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  1. Article: Risk and Protective Factors for African American Kinship Caregiving: A Scoping Review.

    Wu, Qi / Zhu, Yiqi / Brevard, Kanisha / Wu, Shiyou / Krysik, Judy

    Children and youth services review

    2023  Volume 156

    Abstract: Background: African American children are disproportionately placed in kinship care, specifically with kin caregivers who have pressing service needs given their relatively poor physical and mental health, and low economic status. Kinship caregivers ... ...

    Abstract Background: African American children are disproportionately placed in kinship care, specifically with kin caregivers who have pressing service needs given their relatively poor physical and mental health, and low economic status. Kinship caregivers often face challenges, however, they also show resilience when raising relative children. Although the literature has examined risk and protective factors that affect kinship caregiving, no scoping review has been conducted to summarize these factors as they relate to African American kinship caregivers.
    Objectives: This study aims to summarize the risk and protective factors that affect African American kinship caregiving.
    Methods: Twenty-six studies were identified from this scoping review. A data template was used to extract information on data/sample, research methods, and risk and protective factors.
    Results: This review found that the risk and protective factors in the identified studies can be summarized into four types: child, caregiver, relationship, and legal, cultural or social issues. Caregiver factors were examined from the perspective of physical and behavioral health, parenting, and resources. The most common risk factors were caregivers' low social economic status or great financial need, and caregivers' physical health. The most common protective factor was caregivers' spirituality or religion.
    Discussion: This review helps to better understand the risk and protective factors for African American kinship caregivers. Policies should be informed by African American kinship caregivers' unique qualities to provide useful cultural solutions. Evidence based interventions should be developed and provided to African American kinship caregivers to improve their parenting abilities and to provide them with additional resources and supports. Implications for child welfare research are also presented.
    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Journal Article
    ISSN 0190-7409
    ISSN 0190-7409
    DOI 10.1016/j.childyouth.2023.107279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identifying potential targets for lung cancer intervention by analyzing the crosstalk of cancer-associated fibroblasts and immune and metabolism microenvironment.

    Wei, Shiyou / Bao, Minwei / Zhu, Yuming / Zhang, Wentian / Jiang, Lei

    Environmental toxicology

    2023  Volume 38, Issue 8, Page(s) 1951–1967

    Abstract: Background: Cancer-associated fibroblasts (CAFs) have been reported to play a crucial role in the tumor microenvironment and progression.: Methods: The data used in this study were obtained from the Cancer Genome Atlas and Gene Expression Omnibus ... ...

    Abstract Background: Cancer-associated fibroblasts (CAFs) have been reported to play a crucial role in the tumor microenvironment and progression.
    Methods: The data used in this study were obtained from the Cancer Genome Atlas and Gene Expression Omnibus databases, and all analyses were performed using R software.
    Results: We first quantified the CAFs infiltration through single sample gene set enrichment analysis in the TCGA and combined GEO cohort (GSE30219, GSE37745, and GSE50081). Our result showed that patients with high levels of CAF infiltration were associated with worse clinical features and poor prognosis. Immune microenvironment analysis indicated that high CAF infiltration might result in increased infiltration of immune cells, including aDC, B cells, CD8+ T cells, cytotoxic cells, DC, eosinophils, iDC, macrophages, mast cells, neutrophils, NK CD56dim cells, NK cells, pDC, and T cells. Correlation analysis showed a significant positive correlation between CAFs and M2 macrophages, while a negative correlation was found between CAFs and glycerophospholipid metabolism. Kaplan-Meier survival curves indicated that glycerophospholipid metabolism was a protective factor against lung cancer. Biological enrichment analysis showed that pathways such as allograft rejection, epithelial-mesenchymal transition, KRAS signaling, TNF-α signaling, myogenesis, IL6/JAK/STAT3 signaling, IL2/STAT5 signaling were upregulated in the patients with high CAF infiltration. Moreover, patients with high CAF infiltration had a lower proportion of immunotherapy responders. Genome analysis showed that low CAFs infiltration was associated with high genome instability. We identified FGF5 and CELF3 as key genes involved in the interaction between CAFs, M2 macrophages, and glycerophospholipid metabolism, and further analyzed FGF5. In vitro experiments showed that FGF5 promoted the proliferation, invasion and migration of lung cancer cells and was primarily localized in the nucleoli fibrillar center.
    Conclusions: Our study provides novel insights into the roles of CAFs in lung cancer progression and the underlying crosstalk of tumor metabolism and immune microenvironment.
    MeSH term(s) Humans ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Lung Neoplasms/pathology ; Lung/pathology ; Signal Transduction ; Glycerophospholipids/metabolism ; Tumor Microenvironment/genetics
    Chemical Substances Glycerophospholipids
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Single-nucleus RNA and multiomics in situ pairwise sequencing reveals cellular heterogeneity of the abnormal ligamentum teres in patients with developmental dysplasia of the hip.

