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  1. Article ; Online: Dietary cystine restriction increases the proliferative capacity of the small intestine of mice.

    de Jong, Judith C W / van Rooijen, Kristel S / Stigter, Edwin C A / Gülersönmez, M Can / de Zoete, Marcel R / Top, Janetta / Baars, Matthijs J D / Vercoulen, Yvonne / Kuipers, Folkert / van Mil, Saskia W C / Ijssennagger, Noortje

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0290493

    Abstract: Currently, over 88 million people are estimated to have adopted a vegan or vegetarian diet. Cysteine is a semi-essential amino acid, which availability is largely dependent on dietary intake of meat, eggs and whole grains. Vegan/vegetarian diets are ... ...

    Abstract Currently, over 88 million people are estimated to have adopted a vegan or vegetarian diet. Cysteine is a semi-essential amino acid, which availability is largely dependent on dietary intake of meat, eggs and whole grains. Vegan/vegetarian diets are therefore inherently low in cysteine. Sufficient uptake of cysteine is crucial, as it serves as substrate for protein synthesis and can be converted to taurine and glutathione. We found earlier that intermolecular cystine bridges are essential for the barrier function of the intestinal mucus layer. Therefore, we now investigate the effect of low dietary cystine on the intestine. Mice (8/group) received a high fat diet with a normal or low cystine concentration for 2 weeks. We observed no changes in plasma methionine, cysteine, taurine or glutathione levels or bile acid conjugation after 2 weeks of low cystine feeding. In the colon, dietary cystine restriction results in an increase in goblet cell numbers, and a borderline significant increase mucus layer thickness. Gut microbiome composition and expression of stem cell markers did not change on the low cystine diet. Remarkably, stem cell markers, as well as the proliferation marker Ki67, were increased upon cystine restriction in the small intestine. In line with this, gene set enrichment analysis indicated enrichment of Wnt signaling in the small intestine of mice on the low cystine diet, indicative of increased epithelial proliferation. In conclusion, 2 weeks of cystine restriction did not result in apparent systemic effects, but the low cystine diet increased the proliferative capacity specifically of the small intestine and induced the number of goblet cells in the colon.
    MeSH term(s) Humans ; Animals ; Mice ; Cystine ; Cysteine ; Intestine, Small ; Glutathione ; Taurine
    Chemical Substances Cystine (48TCX9A1VT) ; Cysteine (K848JZ4886) ; Glutathione (GAN16C9B8O) ; Taurine (1EQV5MLY3D)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290493
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  2. Article ; Online: Associations between the urban environment and psychotic experiences in adolescents.

    Bouter, D C / Ravensbergen, S J / Lakerveld, J / Hoogendijk, W J G / Grootendorst-van Mil, N H

    Schizophrenia research

    2023  Volume 260, Page(s) 123–131

    Abstract: Objective: In 2050 two-thirds of the world's population is predicted to live in cities, which asks for a better understanding of how the urban environment affects mental health. Urbanicity has repeatedly been found to be a risk factor, in particular for ...

    Abstract Objective: In 2050 two-thirds of the world's population is predicted to live in cities, which asks for a better understanding of how the urban environment affects mental health. Urbanicity has repeatedly been found to be a risk factor, in particular for psychosis. Here, we explored what factors of the urban exposome underlie the association between urban characteristics and psychotic experiences (PE) in adolescents.
    Methods: Participants were 815 adolescents (mean age 14.84 years, SD 0.78) from an at-risk cohort (greater Rotterdam area, the Netherlands) oversampled on their self-reported emotional and behavioral problems. We used linear regression analysis to examine the association with detailed geodata on urbanicity (surrounding address density), green space density (high and low vegetation), and mixed noise levels (road, rail, air, industry, and wind power) with PE in adolescents. Analyses were adjusted for multiple socio-economic and parental confounders. Furthermore, we explored sex-interaction effects.
    Results: Higher surrounding address density and low greenspace density were each independently associated with more PE (B = 0.18, 95 % CI 0.02; 0.34 and B = 0.17, 95 % CI 0.01; 0.32, respectively). High mixed noise levels were only associated with more PE in boys (B = 0.23, 95 % CI 0.01; 0.46). A sex-interaction effect was found for high urbanicity (B = -0.46, 95 % CI -0.77; -0.14) and low greenspace density (B = -0.49, 95 % CI -0.73; -0.11), illustrating that these associations with PE were specific for boys.
    Conclusion: Multiple characteristics of living in an urban area are associated with more PE in adolescent boys. Our observations provide leads for prevention of mental health problems via urban designing.
    MeSH term(s) Male ; Humans ; Adolescent ; Psychotic Disorders/epidemiology ; Psychotic Disorders/etiology ; Cities ; Urban Population ; Risk Factors ; Regression Analysis
    Language English
    Publishing date 2023-08-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2023.08.016
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  3. Article ; Online: Dietary cystine restriction increases the proliferative capacity of the small intestine of mice.

