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  1. Article ; Online: Maternally Inherited Essential Hypertension: Adding Further Complexity to an Already Complex Condition.

    Delles, Christian

    American journal of hypertension

    2022  Volume 35, Issue 1, Page(s) 16–18

    MeSH term(s) DNA, Mitochondrial ; Essential Hypertension/diagnosis ; Essential Hypertension/genetics ; Humans ; Maternal Inheritance ; Pedigree
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpab133
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    Zs.A 2329: Show issues Location:
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  2. Article ; Online: Journal of Human Hypertension special issue on sex and gender differences in hypertension.

    Connelly, Paul J / Delles, Christian

    Journal of human hypertension

    2023  Volume 37, Issue 8, Page(s) 587–588

    MeSH term(s) Female ; Humans ; Male ; Hypertension/diagnosis ; Sex Factors
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-023-00847-5
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    Zs.A 2380: Show issues Location:
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  3. Article ; Online: Endothelin antagonists and the quest for a new therapeutic option in resistant hypertension.

    Dechend, Ralf / Delles, Christian

    Lancet (London, England)

    2022  Volume 400, Issue 10367, Page(s) 1900–1901

    MeSH term(s) Humans ; Endothelin Receptor Antagonists/therapeutic use ; Hypertension/drug therapy ; Antihypertensive Agents/therapeutic use
    Chemical Substances Endothelin Receptor Antagonists ; Antihypertensive Agents
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)02181-X
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    Zs.MG 94: Show issues

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  4. Article ; Online: Does Excess Tissue Sodium Storage Regulate Blood Pressure?

    Rossitto, Giacomo / Delles, Christian

    Current hypertension reports

    2022  Volume 24, Issue 5, Page(s) 115–122

    Abstract: Purpose of review: The regulation of blood pressure is conventionally conceptualised into the product of "circulating blood volume" and "vasoconstriction components". Over the last few years, however, demonstration of tissue sodium storage challenged ... ...

    Abstract Purpose of review: The regulation of blood pressure is conventionally conceptualised into the product of "circulating blood volume" and "vasoconstriction components". Over the last few years, however, demonstration of tissue sodium storage challenged this dichotomous view.
    Recent findings: We review the available evidence pertaining to this phenomenon and the early association made with blood pressure; we discuss open questions regarding its originally proposed hypertonic nature, recently challenged by the suggestion of a systemic, isotonic, water paralleled accumulation that mirrors absolute or relative extracellular volume expansion; we present the established and speculate on the putative implications of this extravascular sodium excess, in either volume-associated or -independent form, on blood pressure regulation; finally, we highlight the prevalence of high tissue sodium in cardiovascular, metabolic and inflammatory conditions other than hypertension. We conclude on approaches to reduce sodium excess and on the potential of emerging imaging technologies in hypertension and other conditions.
    MeSH term(s) Blood Pressure/physiology ; Blood Volume ; Humans ; Hypertension ; Sodium/metabolism ; Vasoconstriction
    Chemical Substances Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-022-01180-x
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    Zs.A 5522: Show issues Location:
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  5. Article ; Online: Impact of intentional weight loss in cardiometabolic disease: what we know about timing of benefits on differing outcomes?

    Sattar, Naveed / Deanfield, John / Delles, Christian

    Cardiovascular research

    2023  Volume 119, Issue 18, Page(s) e167–e171

    MeSH term(s) Humans ; Obesity/diagnosis ; Weight Loss ; Cardiovascular Diseases/diagnosis
    Language English
    Publishing date 2023-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac186
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    Zs.A 565: Show issues Location:
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  6. Article ; Online: Of Snails, Earthworms, and Men: Insights into Strategies to Preserve Water.

    Delles, Christian / Rossitto, Giacomo

    Function (Oxford, England)

    2021  Volume 3, Issue 1, Page(s) zqab071

    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Journal Article
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqab071
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  7. Article ; Online: Cardiovascular disease in transgender people: recent research and emerging evidence.