    Zhao, Zhenhui / Fan, Chuiqin / Wang, Shiyou / Wang, Haoyu / Deng, Hansheng / Zeng, Shuaidan / Tang, Shengping / Li, Li / Xiong, Zhu / Qiu, Xin

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27803

    Abstract: Developmental dysplasia of the hip (DDH) is the most common hip deformity in pediatric orthopedics. One of the common pathological changes in DDH is the thickening and hypertrophy of the ligamentum teres. However, the underlying pathogenic mechanism ... ...

    Abstract Developmental dysplasia of the hip (DDH) is the most common hip deformity in pediatric orthopedics. One of the common pathological changes in DDH is the thickening and hypertrophy of the ligamentum teres. However, the underlying pathogenic mechanism responsible for these changes remains unclear. This study represents the first time that the heterogeneity of cell subsets in the abnormal ligamentum teres of patients with DDH has been resolved at the single-cell and spatial levels by snRNA-Seq and MiP-Seq. Through gene set enrichment and intercellular communication network analyses, we found that receptor-like cells and ligament stem cells may play an essential role in the pathological changes resulting in ligamentum teres thickening and hypertrophy. Eight ligand-receptor pairs related to the ECM-receptor pathway were observed to be closely associated with DDH. Further, using the Monocle R package, we predicted a differentiation trajectory of pericytes into two branches, leading to junctional ligament stem cells or fibroblasts. The expression of extracellular matrix-related genes along pseudotemporal trajectories was also investigated. Using MiP-Seq, we determined the expression distribution of marker genes specific to different cell types within the ligamentum teres, as well as differentially expressed DDH-associated genes at the spatial level.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identifying potential targets for lung cancer intervention by analyzing the crosstalk of cancer‐associated fibroblasts and immune and metabolism microenvironment

    Wei, Shiyou / Bao, Minwei / Zhu, Yuming / Zhang, Wentian / Jiang, Lei

    Environmental Toxicology. 2023 Aug., v. 38, no. 8 p.1951-1967

    2023  

    Abstract: BACKGROUND: Cancer‐associated fibroblasts (CAFs) have been reported to play a crucial role in the tumor microenvironment and progression. METHODS: The data used in this study were obtained from the Cancer Genome Atlas and Gene Expression Omnibus ... ...

    Abstract BACKGROUND: Cancer‐associated fibroblasts (CAFs) have been reported to play a crucial role in the tumor microenvironment and progression. METHODS: The data used in this study were obtained from the Cancer Genome Atlas and Gene Expression Omnibus databases, and all analyses were performed using R software. RESULTS: We first quantified the CAFs infiltration through single sample gene set enrichment analysis in the TCGA and combined GEO cohort (GSE30219, GSE37745, and GSE50081). Our result showed that patients with high levels of CAF infiltration were associated with worse clinical features and poor prognosis. Immune microenvironment analysis indicated that high CAF infiltration might result in increased infiltration of immune cells, including aDC, B cells, CD8+ T cells, cytotoxic cells, DC, eosinophils, iDC, macrophages, mast cells, neutrophils, NK CD56dim cells, NK cells, pDC, and T cells. Correlation analysis showed a significant positive correlation between CAFs and M2 macrophages, while a negative correlation was found between CAFs and glycerophospholipid metabolism. Kaplan‐Meier survival curves indicated that glycerophospholipid metabolism was a protective factor against lung cancer. Biological enrichment analysis showed that pathways such as allograft rejection, epithelial–mesenchymal transition, KRAS signaling, TNF‐α signaling, myogenesis, IL6/JAK/STAT3 signaling, IL2/STAT5 signaling were upregulated in the patients with high CAF infiltration. Moreover, patients with high CAF infiltration had a lower proportion of immunotherapy responders. Genome analysis showed that low CAFs infiltration was associated with high genome instability. We identified FGF5 and CELF3 as key genes involved in the interaction between CAFs, M2 macrophages, and glycerophospholipid metabolism, and further analyzed FGF5. In vitro experiments showed that FGF5 promoted the proliferation, invasion and migration of lung cancer cells and was primarily localized in the nucleoli fibrillar center. CONCLUSIONS: Our study provides novel insights into the roles of CAFs in lung cancer progression and the underlying crosstalk of tumor metabolism and immune microenvironment.
    Keywords computer software ; cytotoxicity ; ecotoxicology ; eosinophils ; fibroblasts ; gene expression ; genes ; genetic instability ; glycerophospholipids ; graft rejection ; immunotherapy ; lung neoplasms ; macrophages ; metabolism ; muscle development ; neoplasm progression ; neutrophils ; prognosis ; sequence analysis
    Language English
    Dates of publication 2023-08
    Size p. 1951-1967.
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23821
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: The Doping Effect on the Intrinsic Ferroelectricity in Hafnium Oxide-Based Nano-Ferroelectric Devices.

