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Article ; Online: Economic values of reproductive and growth traits in Chinese Yiling sheep.

Li, Jihua / Liu, Guiqiong / Jiang, Xunping / Shen, Yumeng / Sun, Ling / Chen, Yan / Wang, Xu / Yang, Shiping / Yang, Han

Tropical animal health and production

2023 Volume 55, Issue 6, Page(s) 400

Abstract: This study aimed to calculate the economic value (EV) of reproductive and growth traits for Yiling ...

Abstract	This study aimed to calculate the economic value (EV) of reproductive and growth traits for Yiling sheep. A bio-economic model was developed to assess the economic value of litter size (LS), litter size at weaning (LSW), age at first lambing (AFL), lambing interval (LI), birth weight (BW), weaning weight (WW), and 6-month body weight (6MW). The sensitivity of the economic value of traits to changes in market prices was also analyzed. In this study, the trait with the highest EV was LSW (427.97 ¥), followed by LS (419.96 ¥), BW (52.13 ¥), 6MW (14.46 ¥), WW (11.03 ¥), AFL (-0.51 ¥), and LI (-9.09 ¥). LS was the most important trait in the production system with a relative economic weight of 22.81%, followed by 6MW and LSW with relative economic weights of 18.98% and 19.01%, respectively. All traits assessed, except AFL and LI, had positive economic values, indicating that genetic improvement of these traits would have a positive impact on profitability. The results of the sensitivity analysis showed that the economic value of AFL was not sensitive to price changes. All growth traits were unaffected by price changes in labor and medical costs. In addition, the LS, LSW, LI, WW, and 6MW were sensitive to changes in liveweight and feed prices. Generally, as feed prices increased, the economic value of all traits except LI and BW decreased. Except for LI and BW, the economic value of all traits increased due to the rise in liveweight prices. This suggested that liveweight and feed prices significantly affect the profitability of the production system.
MeSH term(s)	Animals ; Female ; Pregnancy ; Birth Weight ; Body Weight ; Litter Size ; Phenotype ; Reproduction ; Sheep ; Sheep, Domestic/growth & development ; Weaning
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	603363-5
ISSN	1573-7438 ; 0049-4747
ISSN (online)	1573-7438
ISSN	0049-4747
DOI	10.1007/s11250-023-03810-1
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Article ; Online: Effect of Kisspeptin-54 immunization on performance, carcass characteristics, meat quality and safety of Yiling goats.

Wassie, Teketay / Zeng, Fanmei / Jiang, Xunping / Liu, Guiqiong / Kasimu, Hailati / Ling, Sun / Girmay, Shishay

Meat science

2020 Volume 166, Page(s) 108139

Abstract: ... carcass characteristics, meat quality, and safety of Yiling goats. Thirty buck goats were randomly ...

Abstract	This study aimed to evaluate the effects of kisspeptin-54 immunocastration vaccine on performance, carcass characteristics, meat quality, and safety of Yiling goats. Thirty buck goats were randomly assigned into three groups: PVAX-B2L-Kisspeptin-54-asd immunized (PBK-asd), control, and surgically castrated. PBK-asd immunization significantly stimulated serum anti-kisspeptin antibody production and reduced testosterone hormone compared with the control group (p < .05). Interestingly, PBK-asd plasmid did not integrate into the host genome and had no significant effect on growth hormone, body weight, and average daily gain (ADG). Conversely, surgical castration significantly reduced ADG and carcass weight compared to the control group. Furthermore, PBK-asd immunization did not affect carcass characteristics (dressing percentage, loin area, and fat thickness) and meat quality traits (pH, color, cooking loss, drip loss, and shearing force). These results indicate that the Kisspeptin-54 DNA vaccine is safe and has potential to be used as an alternative to surgical castration for goats without negatively affecting carcass and meat quality.
MeSH term(s)	Animals ; Color ; Cooking ; Goats/growth & development ; Immunization/veterinary ; Kisspeptins/genetics ; Kisspeptins/immunology ; Male ; Meat/analysis ; Orchiectomy/methods ; Orchiectomy/veterinary ; Plasmids/administration & dosage ; Plasmids/immunology ; Testosterone/blood ; Vaccination/veterinary ; Vaccines, DNA/administration & dosage ; Vaccines, DNA/genetics ; Vaccines, DNA/immunology
Chemical Substances	Kisspeptins ; Vaccines, DNA ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2020-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2020.108139
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Article ; Online: Genetic background analysis and breed evaluation of Yiling yellow cattle

