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Article: Nanotechnological advances in cancer: therapy a comprehensive review of carbon nanotube applications.

Gao, Siyang / Xu, Binhan / Sun, Jianwei / Zhang, Zhihui

Frontiers in bioengineering and biotechnology

2024 Volume 12, Page(s) 1351787

Abstract: Nanotechnology is revolutionising different areas from manufacturing to therapeutics in the health field. Carbon nanotubes (CNTs), a promising drug candidate in nanomedicine, have attracted attention due to their excellent and unique mechanical, ... ...

Abstract	Nanotechnology is revolutionising different areas from manufacturing to therapeutics in the health field. Carbon nanotubes (CNTs), a promising drug candidate in nanomedicine, have attracted attention due to their excellent and unique mechanical, electronic, and physicochemical properties. This emerging nanomaterial has attracted a wide range of scientific interest in the last decade. Carbon nanotubes have many potential applications in cancer therapy, such as imaging, drug delivery, and combination therapy. Carbon nanotubes can be used as carriers for drug delivery systems by carrying anticancer drugs and enabling targeted release to improve therapeutic efficacy and reduce adverse effects on healthy tissues. In addition, carbon nanotubes can be combined with other therapeutic approaches, such as photothermal and photodynamic therapies, to work synergistically to destroy cancer cells. Carbon nanotubes have great potential as promising nanomaterials in the field of nanomedicine, offering new opportunities and properties for future cancer treatments. In this paper, the main focus is on the application of carbon nanotubes in cancer diagnostics, targeted therapies, and toxicity evaluation of carbon nanotubes at the biological level to ensure the safety and real-life and clinical applications of carbon nanotubes.
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2024.1351787
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Article ; Online: Acinetobacter baumannii infection in intensive care unit: analysis of distribution and drug resistance.

Zhao, Siyang / Zhang, Bing / Liu, Conghai / Sun, Xiaodong / Chu, Yanpeng

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 120

Abstract: Background: The isolation rate and drug resistance rate of Acinetobacter baumannii (A.baumannii) have increased over the years, which has become one of the main causes of infection and death in intensive care unit (ICU) patients. Analysis of the ... ...

Abstract	Background: The isolation rate and drug resistance rate of Acinetobacter baumannii (A.baumannii) have increased over the years, which has become one of the main causes of infection and death in intensive care unit (ICU) patients. Analysis of the distribution characteristics, drug resistance and influencing factors of A.baumannii in ICU could provide basis and reference for the infection prevention and clinical treatment. Methods and results: In this study, patients diagnosed with A.baumannii infection in ICU from January 2020 to December 2021 were selected. Samples of patients were collected for bacterial culture, drug sensitivity test analysis and drug resistant gene detection of A.baumannii. A total of 197 strains of A.baumannii were cultured in 2021, which was 18 strains more than in 2020. The specimens were mainly from lower respiratory tract secretions, and the isolated strains were multi-drug resistant. The resistance of isolates to tobramycin, gentamicin, and trimethoprim-sulfamethoxazole in 2021 showed a significant increase compared to 2020, while there were no significant differences observed in other resistance changes. The prevalence of multi-drug resistant A.baumannii in ICU remains high. Among them, all imipenem-resistant A.baumannii strains carried OXA-23 gene. Conclusion: Clinical treatment should use antibiotics reasonably based on the characteristics of bacterial resistance, and strengthen the prevention and control of hospital infection, pay more attention to the disinfection and isolation to reduce the risk of cross infection.
MeSH term(s)	Humans ; Acinetobacter baumannii/genetics ; Intensive Care Units ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Drug Resistance
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-09144-3
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Zs.A 1140: Show issues

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Article ; Online: Does fear of infection affect people's dental attendance during COVID-19? A Chinese example to examine the association between COVID anxiety and dental anxiety.

Yuan, Siyang / Zheng, Yuanna / Sun, Zhe / Humphris, Gerry

Frontiers in oral health

2023 Volume 4, Page(s) 1236387

Abstract: Introduction: Little is known about the psychological and behavioural effect of COVID-19 pandemic on patients and their reaction to dental visiting. Patients may delay attendance due to fears of contracting the corona virus at the dentist. The study ... ...