    Li, Zhenhai / Wei, Jinchen / Meng, Jialin / Liu, Yongkai / Yu, Jiajie / Wang, Tianyu / Xu, Kangli / Liu, Pei / Zhu, Hao / Chen, Shiyou / Sun, Qing-Qing / Zhang, David Wei / Chen, Lin

    Nano letters

    2023  Volume 23, Issue 10, Page(s) 4675–4682

    Abstract: Hafnium oxide ( ... ...

    Abstract Hafnium oxide (HfO
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c00085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Discovery of Ingenane Diterpenoids from

    Wu, Shu-Qi / Zhu, Xinying / Yuan, Tao / Yuan, Fang-Yu / Zhou, Shiyou / Huang, Dong / Wang, Ying / Tang, Gui-Hua / Huang, Zhi-Shu / Chen, Xin / Yin, Sheng

    Journal of natural products

    2023  Volume 86, Issue 12, Page(s) 2691–2702

    Abstract: ... Thirteen ... ...

    Abstract Thirteen new
    MeSH term(s) Euphorbia/chemistry ; Diterpenes/pharmacology ; Diterpenes/chemistry ; Phorbols ; Adipogenesis ; Molecular Structure
    Chemical Substances ingenane ; Diterpenes ; Phorbols
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c00822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Building a Flexible and Highly Ionic Conductive Solid Electrolyte Interphase on the Surface of Si@C Anodes by Binary Electrolyte Additives.

    Song, Linhu / Li, Shiyou / Wang, Jie / Zhu, Junlong / Wang, Yinong / Cai, Xingpeng / Zong, Feifei / Wang, Hui / Cui, Xiaoling / Zhao, Dongni

    ACS applied materials & interfaces

    2023  Volume 15, Issue 42, Page(s) 49727–49738

    Abstract: Si@C as a high specific capacity anode material for lithium batteries (LIBs) has attracted a lot of attention. However, the severe volume change during lithium de-embedding causes repeated rupture/reconstruction of the solid electrolyte interphase (SEI), ...

    Abstract Si@C as a high specific capacity anode material for lithium batteries (LIBs) has attracted a lot of attention. However, the severe volume change during lithium de-embedding causes repeated rupture/reconstruction of the solid electrolyte interphase (SEI), resulting in poor cycling stability of the Si-based battery system and thus hindering its application in commercial batteries. Using electrolyte additives to form an excellent SEI is considered to be a cost-effective method to meet this challenge. Here, the classical film-forming additive vinyl carbonate (VC), and the newly emerging lithium salt additive lithium difluorophosphate (LiDFP), are chosen as synergistic additives to improve the electrode-electrolyte interface properties. Final results show that the VC additive generates flexible polycarbonate components at the electrode/electrolyte interface, preventing the fragmentation of Si particles. However, the organic components show high impedance, inhibiting the fast transport of Li
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c08704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Atomic structures of twin boundaries in CoO.

