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Article ; Online: Jin Tiange capsule combined with rehabilitation training for the treatment of skeletal muscle atrophy after orthopedic surgery.

Xu, Jie / Wang, Sheng-Gen / Xu, Jia-Cheng / Zhu, Jian-Wei

2024

Language	English
Publishing date	2024-04-23
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.04.048
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Article: [Carbon Dioxide Mitigation Co-effect Analysis of Structural Adjustment Measures in the "2+26" Cities in the Jing-Jin-Ji Region and Its Surroundings].

Yang, Tian-Qi / Wang, Hong-Chang / Zhang, Chen / Zhu, Jin-Wei / Cui, Yu-Tao / Tan, Yu-Ling / Shu, Yun

Huan jing ke xue= Huanjing kexue

2022 Volume 43, Issue 11, Page(s) 5315–5325

Abstract: The Three-Year Action Plan for Winning the Blue Sky Defense Battle states that structural adjustments of industrial, energy, transportation, and land use are important to significantly reduce ... ...

Abstract	The Three-Year Action Plan for Winning the Blue Sky Defense Battle states that structural adjustments of industrial, energy, transportation, and land use are important to significantly reduce CO
MeSH term(s)	Cities ; Carbon Dioxide/analysis ; Air Pollution/prevention & control ; Air Pollution/analysis ; Air Pollutants/analysis ; Greenhouse Gases/analysis
Chemical Substances	Carbon Dioxide (142M471B3J) ; Air Pollutants ; Greenhouse Gases
Language	Chinese
Publishing date	2022-09-23
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202111234
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Article: Re-analysis on Heidan Disease (Black Jaundice) in Synopsis of Golden Chamber (Jin Gui Yao Lue)

Lin, Tzi Chiang / Yuan, Xiaolin / Wei, Gang / Jin, Shi

Chinese medicine and natural products

2022 Volume 02, Issue 04, Page(s) e179–e184

Abstract: Heidan disease (black jaundice) is a kind of jaundice, which is caused by lingering and chronic jaundice, often with blood stasis and damp-heat, etc. The clinical symptoms of Heidan disease (black jaundice) are similar to those of cirrhosis caused by ... ...

Abstract	Heidan disease (black jaundice) is a kind of jaundice, which is caused by lingering and chronic jaundice, often with blood stasis and damp-heat, etc. The clinical symptoms of Heidan disease (black jaundice) are similar to those of cirrhosis caused by multiple chronic liver diseases in Western medicine. Heidan disease (black jaundice) generally belongs to yin jaundice type, and the pathogenesis is mostly related to blood stasis and dampness stagnation, often with damp-heat residue. According to Zhongjing Zhang, the prescription Xiaoshi Fanshi powder for the treatment of Heidan disease (black jaundice) is based on the understanding that the nature of Heidan disease (black jaundice) is inseparable from the two key pathological factors of dampness and blood stasis. The treatment of jaundice should be based on removing blood stasis and dampness, supplemented by soothing the liver and promoting the transportation function of spleen, removing blood stasis and harmonizing the collaterals, and promoting diuresis and reducing jaundice. In the treatment of jaundice, removing blood stasis and purging turbidity should be stressed, and powerful tonification should be used with caution. Since blood stasis and turbidity are always intermingling and often complicated with damp heat, the method of warm drying should be used with caution. For promoting blood circulation, removing blood stasis, and dredging the liver-biliary collaterals, drastic medicine should be used with caution.
Keywords	Heidan disease ; black jaundice ; Xiaoshi Fanshi powder ; chronic liver disease ; liver cirrhosis ; Yinshao Erjin decoction ; Yinchen Zhizi decoction
Language	English
Publishing date	2022-12-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2749-568X ; 2096-918X
ISSN (online)	2749-568X
ISSN	2096-918X
DOI	10.1055/s-0042-1759793
Database	Thieme publisher's database

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Article ; Online: Network Pharmacology Combined with GEO Analysis of the Mechanism of Qing-Jin-Hua-Tan Decoction in the Treatment of Non-small Cell Lung Cancer.

Wei, Yi / Liu, Chao

Current computer-aided drug design

2023 Volume 20, Issue 4, Page(s) 396–404

Abstract: ... a significant threat to human health. Qing-Jin-Hua-Tan (QJHT) decoction is a classical herbal remedy that has ...