    Judith C W de Jong / Kristel S van Rooijen / Edwin C A Stigter / M Can Gülersönmez / Marcel R de Zoete / Janetta Top / Matthijs J D Baars / Yvonne Vercoulen / Folkert Kuipers / Saskia W C van Mil / Noortje Ijssennagger

    PLoS ONE, Vol 19, Iss 1, p e

    2024  Volume 0290493

    Abstract: Currently, over 88 million people are estimated to have adopted a vegan or vegetarian diet. Cysteine is a semi-essential amino acid, which availability is largely dependent on dietary intake of meat, eggs and whole grains. Vegan/vegetarian diets are ... ...

    Abstract Currently, over 88 million people are estimated to have adopted a vegan or vegetarian diet. Cysteine is a semi-essential amino acid, which availability is largely dependent on dietary intake of meat, eggs and whole grains. Vegan/vegetarian diets are therefore inherently low in cysteine. Sufficient uptake of cysteine is crucial, as it serves as substrate for protein synthesis and can be converted to taurine and glutathione. We found earlier that intermolecular cystine bridges are essential for the barrier function of the intestinal mucus layer. Therefore, we now investigate the effect of low dietary cystine on the intestine. Mice (8/group) received a high fat diet with a normal or low cystine concentration for 2 weeks. We observed no changes in plasma methionine, cysteine, taurine or glutathione levels or bile acid conjugation after 2 weeks of low cystine feeding. In the colon, dietary cystine restriction results in an increase in goblet cell numbers, and a borderline significant increase mucus layer thickness. Gut microbiome composition and expression of stem cell markers did not change on the low cystine diet. Remarkably, stem cell markers, as well as the proliferation marker Ki67, were increased upon cystine restriction in the small intestine. In line with this, gene set enrichment analysis indicated enrichment of Wnt signaling in the small intestine of mice on the low cystine diet, indicative of increased epithelial proliferation. In conclusion, 2 weeks of cystine restriction did not result in apparent systemic effects, but the low cystine diet increased the proliferative capacity specifically of the small intestine and induced the number of goblet cells in the colon.
    Keywords Medicine ; R ; Science ; Q
    Subject code 500
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A longitudinal study of mental health in at-risk adolescents before and during the COVID-19 pandemic.

    Bouter, D C / Zarchev, M / de Neve-Enthoven, N G M / Ravensbergen, S J / Kamperman, A M / Hoogendijk, W J G / Grootendorst-van Mil, N H

    European child & adolescent psychiatry

    2022  Volume 32, Issue 6, Page(s) 1109–1117

    Abstract: Although cross-sectional studies have shown that the COVID-19 pandemic has negatively affected the mental health of adolescents, the effect of the pandemic on adolescents with pre-pandemic symptoms is unclear. We, therefore, tested the hypothesis that ... ...

    Abstract Although cross-sectional studies have shown that the COVID-19 pandemic has negatively affected the mental health of adolescents, the effect of the pandemic on adolescents with pre-pandemic symptoms is unclear. We, therefore, tested the hypothesis that adolescents had increased emotional and behavioral problems during the lockdowns imposed during the pandemic.This study included three measurements in a prospective cohort of 1022 adolescents who were oversampled based on their high risk of developing psychopathology. Before the pandemic, we assessed depressive, anxiety, stress, oppositional defiant problems, psychotic experiences and suicidality, using the Youth Self-Report; 445 and 333 of these 1,022 adolescents subsequently completed the online questionnaire in the first lockdown (in April 2020) and in the second lockdown (in January 2021), respectively. Multilevel random intercept regression models were used to determine the change in psychiatric symptoms, including an interaction term to assess whether these changes differed based on the severity of symptoms prior to the pandemic. Throughout the pandemic, the majority of the participating adolescents reported having emotional and behavioral symptoms that were within the normal range. Moreover, the mean symptom scores for all six outcomes decreased significantly among adolescents with high clinical severity prior to the pandemic.In contrast to our original hypothesis, the effects of the COVID-19 pandemic may not necessarily be detrimental, at least among a specific subgroup of adolescents with pre-existing mental health problems. Moreover, our finding that most adolescents in this at-risk sample did not report experiencing clinically relevant symptoms during the pandemic reflects their resilience during the pandemic.
    MeSH term(s) Adolescent ; Humans ; Mental Health ; COVID-19 ; Pandemics ; Cross-Sectional Studies ; Longitudinal Studies ; Prospective Studies ; Communicable Disease Control
    Language English
    Publishing date 2022-02-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-021-01935-y
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  5. Article ; Online: Niet-alcoholische leververvetting.

