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  1. Article ; Online: Giving Genome Editing the Fingers: An Interview with Dana Carroll.

    Davies, Kevin / Carroll, Dana

    The CRISPR journal

    2019  Volume 2, Page(s) 157–162

    MeSH term(s) Gene Editing/history ; Gene Editing/methods ; History, 21st Century ; Zinc Finger Nucleases
    Chemical Substances Zinc Finger Nucleases (EC 3.1.-)
    Language English
    Publishing date 2019-06-20
    Publishing country United States
    Document type Biography ; Historical Article ; Interview
    ZDB-ID 3017891-5
    ISSN 2573-1602 ; 2573-1599
    ISSN (online) 2573-1602
    ISSN 2573-1599
    DOI 10.1089/crispr.2019.29058.dca
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  2. Article ; Online: RNA in Therapeutics: CRISPR in the Clinic.

    Carroll, Dana

    Molecules and cells

    2022  Volume 46, Issue 1, Page(s) 4–9

    Abstract: The advent of the CRISPR-Cas genome editing platform has greatly enhanced the capabilities of researchers in many areas of biology. Its use has also been turned to the development of therapies for genetic diseases and to the enhancement of cell therapies. ...

    Abstract The advent of the CRISPR-Cas genome editing platform has greatly enhanced the capabilities of researchers in many areas of biology. Its use has also been turned to the development of therapies for genetic diseases and to the enhancement of cell therapies. This review describes some recent advances in these areas.
    MeSH term(s) CRISPR-Cas Systems/genetics ; RNA ; Gene Editing ; Genetic Therapy
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2022.0163
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  3. Article ; Online: Collateral damage: benchmarking off-target effects in genome editing.

    Carroll, Dana

    Genome biology

    2019  Volume 20, Issue 1, Page(s) 114

    Abstract: This editorial discusses what levels of off-target effects can be tolerated in genome editing, in the context of various types of applications. ...

    Abstract This editorial discusses what levels of off-target effects can be tolerated in genome editing, in the context of various types of applications.
    MeSH term(s) Animals ; Benchmarking ; Gene Editing/standards ; Humans ; Risk Assessment
    Language English
    Publishing date 2019-06-03
    Publishing country England
    Document type Editorial
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1465-6906
    ISSN (online) 1474-760X
    ISSN 1465-6906
    DOI 10.1186/s13059-019-1725-0
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  4. Article ; Online: Collateral damage

    Dana Carroll

    Genome Biology, Vol 20, Iss 1, Pp 1-

    benchmarking off-target effects in genome editing

    2019  Volume 3

    Abstract: Abstract This editorial discusses what levels of off-target effects can be tolerated in genome editing, in the context of various types of applications. ...

    Abstract Abstract This editorial discusses what levels of off-target effects can be tolerated in genome editing, in the context of various types of applications.
    Keywords Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: p53 Throws CRISPR a Curve.

    Carroll, Dana

    Trends in pharmacological sciences

    2018  Volume 39, Issue 9, Page(s) 783–784

    Abstract: The efficacy of the powerful CRISPR-Cas9 genome-editing platform depends on DNA repair activities in the cells being targeted. Two new papers show that the low efficiency of targeting in some primary human cell lines is the result of p53-dependent cell ... ...

    Abstract The efficacy of the powerful CRISPR-Cas9 genome-editing platform depends on DNA repair activities in the cells being targeted. Two new papers show that the low efficiency of targeting in some primary human cell lines is the result of p53-dependent cell arrest in response to the Cas9-induced break. This limitation must be overcome for some anticipated therapies.
    MeSH term(s) CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Humans ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Tumor Suppressor Protein p53
    Language English
    Publishing date 2018-07-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2018.06.005
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  6. Article ; Online: Cigarette Filter Ventilation and Biomarkers-Reply.

    Carroll, Dana Mowls / Hatsukami, Dorothy K

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2021  Volume 30, Issue 7, Page(s) 1450

    MeSH term(s) Biomarkers ; Humans ; Smoking ; Tobacco Products
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-21-0312
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    Zs.A 3693: Show issues Location:
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  7. Article ; Online: Life 2.0-A CRISPR path to a sustainable planet.

