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Article ; Online: The heterochronic LIN-14 protein is a BEN domain transcription factor.

Greene, Sharrell / Huang, Ji / Hamilton, Keith / Tong, Liang / Hobert, Oliver / Sun, HaoSheng

2023 Volume 33, Issue 6, Page(s) R217–R218

Abstract: Heterochrony is a foundational concept in animal development and evolution, first introduced by Ernst Haeckel in 1875 and later popularized by Stephen J. ... ...

Abstract	Heterochrony is a foundational concept in animal development and evolution, first introduced by Ernst Haeckel in 1875 and later popularized by Stephen J. Gould
MeSH term(s)	Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; DNA/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation, Developmental ; Transcription Factors/metabolism
Chemical Substances	Caenorhabditis elegans Proteins ; DNA (9007-49-2) ; DNA-Binding Proteins ; Transcription Factors ; LIN-14 protein, C elegans
Language	English
Publishing date	2023-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.02.016
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Article: Correction: Lin. et al. Effects of Substrate-Coating Materials on the Wound-Healing Process.

Lin, Jin-Young / Lo, Kai-Yin / Sun, Yung-Shin

Materials (Basel, Switzerland)

2020 Volume 13, Issue 1

Abstract: The authors wish to make the following correction to this paper [ ... ]. ...

Abstract	The authors wish to make the following correction to this paper [...].
Language	English
Publishing date	2020-01-06
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13010248
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Article ; Online: Isolation of Swine Bone Marrow Lin-/CD45-/CD133 + Cells and Cardio-protective Effects of its Exosomes.

Li, Hongxiao / Gu, Jianjun / Sun, Xiaolin / Zuo, Qisheng / Li, Bichun / Gu, Xiang

Stem cell reviews and reports

2022 Volume 19, Issue 1, Page(s) 213–229

Abstract: Background: The identification in murine bone marrow (BM) of CD133 + /Lin-/CD45- cells, possessing ... unclear.: Objective: To establish an isolation and amplification method of CD133 + /Lin-/CD45- cells ... Lin-/CD45- cells and probe into their biological characteristics further. Furher more, to extract ...

Abstract	Background: The identification in murine bone marrow (BM) of CD133 + /Lin-/CD45- cells, possessing several features of pluripotent stem cells, encouraged us to investigate if similar population of cells could be also isolated from the swine BM. Heart failure is the terminal stage of many cardiovascular diseases, and its key pathological basis is cardiac fibrosis (CF). Research showed that stem cell derived exosomes may play a critical role in cardiac fibrosis. The effect of exosomes (Exos) on CF has remained unclear. Objective: To establish an isolation and amplification method of CD133 + /Lin-/CD45- cells from newbron swine BM in vitro, explore an highly efficient method to enrich swine bone marrow derived CD133 + /Lin-/CD45- cells and probe into their biological characteristics further. Furher more, to extract exosomes from it and explore its effect on CF. Methods: The mononuclear cells isolated from swine bone marrow by red blood cell (RBC) lysing buffer were coated by adding FcR blocking solution and coupled with CD133 antibody immunomagnetic beads, obtaining CD133 + cell group via Magnetic Activated Cell Sorting (MACS). In steps, the CD133 + /Lin-/CD45- cells were collected by fluorescence-activated cell sorting (FACS) labeled with CD133, Lin and CD45 antibodies, which were cultured and amplified in vitro. The biological features of CD133 + /Lin-/CD45- cells were studied in different aspects, including morphological trait observed with inverted microscope, ultrastructural characteristics observed under transmission electron microscope, expression of pluripotent markersidentified by immunofluorescent staining and Alkaline phosphatase staining. The Exos were extracted using a sequential centrifugation approach and its effects on CF were analyzed in Angiotensin II (Ang-II) induced-cardiac fibrosis in vivo. Rats in each group were treated for 4 weeks, and 2D echocardiography was adopted to evaluate the heart function. The degree of cardiac fibrosis was assessed by Hematoxylin-Eosin (HE) and Masson's trichrome staining. Results: The CD133 + /Lin-/CD45- cells accounted for about 0.2%-0.5% of the total mononuclear cells isolated from swine bone marrow. The combination of MACS and FACS to extract CD133 + /Lin-/CD45- cells could improved efficiency and reduced cell apoptosis. The CD133 + /Lin-/CD45- cells featured typical traits of pluripotent stem cells, the nucleus is large, mainly composed of euchromatin, with less cytoplasm and larger nucleoplasmic ratio, which expressed pluripotent markers (SSEA-1, Oct-4, Nanog and Sox-2) and alkaline phosphatase staining was positive.Animal experiment indicated that the cardiac injury related indexes (BNP、cTnI、CK-MB and TNF-α), the expression of key gene Smad3 and the degree of cardiac fibrosis in Exo treatment group were significantly reduced compared with the control group. 4 weeks after the treatment, cardiac ejection fraction (EF) value in the model group showed a remarkable decrease, indicating the induction of HF model. While Exo elevated the EF values, demonstrating cardio-protective effects. Conclusion: The CD133 + /Lin-/CD45- cells derived from swine bone marrow were successfully isolated and amplified, laying a good foundation for further research on this promising therapeutic cell. The Exos may be a promising potential treatment strategy for CF.
MeSH term(s)	Mice ; Rats ; Animals ; Swine ; Cell Differentiation ; Exosomes ; Alkaline Phosphatase ; Bone Marrow ; Fibrosis
Chemical Substances	Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-022-10432-x
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Zs.A 6198: Show issues