    Tushuizen, M E / Holleboom, A G / Koot, B G P / Blokzijl, H / van Mil, S W C / Koek, G H

    Nederlands tijdschrift voor geneeskunde

    2020  Volume 164

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of fatty liver disease. NAFLD is defined as the presence of fatty liver disease observed in imaging or histopathological examinations when there is no secondary cause such as excessive ... ...

    Title translation Non-alcoholic fatty liver disease; a full-bodied epidemic.
    Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common cause of fatty liver disease. NAFLD is defined as the presence of fatty liver disease observed in imaging or histopathological examinations when there is no secondary cause such as excessive alcohol use or use of certain medications. NAFLD encompasses a whole spectrum, from simple steatosis to steatohepatitis ('non-alcoholic steatohepatitis', NASH), fibrosis and - ultimately - cirrhosis and hepatocellular carcinoma. Several factors play a role in the complex pathogenesis of NAFLD such as genetic predisposition, overweight, insulin resistance, inflammation, bile salts, gut microbiome and nutrition. Patients with NAFLD have an increased risk of developing type 2 diabetes mellitus, cardiovascular disease and malignancies such as hepatocellular carcinoma. To date, no medicines have been authorised for the treatment of NAFLD. The cornerstone of NAFLD treatment is lifestyle adjustment aimed at weight reduction.
    MeSH term(s) Body Weight ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/epidemiology ; Cardiovascular Diseases/complications ; Diabetes Mellitus, Type 2/complications ; Health Promotion ; Humans ; Inflammation/complications ; Insulin Resistance ; Life Style ; Liver/physiopathology ; Liver Cirrhosis/complications ; Liver Neoplasms/complications ; Liver Neoplasms/diagnosis ; Liver Neoplasms/epidemiology ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/epidemiology ; Weight Loss
    Language Dutch
    Publishing date 2020-02-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  6. Article ; Online: Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry.

    Gilbert, Myrthe S / Ijssennagger, Noortje / Kies, Arie K / van Mil, Saskia W C

    American journal of physiology. Gastrointestinal and liver physiology

    2018  Volume 315, Issue 2, Page(s) G159–G170

    Abstract: The amount of dietary protein is associated with intestinal disease in different vertebrate species. In humans, this is exemplified by the association between high-protein intake and fermentation metabolite concentrations in patients with inflammatory ... ...

    Abstract The amount of dietary protein is associated with intestinal disease in different vertebrate species. In humans, this is exemplified by the association between high-protein intake and fermentation metabolite concentrations in patients with inflammatory bowel disease. In production animals, dietary protein intake is associated with postweaning diarrhea in piglets and with the occurrence of wet litter in poultry. The underlying mechanisms by which dietary protein contributes to intestinal problems remain largely unknown. Fermentation of undigested protein in the hindgut results in formation of fermentation products including short-chain fatty acids, branched-chain fatty acids, ammonia, phenolic and indolic compounds, biogenic amines, hydrogen sulfide, and nitric oxide. Here, we review the mechanisms by which these metabolites may cause intestinal disease. Studies addressing how different metabolites induce epithelial damage rely mainly on cell culture studies and occasionally on mice or rat models. Often, contrasting results were reported. The direct relevance of such studies for human, pig, and poultry gut health is therefore questionable and does not suffice for the development of interventions to improve gut health. We discuss a roadmap to improve our understanding of gut metabolites and microbial species associated with intestinal health in humans and production animals and to determine whether these metabolite/bacterial networks cause epithelial damage. The outcomes of these studies will dictate proof-of-principle studies to eliminate specific metabolites and or bacterial strains and will provide the basis for interventions aiming to improve gut health.
    MeSH term(s) Animals ; Birds ; Dietary Carbohydrates/metabolism ; Dietary Proteins/metabolism ; Fermentation ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/physiopathology ; Humans ; Intestinal Diseases/metabolism ; Intestinal Diseases/physiopathology ; Swine
    Chemical Substances Dietary Carbohydrates ; Dietary Proteins
    Language English
    Publishing date 2018-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00319.2017
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  7. Article ; Online: Ablation of liver

