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Article ; Online: Explore & actuate: the future of personalized medicine in oncology through emerging technologies.

Babu, Erald / Sen, Subhojit

2024 Volume 36, Issue 2, Page(s) 93–101

Abstract: Purpose of review: The future of medicine is aimed to equip the physician with tools to assess the individual health of the patient for the uniqueness of the disease that separates it from the rest. The integration of omics technologies into clinical ... ...

Abstract	Purpose of review: The future of medicine is aimed to equip the physician with tools to assess the individual health of the patient for the uniqueness of the disease that separates it from the rest. The integration of omics technologies into clinical practice, reviewed here, would open new avenues for addressing the spatial and temporal heterogeneity of cancer. The rising cancer burden patiently awaits the advent of such an approach to personalized medicine for routine clinical settings. Recent findings: To weigh the translational potential, multiple technologies were categorized based on the extractable information from the different types of samples used, to the various omic-levels of molecular information that each technology has been able to advance over the last 2 years. This review uses a multifaceted classification that helps to assess translational potential in a meaningful way toward clinical adaptation. Summary: The importance of distinguishing technologies based on the flow of information from exploration to actuation puts forth a framework that allows the clinicians to better adapt a chosen technology or use them in combination to enhance their goals toward personalized medicine.
MeSH term(s)	Humans ; Precision Medicine ; Medical Oncology ; Neoplasms/genetics ; Neoplasms/therapy
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/CCO.0000000000001016
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Article ; Online: Amino Acid-triggered Water-soluble NBD Derivatives for Differential Organelle Staining and the Role of the Chemical Moiety for their Specific Localization.

Mandal, Subhasis / Singh, Arpana / Paul, Subhojit / Ghosh, Arnab / Sen, Prosenjit

Chemistry, an Asian journal

2022 Volume 17, Issue 20, Page(s) e202200837

Abstract: Apart from being the unit of proteins, amino acids have diverse roles. Here we have shown that amino acids guide the differential transportation of a dye molecule to the cellular organelles depending upon the property of their intrinsic functionality. We ...

Abstract	Apart from being the unit of proteins, amino acids have diverse roles. Here we have shown that amino acids guide the differential transportation of a dye molecule to the cellular organelles depending upon the property of their intrinsic functionality. We have conjugated the nitrobenzofurazan (NBD) moiety with two amino acids (lysine and histidine derivatives) with a linker. Both derivates are water-soluble and biocompatible in nature. Surprisingly, we found that lysine-conjugated NBD (NBD-Lys) stains lipid droplets whereas histidine-conjugated NBD (NBD-His) stains lysosomes. We also measured the spectral properties of these two NBD conjugates. The results depict that both conjugates are extremely stable both in air and under inert atmosphere, and the fluorescence of the derivatives remains almost unaltered at different pH. Further by altering the functionality of the side chain, we established the contribution of each functional group towards this differential organelle targeting.
MeSH term(s)	Fluorescent Dyes/chemistry ; Lysine ; Water ; Histidine ; Amino Acids ; Staining and Labeling ; Organelles
Chemical Substances	Fluorescent Dyes ; Lysine (K3Z4F929H6) ; Water (059QF0KO0R) ; Histidine (4QD397987E) ; Amino Acids
Language	English
Publishing date	2022-09-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2233006-9
ISSN	1861-471X ; 1861-4728
ISSN (online)	1861-471X
ISSN	1861-4728
DOI	10.1002/asia.202200837
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Article ; Online: Coagulation factor VIIa enhances programmed death-ligand 1 expression and its stability in breast cancer cells to promote breast cancer immune evasion.

Paul, Subhojit / Das, Kaushik / Ghosh, Arnab / Chatterjee, Akash / Bhoumick, Avinandan / Basu, Abhimanyu / Sen, Prosenjit

Journal of thrombosis and haemostasis : JTH

2023 Volume 21, Issue 12, Page(s) 3522–3538

Abstract: Background: Immunotherapy for breast cancer has not gained significant success. Coagulation factor VIIa (FVIIa)-tissue factor (TF) mediated activation of protease-activated receptor 2 (PAR2) is shown to promote metastasis and secretion of the immune- ... ...