Abstract	Background: Non-small-cell lung cancer (NSCLC) is one of the most prevalent malignancies and poses a significant threat to human health. Qing-Jin-Hua-Tan (QJHT) decoction is a classical herbal remedy that has demonstrated therapeutic effects in various diseases, including NSCLC, and can improve the quality of life of patients with respiratory conditions. However, the mechanism underlying the effect of the QJHT decoction on NSCLC remains unclear and requires further investigation. Methods: We collected NSCLC-related gene datasets from the GEO database and performed differential gene analysis, followed by using WGCNA to identify the core set of genes associated with NSCLC development. The TCMSP and HERB databases were searched to identify the active ingredients and drug targets, and the core gene target datasets related to NSCLC were merged to identify the intersecting targets of drugs and diseases for GO and KEGG pathway enrichment analysis. We then constructed a protein-protein interaction (PPI) network map of drug diseases using the MCODE algorithm and identified key genes using topology analysis. The disease-gene matrix underwent immunoinfiltration analysis, and we analyzed the association between intersecting targets and immunoinfiltration. Results: We obtained the GSE33532 dataset that met the screening criteria, and a total of 2211 differential genes were identified using differential gene analysis. We performed GSEA analysis and WGCNA analysis for a crossover with differential genes, resulting in 891 key targets for NSCLC. The drug database was screened to obtain 217 active ingredients and 339 drug targets of QJHT. By constructing a PPI network, the active ingredients of QJHT decoction were intersected with the targets of NSCLC, resulting in 31 intersected genes. Enrichment analysis of the intersection targets showed that 1112 biological processes, 18 molecular functions, and 77 cellular compositions were enriched in GO functions, and 36 signaling pathways were enriched in KEGG pathways. Based on immune-infiltrating cell analysis, we found that the intersection targets were significantly associated with multiple infiltrating immune cells. Conclusion: Our analysis using network pharmacology and mining of the GEO database revealed that QJHT decoction can potentially treat NSCLC through multi-target and multi-signaling pathways, while also regulating multiple immune cells.
Language	English
Publishing date	2023-09-28
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6697
ISSN (online)	1875-6697
DOI	10.2174/1573409919666230523155830
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Article ; Online: Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Fei Jin Sheng Formula in the Treatment of Lung Cancer.

Zhang, Yun-Chao / Gao, Wen-Cang / Chen, Wei-Jian / Pang, De-Xiang / Mo, Da-Yu / Yang, Min

Current pharmaceutical design

2023 Volume 29, Issue 14, Page(s) 1121–1134

Abstract: Background: Fei Jin Sheng Formula (FJSF) is widely used in clinical treatment of lung cancer ...

Abstract	Background: Fei Jin Sheng Formula (FJSF) is widely used in clinical treatment of lung cancer. But the underlying active ingredients and mechanisms are unclear. Objective: To investigate the active components and functional mechanisms of FJSF in treating lung cancer using a network pharmacology approach and molecular docking combined with Results: FJSF contained 272 active ingredients and 52 potential targets for lung cancer. GO enrichment analysis is mainly related to cell migration and movement, lipid metabolism, and protein kinase activity. KEGG pathway enrichment analysis mainly involves PI3K-Akt, TNF, HIF-1, and other pathways. Molecular docking shows that the compound Xambioona, quercetin and methyl palmitate in FJSF has a strong binding ability with NTRK1, APC, and DVL2. Analysis of the data in UCSC to analyze the expression of DVL2 in lung cancer shows that DVL2 was overexpressed in lung adenocarcinoma tissues. Kaplan-Meier analysis shows that the higher DVL2 expression in lung cancer patients was associated with poorer overall survival and poorer survival in stage I patients. It was negatively correlated with the infiltration of various immune cells in the lung cancer microenvironment. Conclusion: FJSF may play a role in inhibiting the occurrence and development of lung cancer by downregulating the expression of DVL2 in A549 cells through its active ingredient Methyl Palmitate. These results provide scientific evidence for further investigations into the role of FJSF and Methyl Palmitate in the treatment of lung cancer.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Lung Neoplasms/drug therapy ; A549 Cells ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Tumor Microenvironment
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-05-04
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612829666230503164755
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Article ; Online: Complete Genome Sequence of Glutamicibacter mysorens NBNZ-009, Isolated from Jin Lake Sediment.