    Xing, Wandong / Zhang, Yang / Cui, Jizhe / Liang, Shiyou / Meng, Fanyan / Zhu, Jing / Yu, Rong

    Physical chemistry chemical physics : PCCP

    2021  Volume 23, Issue 45, Page(s) 25590–25596

    Abstract: The twinning plane of crystals with a face-centered-cubic (FCC) structure is usually the (111) plane, as found in FCC metals and oxides with FCC sublattices of oxygen, like rock-salt-type NiO and spinel-type ... ...

    Abstract The twinning plane of crystals with a face-centered-cubic (FCC) structure is usually the (111) plane, as found in FCC metals and oxides with FCC sublattices of oxygen, like rock-salt-type NiO and spinel-type Fe
    Language English
    Publishing date 2021-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d1cp04112f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Clinical efficacy of modified total auricular reconstruction technique by using reformative inflation method and remnant ear without skin grafting.

    Zhang, Yingyi / Liu, Chuanqi / Wei, Shiyou / Zhu, Guonian / Li, Zhengyong

    Annals of translational medicine

    2021  Volume 9, Issue 10, Page(s) 890

    Abstract: Background: As one of the most widely used methods to treat microtia, the auricular reconstruction proposed by Zhuang may have several drawbacks. This study aimed to introduce a modified Zhuang's ear reconstruction technique by using a reformative ... ...

    Abstract Background: As one of the most widely used methods to treat microtia, the auricular reconstruction proposed by Zhuang may have several drawbacks. This study aimed to introduce a modified Zhuang's ear reconstruction technique by using a reformative inflation method and remnant ear to shorten therapy time and avoid skin grafting in a two-stage operation for patients with microtia.
    Methods: A total of 124 patients with microtia were enrolled consecutively from 2014 to 2018. Among them, 66 patients underwent a modified Zhuang's method, and the remaining patients underwent Zhuang's method. The clinical and perioperative characteristics of patients, as well as complications and esthetic outcomes were analyzed.
    Results: Compared with Zhuang's group, our modified Zhuang's group had better average esthetic scores according to two plastic surgeons [11.5 (IQR, 10.5-12.5)
    Conclusions: Our modified Zhuang's technique is a new method to treat microtia which results in a clear contour of the reconstructed ear and matching skin color, minimal scarring, and a short treatment time.
    Language English
    Publishing date 2021-06-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-21-1302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An Improved Phase-Derived Range Method Based on High-Order Multi-Frame Track-Before-Detect for Warhead Detection

    Nannan Zhu / Shiyou Xu / Congduan Li / Jun Hu / Xinlan Fan / Wenzhen Wu / Zengping Chen

    Remote Sensing, Vol 14, Iss 29, p

    2022  Volume 29

    Abstract: It is crucial for a ballistic missile defense system to discriminate the true warhead from decoys. Although a decoy has a similar shape to the warhead, it is believed that the true warhead can be separated by its micro-Doppler features introduced by the ... ...

    Abstract It is crucial for a ballistic missile defense system to discriminate the true warhead from decoys. Although a decoy has a similar shape to the warhead, it is believed that the true warhead can be separated by its micro-Doppler features introduced by the precession and nutation. As is well known, the accuracy of the phase-derived range method, to extract micro-Doppler curves, can reach sub-wavelength. However, it suffers from an inefficiency of energy integration and high computational costs. In this paper, a novel phase-derived range method, using high-order multi-frame track-before-detect is proposed for micro-Doppler curve extraction under a low signal-to-noise ratio (SNR). First, the sinusoidal micro-Doppler range sequence is treated as the state, and the dynamic model is described as a Markov chain to obtain the envelopes and then the ambiguous phases. Instead of processing the whole frames, the proposed method only processes the latest frame at an arbitrary given time, which reduces the computational costs. Then, the correlation of all pairs of adjacent pulses is calculated along the slow time dimension to find the number of cells that the point scatterer crosses, which can be further used in phase unwrapping. Finally, the phase-derived range method is employed to get the micro-Doppler curves. Simulation results show that the proposed method is capable of extracting the micro-Doppler curves with sub-wavelength accuracy, even if SNR = −15 dB, with a lower computational cost.
    Keywords micro-Doppler ; track-before-detect ; high-order motion model ; phase unwrapping ; phase-derived range ; Science ; Q
    Subject code 621
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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