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Article ; Online: Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport

Jean Cacheux / Aurélien Bancaud / Daniel Alcaide / Jun-Ichi Suehiro / Yoshihiro Akimoto / Hiroyuki Sakurai / Yukiko T. Matsunaga

iScience, Vol 26, Iss 7, Pp 107141- (2023)

2023

Abstract: Summary: The endothelial layers of the microvasculature regulate the transport of solutes to the surrounding tissues. It remains unclear how this barrier function is affected by blood flow-induced intraluminal pressure. Using a 3D microvessel model, we ... ...

Abstract	Summary: The endothelial layers of the microvasculature regulate the transport of solutes to the surrounding tissues. It remains unclear how this barrier function is affected by blood flow-induced intraluminal pressure. Using a 3D microvessel model, we compare the transport of macromolecules through endothelial tissues at mechanical rest or with intraluminal pressure, and correlate these data with electron microscopy of endothelial junctions. On application of an intraluminal pressure of 100 Pa, we demonstrate that the flow through the tissue increases by 2.35 times. This increase is associated with a 25% expansion of microvessel diameter, which leads to tissue remodeling and thinning of the paracellular junctions. We recapitulate these data with the deformable monopore model, in which the increase in paracellular transport is explained by the augmentation of the diffusion rate across thinned junctions under mechanical stress. We therefore suggest that the deformation of microvasculatures contributes to regulate their barrier function.
Keywords	Bioengineering ; Tissue engineering ; Cell biology ; Biomechanics ; Computer modeling ; Science ; Q
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport.

Cacheux, Jean / Bancaud, Aurélien / Alcaide, Daniel / Suehiro, Jun-Ichi / Akimoto, Yoshihiro / Sakurai, Hiroyuki / Matsunaga, Yukiko T

iScience

2023 Volume 26, Issue 7, Page(s) 107141

Abstract: The endothelial layers of the microvasculature regulate the transport of solutes to the surrounding tissues. It remains unclear how this barrier function is affected by blood flow-induced intraluminal pressure. Using a 3D microvessel model, we compare ... ...

Abstract	The endothelial layers of the microvasculature regulate the transport of solutes to the surrounding tissues. It remains unclear how this barrier function is affected by blood flow-induced intraluminal pressure. Using a 3D microvessel model, we compare the transport of macromolecules through endothelial tissues at mechanical rest or with intraluminal pressure, and correlate these data with electron microscopy of endothelial junctions. On application of an intraluminal pressure of 100 Pa, we demonstrate that the flow through the tissue increases by 2.35 times. This increase is associated with a 25% expansion of microvessel diameter, which leads to tissue remodeling and thinning of the paracellular junctions. We recapitulate these data with the deformable monopore model, in which the increase in paracellular transport is explained by the augmentation of the diffusion rate across thinned junctions under mechanical stress. We therefore suggest that the deformation of microvasculatures contributes to regulate their barrier function.
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107141
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Article ; Online: Acute myocarditis secondary to

Suehiro, Wako / Nishio, Ryo / Noiri, Jun-Ichi / Takeshige, Ryo / Konishi, Hiroki / Matsuzoe, Hiroki / Matsumoto, Akinori / Ozawa, Makito / Matsumoto, Daisuke / Inaba, Mayumi / Takaishi, Hiroshi

Journal of cardiology cases

2023 Volume 28, Issue 5, Page(s) 185–188

Abstract: Acute myocarditis is a rare complication of : Learning objective: Acute myocarditis is a rare but important complication ... ...

Abstract	Acute myocarditis is a rare complication of Learning objective: Acute myocarditis is a rare but important complication of
Language	English
Publishing date	2023-07-01
Publishing country	Japan
Document type	Case Reports
ISSN	1878-5409
ISSN (online)	1878-5409
DOI	10.1016/j.jccase.2023.06.008
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Article: Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors

Sasaki, Yuji / Higashijima, Yoshiki / Suehiro, Jun-Ichi / Sugasawa, Takehito / Oguri-Nakamura, Eri / Fukuhara, Shigetomo / Nagai, Nao / Hirakawa, Yosuke / Wada, Youichiro / Nangaku, Masaomi / Kanki, Yasuharu

Biochemical and biophysical research communications. 2022 May 21, v. 605

2022

Abstract: Vascular endothelial growth factor (VEGF) signaling plays a central role in vascular development and maintenance of vascular homeostasis. In endothelial cells (ECs), VEGF activates the gene expression of angiogenic transcription factors (TFs), followed ... ...