Wang, Yueying / Su, Xin / Liu, Jie / Fang, Wei / Zhu, Lei

Microbiology resource announcements

2022 Volume 11, Issue 10, Page(s) e0076222

Abstract: Members of the ... ...

Abstract	Members of the genus
Language	English
Publishing date	2022-09-07
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.00762-22
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Article: Zuo Jin Wan Reverses the Resistance of Colorectal Cancer to Oxaliplatin by Regulating the MALAT1/miR-200s/JNK Signaling Pathway.

Wei, Zhenzhen / Zhou, Jing / Yu, Hao / Pu, Yunzhou / Cheng, Yuelei / Zhang, Yi / Ji, Qing / Zhu, Huirong

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 3032407

Abstract: ... of colorectal cancer (CRC). Our previous work showed that Zuo Jin Wan (ZJW), a traditional Chinese medicine ...

Abstract	Background: Oxaliplatin (L-OHP) is a common chemotherapy drug used in the treatment of colorectal cancer (CRC). Our previous work showed that Zuo Jin Wan (ZJW), a traditional Chinese medicine prescription, could improve sensitivity to L-OHP in the treatment of CRC, but the detailed mechanism is not clear. In previous mechanistic studies, we found that the miR-200s expression in CRC is associated with L-OHP sensitivity through regulation of MDR1/p-gp and the downstream c-JunN-terminal kinase (JNK) signaling pathway. Moreover, lncRNA-MALAT1 offers great potential in the regulation of drug resistance by interacting with miR-200s. Therefore, in this work, we explored whether ZJW could reverse L-OHP resistance in CRC by regulating MALAT1, miR-200s, and the downstream signaling pathway. Methods: Cell Counting Kit-8 and flow cytometry were used to detect the effects of ZJW combined with L-OHP on chemotherapy tolerance and cell apoptosis of HCT116/L-OHP cells. Western blotting and quantitative real-time PCR (qRT-PCR) were used to detect the activation of the JNK signaling pathway and the protein and mRNA expression levels of the drug resistance-related MDR1/ABCB1 gene in HCT116/L-OHP cells treated with ZJW. The binding sites of MALAT1 and miR-200s were predicted by bioinformatics tools and confirmed by qRT-PCR. qRT-PCR was used to detect the expression of miR-200s and MALAT1 in HCT116/L-OHP cells treated with ZJW. A xenograft model of CRC in nude mice was established to observe the effect of ZJW combined with L-OHP on the growth of subcutaneously transplanted tumors. Apoptosis in tumor cells was detected by TUNEL staining. The activation of the JNK signaling pathway and the expression of drug resistance-related proteins were detected by immunohistochemistry and immunofluorescence. qRT-PCR was used to detect the expression of miR-200s and the MALAT1 gene in the tumors. Results: Our study showed that ZJW could significantly decrease the proliferation and promote apoptosis of HCT116/L-OHP cells treated with L-OHP. We further proved that ZJW could reverse the drug resistance of HCT116/L-OHP cells by reducing MALAT1, indirectly upregulating miR-200s, alleviating the activation of the JNK signaling axis, and downregulating the expression of resistance proteins such as MDR1/ABCB1 and ABCG2. ZJW combined with L-OHP inhibited the growth of subcutaneously transplanted tumors and induced apoptosis in nude mice. ZJW reduced the expression of MALAT1 and upregulated the expression of miR-200s in transplanted tumors. In addition, ZJW also alleviated the activation of the JNK signaling pathway while reducing the expression of MDR1/ABCB1 and ABCG2. Conclusions: Our study identified that MALAT1 promotes colorectal cancer resistance to oxaliplatin by reducing the miR-200s expression. ZJW may reverse chemoresistance by inhibiting the expression of MALAT1 and regulating the miR-200s/JNK pathway, providing an experimental basis for the clinical application of ZJW in relieving chemotherapy resistance.
Language	English
Publishing date	2022-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/3032407
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Article: Yu Jin Pulvis inhibits carbon tetrachloride-induced liver fibrosis by blocking the MAPK and PI3K/Akt signaling pathways.

Wu, Wei / Piao, Haiyu / Wu, Fushun / Han, Yong / An, Dongzhu / Wu, Yanling / Lin, Zhenhua / Piao, Yingshi / Jin, Jingchun

American journal of translational research

2019 Volume 11, Issue 9, Page(s) 5998–6006

Abstract: Traditional Chinese medicine theory indicates that Yu Jin Pulvis (YJP) could prevent liver fibrosis ...