Xu Ling / Wen-gang ZHANG / Jun-ya LI / De-jiang ZHU / Xiao-cheng XU / Yan-zi TIAN / Xiong XIONG / Ai-zhen GUO / Bing-hai CAO / Hong NIU / Bo ZHU / Ze-zhao WANG / Yong-hu LIANG / Hong-xue SHEN / Yan CHEN

Journal of Integrative Agriculture, Vol 16, Iss 10, Pp 2246-

2017 Volume 2256

Abstract: ... representative indigenous cattle breeds of Hubei Province of China: Yiling yellow cattle (YL), Bashan cattle (BS ... NJ)-tree revealed a separation of Yiling yellow cattle from other geographic nearby local ...

Abstract	Abstract: Traditionally, Chinese indigenous cattle is geographically widespread. The present study analyzed based on genome-wide variants to evaluate the genetic background among 157 individuals from four representative indigenous cattle breeds of Hubei Province of China: Yiling yellow cattle (YL), Bashan cattle (BS), Wuling cattle (WL), Zaobei cattle (ZB), and 21 individuals of Qinchuan cattle (QC) from the nearby Shanxi Province of China. Linkage disequilibrium (LD) analysis showed the LD of YL was the lowest (r2=0.32) when the distance between markers was approximately 2 kb. Principle component analysis (PCA), and neighbor-joining (NJ)-tree revealed a separation of Yiling yellow cattle from other geographic nearby local cattle breeds. In PCA plot, the YL and QC groups were segregated as expected; moreover, YL individuals clustered together more obviously. In the NJ-tree, the YL group formed an independent branch and BS, WL, ZB groups were mixed. We then used the FST statistic approach to reveal long-term selection sweep of YL and other 4 cattle breeds. According to the selective sweep, we identified the unique pathways of YL, associated with production traits. Based on the results, it can be proposed that YL has its unique genetic characteristics of excellence resource, and it is an indispensable cattle breed in China.
Keywords	Yiling yellow cattle ; breed evaluation ; principle component analysis ; neighbor-joining tree ; Agriculture (General) ; S1-972
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Genetic background analysis and breed evaluation of Yiling yellow cattle

Ling, Xu / Ai-zhen GUO / Bing-hai CAO / Bo ZHU / De-jiang ZHU / Hong NIU / Hong-xue SHEN / Jun-ya LI / Wen-gang ZHANG / Xiao-cheng XU / Xiong XIONG / Yan CHEN / Yan-zi TIAN / Yong-hu LIANG / Ze-zhao WANG

CAAS. Publishing services by Elsevier B.V Journal of integrative agriculture. 2017 Oct., v. 16, no. 10

2017

Abstract	Traditionally, Chinese indigenous cattle is geographically widespread. The present study analyzed based on genome-wide variants to evaluate the genetic background among 157 individuals from four representative indigenous cattle breeds of Hubei Province of China: Yiling yellow cattle (YL), Bashan cattle (BS), Wuling cattle (WL), Zaobei cattle (ZB), and 21 individuals of Qinchuan cattle (QC) from the nearby Shanxi Province of China. Linkage disequilibrium (LD) analysis showed the LD of YL was the lowest (r2=0.32) when the distance between markers was approximately 2 kb. Principle component analysis (PCA), and neighbor-joining (NJ)-tree revealed a separation of Yiling yellow cattle from other geographic nearby local cattle breeds. In PCA plot, the YL and QC groups were segregated as expected; moreover, YL individuals clustered together more obviously. In the NJ-tree, the YL group formed an independent branch and BS, WL, ZB groups were mixed. We then used the FST statistic approach to reveal long-term selection sweep of YL and other 4 cattle breeds. According to the selective sweep, we identified the unique pathways of YL, associated with production traits. Based on the results, it can be proposed that YL has its unique genetic characteristics of excellence resource, and it is an indispensable cattle breed in China.
Keywords	cattle ; cattle breeds ; genetic background ; geographical distribution ; linkage disequilibrium ; principal component analysis ; China
Language	English
Dates of publication	2017-10
Size	p. 2246-2256.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2660426-7
ISSN	2095-3119
ISSN	2095-3119
DOI	10.1016/S2095-3119(17)61679-4
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Article ; Online: Response to: "Merit of integrating in situ transcriptomics and anatomical information for cell annotation and lineage construction in single-cell analyses of Populus".