Abstract	Vascular endothelial growth factor (VEGF) signaling plays a central role in vascular development and maintenance of vascular homeostasis. In endothelial cells (ECs), VEGF activates the gene expression of angiogenic transcription factors (TFs), followed by induction of downstream angiogenic responsive genes. Recent findings support that histone modification dynamics contribute to the transcriptional control of genes that are important for EC functions. Lysine demethylase 2B (KDM2B) demethylates histone H3K4me3 and H3K36me2/3 and mediates the monoubiquitination of histone H2AK119. KDM2B functions as a transcriptional repressor in somatic cell reprogramming and tumor development. However, the role of KDM2B in VEGF signaling remains to be elucidated. Here, we show that KDM2B knockdown enhances VEGF-induced angiogenesis in cultured human ECs via increased migration and proliferation. In contrast, ectopic expression of KDM2B inhibits angiogenesis. The function of KDM2B may depend on its catalytic Jumonji C domain. Genome-wide analysis further reveals that KDM2B selectively controls the transcription of VEGF-induced angiogenic TFs that are associated with increased H3K4me3/H3K36me3 and decreased H2AK119ub. These findings suggest an essential role of KDM2B in VEGF signaling in ECs. As dysregulation of VEGF signaling in ECs is involved in various diseases, including cancer, KDM2B may be a potential therapeutic target in VEGF-mediated vasculopathic diseases.
Keywords	angiogenesis ; gene expression ; genome-wide association study ; histone code ; histones ; homeostasis ; humans ; lysine ; neoplasms ; repressor proteins ; research ; somatic cells ; therapeutics ; transcription (genetics) ; vascular endothelial growth factors
Language	English
Dates of publication	2022-0521
Size	p. 16-23.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.03.054
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Involvement of GLCCI1 in mouse spermatogenesis.

Takada, Masaru / Fukuhara, Daisuke / Takiura, Toshihiko / Nishibori, Yukino / Kotani, Masashi / Kiuchi, Zentaro / Kudo, Akihiko / Beltcheva, Olga / Ito-Nitta, Noriko / Nitta, Kazuhiro R / Kimura, Toru / Suehiro, Jun-Ichi / Katada, Tomohisa / Takematsu, Hiromu / Yan, Kunimasa

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2022 Volume 37, Issue 1, Page(s) e22680

Abstract: Spermatid production is a complex regulatory process in which coordination between hormonal control and apoptosis plays a pivotal role in maintaining a balanced number of sperm cells. Apoptosis in spermatogenesis is controlled by pro-apoptotic and anti- ... ...

Abstract	Spermatid production is a complex regulatory process in which coordination between hormonal control and apoptosis plays a pivotal role in maintaining a balanced number of sperm cells. Apoptosis in spermatogenesis is controlled by pro-apoptotic and anti-apoptotic molecules. Hormones involved in the apoptotic process during spermatogenesis include gonadotrophins, sex hormones, and glucocorticoid (GC). GC acts broadly as an apoptosis inducer by binding to its receptor (glucocorticoid receptor: GR) during organ development processes, such as spermatogenesis. However, the downstream pathway induced in GC-GR signaling and the apoptotic process during spermatogenesis remains poorly understood. We reported previously that GC induces full-length glucocorticoid-induced transcript 1 (GLCCI1-long), which functions as an anti-apoptotic mediator in thymic T cell development. Here, we demonstrate that mature murine testis expresses a novel isoform of GLCCI1 protein (GLCCI1-short) in addition to GLCCI1-long. We demonstrate that GLCCI1-long is expressed in spermatocytes along with GR. In contrast, GLCCI1-short is primarily expressed in spermatids where GR is absent; instead, the estrogen receptor is expressed. GLCCI1-short also binds to LC8, which is a known mediator of the anti-apoptotic effect of GLCCI1-long. A luciferase reporter assay revealed that β-estradiol treatment synergistically increased Glcci1-short promotor-driven luciferase activity in Erα-overexpressing cells. Together with the evidence that the conversion of testosterone to estrogen is preceded by aromatase expression in spermatids, we hypothesize that estrogen induces GLCCI1-short, which, in turn, may function as a novel anti-apoptotic mediator in mature murine testis.
MeSH term(s)	Male ; Mice ; Animals ; Glucocorticoids ; Semen ; Spermatogenesis ; Spermatids ; Estrogens
Chemical Substances	Glucocorticoids ; Estrogens
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202101667RR
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors.