Abstract	Traditional Chinese medicine theory indicates that Yu Jin Pulvis (YJP) could prevent liver fibrosis progression and this has been verified in liver fibrosis patients. However, the mechanism underlying the protective effects of YJP against liver fibrosis remains unclear. While different signaling pathways are involved in liver fibrosis progression, mitogen-activated protein kinase (MAPK) and phosphoinositide-3-kinase-protein kinase B/Akt (PI3K/Akt) are the most crucial. To determine whether YJP regulates these signaling pathways to prevent liver fibrosis, we used a mouse model of liver fibrosis induced by intraperitoneal injection of carbon tetrachloride (CCl
Language	English
Publishing date	2019-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Analysis of the driving factors of precipitation change during the development of the Jing-Jin-Ji urban agglomeration

Wei, Feili / Li, Shuangcheng / Liu, Dahai / Liang, Ze / Wang, Yongxun / Wang, Huan / Wang, Yueyao / Zhang, Yajuan / Liu, Yinglü

Urban Climate. 2023, p.101613-

2023 , Page(s) 101613–

Abstract: ... in Beijing-Tianjin-Hebei (Jing-Jin-Ji) urban agglomeration for the summers of 2001-2019, and identified ... key results. 1) The factors that had the greatest impact on urban precipitation changes in Jing-Jin-Ji ... the leading factor driving precipitation changes during the urbanization of Jing-Jin-Ji. 2) In the different ...

Abstract	Urbanization has an important impact on local precipitation changes. Previous studies of urban precipitation have largely considered single precipitation events, with few long-term statistical studies based on multiple samples. Therefore, based on WRF model simulations, this study extracted the latent heat flux, sensible heat flux, net radiation, friction velocity, albedo, and precipitation of 156 urban units in Beijing-Tianjin-Hebei (Jing-Jin-Ji) urban agglomeration for the summers of 2001-2019, and identified the main factors driving long-term urban precipitation changes based on multiple samples. There were three key results. 1) The factors that had the greatest impact on urban precipitation changes in Jing-Jin-Ji were the sensible heat flux, latent heat flux, and friction velocity. The latent heat flux was the leading factor driving precipitation changes during the urbanization of Jing-Jin-Ji. 2) In the different stages of urbanization, there were different factors affecting urban precipitation changes. In highly urbanized cities, the sensible heat flux had the greatest impact on precipitation changes, followed by the friction velocity. For medium-sized cities, the friction velocity was the most important variable. For small cities, the latent heat flux was the most important factor. 3) The friction velocity was the leading factor in precipitation change at the 0.95 quantile in Jing-Jin-Ji, and was therefore the most important factor driving changes in urban extreme precipitation. The results provide a theoretical basis for the formulation of climate policies, and disaster prevention and mitigation in Jing-Jin-Ji. They will also assist in promoting the construction of an ecological civilization and building safe and livable cities.
Keywords	climate ; disaster preparedness ; friction velocity ; latent heat flux ; net radiation ; sensible heat flux ; urbanization ; weather research and forecasting model ; WRF simulation ; Precipitation ; Leading factor ; Climate policies
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ISSN	2212-0955
DOI	10.1016/j.uclim.2023.101613
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Designing cross-region ecological compensation scheme by integrating habitat maintenance services production and consumption-A case study of Jing-Jin-Ji region.

Wei, Yiping / Song, Bo / Wang, Yalin

Journal of environmental management

2022 Volume 311, Page(s) 114820

Abstract: ... to a three-level hierarchy of the Jing-Jin-Ji region for 2000, 2008 and 2013. At the provincial level ...

Abstract	Establishing a practicable ecological compensation scheme is crucial to raise sufficient funds for habitat conservation. This study proposes a cross-region ecological compensation scheme by integrating habitat maintenance services production and consumption. In addition, the suitability evaluation method and InVEST model of habitat quality were employed to estimate the habitat maintenance services production and consumption, respectively. We used 1980 as the benchmark year and applied the scheme to a three-level hierarchy of the Jing-Jin-Ji region for 2000, 2008 and 2013. At the provincial level, Beijing paid the most habitat maintenance services ecological compensation, with an increasing trend from 1.64 × 10
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.114820
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