    Ijssennagger, Noortje / van Rooijen, Kristel S / Magnúsdóttir, Stefanía / Ramos Pittol, José M / Willemsen, Ellen C L / de Zoete, Marcel R / Baars, Matthijs J D / Stege, Paul B / Colliva, Carolina / Pellicciari, Roberto / Youssef, Sameh A / de Bruin, Alain / Vercoulen, Yvonne / Kuipers, Folkert / van Mil, Saskia W C

    JHEP reports : innovation in hepatology

    2021  Volume 3, Issue 5, Page(s) 100344

    Abstract: Background & aims: The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from the liver into the intestine, interact with the microbiome, and upon ... ...

    Abstract Background & aims: The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from the liver into the intestine, interact with the microbiome, and upon absorption reach back to the liver. The bile acid-activated farnesoid X receptor (
    Methods: Fxr floxed/floxed mice were crossed with cre-expressing mice to yield
    Results: Despite relatively small changes in biliary bile acid concentration and composition, more genes were differentially expressed in the colons of
    Conclusions: Targeting of
    Lay summary: This study shows that the communication of the liver to the intestine is crucial for intestinal health. Bile acids are key players in this liver-to-gut communication, and when
    Language English
    Publishing date 2021-08-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2021.100344
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  8. Article: The arrhythmogenic cardiomyopathy phenotype associated with PKP2 c.1211dup variant.

    Bos, Thomas A / Piers, Sebastiaan R D / Wessels, Marja W / Houweling, Arjan C / Bökenkamp, Regina / Bootsma, Marianne / Bosman, Laurens P / Evertz, Reinder / Hellebrekers, Debby M E I / Hoedemaekers, Yvonne M / Knijnenburg, Jeroen / Lekanne Deprez, Ronald / van Mil, Anneke M / Te Riele, Anneline S J M / van Slegtenhorst, Marjon A / Wilde, Arthur A M / Yap, Sing-Chien / Dooijes, Dennis / Koopmann, Tamara T /
    van Tintelen, J Peter / Barge-Schaapveld, Daniela Q C M

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2023  Volume 31, Issue 7-8, Page(s) 315–323

    Abstract: ... associated with the variant c.1211dup (p.Val406Serfs*4) in the plakophilin‑2 gene (PKP2) and compare ... from medical records of 106 PKP2 c.1211dup heterozygous carriers. Using data from the Netherlands ACM Registry, c ... 1211dup was compared with 3 other truncating PKP2 variants (c.235C > T (p.Arg79*), c.397C > T (p.Gln133 ...

    Abstract Background: The arrhythmogenic cardiomyopathy (ACM) phenotype, with life-threatening ventricular arrhythmias and heart failure, varies according to genetic aetiology. We aimed to characterise the phenotype associated with the variant c.1211dup (p.Val406Serfs*4) in the plakophilin‑2 gene (PKP2) and compare it with previously reported Dutch PKP2 founder variants.
    Methods: Clinical data were collected retrospectively from medical records of 106 PKP2 c.1211dup heterozygous carriers. Using data from the Netherlands ACM Registry, c.1211dup was compared with 3 other truncating PKP2 variants (c.235C > T (p.Arg79*), c.397C > T (p.Gln133*) and c.2489+1G > A (p.?)).
    Results: Of the 106 carriers, 47 (44%) were diagnosed with ACM, at a mean age of 41 years. By the end of follow-up, 29 (27%) had experienced sustained ventricular arrhythmias and 12 (11%) had developed heart failure, with male carriers showing significantly higher risks than females on these endpoints (p < 0.05). Based on available cardiac magnetic resonance imaging and echocardiographic data, 46% of the carriers showed either right ventricular dilatation and/or dysfunction, whereas a substantial minority (37%) had some form of left ventricular involvement. Both geographical distribution of carriers and haplotype analysis suggested PKP2 c.1211dup to be a founder variant originating from the South-Western coast of the Netherlands. Finally, a Cox proportional hazards model suggested significant differences in ventricular arrhythmia-free survival between 4 PKP2 founder variants, including c.1211dup.
    Conclusions: The PKP2 c.1211dup variant is a Dutch founder variant associated with a typical right-dominant ACM phenotype, but also left ventricular involvement, and a possibly more severe phenotype than other Dutch PKP2 founder variants.
    Language English
    Publishing date 2023-07-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-023-01791-2
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    Zs.A 6216: Show issues Location:
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  9. Article ; Online: Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas.

