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  1. Article: Artificially Edited Alleles of the Eukaryotic Translation Initiation Factor 4E1 Gene Differentially Reduce Susceptibility to Cucumber Mosaic Virus and Potato Virus Y in Tomato.

    Atarashi, Hiroki / Jayasinghe, Wikum Harshana / Kwon, Joon / Kim, Hangil / Taninaka, Yosuke / Igarashi, Manabu / Ito, Kotaro / Yamada, Tetsuya / Masuta, Chikara / Nakahara, Kenji S

    Frontiers in microbiology

    2020  Volume 11, Page(s) 564310

    Abstract: Eukaryotic translation initiation factors, including eIF4E, are susceptibility factors for viral infection in host plants. Mutation and double-stranded RNA-mediated silencing of ... ...

    Abstract Eukaryotic translation initiation factors, including eIF4E, are susceptibility factors for viral infection in host plants. Mutation and double-stranded RNA-mediated silencing of tomato
    Language English
    Publishing date 2020-12-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.564310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Fertility preservation in the pediatric and adolescent populations, volume II.

    Salama, Mahmoud / Jayasinghe, Yasmin

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1372225

    MeSH term(s) Humans ; Adolescent ; Child ; Fertility Preservation ; Neoplasms
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1372225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Fertility preservation in the pediatric population.

    Chattha, Asma J / Salama, Mahmoud / Jayasinghe, Yasmin

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1149532

    MeSH term(s) Child ; Humans ; Fertility Preservation
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1149532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Heavy menstrual bleeding and dysmenorrhea in adolescents: A systematic review of self-management strategies, quality of life, and unmet needs.

    Pouraliroudbaneh, Shiva / Marino, Jennifer / Riggs, Elisha / Saber, Ashraf / Jayasinghe, Yasmin / Peate, Michelle

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2024  

    Abstract: Background: Heavy menstrual bleeding (HMB) and dysmenorrhea (DM) are common gynecological problems.: Objective: To systematically review the needs, quality of life (QOL), and effectiveness of self-management strategies among young women (12-25 years) ...

    Abstract Background: Heavy menstrual bleeding (HMB) and dysmenorrhea (DM) are common gynecological problems.
    Objective: To systematically review the needs, quality of life (QOL), and effectiveness of self-management strategies among young women (12-25 years) with DM or HMB.
    Search strategy: Relevant terms were searched through PubMed, EBSCO, Google Scholar, ProQuest, and Ovid between 2010 and 2022.
    Selection criteria: Qualitative and quantitative studies published in peer-reviewed journals, females aged 12-25, exploring DM or HMB, reporting supportive care needs, quality of life, self-treatment strategies, and/or treatment-seeking behavior.
    Data collection and analysis: Abstracts were reviewed for eligibility by two researchers. Included studies were extracted and assessed for quality independently by two authors, with discrepancies resolved through consensus or the involvement of a third researcher. Data extracted included study details, menstrual history, symptoms, self-care strategies, and quality of life. The Joanna Briggs Institute checklists were used for quality assessment.
    Main results: The search returned 285 190 studies, of which 55 were eligible for inclusion. Prevalence rates of HMB and DM were in the ranges 4%-63% and 42%-94%, respectively. Over 80% of young women with DM and HMB experienced physical and psychological problems, including pelvic pain, sleep issues, mood disturbance, diarrhea, and nausea. Academic performance and daily activities were severely affected. Most (>62%) named their mothers as their primary source of information, and friends as the secondary source (10%-65%). Few studies explored needs, but they could be inferred and fell under school-related and social needs. QOL was poorer in those who had DM than those who did not. Pain was the most common issue that drove young women to find treatment. More than 70% used medication to reduce pain. More than half chose home remedies (e.g., heat therapy, massages, herbal tea, hot drinks). No studies provided information about the efficacy and dosage of medication and herbal remedies.
    Conclusions: HMB and DM have a large impact on daily living, with large areas of unmet need. Limited access to information impairs the management of symptoms and consequent QOL.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.15554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Highly shape- and size-tunable membrane nanopores made with DNA.

    Xing, Yongzheng / Dorey, Adam / Jayasinghe, Lakmal / Howorka, Stefan

    Nature nanotechnology

    2022  Volume 17, Issue 7, Page(s) 708–713

    Abstract: Membrane nanopores are key for molecular transport in biology, portable DNA ... ...

    Abstract Membrane nanopores are key for molecular transport in biology, portable DNA sequencing
    MeSH term(s) DNA/chemistry ; Nanopores ; Nanotechnology ; Proteins/chemistry ; Sequence Analysis, DNA
    Chemical Substances Proteins ; DNA (9007-49-2)
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/s41565-022-01116-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effect of addition of titanium dioxide nanoparticles on the antimicrobial properties, surface roughness and surface hardness of polymethyl methacrylate: A Systematic Review.

    Kaurani, Pragati / Hindocha, Amit D / Jayasinghe, Rasika Manori / Pai, Umesh Y / Batra, Kavita / Price, Carrie

    F1000Research

    2023  Volume 12, Page(s) 577

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Hardness ; Polymethyl Methacrylate ; Materials Testing ; Denture Bases ; Surface Properties ; Nanoparticles ; Anti-Infective Agents
    Chemical Substances Polymethyl Methacrylate (9011-14-7) ; titanium dioxide (15FIX9V2JP) ; Anti-Infective Agents
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.130028.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Preventive care and evaluation of the adolescent with a breast mass.