    Carroll, Dana / Meyer, Barbara J

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 22

    MeSH term(s) Animals ; CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Editing ; Humans ; Organisms, Genetically Modified ; Sustainable Development
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Congress
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2107418118
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    Zs.A 1148: Show issues Location:
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  8. Article ; Online: Prioritize Health Equity When Implementing a Nicotine Product Standard.

    Mowls Carroll, Dana / Hatsukami, Dorothy / Denlinger-Apte, Rachel

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2022  Volume 25, Issue 1, Page(s) 173–174

    MeSH term(s) Humans ; Health Equity ; Nicotine
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntac173
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    Zs.A 5789: Show issues Location:
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  9. Article ; Online: Differences in Normative Beliefs and Tobacco Product Use by Age Among Adults Who Smoke: Cross-Sectional Analysis of a Nationally Representative Sample.

    Rubenstein, Dana / Carroll, Dana M / Denlinger-Apte, Rachel L / Cornacchione Ross, Jennifer / McClernon, F Joseph

    Substance use & addiction journal

    2024  Volume 45, Issue 1, Page(s) 54–64

    Abstract: Background: The prevalence of combusted cigarette (CC) smoking among older adults is stagnant, with 0 declines attributable to e-cigarette (EC) use. Given that normative beliefs are associated with quitting and switching to ECs, we assessed cross- ... ...

    Abstract Background: The prevalence of combusted cigarette (CC) smoking among older adults is stagnant, with 0 declines attributable to e-cigarette (EC) use. Given that normative beliefs are associated with quitting and switching to ECs, we assessed cross-sectional associations between age, CC, and EC descriptive and injunctive norms and potential interactions with tobacco use behavior.
    Methods: Data are from people with current, established (≥100 lifetime CCs) CC use (n = 8072) at Wave 5 (2018-2019) of the adult Population Assessment of Tobacco and Health Study. We used adjusted multivariable logistic regressions to model social norms as a function of age (18-24, 25-34, 35-44, 45-54, 55-64, ≥65 years). We also dichotomized age (≥55 vs 18-54) to investigate interactions between age and social norms on past 12-month CC quit attempts and past-month EC use.
    Results: Older age was positively associated with pro- and anti-CC norms and anti-EC norms. Significant interactive effects revealed that being advised to quit smoking by a healthcare provider was more strongly associated with CC quit attempts among adults ≥55 years (adjusted odds ratio [aOR] [95% CI]: 2.12 [1.66, 2.71]) than adults <55 years (aOR: 1.63 [1.34, 2.00]). Reporting people close to you use ECs was also more strongly associated with EC use among adults ≥55 years (aOR: 4.37 [3.35, 5.69]) than among adults <55 years (aOR: 3.43 [2.89, 4.08]).
    Conclusions: This study identified modifiable risk factors for tobacco use that may be particularly beneficial for older adults. Behavioral and communication interventions that target normative beliefs may maximize smoking cessation, or harm reduction when cessation is not possible.
    MeSH term(s) Humans ; Aged ; Cross-Sectional Studies ; Electronic Nicotine Delivery Systems ; Tobacco Use/epidemiology ; Cigarette Smoking ; Tobacco Products
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2976-7350
    ISSN (online) 2976-7350
    DOI 10.1177/29767342231210554
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  10. Article ; Online: Genome Editing: Past, Present, and Future.

    Carroll, Dana

    The Yale journal of biology and medicine

    2017  Volume 90, Issue 4, Page(s) 653–659

    Abstract: The CRISPR-Cas genome editing tools have been adopted rapidly in the research community, and they are quickly finding applications in the commercial sector as well. Lest we lose track of the broader context, this Perspective presents a brief review of ... ...

    Abstract The CRISPR-Cas genome editing tools have been adopted rapidly in the research community, and they are quickly finding applications in the commercial sector as well. Lest we lose track of the broader context, this Perspective presents a brief review of the history of the genome editing platforms and considers a few current technological issues. It then takes a very limited view into the future of this technology and highlights some of the societal issues that require examination and discussion.
    MeSH term(s) Animals ; CRISPR-Cas Systems ; DNA Breaks, Double-Stranded ; Food ; Gene Drive Technology ; Gene Editing/ethics ; Gene Editing/methods ; Genetic Therapy/methods ; Genome ; Humans
    Language English
    Publishing date 2017-12-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
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