Abstract	Background: Immunotherapy for breast cancer has not gained significant success. Coagulation factor VIIa (FVIIa)-tissue factor (TF) mediated activation of protease-activated receptor 2 (PAR2) is shown to promote metastasis and secretion of the immune-modulatory cytokines but the role of FVIIa in cancer immunology is still not well understood. Objectives: Here, we aim to investigate whether FVIIa protects breast cancer cells from CD8 T-cell-mediated killing. Methods: Peripheral blood mononuclear cell-derived CD8 T cells were cocultured with vehicle or FVIIa pretreated MDAMB468 cells. The proliferation and activity of CD8 T cells were measured by flow cytometry and ELISA. An allograft model, using wild-type or TF/PAR2-deleted 4T1 cells, was employed to determine the effect of FVIIa on breast cancer immune evasion in vivo. Results: Here, we demonstrate that TF-FVIIa induces programmed death-ligand 1 (PD-L1) in breast cancer cells by activating PAR2. PAR2 activation triggers large tumor suppressor kinase 1 (LATS1) inactivation leading to loss of yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) phosphorylation and subsequent nuclear localization of YAP/TAZ. YAP/TAZ inhibition reduces PD-L1 expression and increases CD8 T-cell activity. We further demonstrate that, apart from transcriptional induction of PD-L1, PAR2 activation also increases PD-L1 stability by enhancing its glycosylation through N-glycosyltransferases STT3A and STT3B. Conclusion: In a mouse model of breast cancer, tumor cell-specific PAR2 depletion leads to PD-L1 downregulation and increases anti-PD-1 immunotherapy efficacy. In conclusion, we showed that FVIIa-mediated signaling cascade in cancer cells serves as a tumor intrinsic mechanism of immunosuppression to promote cancer immune evasion.
MeSH term(s)	Animals ; Mice ; B7-H1 Antigen ; Cell Line, Tumor ; Factor VIIa/metabolism ; Immune Evasion ; Leukocytes, Mononuclear/metabolism ; Thromboplastin/genetics ; Thromboplastin/metabolism ; Receptor, PAR-2/genetics ; Receptor, PAR-2/metabolism ; Neoplasms
Chemical Substances	CD274 protein, human ; B7-H1 Antigen ; Factor VIIa (EC 3.4.21.21) ; Thromboplastin (9035-58-9) ; Receptor, PAR-2
Language	English
Publishing date	2023-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2023.08.008
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Article ; Online: Correction to: Effect of heavy load carriage on cardiorespiratory responses with varying gradients and modes of carriage.

Chatterjee, Subhojit / Chatterjee, Tirthankar / Bhattacharyya, Debojyoti / Sen, Suranjana / Pal, Madhusudan

Military Medical Research

2019 Volume 6, Issue 1, Page(s) 14

Abstract: ...

Abstract	.
Language	English
Publishing date	2019-05-08
Publishing country	England
Document type	Published Erratum
ZDB-ID	2768940-2
ISSN	2054-9369 ; 2095-7467
ISSN (online)	2054-9369
ISSN	2095-7467
DOI	10.1186/s40779-019-0205-x
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Article ; Online: A potential screening method for epigenetic drugs: uncovering stress-induced gene silencing in

Kaginkar, Snehal / Priya, Srishti / Sharma, Upnishad / D'Souza, Jacinta S / Sen, Subhojit

Free radical research

2021 Volume 55, Issue 5, Page(s) 533–546

Abstract: Histone modifications and DNA methylation together govern promoter availability, thereby influencing gene expression. This study queries the unicellular chlorophyte, ...

Abstract	Histone modifications and DNA methylation together govern promoter availability, thereby influencing gene expression. This study queries the unicellular chlorophyte,
MeSH term(s)	Animals ; Chlamydomonas/genetics ; Epigenomics/methods ; Gene Silencing/immunology ; Mass Screening
Language	English
Publishing date	2021-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2021.1876231
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Zs.A 2236: Show issues

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Article ; Online: Correction to

Subhojit Chatterjee / Tirthankar Chatterjee / Debojyoti Bhattacharyya / Suranjana Sen / Madhusudan Pal

Military Medical Research, Vol 6, Iss 1, Pp 1-

Effect of heavy load carriage on cardiorespiratory responses with varying gradients and modes of carriage

2019 Volume 1

Abstract: ...

Abstract	.
Keywords	Medicine (General) ; R5-920 ; Military Science ; U
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of shod walking on plantar pressure with varying uphill gradients

Suranjana Sen / Debojyoti Bhattacharyya / Subhojit Chaterjee / Bhuvnesh Kumar / Madhusudan Pal

Asian Journal of Medical Sciences, Vol 11, Iss 6, Pp 38-

2020 Volume 45

Abstract: Background: Uphill walking is biomechanically stressful. Changes in plantar pressure, is one of the important predictors of this stress and increased risk of foot injuries. It has been reported that civilians as well as different occupational workers ... ...

