LIVIVO - Search results -

Search results

Result 1 - 10 of total 215

Search options

Article ; Online: Safflower (Carthamus tinctorius L.) crop adaptation to residual moisture stress

Manikanta, C / Pasala, R / Kaliamoorthy, S / Basavaraj, P S / Pandey, B B / Vadlamudi, D R / Nidamarty, M / Guhey, A / Kadirvel, P

conserved water use and canopy temperature modulation are better adaptive mechanisms

2023

Abstract: Oilseeds with high productivity and tolerance to various environmental stresses are in high demand in the food and industrial sectors. Safflower, grown under residual moisture in the semi-arid tropics, is adapted to moisture stress at certain levels. ... ...

Abstract	Oilseeds with high productivity and tolerance to various environmental stresses are in high demand in the food and industrial sectors. Safflower, grown under residual moisture in the semi-arid tropics, is adapted to moisture stress at certain levels. However, a substantial reduction in soil moisture has a significant impact on its productivity. Therefore, assessing genetic variation for water use efficiency traits like transpiration efficiency (TE), water uptake, and canopy temperature depression (CTD) is essential for enhancing crop adaptation to drought. The response of safflower genotypes (n = 12) to progressive soil moisture depletion was studied in terms of water uptake, TE, and CTD under a series of pot and field experiments. The normalised transpiration rate (NTR) in relation to the fraction of transpirable soil water (FTSW) varied significantly among genotypes. The genotypes A-1, Bhima, GMU-2347, and CO-1 had higher NTR-FTSW threshold values of 0.79 (R2 = 0.92), 0.74 (R2 = 0.96), 0.71 (R2 = 0.96), and 0.71 (R2 = 0.91), respectively, whereas GMU-2644 had the lowest 0.38 (R2 = 0.93). TE was high in genotype GMU-2347, indicating that it could produce maximum biomass per unit of water transpired. At both the vegetative and reproductive stages, significant positive relationships between TE, SPAD chlorophyll metre reading (SCMR) (p < 0.01) and CTD (p < 0.01) were observed under field conditions by linear regression. The genotypes with high FTSW-NTR thresholds, high SCMR, and low CTD may be useful clues in identifying a genotype’s ability to adapt to moisture stress. The findings showed that the safflower genotypes A-1, Bhima, GMU-2347, and CO-1 exhibited an early decline and regulated water uptake by conserving it for later growth stages under progressive soil water depletion.
Keywords	Agriculture ; Soil
Subject code	550
Language	English
Publishing date	2023-09-11
Publisher	PeerJ
Publishing country	in
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Safflower (Carthamus tinctorius L.) crop adaptation to residual moisture stress

Chennamsetti Manikanta / Ratnakumar Pasala / Sivasakthi Kaliamoorthy / P. S. Basavaraj / Brij Bihari Pandey / Dinesh Rahul Vadlamudi / Mukta Nidamarty / Arti Guhey / Palchamy Kadirvel

PeerJ, Vol 11, p e

conserved water use and canopy temperature modulation are better adaptive mechanisms

2023 Volume 15928

Abstract	Oilseeds with high productivity and tolerance to various environmental stresses are in high demand in the food and industrial sectors. Safflower, grown under residual moisture in the semi-arid tropics, is adapted to moisture stress at certain levels. However, a substantial reduction in soil moisture has a significant impact on its productivity. Therefore, assessing genetic variation for water use efficiency traits like transpiration efficiency (TE), water uptake, and canopy temperature depression (CTD) is essential for enhancing crop adaptation to drought. The response of safflower genotypes (n = 12) to progressive soil moisture depletion was studied in terms of water uptake, TE, and CTD under a series of pot and field experiments. The normalised transpiration rate (NTR) in relation to the fraction of transpirable soil water (FTSW) varied significantly among genotypes. The genotypes A-1, Bhima, GMU-2347, and CO-1 had higher NTR-FTSW threshold values of 0.79 (R2 = 0.92), 0.74 (R2 = 0.96), 0.71 (R2 = 0.96), and 0.71 (R2 = 0.91), respectively, whereas GMU-2644 had the lowest 0.38 (R2 = 0.93). TE was high in genotype GMU-2347, indicating that it could produce maximum biomass per unit of water transpired. At both the vegetative and reproductive stages, significant positive relationships between TE, SPAD chlorophyll metre reading (SCMR) (p < 0.01) and CTD (p < 0.01) were observed under field conditions by linear regression. The genotypes with high FTSW-NTR thresholds, high SCMR, and low CTD may be useful clues in identifying a genotype’s ability to adapt to moisture stress. The findings showed that the safflower genotypes A-1, Bhima, GMU-2347, and CO-1 exhibited an early decline and regulated water uptake by conserving it for later growth stages under progressive soil water depletion.
Keywords	Safflower ; Soil moisture depletion ; Transpiration efficiency ; Canopy temperature depression ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	550
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Characterization of rhizobia isolated from leguminous plants and their impact on the growth of ICCV 2 variety of chickpea (Cicer arietinum L.)

