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  1. Book: Risk factors for cerebrovascular disease and stroke

    Seshadri, Sudha / Debette, Stéphanie

    2016  

    Author's details ed. by Sudha Seshadri and Stéphanie Debette
    Keywords Cerebrovascular Disorders / etiology ; Stroke / epidemiology ; Cerebrovascular Disorders / genetics
    Language English
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018956849
    ISBN 978-0-19-989584-7 ; 0-19-989584-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1045 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Stroke Genetics, Genomics, and Precision Medicine.

    Debette, Stéphanie / Paré, Guillaume

    Stroke

    2024  

    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.044212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multiomic approaches to stroke: the beginning of a journey.

    Debette, Stéphanie / Chasman, Daniel I

    Nature reviews. Neurology

    2023  Volume 20, Issue 2, Page(s) 65–66

    MeSH term(s) Humans ; Multiomics ; Stroke/therapy
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-023-00908-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives.

    Debette, Stéphanie / Markus, Hugh S

    Circulation research

    2022  Volume 130, Issue 8, Page(s) 1095–1111

    Abstract: Stroke is the second leading cause of death worldwide and a complex, heterogeneous condition. In this review, we provide an overview of the current knowledge on monogenic and multifactorial forms of stroke, highlighting recent insight into the continuum ... ...

    Abstract Stroke is the second leading cause of death worldwide and a complex, heterogeneous condition. In this review, we provide an overview of the current knowledge on monogenic and multifactorial forms of stroke, highlighting recent insight into the continuum between these. We describe how, in recent years, large-scale genome-wide association studies have enabled major progress in deciphering the genetic basis for stroke and its subtypes, although more research is needed to interpret these findings. We cover the potential of stroke genetics to reveal novel pathophysiological processes underlying stroke, to accelerate the discovery of new therapeutic approaches, and to identify individuals in the population who are at high risk of stroke and could be targeted for tailored preventative interventions.
    MeSH term(s) Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Stroke/genetics ; Stroke/therapy
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.122.319950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Population Neuroscience of Development and Aging.

    Paus, Tomáš / Debette, Stephanie / Seshadri, Sudha

    Frontiers in systems neuroscience

    2022  Volume 16, Page(s) 897943

    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2022.897943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comment: Tackling shared genetic underpinnings of migraine and ischemic stroke.

    Debette, Stéphanie

    Neurology

    2015  Volume 84, Issue 21, Page(s) 2143

    MeSH term(s) Brain Ischemia/genetics ; Genome-Wide Association Study ; Humans ; Migraine with Aura/genetics ; Migraine without Aura/genetics ; Stroke/genetics
    Language English
    Publishing date 2015-05-26
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000001620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetics of common cerebral small vessel disease.

    Bordes, Constance / Sargurupremraj, Muralidharan / Mishra, Aniket / Debette, Stéphanie

    Nature reviews. Neurology

    2022  Volume 18, Issue 2, Page(s) 84–101

    Abstract: Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI but does not manifest as clinical stroke, is highly prevalent in the general ...

    Abstract Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI but does not manifest as clinical stroke, is highly prevalent in the general population, particularly with increasing age. Advances in technologies and collaborative work have led to substantial progress in the identification of common genetic variants that are associated with cSVD-related stroke (ischaemic and haemorrhagic) and MRI-defined covert cSVD. In this Review, we provide an overview of collaborative studies - mostly genome-wide association studies (GWAS) - that have identified >50 independent genetic loci associated with the risk of cSVD. We describe how these associations have provided novel insights into the biological mechanisms involved in cSVD, revealed patterns of shared genetic variation across cSVD traits, and shed new light on the continuum between rare, monogenic and common, multifactorial cSVD. We consider how GWAS summary statistics have been leveraged for Mendelian randomization studies to explore causal pathways in cSVD and provide genetic evidence for drug effects, and how the combination of findings from GWAS with gene expression resources and drug target databases has enabled identification of putative causal genes and provided proof-of-concept for drug repositioning potential. We also discuss opportunities for polygenic risk prediction, multi-ancestry approaches and integration with other omics data.
    MeSH term(s) Cerebral Small Vessel Diseases/complications ; Cerebral Small Vessel Diseases/genetics ; Genome-Wide Association Study ; Humans ; Magnetic Resonance Imaging ; Neuroimaging ; Stroke/complications
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-021-00592-8
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  8. Article ; Online: Extracellular matrix protein signature in cervical artery dissection: The key differentiator?