Liang, Shaoming / Li, Yiling / Chen, Yang / Huang, Heng / Li, Sijia / Jiang, Yuanzhong / Ma, Tao

Genome biology

2024 Volume 25, Issue 1, Page(s) 86

MeSH term(s)	Populus/genetics ; Gene Expression Profiling ; Genes, Plant ; Single-Cell Analysis
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2040529-7
ISSN	1474-760X ; 1474-760X
ISSN (online)	1474-760X
ISSN	1474-760X
DOI	10.1186/s13059-024-03228-4
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Article ; Online: Association of social isolation and loneliness with the risk of hypertension in middle aged and older adults: Findings from a national representative longitudinal survey.

Wang, Shiqi / Zhang, Hao / Lou, Yiling / You, Qiqi / Jiang, Qingqing / Cao, Shiyi

Journal of affective disorders

2024 Volume 349, Page(s) 577–582

Abstract: Background: Social isolation and loneliness have been proved to be associated with many adverse health outcomes, but their influence on hypertension remains unclear. This study aimed to assess the relationship of social isolation and loneliness with ... ...

Abstract	Background: Social isolation and loneliness have been proved to be associated with many adverse health outcomes, but their influence on hypertension remains unclear. This study aimed to assess the relationship of social isolation and loneliness with hypertension risk among middle-aged and older adults in China. Methods: We used data from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study. Participants were assessed for social isolation and loneliness at baseline, and hypertension was identified by self-report and blood pressure measurement at follow-up in 2015. Binary logistic regression analyses were conducted to assess the association of social isolation and loneliness with the risk of hypertension. Results: A total of 3711 residents were included. 13.7 % of the participants had high level of social isolation and 18.1 % felt lonely. During the four-year follow up period, 651 participants developed hypertension. People with high level of social isolation had an increased risk of hypertension (odds ratio [OR]: 1.40, 95 % confidence interval [CI]: 1.09-1.79). Similar results were found between social isolation score and hypertension risk (OR: 1.14, 95 % CI: 1.04-1.26). No significant association between loneliness and hypertension or any interaction effect of social isolation and loneliness on hypertension were observed. Limitations: Limited by the structure of questionnaire, some of the information was derived by self-report, which may lead to recalling bias. Conclusion: Social isolation, rather than loneliness was associated with hypertension for middle aged and older adults. Social support needs to be strengthened for hypertension prevention in community.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Loneliness ; Longitudinal Studies ; Social Isolation ; Social Support ; Hypertension/epidemiology
Language	English
Publishing date	2024-01-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.01.008
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Article ; Online: Pathological features of gastric‑type endocervical adenocarcinoma: A report of two cases.

Zhou, Jiahui / Zhang, Xiangning / Mao, Weibo / Zhu, Yiling / Yan, Liping / Jiang, Jiangle / Zhang, Min

Oncology letters

2024 Volume 27, Issue 4, Page(s) 149

Abstract: Gastric-type endocervical adenocarcinoma (GEA) is an uncommon form of uterine cervical adenocarcinoma with an unfavorable prognosis. The tumor consists of glands exhibiting a morphological resemblance to gastric cells and occasionally manifests features ... ...