Mir, M I / Kumar, B K / Gopalakrishnan, S / Vadlamudi, S / Hameeda, B

2021

Abstract: Six rhizobia-like-bacterial strains in total, secluded from the root and stem nodules of various leguminous plants were characterized for growth promoting ability on ICCV 2 variety of chickpea. Bacterial strains showed production of IAA, NH3, siderophore, ...

Abstract	Six rhizobia-like-bacterial strains in total, secluded from the root and stem nodules of various leguminous plants were characterized for growth promoting ability on ICCV 2 variety of chickpea. Bacterial strains showed production of IAA, NH3, siderophore, HCN, ACC deaminase, hydrolytic enzyme production such as chitinase, amylase, protease, lipase, β-1, 3-glucanase and solubilization of nutrients such as phosphate, zinc and potassium. However the performance of PGP traits characterized in-vitro varied among the six bacterial strains. The sequences of 16S rRNA gene of bacterial strains IHSR, IHRG, IHAA, IHGN-3, IHCP-1 and IHCP-2 showed maximum identity with Rhizobium sp., Rhizobium tropici, Rhizobium multihospitium, Mesorhizobium sp., Burkholderia cepacia and Rhizobium pusense. In plate culture conditions the bacterial strains changed the colour of media (NFB) from green to blue and showed amplification of nifH gene by PCR, and also enhanced nodule formation in chickpea under greenhouse conditions, which explains their nitrogen fixing ability. Scanning electron microscopy studies of chickpea roots showed colonization by all the six bacterial strains in solo and by consortium (IHRG þ IHGN-3). Under greenhouse conditions, chickpea plants inoculated with different strains showed improvement in plant height, number of branches, total chlorophyll, nodule number, nodule weight, shoot weight, root weight, root volume and root surface area at 30 and 45 days after sowing (DAS) over the uninoculated control plants. It was also observed at the crop maturity stage all the bacterial strains inoculated separately enhanced pod number, seed number and total NPK compared to uninoculated control plants. This study suggests that bacteria associated with root and stem nodules can be a promising resource to enhance nodulation, PGP and crop yields in chickpea.
Keywords	Chickpea ; Legume Crops
Subject code	580
Language	English
Publisher	Elsevier
Publishing country	in
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Characterization of rhizobia isolated from leguminous plants and their impact on the growth of ICCV 2 variety of chickpea (Cicer arietinum L.)

Mohammad Imran Mir / B. Kiran Kumar / Subramaniam Gopalakrishnan / Srinivas Vadlamudi / Bee Hameeda

Heliyon, Vol 7, Iss 11, Pp e08321- (2021)