    Martens, Anne W J / Rietveld, Joanne M / de Boer, Renate / Peters, Fleur S / Ngo, An / van Mil, Lotte W H G / de Heer, Koen / Spaargaren, Marcel / Verkleij, Christie P M / van de Donk, Niels W C J / Adams, Homer C / Eldering, Eric / van Noesel, Carel J M / Verona, Raluca / Kater, Arnon P

    Cancer research communications

    2022  Volume 2, Issue 5, Page(s) 330–341

    Abstract: T-cell redirecting bispecific antibodies hold high promise for treatment of B-cell malignancies. B-cell maturation antigen (BCMA) exhibits high expression on normal and malignant mature B cells including plasma cells, which can be enhanced by inhibition ... ...

    Abstract T-cell redirecting bispecific antibodies hold high promise for treatment of B-cell malignancies. B-cell maturation antigen (BCMA) exhibits high expression on normal and malignant mature B cells including plasma cells, which can be enhanced by inhibition of γ-secretase. BCMA is considered a validated target in multiple myeloma but whether mature B-cell lymphomas can be targeted by the BCMAxCD3 T-cell redirector teclistamab is currently unknown. BCMA expression on B-cell non-Hodgkin lymphoma and primary chronic lymphocytic leukemia (CLL) cells was assessed by flow cytometry and/or IHC. To assess teclistamab efficacy, cells were treated with teclistamab in presence of effector cells with/without γ-secretase inhibition. BCMA could be detected on all tested mature B-cell malignancy cell lines, while expression levels varied per tumor type. γ-secretase inhibition universally increased BCMA surface expression. These data were corroborated in primary samples from patients with Waldenstrom's macroglobulinemia, CLL, and diffuse large B-cell lymphoma. Functional studies with the B-cell lymphoma cell lines revealed teclistamab-mediated T-cell activation, proliferation, and cytotoxicity. This was independent of the level of BCMA expression, but generally lower in mature B-cell malignancies compared with multiple myeloma. Despite low BCMA levels, healthy donor T cells and CLL-derived T cells induced lysis of (autologous) CLL cells upon addition of teclistamab. These data show that BCMA is expressed on various B-cell malignancies and that lymphoma cell lines and primary CLL can be targeted using teclistamab. Further studies to understand the determinants of response to teclistamab are required to identify which other diseases might be suitable for teclistamab targeting.
    Significance: Besides reported BCMA expression on multiple myeloma, we demonstrate BCMA can be detected and enhanced using γ-secretase inhibition on cell lines and primary material of various B-cell malignancies. Furthermore, using CLL we demonstrate that low BCMA-expressing tumors can be targeted efficiently using the BCMAxCD3 DuoBody teclistamab.
    MeSH term(s) Humans ; Amyloid Precursor Protein Secretases ; Antibodies, Bispecific/pharmacology ; Antibodies, Bispecific/therapeutic use ; Antineoplastic Agents ; B-Cell Maturation Antigen ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Lymphoma, B-Cell/drug therapy ; Multiple Myeloma ; T-Lymphocytes
    Chemical Substances Amyloid Precursor Protein Secretases (EC 3.4.-) ; Antibodies, Bispecific ; Antineoplastic Agents ; B-Cell Maturation Antigen
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-22-0083
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  10. Article ; Online: Een neonaat met een interlabiale cyste.

    Kuipers, Bart C W / Jansen, Esther J S / van Mil, Edgar G A H

    Nederlands tijdschrift voor geneeskunde

    2015  Volume 159, Page(s) A8355

    Abstract: During a routine physical examination of a term, healthy neonate of Somalian origin we observed an anteriorly located interlabial yellow cyst with visible vascularisation on the outer surface. It caused lateralisation of the urinary meatus without ... ...

    Title translation A neonate with an interlabial cyst.
    Abstract During a routine physical examination of a term, healthy neonate of Somalian origin we observed an anteriorly located interlabial yellow cyst with visible vascularisation on the outer surface. It caused lateralisation of the urinary meatus without notable obstruction. A Skene's duct cyst, or paraurethral cyst, was clinically diagnosed with spontaneous regression. This is a self-limiting phenomenon of unknown origin that rarely requires surgical drainage in case of urinary obstruction.
    MeSH term(s) Cysts/diagnosis ; Female ; Humans ; Infant, Newborn ; Neovascularization, Pathologic ; Vaginal Diseases/diagnosis ; Vulva/pathology
    Language Dutch
    Publishing date 2015
    Publishing country Netherlands
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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