Abstract	Gastric-type endocervical adenocarcinoma (GEA) is an uncommon form of uterine cervical adenocarcinoma with an unfavorable prognosis. The tumor consists of glands exhibiting a morphological resemblance to gastric cells and occasionally manifests features akin to pancreaticobiliary mucinous adenocarcinoma. GEA differs from the typical cervical cancer, particularly in its lack of association with the human papillomavirus. Immunophenotypic analysis suggests intestinal differentiation. The present study reports two cases of GEA occurring in postmenopausal individuals who were diagnosed in Lishui Central Hospital (Lishui, China) between January 2015 and January 2023. Microscopic examination revealed cysts lined with mucinous cells within the tumors. Immunohistochemical assays confirmed the positivity of the tumors for cytokeratin 7, mucin (MUC)5AC, and mutant tumor protein p53, while the results were negative for tumor suppressor p16, and in one case for paired box protein 8, consistent with characteristics of mucinous adenocarcinoma originating from the gastrointestinal tract. Programmed death-ligand 1 expression was also negative. The proto-oncogene K-ras was identified using amplification refractory mutation system polymerase chain reaction. Both cases were negative for mutations in codons 12 and 13 of exon 2, codon 61 of exon 3 and codon 146 of exon 4, but were positive for wild-type K-ras. Clinical follow-up revealed a potential association between histopathological features and resistance to chemotherapeutic drugs. The infrequency of this tumor type may contribute to diagnostic challenges.
Language	English
Publishing date	2024-02-09
Publishing country	Greece
Document type	Case Reports
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14282
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Article ; Online: Fe-involved nanostructures act as photothermal transduction agents in cancer photothermal therapy.

Jiang, Zewei / Jiang, Zhikai / Jiang, Yiling / Cheng, Yingfeng / Yao, Qing / Chen, Ruijie / Kou, Longfa

Colloids and surfaces. B, Biointerfaces

2023 Volume 228, Page(s) 113438

Abstract: Cancer, a disease notorious for its difficult therapy regimen, has long puzzled researchers. Despite attempts to cure cancer using surgery, chemotherapy, radiotherapy, and immunotherapy, their effectiveness is limited. Recently, photothermal therapy (PTT) ...

Abstract	Cancer, a disease notorious for its difficult therapy regimen, has long puzzled researchers. Despite attempts to cure cancer using surgery, chemotherapy, radiotherapy, and immunotherapy, their effectiveness is limited. Recently, photothermal therapy (PTT), a rising strategy, has gained attention. PTT can increase the surrounding temperature of cancer tissues and cause damage to them. Fe is widely used in PTT nanostructures due to its strong chelating ability, good biocompatibility, and the potential to induce ferroptosis. In recent years, many nanostructures incorporating Fe
MeSH term(s)	Humans ; Photothermal Therapy ; Nanostructures/chemistry ; Phototherapy ; Neoplasms/drug therapy ; Hyperthermia, Induced ; Nanoparticles
Language	English
Publishing date	2023-07-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2023.113438
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Article ; Online: PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model.

Zhang, Peibei / Jiang, Youjun / Ye, Xianwei / Zhang, Cheng / Tang, Yiling

Experimental and therapeutic medicine

2023 Volume 25, Issue 5, Page(s) 223

Abstract: A number of previous studies have demonstrated the pivotal role of PI3K/AKT signalling in cigarette smoke (CS)-induced emphysema, where phosphoinositide dependent protein kinase 1 (PDK1) is a critical component of this pathway. Therefore, the present ... ...