2021

Abstract	Six rhizobia-like-bacterial strains in total, secluded from the root and stem nodules of various leguminous plants were characterized for growth promoting ability on ICCV 2 variety of chickpea. Bacterial strains showed production of IAA, NH3, siderophore, HCN, ACC deaminase, hydrolytic enzyme production such as chitinase, amylase, protease, lipase, β-1, 3-glucanase and solubilization of nutrients such as phosphate, zinc and potassium. However the performance of PGP traits characterized in-vitro varied among the six bacterial strains. The sequences of 16S rRNA gene of bacterial strains IHSR, IHRG, IHAA, IHGN-3, IHCP-1 and IHCP-2 showed maximum identity with Rhizobium sp., Rhizobium tropici, Rhizobium multihospitium, Mesorhizobium sp., Burkholderia cepacia and Rhizobium pusense. In plate culture conditions the bacterial strains changed the colour of media (NFB) from green to blue and showed amplification of nifH gene by PCR, and also enhanced nodule formation in chickpea under greenhouse conditions, which explains their nitrogen fixing ability. Scanning electron microscopy studies of chickpea roots showed colonization by all the six bacterial strains in solo and by consortium (IHRG + IHGN-3). Under greenhouse conditions, chickpea plants inoculated with different strains showed improvement in plant height, number of branches, total chlorophyll, nodule number, nodule weight, shoot weight, root weight, root volume and root surface area at 30 and 45 days after sowing (DAS) over the uninoculated control plants. It was also observed at the crop maturity stage all the bacterial strains inoculated separately enhanced pod number, seed number and total NPK compared to uninoculated control plants. This study suggests that bacteria associated with root and stem nodules can be a promising resource to enhance nodulation, PGP and crop yields in chickpea.
Keywords	Root-stem nodules ; Rhizobium spp ; PGP traits ; 16S rRNA ; Chickpea ; SEM analysis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	580
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Characterization of rhizobia isolated from leguminous plants and their impact on the growth of ICCV 2 variety of chickpea (Cicer arietinum L.)

Mir, Mohammad Imran / Kumar, B. Kiran / Gopalakrishnan, Subramaniam / Vadlamudi, Srinivas / Hameeda, Bee

Heliyon. 2021 Nov., v. 7, no. 11

2021

Abstract	Six rhizobia-like-bacterial strains in total, secluded from the root and stem nodules of various leguminous plants were characterized for growth promoting ability on ICCV 2 variety of chickpea. Bacterial strains showed production of IAA, NH₃, siderophore, HCN, ACC deaminase, hydrolytic enzyme production such as chitinase, amylase, protease, lipase, β-1, 3-glucanase and solubilization of nutrients such as phosphate, zinc and potassium. However the performance of PGP traits characterized in-vitro varied among the six bacterial strains. The sequences of 16S rRNA gene of bacterial strains IHSR, IHRG, IHAA, IHGN-3, IHCP-1 and IHCP-2 showed maximum identity with Rhizobium sp., Rhizobium tropici, Rhizobium multihospitium, Mesorhizobium sp., Burkholderia cepacia and Rhizobium pusense. In plate culture conditions the bacterial strains changed the colour of media (NFB) from green to blue and showed amplification of nifH gene by PCR, and also enhanced nodule formation in chickpea under greenhouse conditions, which explains their nitrogen fixing ability. Scanning electron microscopy studies of chickpea roots showed colonization by all the six bacterial strains in solo and by consortium (IHRG + IHGN-3). Under greenhouse conditions, chickpea plants inoculated with different strains showed improvement in plant height, number of branches, total chlorophyll, nodule number, nodule weight, shoot weight, root weight, root volume and root surface area at 30 and 45 days after sowing (DAS) over the uninoculated control plants. It was also observed at the crop maturity stage all the bacterial strains inoculated separately enhanced pod number, seed number and total NPK compared to uninoculated control plants. This study suggests that bacteria associated with root and stem nodules can be a promising resource to enhance nodulation, PGP and crop yields in chickpea.
Keywords	1-aminocyclopropane-1-carboxylate deaminase ; Burkholderia cepacia ; Cicer arietinum ; Mesorhizobium ; Rhizobium tropici ; amylases ; carboxylic ester hydrolases ; chickpeas ; chitinase ; chlorophyll ; color ; genes ; greenhouses ; maturity stage ; nitrogen ; nodulation ; phosphates ; plant height ; potassium ; proteinases ; siderophores ; solubilization ; surface area ; zinc
Language	English
Dates of publication	2021-11
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e08321
Database	NAL-Catalogue (AGRICOLA)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: A developmental study on anther wall and pollen in Mangifera indica L. var. Beneshan (Anacardiaceae)

Muniraja, Mondam / Gujjula Vijayalakshmi / Mude Lakshmipathi Naik / Patan Shaik Sha Valli Khan / Vadlamudi Vijaya Bhaskar

SAAB South African journal of botany. 2018 Nov., v. 119

2018

Abstract: ... hermaphrodite flower buds of Mangifera indica L. var. Beneshan by combining light (LM), fluorescence (FM) and ...