Abstract	Introduction: Little is known about the psychological and behavioural effect of COVID-19 pandemic on patients and their reaction to dental visiting. Patients may delay attendance due to fears of contracting the corona virus at the dentist. The study aims to confirm the psychometric properties of the two COVID-19 scales and then use dental patient responses to assess the associations between the COVID-19 Anxiety Scale (CAS), dental anxiety (MDAS) and the clinical care COVID-19 Anxiety (CCAS). Methods: A cross-sectional study was conducted among 503 patients visiting a polyclinic of a stomatological hospital in East China in 2020. Patients completed a survey consisting of demographical information, dental attendance, COVID-19 Anxiety Scale, Clinical Care COVID-19 Anxiety Scale and Modified Dental Anxiety Scale. Confirmatory factor analysis was conducted to determine the psychometric characteristics. A further structural model was tested with the combined measurement model and a path analysis was calculated. Results: The sample ( Discussion: The Clinical Care COVID-19 Anxiety has shown satisfactory psychometric properties. Both dental anxiety and general anxiety about the pandemic have strong associations to patients' fear of contracting corona virus when using dental facilities. Our study has practical implications to help healthcare providers better understand how environmental stressors influence patients' overall concerns on infection risks and appropriate dental treatments during the pandemic.
Language	English
Publishing date	2023-10-09
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-4842
ISSN (online)	2673-4842
DOI	10.3389/froh.2023.1236387
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Article: An efficient

Guan, Shixin / Kang, Xuening / Ge, Jiayuan / Fei, Riwen / Duan, Siyang / Sun, Xiaomei

Frontiers in plant science

2022 Volume 13, Page(s) 999433

Abstract: ... Paeonia ... ...

Abstract	Paeonia lactiflora
Language	English
Publishing date	2022-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.999433
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Article ; Online: PFKFB3 knockdown attenuates Amyloid β-Induced microglial activation and retinal pigment epithelium disorders in mice.

Wang, Yusong / Han, Siyang / Chen, Jieqiong / Sun, Junran / Sun, Xiaodong

International immunopharmacology

2023 Volume 115, Page(s) 109691

Abstract: Age-related macular degeneration (AMD) is characterized by progressive accumulation of drusen deposits and retinal pigment epithelium (RPE) disorders. As the main component of drusen, amyloid β (Aβ) plays a critical role in activating microglia and ... ...

Abstract	Age-related macular degeneration (AMD) is characterized by progressive accumulation of drusen deposits and retinal pigment epithelium (RPE) disorders. As the main component of drusen, amyloid β (Aβ) plays a critical role in activating microglia and causing neuroinflammation in AMD pathogenesis. However, the role of activated microglia-mediated neuroinflammation in RPE senescence remains unclear. Recent evidence indicates that inflammatory microglia are glycolytic and driven by an increase in 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), an enzyme described as the master regulator of glycolysis. In this study, we mimicked the retinal inflammatory microenvironment of AMD by intravitreal injection of oligomeric Aβ
MeSH term(s)	Mice ; Animals ; Retinal Pigment Epithelium ; Microglia ; Amyloid beta-Peptides/metabolism ; Neuroinflammatory Diseases ; Retina/pathology ; Macular Degeneration/genetics
Chemical Substances	Amyloid beta-Peptides
Language	English
Publishing date	2023-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.109691
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Article: Elucidating Biological Functions of 9-

Fei, Riwen / Guan, Shixin / Duan, Siyang / Ge, Jiayuan / Sun, Tianyi / Sun, Xiaomei

Plants (Basel, Switzerland)

2023 Volume 12, Issue 4

Abstract: Abscisic acid (ABA) is a major phytohormone affecting seed dormancy and germination in plants. ABA is synthesized mainly through the C40 carotenoid pathway. In the ABA biosynthesis pathway, 9- ...

Abstract	Abscisic acid (ABA) is a major phytohormone affecting seed dormancy and germination in plants. ABA is synthesized mainly through the C40 carotenoid pathway. In the ABA biosynthesis pathway, 9-
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12040710
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Article ; Online: Predictable navigation through spontaneous brain states with cognitive-map-like representations.

Li, Siyang / Li, Zhipeng / Liu, Qiuyi / Ren, Peng / Sun, Lili / Cui, Zaixu / Liang, Xia

Progress in neurobiology

2024 Volume 233, Page(s) 102570

Abstract: Just as navigating a physical environment, navigating through the landscapes of spontaneous brain states may also require an internal cognitive map. Contemporary computation theories propose modeling a cognitive map from a reinforcement learning ... ...