Abstract	Background: Uphill walking is biomechanically stressful. Changes in plantar pressure, is one of the important predictors of this stress and increased risk of foot injuries. It has been reported that civilians as well as different occupational workers have to walk over uphill gradient with footwear which may cause changes in plantar pressure. Till date published data on plantar pressure is not available of Indian population during shod walking with uphill gradients. Aims and Objective: The present study was aimed to generation of data base on plantar pressure and find out the effect of shod walking (wearing occupational boot) on plantar pressure at different uphill gradients. Materials and Methods: Twenty healthy male participated in this study. Plantar pressure was recorded using the pressure measurement system during walking at 4 km/hr speed on treadmill at level and different uphill gradients. Results: It was observed that the PP at all the five regions of both right and left foot (Forefoot, Mid-foot, Medial, Lateral, Heel and Overall) increased gradually along with the increase in gradients. There was significant increase of 8.94%, 9.93%, 18.22%, 16.06%, 10.27%, 12.92% respectively at left forefoot, mid-foot, heel, medial, lateral and overall regions at 10% gradient compared to level walking. Similarly, in right foot the increase was observed 8.20%, 10.82%, 14.28%, 13.75%, 8.27%, 10.88% in respective foot regions compared to level walking. Conclusion: Observations of the present study stated that with increasing gradient plantar pressure at various foot regions increased in both feet in comparison to level walking, maximum plantar pressure observed in heel region in both feet in comparison to other studied regions. This data will be considered as normal planter pressure value of adults at level and uphill gradients shod walking and may be utilized for prognosis of foot disorders and efficacy of treatment modalities of population comparable with studied individuals (for similar age, height and weight).
Keywords	plantar pressure ; foot regions ; uphill walking ; foot injury risk ; Medicine ; R
Subject code	629
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of heavy load carriage on cardiorespiratory responses with varying gradients and modes of carriage

Subhojit Chatterjee / Tirthankar Chatterjee / Debojyoti Bhattacharyya / Suranjana Sen / Madhusudan Pal

Military Medical Research, Vol 5, Iss 1, Pp 1-

2018 Volume 7

Abstract: Abstract Background The present study was undertaken to determine the effect of different uphill and downhill gradients on cardiorespiratory and metabolic responses of soldiers while carrying heavy military loads in two different modes. Methods Eight ... ...

Abstract	Abstract Background The present study was undertaken to determine the effect of different uphill and downhill gradients on cardiorespiratory and metabolic responses of soldiers while carrying heavy military loads in two different modes. Methods Eight physically fit male soldiers with a mean age 32.0 ± 2.0 years, a mean height of 169.5 ± 4.9 cm, and a mean weight of 63.8 ± 8.4 kg volunteered for this study. Each volunteer completed treadmill walking trials at a speed of 3.5 km/h while carrying no external load, 31.4 kg load in a distributed mode (existing load carriage ensembles) and compact mode (new back pack) over 5 different downhill and uphill gradients (− 5, − 10%, 0, 5, 10%) for 6 min at each gradient. During the walking trials, heart rate (HR), oxygen uptake (VO2), respiratory frequency (RF) and energy expenditure (EE) were determined by the process of breath-by-breath gas analysis using a K4b2 system. The average of the last 2 min data from each 6 min walking trial for each individual was subjected to statistical analysis. Results All parameters (HR, VO2, RF, and EE) gradually increased with the change in gradient from downhill to level to uphill. The distributed mode showed higher values compared to compact mode for all gradients, e.g., for VO2, there was a 10.7, 7.4, 5.1, 28.2 and 18.7% increase in the distributed mode across the 5 different gradients. Conclusion It can be concluded from the present study that the compact mode of load carriage is more beneficial than the distributed mode in terms of cardiorespiratory responses while walking on downhill and uphill surfaces with a 31.4 kg load.
Keywords	Medicine (General) ; R5-920 ; Military Science ; U
Subject code	629
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of heavy load carriage on cardiorespiratory responses with varying gradients and modes of carriage.

Chatterjee, Subhojit / Chatterjee, Tirthankar / Bhattacharyya, Debojyoti / Sen, Suranjana / Pal, Madhusudan

Military Medical Research

2018 Volume 5, Issue 1, Page(s) 26

Abstract: Background: The present study was undertaken to determine the effect of different uphill and downhill gradients on cardiorespiratory and metabolic responses of soldiers while carrying heavy military loads in two different modes.: Methods: Eight ... ...