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Article ; Online: Metformin prevented high glucose-induced endothelial reactive oxygen species via OGG1 in an AMPKα-Lin-28 dependent pathway.

Tao, Liangliang / Fan, Xiucai / Sun, Jin / Zhang, Zhu

Life sciences

2021 Volume 268, Page(s) 119015

Abstract: ... inhibition of AMPKα and Lin-28. Furthermore, the effect of OGG1 on HG-induced ROS was partially dependent ... induced endothelial ROS via the AMPKα/Lin-28/OGG1 pathway. ...

Abstract	Aims: Metformin improves vascular function in obese type 2 diabetic patients. 8-Oxoguanine glycosylase (OGG1) is a main DNA glycosylase that is involved in vascular complications in various diseases. However, whether metformin suppresses endothelial reactive species oxygen production via the OGG1 pathway is unclear. Main methods: Human umbilical vein endothelial cells (HUVECs) were exposed to HG (high glucose) with or without metformin. OGG1 and AMPKα levels were measured after metformin treatment, while HG-induced ROS were measured by a DHE probe. Key findings: Metformin reduced HG-induced endothelial ROS by upregulating OGG1. Additionally, OGG1 protein expression was dependent on its mRNA stability, which was reversed by genetic inhibition of AMPKα and Lin-28. Furthermore, the effect of OGG1 on HG-induced ROS was partially dependent on the AHR/Nrf2 pathway in HUVECs. Significance: These results suggested that metformin modulated HG-induced endothelial ROS via the AMPKα/Lin-28/OGG1 pathway.
MeSH term(s)	AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; DNA Glycosylases/genetics ; DNA Glycosylases/metabolism ; Gene Expression Regulation/drug effects ; Glucose/pharmacology ; Human Umbilical Vein Endothelial Cells ; Humans ; Metformin/pharmacology ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Phosphorylation ; RNA Stability ; RNA-Binding Proteins/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, Aryl Hydrocarbon/metabolism
Chemical Substances	AHR protein, human ; Basic Helix-Loop-Helix Transcription Factors ; Lin28A protein, human ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; RNA-Binding Proteins ; Reactive Oxygen Species ; Receptors, Aryl Hydrocarbon ; Metformin (9100L32L2N) ; PRKAA1 protein, human (EC 2.7.11.1) ; PRKAA2 protein, human (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; DNA Glycosylases (EC 3.2.2.-) ; oxoguanine glycosylase 1, human (EC 3.2.2.-) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-01-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.119015
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Uc I Zs.368: Show issues

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Article ; Online: Analysis and comparison of fungal communities in wheat Qus and Lin‐fan yeast starters used as traditional starter cultures of Shaoxing Huangjiu

Yang, Huanyi / Kong, Xiangwei / Sun, Guochang / Du, Zhenna / Fu, Zukang / Shao, Shengnan / Shen, Ji / Zang, Wei / Sun, Jianqiu / Zhou, Jiandi

International Journal of Food Science & Technology. 2023 Oct., v. 58, no. 10 p.5183-5192

2023

Abstract: The wheat Qu and Lin‐fan yeast starter are two vital components of Huangjiu brewing, the microbiome ... to investigate and compare the fungal diversity of eight starters, including four wheat Qus and four Lin‐fan ... genera in wheat Qus. In contrast, Lin‐fan yeast starters possessed relatively simple fungal communities ...

