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Book ; Online: Carbon geochemistry of sediments from the Amazon deep sea fan, supplementary data to: Schl?nz, Birger; Schneider, Ralph R; M?ller, Peter J; Showers, William J; Wefer, Gerold (1999): Terrestrial organic carbon accumulation on the Amazon deep sea fan during the last glacial sea-level low stand. Chemical Geology, 159(1-4), 263-281

Schl?nz, Birger / M?ller, Peter J / Schneider, Ralph R / Showers, William J / Wefer, Gerold

1999

Abstract: ... of the organic matter (OM), as well as variations in the depositional processes. In addition, we studied up to 300 m ...

Abstract	Sediment cores from the Amazon deep sea fan recovered during R/V Meteor cruise 16-2 show in detail the modern areal distribution of sedimentary organic carbon, stable organic carbon isotopes of the organic matter (OM), as well as variations in the depositional processes. In addition, we studied up to 300 m long drilled sediment records recovered during ODP Leg 155 which allow evaluation of temporal variations on the Amazon fan. Our results reveal new evidence for a very rapid change of fan depositional processes and organic carbon source at times of sea-level change over the middle and lower Amazon fan. To estimate the amount of terrestrial organic carbon stored in sediments from the last glacial in the Amazon fan we used stable organic carbon isotopes of the OM (delta13Corg), organic carbon content (Corg), and age models based on oxygen isotopes, faunal data, and magnetic excursions. Following our results, the organic carbon accumulation on the Amazon deep sea fan is controlled by glacio-eustatic sea-level oscillations. Interglacial sea-level high stand sediments are dominated by marine OM whereas during glacial sea-level low stands terrestrial organic carbon is transported beyond the continental shelf through the Amazon canyon and deposited directly onto the Amazon deep sea fan. Glacial sediments of the Amazon fan stored approximately 731015 g terrestrial Corg in 20,000 years or 3.710*12 g terrestrial Corg/yr (equivalent to 7-12% of the riverine organic carbon discharge; assuming constant paleo discharge), which is about the same amount of terrestrial organic carbon as deposited on the Amazon shelf today (3.110**12 g terrestrial Corg/yr or 6-10% of the modern riverine organic carbon discharge). REFERENCE: Schl?nz, Birger (1998): Riverine Organic Carbon Input into the Ocean in Relation to Late Quaternary Climate Change. Berichte aus dem Fachbereich Geowissenschaften der Universit?t Bremen, 116, 136 pp
Language	English
Dates of publication	1999-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is cited by urn:urn:nbn:de:gbv:46-ep000102361 ; This dataset is supplement to doi:10.1016/S0009-2541(99)00041-8
DOI	10.1594/PANGAEA.730471
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Preparing for the Next Pandemic.

Jaquis, William P / Schneider, Sandra M

Annals of emergency medicine

2021 Volume 78, Issue 2, Page(s) 212–219

MeSH term(s)	COVID-19/epidemiology ; Disaster Planning/trends ; Emergency Medicine/trends ; Health Policy/trends ; Humans ; Information Dissemination/methods ; Pandemics/prevention & control ; Public Health/trends ; United States
Language	English
Publishing date	2021-04-29
Publishing country	United States
Document type	Editorial
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/j.annemergmed.2021.03.010
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Article ; Online: Correction: Two C18 hydroxy-cyclohexenone fatty acids from mammalian epidermis: Potential relation to 12R-lipoxygenase and covalent binding of ceramides.

Brash, Alan R / Noguchi, Saori / Boeglin, William E / Calcutt, M Wade / Stec, Donald F / Schneider, Claus / Meyer, Jason M

The Journal of biological chemistry

2024 Volume 300, Issue 4, Page(s) 107239

Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2024.107239
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Article ; Online: Flavivirus-host interactions: an expanding network of proviral and antiviral factors.

Schneider, William M / Hoffmann, Hans-Heinrich

Current opinion in virology

2021 Volume 52, Page(s) 71–77

Abstract: Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infect. A ...

Abstract	Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infect. A better understanding of these interactions may ultimately lead to novel therapeutic targets. We highlight several studies that employed low-biased methods to discover new protein-protein, protein-RNA, and genetic interactions, and spotlight recent work characterizing the host protein, TMEM41B, which has been shown to be critical for infection by diverse flaviviruses and coronaviruses.
MeSH term(s)	Animals ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Flavivirus/genetics ; Flavivirus/metabolism ; Flavivirus Infections ; Host-Pathogen Interactions/genetics ; Humans ; Proviruses ; Virus Replication
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-12-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2611378-8
ISSN	1879-6265 ; 1879-6257
ISSN (online)	1879-6265
ISSN	1879-6257
DOI	10.1016/j.coviro.2021.11.007
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Article: Rapid Detection of Quinolone Resistance Mutations in

Haumaier, Franziska / Schneider-Fuchs, Anna / Backert, Steffen / Vieth, Michael / Sterlacci, William / Wöhrl, Birgitta M

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 1

Abstract: The treatment of infections by the gastric ... ...