Abstract	Background: The present study was undertaken to determine the effect of different uphill and downhill gradients on cardiorespiratory and metabolic responses of soldiers while carrying heavy military loads in two different modes. Methods: Eight physically fit male soldiers with a mean age 32.0 ± 2.0 years, a mean height of 169.5 ± 4.9 cm, and a mean weight of 63.8 ± 8.4 kg volunteered for this study. Each volunteer completed treadmill walking trials at a speed of 3.5 km/h while carrying no external load, 31.4 kg load in a distributed mode (existing load carriage ensembles) and compact mode (new back pack) over 5 different downhill and uphill gradients (- 5, - 10%, 0, 5, 10%) for 6 min at each gradient. During the walking trials, heart rate (HR), oxygen uptake (VO Results: All parameters (HR, VO Conclusion: It can be concluded from the present study that the compact mode of load carriage is more beneficial than the distributed mode in terms of cardiorespiratory responses while walking on downhill and uphill surfaces with a 31.4 kg load.
MeSH term(s)	Adult ; Biomechanical Phenomena ; Energy Metabolism/physiology ; Heart Rate/physiology ; Humans ; Male ; Military Personnel ; Oxygen Consumption/physiology ; Respiratory Function Tests ; Walk Test ; Weight-Bearing/physiology
Language	English
Publishing date	2018-07-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2768940-2
ISSN	2054-9369 ; 2095-7467
ISSN (online)	2054-9369
ISSN	2095-7467
DOI	10.1186/s40779-018-0171-8
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Article ; Online: A Novel Method to Generate MNase Ladders Reveal Rapid Chromatin Remodeling upon Gametogenesis and Mating in Chlamydomonas.

Potdar, Pooja / Pinto, Patricia / D'Souza, Nicole / Joshi, Prajakta / Malwade, Akshay / Sen, Subhojit

Protist

2018 Volume 169, Issue 5, Page(s) 632–644

Abstract: To circumvent nuclei isolation for nucleosomal mapping of wild-type (cell walled) algal cells, we developed a quick and versatile methodology, by abrasion of whole cells (Chlamydomonas, Scenedesmus and yeast), allowing Micrococcal Nuclease (MNase) direct ...

Abstract	To circumvent nuclei isolation for nucleosomal mapping of wild-type (cell walled) algal cells, we developed a quick and versatile methodology, by abrasion of whole cells (Chlamydomonas, Scenedesmus and yeast), allowing Micrococcal Nuclease (MNase) direct access to nuclear chromatin, in situ. Varying parameters such as bead abrasion, vortex and incubation conditions, we optimized capture of an 'early digest' which may probe chromatin differentially, based on nucleosome accessibility. A comparison of such ladders across vegetative cells, gametes and zygotes revealed an increase in the average nucleosomal repeat length (+17-34nt) upon gametogenesis, indicating a trend of chromatin compaction. Using PCR, we compared promoter enrichment in increasing orders of fractionated nucleosomal repeats (mono-, di-, up to penta-), each differing in cleavability based on chromatin accessibility. Concordant with higher gene expression (mating locus), promoters revealed an enrichment in mono-nucleosomal fractions. Interestingly, the zygote specific gene, MT0828 displayed rapid remodelling from penta-nucleosomal enrichment when completely repressed (vegetative), to intermediate states during gametogenesis (24hrs), which finally shifted to being largely mono-nucleosomal, when induced (1h zygotes). Summarizing three candidate genes from the mating locus, we conclude that the MNase based 'Chromatin Accessibility Assay' can track a range of large-scale rapid chromatin remodelling transitions within the binaries of gene expression.
MeSH term(s)	Biocatalysis ; Chlamydomonas/chemistry ; Chlamydomonas/cytology ; Chlamydomonas/genetics ; Chlamydomonas/physiology ; Chromatin/chemistry ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Gametogenesis ; Micrococcal Nuclease/chemistry ; Nucleosomes/chemistry ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Reproduction ; Restriction Mapping/methods
Chemical Substances	Chromatin ; Nucleosomes ; Micrococcal Nuclease (EC 3.1.31.1)
Language	English
Publishing date	2018-07-17
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036014-9
ISSN	1618-0941 ; 1434-4610
ISSN (online)	1618-0941
ISSN	1434-4610
DOI	10.1016/j.protis.2018.06.006
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