Biochemical and biophysical research communications

2022 Volume 605, Page(s) 16–23

Abstract	Vascular endothelial growth factor (VEGF) signaling plays a central role in vascular development and maintenance of vascular homeostasis. In endothelial cells (ECs), VEGF activates the gene expression of angiogenic transcription factors (TFs), followed by induction of downstream angiogenic responsive genes. Recent findings support that histone modification dynamics contribute to the transcriptional control of genes that are important for EC functions. Lysine demethylase 2B (KDM2B) demethylates histone H3K4me3 and H3K36me2/3 and mediates the monoubiquitination of histone H2AK119. KDM2B functions as a transcriptional repressor in somatic cell reprogramming and tumor development. However, the role of KDM2B in VEGF signaling remains to be elucidated. Here, we show that KDM2B knockdown enhances VEGF-induced angiogenesis in cultured human ECs via increased migration and proliferation. In contrast, ectopic expression of KDM2B inhibits angiogenesis. The function of KDM2B may depend on its catalytic Jumonji C domain. Genome-wide analysis further reveals that KDM2B selectively controls the transcription of VEGF-induced angiogenic TFs that are associated with increased H3K4me3/H3K36me3 and decreased H2AK119ub. These findings suggest an essential role of KDM2B in VEGF signaling in ECs. As dysregulation of VEGF signaling in ECs is involved in various diseases, including cancer, KDM2B may be a potential therapeutic target in VEGF-mediated vasculopathic diseases.
MeSH term(s)	Cell Proliferation ; Endothelial Cells/metabolism ; F-Box Proteins/genetics ; F-Box Proteins/metabolism ; Histones/metabolism ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Lysine/metabolism ; Transcription Factors/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	F-Box Proteins ; Histones ; Transcription Factors ; Vascular Endothelial Growth Factor A ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2022-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.03.054
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Article ; Online: Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis

Yasuharu Kanki / Masashi Muramatsu / Yuri Miyamura / Kenta Kikuchi / Yoshiki Higashijima / Ryo Nakaki / Jun-ichi Suehiro / Yuji Sasaki / Yoshiaki Kubota / Haruhiko Koseki / Hiroshi Morioka / Tatsuhiko Kodama / Mitsuyoshi Nakao / Daisuke Kurotaki / Hiroyuki Aburatani / Takashi Minami

Cell Reports, Vol 38, Iss 6, Pp 110332- (2022)

2022

Abstract: Summary: Endothelial cells (ECs) are phenotypically heterogeneous, mainly due to their dynamic response to the tissue microenvironment. Vascular endothelial cell growth factor (VEGF), the best-known angiogenic factor, activates calcium-nuclear factor of ... ...

Abstract	Summary: Endothelial cells (ECs) are phenotypically heterogeneous, mainly due to their dynamic response to the tissue microenvironment. Vascular endothelial cell growth factor (VEGF), the best-known angiogenic factor, activates calcium-nuclear factor of activated T cells (NFAT) signaling following acute angiogenic gene transcription. Here, we evaluate the global mapping of VEGF-mediated dynamic transcriptional events, focusing on major histone-code profiles using chromatin immunoprecipitation sequencing (ChIP-seq). Remarkably, the gene loci of immediate-early angiogenic transcription factors (TFs) exclusively acquire bivalent H3K4me3-H3K27me3 double-positive histone marks after the VEGF stimulus. Moreover, NFAT-associated Pax transactivation domain-interacting protein (PTIP) directs bivalently marked TF genes transcription through a limited polymerase II running. The non-canonical polycomb1 variant PRC1.3 specifically binds to and allows the transactivation of PRC2-enriched bivalent angiogenic TFs until conventional PRC1-mediated gene silencing is achieved. Knockdown of these genes abrogates post-natal aberrant neovessel formation via the selective inhibition of indispensable bivalent angiogenic TF gene transcription. Collectively, the reported dynamic histone mark landscape may uncover the importance of immediate-early genes and the development of advanced anti-angiogenic strategies.
Keywords	VEGF ; endothelial cells ; bivalent histone marks ; noncanonical polycomb ; PTIP ; angiogenesis ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis.

Kanki, Yasuharu / Muramatsu, Masashi / Miyamura, Yuri / Kikuchi, Kenta / Higashijima, Yoshiki / Nakaki, Ryo / Suehiro, Jun-Ichi / Sasaki, Yuji / Kubota, Yoshiaki / Koseki, Haruhiko / Morioka, Hiroshi / Kodama, Tatsuhiko / Nakao, Mitsuyoshi / Kurotaki, Daisuke / Aburatani, Hiroyuki / Minami, Takashi

Cell reports

2022 Volume 38, Issue 6, Page(s) 110332

Abstract: Endothelial cells (ECs) are phenotypically heterogeneous, mainly due to their dynamic response to the tissue microenvironment. Vascular endothelial cell growth factor (VEGF), the best-known angiogenic factor, activates calcium-nuclear factor of activated ...