Abstract	The treatment of infections by the gastric pathogen
Language	English
Publishing date	2022-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11010059
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Article ; Online: Tactile localization accuracy at the low back.

Pratt, Simon / Wand, Benedict M / Hince, Dana A / Travers, Mervyn J / Schneider, Lee / Kelly, Sara / Gibson, William

Attention, perception & psychophysics

2024 Volume 86, Issue 3, Page(s) 1008–1021

Abstract: Localizing tactile stimulation is an important capability for everyday function and may be impaired in people with persistent pain. This study sought to provide a detailed description of lumbar spine tactile localization accuracy in healthy individuals. ... ...

Abstract	Localizing tactile stimulation is an important capability for everyday function and may be impaired in people with persistent pain. This study sought to provide a detailed description of lumbar spine tactile localization accuracy in healthy individuals. Sixty-nine healthy participants estimated where they were touched at nine different points, labelled in a 3 × 3 grid over the lumbar spine. Mislocalization between the perceived and actual stimulus was calculated in horizontal (x) and vertical (y) directions, and a derived hypotenuse (c) mislocalization was calculated to represent the direct distance between perceived and actual points. In the horizontal direction, midline sites had the smallest mislocalization. Participants exhibited greater mislocalization for left- and right-sided sites, perceiving sites more laterally than they actually were. For all vertical values, stimulated sites were perceived lower than reality. A greater inaccuracy was observed in the vertical direction. This study measured tactile localization for the low back utilizing a novel testing method. The large inaccuracies point to a possible distortion in the underlying perceptual maps informing the superficial schema; however, further testing comparing this novel method with an established tactile localization task, such as the point-to-point method, is suggested to confirm these findings.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Touch Perception/physiology ; Young Adult ; Touch/physiology ; Space Perception/physiology ; Adolescent ; Lumbar Vertebrae/physiology ; Lumbosacral Region
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2464550-3
ISSN	1943-393X ; 1943-3921
ISSN (online)	1943-393X
ISSN	1943-3921
DOI	10.3758/s13414-024-02843-4
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Article ; Online: Mortality in randomised controlled trials using paclitaxel-coated devices for femoropopliteal interventional procedures: an updated patient-level meta-analysis.

Parikh, Sahil A / Schneider, Peter A / Mullin, Christopher M / Rogers, Tyson / Gray, William A

Lancet (London, England)

2023 Volume 402, Issue 10415, Page(s) 1848–1856

Abstract: Background: Numerous randomised clinical trials and real-world studies have supported the safety of paclitaxel-coated devices for the treatment of femoropopliteal occlusive disease. However, a 2018 summary-level meta-analysis suggested an increased ... ...

Abstract	Background: Numerous randomised clinical trials and real-world studies have supported the safety of paclitaxel-coated devices for the treatment of femoropopliteal occlusive disease. However, a 2018 summary-level meta-analysis suggested an increased mortality risk for paclitaxel-coated devices compared with uncoated control devices. This study presents an updated analysis of deaths using the most complete and current data available from pivotal trials of paclitaxel-coated versus control devices. Methods: Ten trials comparing paclitaxel-coated versus control devices were included in a patient-level pooled analysis. Cox regression models were used to evaluate the effect of paclitaxel exposure on risk of death in both intention-to-treat (ITT; primary analysis) and three as-treated analysis sets accounting for treatment group crossover at the index procedure and over time. The effect of paclitaxel dose and baseline covariates were also evaluated. Findings: A total of 2666 participants were included with a median follow-up of 4·9 years. No significant increase in deaths was observed for patients treated with paclitaxel-coated devices. This was true in the ITT analysis (hazard ratio [HR] 1·14, 95% CI 0·93-1·40), the as-treated analysis (HR 1·13, 95% CI 0·92-1·39), and in two crossover analyses: 1·07 (0·87-1·31) when late crossovers were censored and 1·04 (0·84-1·28) when crossovers were analysed from the date of paclitaxel exposure. There was no significant effect of paclitaxel dose on mortality risk. Interpretation: This meta-analysis found no association between paclitaxel-coated device exposure and risk of death, providing reassurance to patients, physicians, and regulators on the safety of paclitaxel-coated devices. Funding: Becton Dickinson, Boston Scientific, Cook, Medtronic, Philips, Surmodics, and TriReme Medical.
MeSH term(s)	Humans ; Paclitaxel/adverse effects ; Peripheral Arterial Disease/drug therapy ; Femoral Artery ; Time Factors ; Boston ; Treatment Outcome ; Coated Materials, Biocompatible ; Cardiovascular Agents/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Paclitaxel (P88XT4IS4D) ; Coated Materials, Biocompatible ; Cardiovascular Agents
Language	English
Publishing date	2023-10-24
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(23)02189-X
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Article ; Online: Nonoperative Treatment of a Fractured Uncemented Extensively Coated Femoral Stem: A Case Report with 2-Year Follow-up.