Abstract	A number of previous studies have demonstrated the pivotal role of PI3K/AKT signalling in cigarette smoke (CS)-induced emphysema, where phosphoinositide dependent protein kinase 1 (PDK1) is a critical component of this pathway. Therefore, the present study aimed to investigate the effects of a PDK1 inhibitor (GSK-2334470) on the expression levels of PI3K, AKT, cyclin-dependent kinase inhibitor 2A (p16) and LC3B in a CS + CS extract (CSE)-induced mouse emphysema model. CS exposure and intraperitoneal injections of CSE were combined for 4 weeks to establish an emphysema model. Mice (n=35) were randomly divided into the normal control, emphysema (CS), PI3K inhibitor (CS3) and PDK1 inhibitor (CS1) groups. Immunohistochemistry staining of lung tissues was used to measure the expression of the PI3K, PDK1 and AKT proteins in airway epithelial tissues. Immunofluorescence staining was also used to measure the levels of p16 and LC3BII protein expression in the airway epithelial tissues. In addition, PI3K, PDK1, AKT, p16 and LC3B protein expression was semi-quantified using western blotting. The expression of PDK1, PI3K and AKT proteins in the airway epithelial tissues was significantly increased in the CS + CSE group compared with that in the control group. The expression levels of p16 and LC3B were also increased as well in the CS + CSE group compared with those in the control group. The expression levels of PI3K, PDK1, AKT, LC3B and p16 in the airway epithelial tissues of the CS3 group were lower compared with those in the CS + CSE group. A decrease in the expression levels of PDK1, AKT, p16 and LC3B in the airway epithelial tissues of the CS1 group compared with those in the CS + CSE group was also observed. However, there were no significant differences in the expression levels of PI3K between the CS1 and the CS groups. The present study concluded that the inhibition of PDK1 can potentially reduce autophagy and cell senescence by downregulating the expression of PI3K/AKT pathway related proteins in airway epithelial cells, thereby protecting against CS + CSE-induced emphysema in mice.
Language	English
Publishing date	2023-03-30
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2023.11922
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Article ; Online: Association of changes in plant-based diet consumption with all-cause mortality among older adults in China: a prospective study from 2008 to 2019.

Huang, Shen / Lou, Yiling / Wang, Shiqi / You, Qiqi / Jiang, Qingqing / Cao, Shiyi

The journal of nutrition, health & aging

2024 Volume 28, Issue 2, Page(s) 100027

Abstract: Objectives: To examine the association of changes in plant-based diet consumption with all-cause mortality among older adults in China.: Design: Cohort study.: Setting: This cohort study of 11 years used data from the Chinese Longitudinal Healthy ... ...

Abstract	Objectives: To examine the association of changes in plant-based diet consumption with all-cause mortality among older adults in China. Design: Cohort study. Setting: This cohort study of 11 years used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a long-term, nationwide survey covering 23 provinces in China. Participants: A total of 7843 older participants aged ≥60 years were included in this study. Measurements: Changes in plant-based diets consumption (2008-2011) were assessed by 3 graded plant-based diet indices, including an overall plant-based diet index (PDI), a healthful plant-based diet index (hPDI), and an unhealthful plant-based diet index (uPDI). The main outcome was all-cause mortality. Multivariable-adjusted Cox proportional-hazards models were fitted to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) of mortality for changes in PDI, hPDI, and uPDI. Results: A total of 7843 participants (mean [SD] age, 82.2 [10.9] years; 3588 [45.7%] men) were included in this study. During a median (IQR) of 9 (5-10) years of follow-up, 3749 deaths were documented. Compared with older adults whose plant-based diet indices were relatively stable, older adults with the greatest decrease (quintile 1) in PDI, hPDI, and uPDI had respectively 32% (95% CI, 19%-47%) higher, 21% (95% CI, 9%-33%) higher, and 10% (95% CI, 4%-21%) lower risk of death. Compared with older adults whose diet indices were relatively stable, older adults with the greatest increase (quintile 5) in uPDI had a 13% higher risk of death (95% CI, 1%-21%), while no significant associations of the increased PDI and hPDI with all-cause mortality were observed. Conclusion: Maintaining the consumption of overall and healthful plant-based diets, and decreasing the consumption of an unhealthful plant-based diet can be beneficial in preventing or delaying premature death among Chinese older adults.
MeSH term(s)	Male ; Humans ; Aged ; Aged, 80 and over ; Female ; Prospective Studies ; Cohort Studies ; Diet, Plant-Based ; China/epidemiology ; Diet, Healthy ; Diet
Language	English
Publishing date	2024-01-01
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1016/j.jnha.2023.100027
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