Abstract	The wheat Qu and Lin‐fan yeast starter are two vital components of Huangjiu brewing, the microbiome composition of which can have a major impact on the end product's quality. This investigation aimed to investigate and compare the fungal diversity of eight starters, including four wheat Qus and four Lin‐fan yeast starters collected from different manufacturers of Shaoxing Huangjiu using high‐throughput sequencing (HTS) technology. Significant variation was observed in the fungal community composition among different starter samples. Fusarium, Epicoccum, Aspergillus and Alternaria were the most predominant fungal genera in wheat Qus. In contrast, Lin‐fan yeast starters possessed relatively simple fungal communities and were predominated by Saccharomyces and Saccharomycopsis. LEfSe analysis showed that nine genus‐level fungal taxa could be retrieved to differentiate the two starter types. Furthermore, the complicated association among the dominant fungi in traditional starters was revealed by utilising Spearman's correlation‐based network analysis. A total of 42 positive and 28 negative correlations were identified respectively. Ultimately, this investigation described the fungal communities in wheat Qus and Lin‐fan yeast starters and will aid in screening fermentation strains, which can remarkably enhance the quality of Shaoxing Huangjiu.
Keywords	Alternaria ; Aspergillus ; Epicoccum ; Fusarium ; Saccharomyces ; Saccharomycopsis ; community structure ; fermentation ; food science ; fungal communities ; microbiome ; wheat ; yeasts
Language	English
Dates of publication	2023-10
Size	p. 5183-5192.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	883561-5
ISSN	0950-5423
ISSN	0950-5423
DOI	10.1111/ijfs.16616
Database	NAL-Catalogue (AGRICOLA)

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Z 2121: Show issues

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Article ; Online: Investigation of Ramsey spectroscopy in a lin-par-lin Ramsey coherent population trapping clock with dispersion detection.

Sun, X L / Zhang, J W / Cheng, P F / Xu, C / Zhao, L / Wang, L J

Optics express

2016 Volume 24, Issue 5, Page(s) 4532–4541

Abstract: We demonstrate that the lin-par-lin Ramsey coherent population trapping ...

Abstract	We demonstrate that the lin-par-lin Ramsey coherent population trapping
Language	English
Publishing date	2016-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.24.004532
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Article: Metformin prevented high glucose-induced endothelial reactive oxygen species via OGG1 in an AMPKα-Lin-28 dependent pathway

Tao, Liangliang / Fan, Xiucai / Sun, Jin / Zhang, Zhu

Life sciences. 2021 Mar. 01, v. 268

2021

Abstract: ... on its mRNA stability, which was reversed by genetic inhibition of AMPKα and Lin-28. Furthermore, the effect ... suggested that metformin modulated HG-induced endothelial ROS via the AMPKα/Lin-28/OGG1 pathway. ...

Abstract	Metformin improves vascular function in obese type 2 diabetic patients. 8-Oxoguanine glycosylase (OGG1) is a main DNA glycosylase that is involved in vascular complications in various diseases. However, whether metformin suppresses endothelial reactive species oxygen production via the OGG1 pathway is unclear.Human umbilical vein endothelial cells (HUVECs) were exposed to HG (high glucose) with or without metformin. OGG1 and AMPKα levels were measured after metformin treatment, while HG-induced ROS were measured by a DHE probe.Metformin reduced HG-induced endothelial ROS by upregulating OGG1. Additionally, OGG1 protein expression was dependent on its mRNA stability, which was reversed by genetic inhibition of AMPKα and Lin-28. Furthermore, the effect of OGG1 on HG-induced ROS was partially dependent on the AHR/Nrf2 pathway in HUVECs.These results suggested that metformin modulated HG-induced endothelial ROS via the AMPKα/Lin-28/OGG1 pathway.
Keywords	DNA glycosylases ; glucose ; metformin ; noninsulin-dependent diabetes mellitus ; oxygen production ; protein synthesis ; reactive oxygen species ; umbilical veins
Language	English
Dates of publication	2021-0301
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.119015
Database	NAL-Catalogue (AGRICOLA)

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Z 73/732: Show issues

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Article: [Clinical experience of Dr. Huang Shi-lin in diagnosing and treating immune thrombocytopenia].