    Connelly, Paul J / Delles, Christian

    Cardiovascular research

    2021  Volume 117, Issue 14, Page(s) e174–e176

    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/therapy ; Cardiovascular System/physiopathology ; Female ; Health Services for Transgender Persons ; Humans ; Male ; Prognosis ; Risk Assessment ; Risk Factors ; Sex Characteristics ; Sex Factors ; Sex Reassignment Procedures/adverse effects ; Transgender Persons ; Transsexualism/epidemiology ; Transsexualism/physiopathology ; Transsexualism/therapy
    Language English
    Publishing date 2021-09-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab288
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    Zs.A 565: Show issues Location:
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  8. Article ; Online: Mechanisms of sodium-mediated injury in cardiovascular disease: old play, new scripts.

    Rossitto, Giacomo / Delles, Christian

    The FEBS journal

    2021  Volume 289, Issue 23, Page(s) 7260–7273

    Abstract: There is a strong association between salt intake and cardiovascular diseases, particularly hypertension, on the population level. The mechanisms that explain this association remain incompletely understood and appear to extend beyond blood pressure. In ... ...

    Abstract There is a strong association between salt intake and cardiovascular diseases, particularly hypertension, on the population level. The mechanisms that explain this association remain incompletely understood and appear to extend beyond blood pressure. In this review, we describe some of the 'novel' roles of Na
    MeSH term(s) Humans ; Sodium ; Cardiovascular Diseases/etiology
    Chemical Substances Sodium (9NEZ333N27)
    Language English
    Publishing date 2021-08-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16155
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    Zs.A 260: Show issues Location:
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  9. Article ; Online: Tackling cardiovascular healthcare disparities for LGBTQIA+ population: a call to action in the European Society of Cardiology.

    Kharlamov, Alexander / Sherriff, Nigel / Delles, Christian / van der Harst, Pim

    European heart journal

    2023  Volume 45, Issue 15, Page(s) 1291–1294

    MeSH term(s) Humans ; Healthcare Disparities ; Cardiology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Cardiovascular System ; Sexual and Gender Minorities
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad882
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  10. Article ; Online: Sex differences in the cardiovascular effects of GnRH analogues.

    Lim, Matthew W S / Lucas-Herald, Angela K / Mason, Avril / Delles, Christian / Connelly, Paul J

    The Journal of endocrinology

    2024  Volume 261, Issue 1

    Abstract: The integral role of the hypothalamic-pituitary-gonadal axis in reproductive processes makes it a prime therapeutic target. By inhibiting sex steroid synthesis, gonadotropin-releasing hormone (GnRH) analogues are used in the management of cancers, benign ...

    Abstract The integral role of the hypothalamic-pituitary-gonadal axis in reproductive processes makes it a prime therapeutic target. By inhibiting sex steroid synthesis, gonadotropin-releasing hormone (GnRH) analogues are used in the management of cancers, benign neoplasms, infertility and gender dysphoria. However, the wide application of these therapeutics raises concerns regarding the unintended effects upon the cardiovascular system. In males with prostate cancer, GnRH analogues when used as an androgen deprivation therapy appear to increase the risk of cardiovascular disease, which is the leading cause of death in this population. Therefore, due to the utilisation of GnRH analogues across the lifespan and gender spectrum, this relationship merits discussion. Existing data suggest an association between GnRH analogues and major adverse cardiovascular events in males. Conversely, females receiving GnRH analogues for breast cancer treatment appear to be at an increased risk of developing hypertension. In this narrative review, we describe the uses of GnRH analogues in adults, adolescents and children. We discuss whether sex plays a role in the cardiovascular effects of GnRH analogues and explore the significance of sex hormone receptors in the vasculature. We also consider confounding factors such as malignancy, advanced age and infertility.
    MeSH term(s) Adolescent ; Adult ; Child ; Humans ; Male ; Gonadotropin-Releasing Hormone/pharmacology ; Prostatic Neoplasms ; Sex Characteristics ; Androgen Antagonists/therapeutic use ; Gonadal Steroid Hormones ; Cardiovascular System ; Infertility/drug therapy
    Chemical Substances Gonadotropin-Releasing Hormone (33515-09-2) ; Androgen Antagonists ; Gonadal Steroid Hormones
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3028-4
    ISSN 1479-6805 ; 0022-0795
    ISSN (online) 1479-6805
    ISSN 0022-0795
    DOI 10.1530/JOE-23-0309
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