Abstract	The Anacardiaceae is a well-recognized family consists of an economically important nut and fruit crops. In this family, the studies on both anther wall and pollen development are very limited. The present paper describes a comparative study on the development of both anther wall and pollen of male and hermaphrodite flower buds of Mangifera indica L. var. Beneshan by combining light (LM), fluorescence (FM) and transmission electron microscopy (TEM). Moreover, a description of the anatomy of the sterile staminodes of male flower buds also provided. Our study showed that the (1) anther wall contains two cell thick middle layers, (2) the presence of a secretory type tapetum, (3) tapetum cells contain large and uninucleate nucleus, (4) the presence of simultaneous cytokinesis (5) haploid microspores arranged in tetrahedral tetrads (6) the pollen grains shed at two-celled stage, (7) druse type calcium oxalate (CaOx) crystals were found in idioblast cells of anther connective tissue (8) both the anther wall and pollen developmental events in male and hermaphrodite flowers were found to be similar and (9) staminodes have failed to differentiate and form pollen grains. Overall, the study confirms the placement of M. indica in the tribe Anacardieae of Anacardiaceae and also provides information on correlation of the microspore development stage with flower bud and anther developmental stage for the establishment of in vitro culture for the production of doubled haploids in mango.
Keywords	buds ; calcium oxalate ; crystals ; cytokinesis ; doubled haploids ; flowers ; fluorescence ; fruit crops ; haploidy ; hermaphroditism ; in vitro culture ; males ; Mangifera indica ; mangoes ; microspores ; pollen ; transmission electron microscopy
Language	English
Dates of publication	2018-11
Size	p. 142-153.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2018.08.021
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Nitrogen fixation, plant growth and yield enhancements by diazotrophic growth-promoting bacteria in two cultivars of chickpea (Cicer arietinum L.)

Gopalakrishnan, Subramaniam / Srinivasan Samineni / Vadlamudi Srinivas

Biocatalysis and agricultural biotechnology. 2017 July, v. 11

2017

Abstract: A total of 11 rhizobia-like-bacteria, isolated from the nodules of chickpea, were characterized for nitrogen fixation potential and growth promoting ability. All the isolates nodulated chickpea, amplified nifH gene and fixed nitrogen but, four isolates ( ... ...

Abstract	A total of 11 rhizobia-like-bacteria, isolated from the nodules of chickpea, were characterized for nitrogen fixation potential and growth promoting ability. All the isolates nodulated chickpea, amplified nifH gene and fixed nitrogen but, four isolates (ICKM-9, ICKM-15, ICS-31 and ICS-32) were found to fix nitrogen more than 4.0 nmoles of ethyleneg−1 fresh weight of nodulesh−1. Under field conditions, seeds of chickpea varieties ICCV 2 and JG 11, when treated with the bacteria, enhanced the nodule number (up to 46% and 46%), nodule mass (up to 76% and 50%), shoot mass (up to 21% and 42%) and grain yield (up to 27% and 25%), respectively, over the un-inoculated control. At the harvest, organic carbon (up to 7% and 24%), total nitrogen (up to 11% and 19%) and available phosphorous (up to 14% and 29%) were found enhanced, respectively, in the rhizosphere of ICCV-2 and JG-11 treated with bacteria over the un-inoculated control. All the isolates produced plant growth-promoting traits including indole acetic acid, β-1,3-glucanase, hydro cyanic acid (except ICKM-17 and ICS-31) and siderophore (except ICS-31). The 16S rDNA gene sequences of bacterial isolates of ICKM-1, ICKM-4, ICKM-7, ICKM-9, ICKM-12, ICKM-14, ICKM-15, ICKM-17, ICS-30, ICS-31 and ICS-32 showed maximum identity with Pantoea dispersa, Chryseobacterium indologenes, Pseudomonas geniculata, Stenotrophomonas pavanii, P. geniculata, P. geniculata, Stenotrophomonas maltophilia, Chryseobacterium sp., P. geniculata, Chryseobacterium indologenes and Stenotrophomonas acidaminiphila, respectively. This study indicates nodule-associated bacteria could be a valuable pool for improving nitrogen fixation and crop yields in chickpea.
Keywords	beta-glucanase ; carbon ; chickpeas ; Chryseobacterium indologenes ; Cicer arietinum ; cultivars ; genes ; grain yield ; indole acetic acid ; nitrogen ; nitrogen content ; nitrogen fixation ; nucleotide sequences ; Pantoea dispersa ; phosphorus ; plant growth ; plant growth-promoting rhizobacteria ; Pseudomonas geniculata ; rhizosphere ; ribosomal DNA ; seeds ; siderophores ; Stenotrophomonas maltophilia
Language	English
Dates of publication	2017-07
Size	p. 116-123.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2642052-1
ISSN	1878-8181
ISSN	1878-8181
DOI	10.1016/j.bcab.2017.06.012
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Biological control of Botrytis cinerea and plant growth promotion potential by Penicillium citrinum in chickpea (Cicer arietinum L.)