    Traenka, Christopher / Debette, Stéphanie

    Neurology

    2020  Volume 95, Issue 15, Page(s) 663–664

    MeSH term(s) Arteries ; Extracellular Matrix ; Extracellular Matrix Proteins ; Humans ; Vertebral Artery Dissection/diagnostic imaging
    Chemical Substances Extracellular Matrix Proteins
    Language English
    Publishing date 2020-09-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pathophysiology and risk factors of cervical artery dissection: what have we learnt from large hospital-based cohorts?

    Debette, Stéphanie

    Current opinion in neurology

    2014  Volume 27, Issue 1, Page(s) 20–28

    Abstract: Purpose of review: Cervical artery dissection (CeAD) is a major cause of ischemic stroke in young and middle-aged adults, although relatively uncommon in the community. Recent large collaborative projects have provided new insights into mechanisms and ... ...

    Abstract Purpose of review: Cervical artery dissection (CeAD) is a major cause of ischemic stroke in young and middle-aged adults, although relatively uncommon in the community. Recent large collaborative projects have provided new insights into mechanisms and risk factors of CeAD.
    Recent findings: Pathologic changes observed at the media-adventitia border in temporal arteries of CeAD patients suggest a predisposing arterial wall weakness. In large multicenter series of CeAD patients, compared to age-matched healthy controls and patients with an ischemic stroke of another cause, hypertension and migraine, especially without aura, were confirmed as risk factors for CeAD, in addition to cervical trauma and recent infection. Hypercholesterolemia and being overweight were shown to be inversely associated with CeAD. Differences in risk factor profile and structural features between carotid and vertebral dissection suggest that their pathophysiology may partly differ. An association of CeAD with fibromuscular dysplasia and reversible cerebral vasoconstriction syndrome was described. Genetic risk factors of CeAD are still poorly understood.
    Summary: Large cohorts of CeAD patients have refined our understanding of the pathophysiology and risk factors of CeAD, but the molecular mechanisms are still poorly understood. Ongoing high-throughput genetic projects will hopefully provide novel insight into the biological substrate of CeAD.
    MeSH term(s) Cohort Studies ; Environment ; Hospitals/statistics & numerical data ; Humans ; Hypertension/complications ; Migraine Disorders/complications ; Risk Factors ; Stroke/complications ; Vertebral Artery Dissection/epidemiology ; Vertebral Artery Dissection/etiology ; Vertebral Artery Dissection/genetics
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Early detection of white matter hyperintensities using SHIVA-WMH detector.

    Tsuchida, Ami / Boutinaud, Philippe / Verrecchia, Violaine / Tzourio, Christophe / Debette, Stéphanie / Joliot, Marc

    Human brain mapping

    2023  Volume 45, Issue 1, Page(s) e26548

    Abstract: White matter hyperintensities (WMHs) are well-established markers of cerebral small vessel disease, and are associated with an increased risk of stroke, dementia, and mortality. Although their prevalence increases with age, small and punctate WMHs have ... ...

    Abstract White matter hyperintensities (WMHs) are well-established markers of cerebral small vessel disease, and are associated with an increased risk of stroke, dementia, and mortality. Although their prevalence increases with age, small and punctate WMHs have been reported with surprisingly high frequency even in young, neurologically asymptomatic adults. However, most automated methods to segment WMH published to date are not optimized for detecting small and sparse WMH. Here we present the SHIVA-WMH tool, a deep-learning (DL)-based automatic WMH segmentation tool that has been trained with manual segmentations of WMH in a wide range of WMH severity. We show that it is able to detect WMH with high efficiency in subjects with only small punctate WMH as well as in subjects with large WMHs (i.e., with confluency) in evaluation datasets from three distinct databases: magnetic resonance imaging-Share consisting of young university students, MICCAI 2017 WMH challenge dataset consisting of older patients from memory clinics, and UK Biobank with community-dwelling middle-aged and older adults. Across these three cohorts with a wide-ranging WMH load, our tool achieved voxel-level and individual lesion cluster-level Dice scores of 0.66 and 0.71, respectively, which were higher than for three reference tools tested: the lesion prediction algorithm implemented in the lesion segmentation toolbox (LPA: Schmidt), PGS tool, a DL-based algorithm and the current winner of the MICCAI 2017 WMH challenge (Park et al.), and HyperMapper tool (Mojiri Forooshani et al.), another DL-based method with high reported performance in subjects with mild WMH burden. Our tool is publicly and openly available to the research community to facilitate investigations of WMH across a wide range of severity in other cohorts, and to contribute to our understanding of the emergence and progression of WMH.
    MeSH term(s) Middle Aged ; Humans ; Aged ; White Matter/diagnostic imaging ; White Matter/pathology ; Stroke/pathology ; Algorithms ; Magnetic Resonance Imaging/methods ; Cerebral Small Vessel Diseases/pathology
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.26548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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