Sun, Shu-jun / Huang, Shi-lin

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2014 Volume 34, Issue 5, Page(s) 619–621

MeSH term(s)	Humans ; Purpura, Thrombocytopenic/diagnosis ; Purpura, Thrombocytopenic/therapy
Language	Chinese
Publishing date	2014-05
Publishing country	China
Document type	Journal Article
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
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Zs.B 2863: Show issues

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Article ; Online: Adipogenic and osteogenic differentiation of Lin(-)CD271(+)Sca-1(+) adipose-derived stem cells.

Xiao, Jingang / Yang, Xiaojuan / Jing, Wei / Guo, Weihua / Sun, Qince / Lin, Yunfeng / Liu, Lei / Meng, Wentong / Tian, Weidong

Molecular and cellular biochemistry

2013 Volume 377, Issue 1-2, Page(s) 107–119

Abstract: ... Here, we prospectively isolated and identified a restricted homogeneous subpopulation of ASCs (Lin ... Thus we proved that Lin, CD271, and Sca-1 could be used as the specific markers to purify ASCs ...

Abstract	Adipose-derived stem cells (ASCs) have been defined as cells that undergo sustained in vitro growth and have multilineage differentiation potential. However, the identity and purification of ASCs has proved elusive due to the lack of specific markers and poor understanding of their physiological roles. Here, we prospectively isolated and identified a restricted homogeneous subpopulation of ASCs (Lin(-)CD271(+)Sca-1(+)) from mouse adipose tissues on the basis of cell-surface markers. Individual ASCs generated colony-forming unit-fibroblast at a high frequency and could differentiate into adipocytes, osteoblasts, and chondrocytes in vitro. Expansion of ASCs in a large quantity was feasible in medium supplemented with fibroblast growth factor-2 and leukemia inhibitory factor, without loss of adipogenic and osteogenic differentiation capacity. Moreover, we found that the transplanted ASCs can differentiate into adipocytes in adipogenic microenvironment in vivo and osteoblasts in osteogenic microenvironment in vivo. Thus we proved that Lin, CD271, and Sca-1 could be used as the specific markers to purify ASCs from adipose tissue. The method we established to identify ASCs as defined in vivo entities will help develop ASCs transplantation as a new therapeutic strategy for bone regeneration and adipose tissue regeneration in clinic.
MeSH term(s)	Abdominal Fat/cytology ; Adapalene ; Adipogenesis ; Animals ; Antigens, Ly/metabolism ; Bone Regeneration ; Cell Proliferation ; Cells, Cultured ; Fibroblast Growth Factor 2/physiology ; Flow Cytometry ; Hydroxyapatites/chemistry ; Leukemia Inhibitory Factor/physiology ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Naphthalenes/metabolism ; Osteogenesis ; Phenotype ; Side-Population Cells/metabolism ; Stem Cell Transplantation ; Stem Cells/physiology ; Tissue Engineering ; Tissue Scaffolds/chemistry
Chemical Substances	Antigens, Ly ; Hydroxyapatites ; LIF protein, human ; Leukemia Inhibitory Factor ; Ly6a protein, mouse ; Membrane Proteins ; Naphthalenes ; hydroxyapatite-beta tricalcium phosphate ; Fibroblast Growth Factor 2 (103107-01-3) ; Adapalene (1L4806J2QF)
Language	English
Publishing date	2013-02-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-013-1575-0
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Zs.A 892: Show issues

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Book: Lin chuang di shi li xue

Sun, Baochen

2013

Author's details	zhu bian Sun Baochen, Hu Ailian
MeSH term(s)	Vision, Low/rehabilitation ; Vision Disorders/prevention & control
Language	Chinese
Size	15, 408, 4 pages :, illustrations, portraits.
Edition	Di 1 ban.
Document type	Book
ISBN	9787117183833 ; 7117183837
Database	Catalogue of the US National Library of Medicine (NLM)

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