    Jayasinghe, Yasmin

    Seminars in plastic surgery

    2014  Volume 27, Issue 1, Page(s) 13–18

    Abstract: Adolescents have little knowledge of preventive breast care or breast screening, yet exposures in youth influence the risk of future breast disease.Nipple piercing increases the risk of trauma and breast infection. Alcohol consumption, smoking, nutrition, ...

    Abstract Adolescents have little knowledge of preventive breast care or breast screening, yet exposures in youth influence the risk of future breast disease.Nipple piercing increases the risk of trauma and breast infection. Alcohol consumption, smoking, nutrition, obesity, reproductive factors, previous cancer and chest radiotherapy, family history of breast cancer or genetic mutation increase the risk of breast cancer. Breast cancer is rare in adolescents and currently genetic testing is not recommended in those under 18 years, as medical surveillance is not usually recommended until around 25 years. Screening measures include clinical breast exam every 1 to 3 years, and breast self-awareness in healthy women from 20 years; and at least annual breast self examination, with annual clinical breast examination, mammography and magnetic resonance imaging in high-risk patients from 25 years. Breast ultrasound is used in diagnostic evaluation of breast masses in adolescents as mammography is less sensitive in young women.
    Language English
    Publishing date 2014-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2077828-4
    ISSN 1535-2188
    ISSN 1535-2188
    DOI 10.1055/s-0033-1343990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Accidental and Deliberate Self-Poisoning with Medications and Medication Errors among Children in Rural Sri Lanka.

    Dayasiri, Kavinda / Jayamanne, S F / Jayasinghe, C Y

    Emergency medicine international

    2020  Volume 2020, Page(s) 9872821

    Abstract: ... ...

    Abstract Context
    Language English
    Publishing date 2020-08-03
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2596429-X
    ISSN 2090-2859 ; 2090-2840
    ISSN (online) 2090-2859
    ISSN 2090-2840
    DOI 10.1155/2020/9872821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A plant virus satellite RNA directly accelerates wing formation in its insect vector for spread.

    Jayasinghe, Wikum H / Kim, Hangil / Nakada, Yusuke / Masuta, Chikara

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 7087

    Abstract: ... When infected with CMV in the presence of Y-satellite RNA (Y-sat), tobacco leaves develop a green mosaic ... then turn yellow. Y-sat has been identified in the fields in Japan. Here, we show that the yellow leaf ... colour preferentially attracts aphids, and that the aphids fed on yellow plants, which harbour Y-sat ...

    Abstract Cucumber mosaic virus (CMV) often accompanies a short RNA molecule called a satellite RNA (satRNA). When infected with CMV in the presence of Y-satellite RNA (Y-sat), tobacco leaves develop a green mosaic, then turn yellow. Y-sat has been identified in the fields in Japan. Here, we show that the yellow leaf colour preferentially attracts aphids, and that the aphids fed on yellow plants, which harbour Y-sat-derived small RNAs (sRNAs), turn red and subsequently develop wings. In addition, we found that leaf yellowing did not necessarily reduce photosynthesis, and that viral transmission was not greatly affected despite the low viral titer in the Y-sat-infected plants. Y-sat-infected plants can therefore support a sufficient number of aphids to allow for efficient virus transmission. Our results demonstrate that Y-sat directly alters aphid physiology via Y-sat sRNAs to promote wing formation, an unprecedented survival strategy that enables outward spread via the winged insect vector.
    MeSH term(s) Animals ; Aphids/genetics ; Aphids/physiology ; Aphids/virology ; Cucumovirus/genetics ; Cucumovirus/physiology ; Gene Expression Regulation ; Host-Pathogen Interactions ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Insect Vectors/genetics ; Insect Vectors/physiology ; Insect Vectors/virology ; Plant Diseases/genetics ; Plant Diseases/parasitology ; Plant Diseases/virology ; Plant Leaves/genetics ; Plant Leaves/parasitology ; Plant Leaves/virology ; Plants, Genetically Modified ; RNA, Satellite/genetics ; RNA, Satellite/physiology ; RNA, Viral/genetics ; RNA, Viral/physiology ; Nicotiana/genetics ; Nicotiana/parasitology ; Nicotiana/virology ; Virion/genetics ; Virion/physiology ; Virus Replication/genetics ; Virus Replication/physiology
    Chemical Substances Insect Proteins ; RNA, Satellite ; RNA, Viral
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-27330-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: FIGIJ Advocacy Statement in Support of Comprehensive Sexuality Education.

    Aguilar, Angela / Vatopoulou, Anastasia / Nunzio, Clara Di / Panova, Daniela Ivanova / Rome, Ellen / Simms-Cendan, Judith / Drejza, Michalina / Jayasinghe, Yasmin

    Journal of pediatric and adolescent gynecology

    2024  Volume 37, Issue 1, Page(s) 5–6

    MeSH term(s) Humans ; Sex Education ; Schools ; Parents
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1325079-6
    ISSN 1873-4332 ; 1083-3188
    ISSN (online) 1873-4332
    ISSN 1083-3188
    DOI 10.1016/j.jpag.2023.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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