Abstract	Endothelial cells (ECs) are phenotypically heterogeneous, mainly due to their dynamic response to the tissue microenvironment. Vascular endothelial cell growth factor (VEGF), the best-known angiogenic factor, activates calcium-nuclear factor of activated T cells (NFAT) signaling following acute angiogenic gene transcription. Here, we evaluate the global mapping of VEGF-mediated dynamic transcriptional events, focusing on major histone-code profiles using chromatin immunoprecipitation sequencing (ChIP-seq). Remarkably, the gene loci of immediate-early angiogenic transcription factors (TFs) exclusively acquire bivalent H3K4me3-H3K27me3 double-positive histone marks after the VEGF stimulus. Moreover, NFAT-associated Pax transactivation domain-interacting protein (PTIP) directs bivalently marked TF genes transcription through a limited polymerase II running. The non-canonical polycomb1 variant PRC1.3 specifically binds to and allows the transactivation of PRC2-enriched bivalent angiogenic TFs until conventional PRC1-mediated gene silencing is achieved. Knockdown of these genes abrogates post-natal aberrant neovessel formation via the selective inhibition of indispensable bivalent angiogenic TF gene transcription. Collectively, the reported dynamic histone mark landscape may uncover the importance of immediate-early genes and the development of advanced anti-angiogenic strategies.
MeSH term(s)	Angiogenesis Inducing Agents/metabolism ; Animals ; Chromatin Immunoprecipitation ; Chromatin Immunoprecipitation Sequencing ; Endothelial Cells/metabolism ; Epigenesis, Genetic/genetics ; Gene Silencing/physiology ; Genes, Immediate-Early/genetics ; Histones/metabolism ; Humans ; Mice ; Neovascularization, Pathologic/genetics ; Promoter Regions, Genetic/genetics ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Angiogenesis Inducing Agents ; Histones ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2022-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.110332
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Article: A wide QRS complex tachycardia utilizing an atypical accessory pathway in latent Wolff-Parkinson-White syndrome: Manifestation of anterograde conduction during atrial fibrillation without delta waves in sinus rhythm.

Nakamura, Toshihiro / Fukuzawa, Koji / Kurose, Jun / Suehiro, Hideya / Matsumoto, Kensuke / Hirata, Ken-Ichi

HeartRhythm case reports

2019 Volume 5, Issue 8, Page(s) 419–423

Language	English
Publishing date	2019-05-22
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2019.05.001
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Article ; Online: Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters.

Otsuki, Hideo / Kimura, Toru / Yamaga, Takashi / Kosaka, Takeo / Suehiro, Jun-Ichi / Sakurai, Hiroyuki

The Prostate

2016 Volume 77, Issue 2, Page(s) 222–233

Abstract: Background: Leucine stimulates cancer cell proliferation through the mTOR pathway, therefore, inhibiting leucine transporters may be a novel therapeutic target for cancer. L-type amino acid transporter (LAT) 1, a Na: Methods: LNCaP and DU145 and PC-3 ...

Abstract	Background: Leucine stimulates cancer cell proliferation through the mTOR pathway, therefore, inhibiting leucine transporters may be a novel therapeutic target for cancer. L-type amino acid transporter (LAT) 1, a Na Methods: LNCaP and DU145 and PC-3 cell lines were used as a model of androgen dependent, and metastatic prostate cancer. A new "LN-cr" cell line was established after culturing LNCaP cells for 6 months under androgen-free conditions, which is considered a model of castration resistant prostate cancer (CRPC) with androgen AR expression. The expression of leucine transporters was investigated with quantitative PCR and immunofluorescence. Uptake of Results: Cell viability showed a 90% decrease in the absence of leucine in all four cell lines. LNCaP cells principally expressed LAT3, and their leucine uptake was more than 90% Na Conclusions: New CRPC cell line with increased expression of y
MeSH term(s)	Amino Acid Transport Systems/metabolism ; Cell Line, Tumor ; Cell Survival/physiology ; Humans ; Leucine/metabolism ; Male ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Prostatic Neoplasms, Castration-Resistant/pathology ; Receptors, Androgen/metabolism
Chemical Substances	AR protein, human ; Amino Acid Transport Systems ; Receptors, Androgen ; Leucine (GMW67QNF9C)
Language	English
Publishing date	2016-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	604707-5
ISSN	1097-0045 ; 0270-4137
ISSN (online)	1097-0045
ISSN	0270-4137
DOI	10.1002/pros.23263
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