Sreevidya, Meesala / Gopalakrishnan, Subramaniam / Melø, Torunn M / Simic, Nebojsa / Bruheim, Per / Sharma, Mamta / Srinivas, Vadlamudi / Alekhya, Gottumukkala

Biocontrol science and technology. 2015 July 3, v. 25, no. 7

2015

Abstract: A total of 48 fungi were characterised for their antagonistic potential against Botrytis cinerea causing Botrytis Gray Mold (BGM) disease in chickpea by dual culture and metabolite production assays. The culture filtrate of the most promising isolate, ... ...

Abstract	A total of 48 fungi were characterised for their antagonistic potential against Botrytis cinerea causing Botrytis Gray Mold (BGM) disease in chickpea by dual culture and metabolite production assays. The culture filtrate of the most promising isolate, VFI-51, was purified by various chromatographic techniques and identified as ‘citrinin’ by nuclear magnetic resonance and mass spectrometry studies. The efficacy of citrinin was demonstrated to control BGM in chickpea under greenhouse conditions. The sequences of 18S rDNA gene of the VFI-51 matched with Penicillium citrinum in BLAST analysis. The VFI-51 produced siderophore, hydrocyanic acid, indole-3-acetic acid, lipase, protease and β -1,3-glucanase; grew well in NaCl (up to 15%), at pH between 7 and 11 and temperatures between 20°C and 40°C; and was compatible with fungicides bavistin and thiram. Under greenhouse and field conditions, VFI-51 significantly enhanced the nodule number, nodule weight, root and shoot weight and stover and grain yield over the un-inoculated control. In the rhizosphere, VFI-51 also significantly enhanced total N, available P and OC over the un-inoculated control. Scanning electron microscopy analysis revealed that VFI-51 colonised on the roots of chickpea. This study concluded that VFI-51 has the potential for biocontrol of BGM and plant growth promotion in chickpea.
Keywords	Botrytis cinerea ; Cicer arietinum ; Penicillium citrinum ; biological control ; carbendazim ; chickpeas ; chromatography ; citrinin ; culture filtrates ; fungi ; genes ; grain yield ; gray mold ; greenhouses ; growth promotion ; hydrogen cyanide ; indole acetic acid ; mass spectrometry ; metabolites ; nuclear magnetic resonance spectroscopy ; pH ; plant growth ; proteinases ; rhizosphere ; ribosomal DNA ; roots ; scanning electron microscopy ; shoots ; siderophores ; sodium chloride ; stover ; temperature ; thiram
Language	English
Dates of publication	2015-0703
Size	p. 739-755.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1470651-9
ISSN	1360-0478 ; 0958-3157
ISSN (online)	1360-0478
ISSN	0958-3157
DOI	10.1080/09583157.2015.1010483
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Clinically significant changes in genes and variants associated with epilepsy over time: implications for re-analysis.