Schneider, Andrew M / Brown, Nicholas M / Hopkinson, William J

JBJS case connector

2021 Volume 11, Issue 3

Abstract: Case: A 62-year-old man who underwent total hip arthroplasty (THA) 17 years earlier presented with a fractured uncemented extensively coated diaphyseal engaging femoral stem. Treatment options, including revision surgery, were discussed, and the patient ...

Abstract	Case: A 62-year-old man who underwent total hip arthroplasty (THA) 17 years earlier presented with a fractured uncemented extensively coated diaphyseal engaging femoral stem. Treatment options, including revision surgery, were discussed, and the patient elected for nonoperative treatment. At 2 years of follow-up, the patient is asymptomatic, radiographs are stable, and he lives an active lifestyle without restrictions. Conclusion: Fractures of well-fixed femoral prostheses are rare complications of THA and almost universally require revision surgery. Nonoperative treatment without activity restrictions may be a viable treatment option in select patients to preserve function and maintain quality of life.
MeSH term(s)	Arthroplasty, Replacement, Hip/adverse effects ; Femoral Fractures/etiology ; Femoral Fractures/surgery ; Follow-Up Studies ; Hip Prosthesis/adverse effects ; Humans ; Male ; Middle Aged ; Quality of Life
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2160-3251
ISSN (online)	2160-3251
DOI	e21.00152
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Article ; Online: The power of the future: Intergenerational income mobility and child maltreatment in the United States.

Bullinger, Lindsey Rose / Raissian, Kerri M / Schneider, William

Child abuse & neglect

2021 Volume 130, Issue Pt 4, Page(s) 105175

Abstract: Background: Recent research has shown that the likelihood of children experiencing intergenerational, upward income mobility depends on the community in which they are raised. Whether parents consider their children's economic chances in their parenting ...

Abstract	Background: Recent research has shown that the likelihood of children experiencing intergenerational, upward income mobility depends on the community in which they are raised. Whether parents consider their children's economic chances in their parenting decisions, however, is not well understood. Objective: To examine the relationship between county-level income mobility-distinct from income inequality and poverty-and child maltreatment. Participants and setting: Administrative data from the National Child Abuse and Neglect Data System: Child File for 2406 counties were merged with measures of intergenerational income mobility from Chetty et al. (2014a), including the probability that a child born in the bottom quintile of the national income distribution reaches the top quintile by age thirty. Methods: Weighted least squares analyses were used to empirically estimate the relationship between intergenerational income mobility and child maltreatment report rates. Maltreatment reports were also divided into subgroups by age and metropolitan status. Results: Counties where children have a greater chance of moving up the income ladder have lower child maltreatment report rates, independent from income inequality and poverty rates. This relationship is consistent across all child ages (0-17). The relationship between upward income mobility and substantiated child maltreatment is also negatively correlated among non-metropolitan counties. Conclusions: Children experience a lower risk for maltreatment if they are more likely to move up the income ladder in adulthood. Macroeconomic factors and policies that reduce income inequality and enhance economic mobility are likely to prevent child maltreatment.
MeSH term(s)	Adult ; Child ; Child Abuse ; Humans ; Income ; Parenting ; Parents ; Poverty ; United States/epidemiology
Language	English
Publishing date	2021-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2021.105175
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Article ; Online: New Primary Total Knee Arthroplasty Components Versus Other Contemporary Types of Spacers for the Treatment of Chronic Periprosthetic Knee Infection With a Two-Stage Protocol.

Schneider, Andrew M / Holzmeister, Adam M / FrazzettA, Joseph / Adams, William / Hopkinson, William J / Brown, Nicholas M

Orthopedics

2022 Volume 45, Issue 2, Page(s) 109–115

Abstract: The optimal type of antibiotic spacer for the treatment of a knee periprosthetic joint infection (PJI) remains a topic of debate. Although the ultimate goal of an antibiotic spacer is infection control, contemporary spacer iterations, such as the use of ... ...

Abstract	The optimal type of antibiotic spacer for the treatment of a knee periprosthetic joint infection (PJI) remains a topic of debate. Although the ultimate goal of an antibiotic spacer is infection control, contemporary spacer iterations, such as the use of a new femoral component (NFC), may offer unique advantages. The primary goal of this study was to compare rates of infection control and functional outcomes between contemporary spacer types. We retrospectively reviewed 96 patients who underwent removal of a total knee arthroplasty with insertion of an antibiotic spacer for knee PJI over a 14-year period at a single institution with a minimum 1-year follow-up. Three patient cohorts were defined based on spacer type: NFC (n=30), cement-on-cement (n=19), and static (n=47). There was no association between spacer type and the odds of infection clearance (
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Arthroplasty, Replacement, Knee/adverse effects ; Humans ; Knee Prosthesis/adverse effects ; Prospective Studies ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/surgery ; Reoperation/methods ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	424447-3
ISSN	1938-2367 ; 0147-7447
ISSN (online)	1938-2367
ISSN	0147-7447
DOI	10.3928/01477447-20211227-09
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