Abstract	Just as navigating a physical environment, navigating through the landscapes of spontaneous brain states may also require an internal cognitive map. Contemporary computation theories propose modeling a cognitive map from a reinforcement learning perspective and argue that the map would be predictive in nature, representing each state as its upcoming states. Here, we used resting-state fMRI to test the hypothesis that the spaces of spontaneously reoccurring brain states are cognitive map-like, and may exhibit future-oriented predictivity. We identified two discrete brain states of the navigation-related brain networks during rest. By combining pattern similarity and dimensional reduction analysis, we embedded the occurrences of each brain state in a two-dimensional space. Successor representation modeling analysis recognized that these brain state occurrences exhibit place cell-like representations, akin to those observed in a physical space. Moreover, we observed predictive transitions of reoccurring brain states, which strongly covaried with individual cognitive and emotional assessments. Our findings offer a novel perspective on the cognitive significance of spontaneous brain activity and support the theory of cognitive map as a unifying framework for mental navigation.
MeSH term(s)	Humans ; Brain/diagnostic imaging ; Emotions ; Magnetic Resonance Imaging ; Cognition
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	185535-9
ISSN	1873-5118 ; 0301-0082
ISSN (online)	1873-5118
ISSN	0301-0082
DOI	10.1016/j.pneurobio.2024.102570
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Article ; Online: Construction of 2D sandwich-like Na

Sun, Rui / Dong, Siyang / Guo, Xincheng / Xia, Peng / Lu, Shengjun / Zhang, Yufei / Fan, Haosen

Journal of colloid and interface science

2023 Volume 655, Page(s) 226–233

Abstract: Aqueous zinc ion batteries (AZIBs) have attained enormous attention in the last few years. The cathode materials of aqueous zinc ion batteries play a vital effect in their electrochemical and battery properties. In this manuscript, Sandwich-like MXene@ ... ...

Abstract	Aqueous zinc ion batteries (AZIBs) have attained enormous attention in the last few years. The cathode materials of aqueous zinc ion batteries play a vital effect in their electrochemical and battery properties. In this manuscript, Sandwich-like MXene@Na
Language	English
Publishing date	2023-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.11.020
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Article ; Online: Single-tube protocol for culture-independent spoligotyping of

Xia, Zihan / Su, Biyi / Tu, Chunxia / Sun, Siyang / Tan, Yaoju / Xu, Ye / Li, Qingge

Journal of clinical microbiology

2023 Volume 62, Issue 1, Page(s) e0118323

Abstract: Importance: Spacer oligonucleotide typing (spoligotyping), the first-line genotyping assay ... ...

Abstract	Importance: Spacer oligonucleotide typing (spoligotyping), the first-line genotyping assay for
MeSH term(s)	Humans ; Mycobacterium tuberculosis/genetics ; Tuberculosis/microbiology ; Molecular Epidemiology/methods ; Real-Time Polymerase Chain Reaction ; Multiplex Polymerase Chain Reaction ; Bacterial Typing Techniques/methods ; Genotype
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.01183-23
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Book ; Online: Multiple receptive fields and small-object-focusing weakly-supervised segmentation network for fast object detection

Sun, Siyang

2019

Abstract: Object detection plays an important role in various visual applications. However, the precision and speed of detector are usually contradictory. One main reason for fast detectors' precision reduction is that small objects are hard to be detected. To ... ...

Abstract	Object detection plays an important role in various visual applications. However, the precision and speed of detector are usually contradictory. One main reason for fast detectors' precision reduction is that small objects are hard to be detected. To address this problem, we propose a multiple receptive field and small-object-focusing weakly-supervised segmentation network (MRFSWSnet) to achieve fast object detection. In MRFSWSnet, multiple receptive fields block (MRF) is used to pay attention to the object and its adjacent background's different spatial location with different weights to enhance the feature's discriminability. In addition, in order to improve the accuracy of small object detection, a small-object-focusing weakly-supervised segmentation module which only focuses on small object instead of all objects is integrated into the detection network for auxiliary training to improve the precision of small object detection. Extensive experiments show the effectiveness of our method on both PASCAL VOC and MS COCO detection datasets. In particular, with a lower resolution version of 300x300, MRFSWSnet achieves 80.9% mAP on VOC2007 test with an inference speed of 15 milliseconds per frame, which is the state-of-the-art detector among real-time detectors.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2019-04-19
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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