlations between states' age-adjusted AD mortality rates, AD prevalence, subjective cognitive decline (SCD) prevalence, and oral health data. Data ... ...

    Abstract Given the association between periodontal disease (PdD) and Alzheimer's disease (AD), we examined correlations between states' age-adjusted AD mortality rates, AD prevalence, subjective cognitive decline (SCD) prevalence, and oral health data. Data sources include the Centers for Disease Control and Prevention, scientific literature, and oral health rankings formulated by WalletHub.com and Toothbrush.org. Pearson (r) or Spearman (r
    MeSH term(s) Adult ; Alzheimer Disease/epidemiology ; Alzheimer Disease/mortality ; Cognitive Dysfunction/epidemiology ; Female ; Humans ; Male ; Oral Health ; Prevalence ; United States/epidemiology
    Language English
    Publishing date 2020-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-77937-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer’s disease phenotype in mice

    Nathaniel L. Gould / Gila R. Scherer / Silvia Carvalho / Khriesto Shurrush / Haneen Kayyal / Efrat Edry / Alina Elkobi / Orit David / Maria Foqara / Darshit Thakar / Tommaso Pavesi / Vijendra Sharma / Matthew Walker / Matthew Maitland / Orly Dym / Shira Albeck / Yoav Peleg / Nicolas Germain / Ilana Babaev /
    Haleli Sharir / Maya Lalzar / Boris Shklyar / Neta Hazut / Mohammad Khamaisy / Maxime Lévesque / Gilles Lajoie / Massimo Avoli / Gabriel Amitai / Bruce Lefker / Chakrapani Subramanyam / Brian Shilton / Haim Barr / Kobi Rosenblum

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 19

    Abstract: ... risk factor for cognitive decline and Alzheimer’s disease (AD). Recently, we identified and described ...

    Abstract Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer’s disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the brain, in which QR2 acts as a removable memory constraint and metabolic buffer within neurons. QR2 becomes overexpressed with age, and it is possibly a novel contributing factor to age-related metabolic stress and cognitive deficit. We found that, in human cells, genetic removal of QR2 produced a shift in the proteome opposing that found in AD brains while simultaneously reducing oxidative stress. We therefore created highly specific QR2 inhibitors (QR2is) to enable evaluation of chronic QR2 inhibition as a means to reduce biological age–related metabolic stress and cognitive decline. QR2is replicated results obtained by genetic removal of QR2, while local QR2i microinjection improved hippocampal and cortical-dependent learning in rats and mice. Continuous consumption of QR2is in drinking water improved cognition and reduced pathology in the brains of AD-model mice (5xFAD), with a noticeable between-sex effect on treatment duration. These results demonstrate the importance of QR2 activity and pathway function in the healthy and neurodegenerative brain and what we believe to be the great therapeutic potential of QR2is as first-in-class drugs.
    Keywords Neuroscience ; Medicine ; R
    Subject code 570
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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