Robertson, Alan J / Tran, Khoa A / Bennett, Carmen / Sullivan, Clair / Stark, Zornitza / Vadlamudi, Lata / Waddell, Nicola

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7717

Abstract: Despite the significant advances in understanding the genetic architecture of epilepsy, many patients do not receive a molecular diagnosis after genomic testing. Re-analysing existing genomic data has emerged as a potent method to increase diagnostic ... ...

Abstract	Despite the significant advances in understanding the genetic architecture of epilepsy, many patients do not receive a molecular diagnosis after genomic testing. Re-analysing existing genomic data has emerged as a potent method to increase diagnostic yields-providing the benefits of genomic-enabled medicine to more individuals afflicted with a range of different conditions. The primary drivers for these new diagnoses are the discovery of novel gene-disease and variants-disease relationships; however, most decisions to trigger re-analysis are based on the passage of time rather than the accumulation of new knowledge. To explore how our understanding of a specific condition changes and how this impacts re-analysis of genomic data from epilepsy patients, we developed Vigelint. This approach combines the information from PanelApp and ClinVar to characterise how the clinically relevant genes and causative variants available to laboratories change over time, and this approach to five clinical-grade epilepsy panels. Applying the Vigelint pipeline to these panels revealed highly variable patterns in new, clinically relevant knowledge becoming publicly available. This variability indicates that a more dynamic approach to re-analysis may benefit the diagnosis and treatment of epilepsy patients. Moreover, this work suggests that Vigelint can provide empirical data to guide more nuanced, condition-specific approaches to re-analysis.
MeSH term(s)	Humans ; Epilepsy/diagnosis ; Epilepsy/genetics ; Genomics ; Genetic Testing
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57976-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Lacosamide and pregnancy: Data from spontaneous and solicited reports.

Perucca, Piero / Bourikas, Dimitrios / Voinescu, P Emanuela / Vadlamudi, Lata / Chellun, Daya / Kumke, Thomas / Werhahn, Konrad J / Schmitz, Bettina

Epilepsia

2024

Abstract: Objective: In pregnancy, it is important to balance the risks of uncontrolled epileptic seizures to the mother and fetus against the potential teratogenic effects of antiseizure medications. Data are limited on pregnancy outcomes among patients taking ... ...

Abstract	Objective: In pregnancy, it is important to balance the risks of uncontrolled epileptic seizures to the mother and fetus against the potential teratogenic effects of antiseizure medications. Data are limited on pregnancy outcomes among patients taking lacosamide (LCM), particularly when taken as monotherapy. The objective of this analysis was to evaluate the pregnancy outcomes of LCM-exposed pregnancies. Methods: This analysis included all reports in the UCB Pharma pharmacovigilance database of exposure to LCM during pregnancy from spontaneous sources (routine clinical settings) or solicited reports from interventional clinical studies and noninterventional postmarketing studies. Prospective and retrospective reports were analyzed separately. Results: At the data cutoff (August 31, 2021), there were 202 prospective pregnancy cases with maternal exposure to LCM and known outcomes. Among these cases, 44 (21.8%) patients received LCM monotherapy and 158 (78.2%) received LCM polytherapy. Most patients received LCM during the first trimester (LCM monotherapy: 39 [88.6%]; LCM polytherapy: 143 [90.5%]). From the prospective pregnancy cases with maternal LCM exposure, there were 204 reported outcomes (two twin pregnancies occurred in the polytherapy group). The proportion of live births was 84.1% (37/44) in patients who received LCM as monotherapy, and 76.3% (122/160) for LCM polytherapy. The overall proportion of abortions (for any reason) was 15.9% (7/44) with LCM monotherapy, and 22.5% (36/160) with LCM polytherapy. Congenital malformations were reported in 2.3% (1/44) of known pregnancy outcomes with maternal exposure to LCM monotherapy, and 6.9% (11/160) with polytherapy. Significance: Our preliminary data do not raise major concerns on the use of LCM during pregnancy. Most pregnancies with LCM exposure resulted in healthy live births, and no new safety issues were identified. These findings should be interpreted with caution, as additional data are needed to fully evaluate the safety profile of LCM in pregnancy.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17924
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 517: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 475: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito