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  1. Article: Mid-Term Estimates of Influenza Vaccine Effectiveness against the A(H1N1)pdm09 Prevalent Circulating Subtype in the 2023/24 Season: Data from the Sicilian RespiVirNet Surveillance System.

    Costantino, Claudio / Mazzucco, Walter / Graziano, Giorgio / Maida, Carmelo Massimo / Vitale, Francesco / Tramuto, Fabio

    Vaccines

    2024  Volume 12, Issue 3

    Abstract: The current influenza season started in Italy in October 2023, approaching the epidemic peak in late December (52nd week of the year). We aimed to explore the mid-term virologic surveillance data of the 2023/2024 influenza season (from 16 October 2023 to ...

    Abstract The current influenza season started in Italy in October 2023, approaching the epidemic peak in late December (52nd week of the year). We aimed to explore the mid-term virologic surveillance data of the 2023/2024 influenza season (from 16 October 2023 to 7 January 2024) in Sicily, the fourth most populous Italian region. A test-negative design was used to estimate the effectiveness of seasonal influenza vaccine (VE) against A(H1N1)pdm09 virus, the predominant subtype in Sicily (96.2% of laboratory-confirmed influenza cases). Overall, 29.2% (
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12030305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Molecular Epidemiology and Genetic Diversity of Human Respiratory Syncytial Virus in Sicily during Pre- and Post-COVID-19 Surveillance Seasons.

    Tramuto, Fabio / Maida, Carmelo Massimo / Mazzucco, Walter / Costantino, Claudio / Amodio, Emanuele / Sferlazza, Giuseppe / Previti, Adriana / Immordino, Palmira / Vitale, Francesco

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Human respiratory syncytial virus (hRSV) is an important pathogen of acute respiratory tract infection of global significance. In this study, we investigated the molecular epidemiology and the genetic variability of hRSV over seven surveillance seasons ... ...

    Abstract Human respiratory syncytial virus (hRSV) is an important pathogen of acute respiratory tract infection of global significance. In this study, we investigated the molecular epidemiology and the genetic variability of hRSV over seven surveillance seasons between 2015 and 2023 in Sicily, Italy. hRSV subgroups co-circulated through every season, although hRSV-B mostly prevailed. After the considerable reduction in the circulation of hRSV due to the widespread implementation of non-pharmaceutical preventive measures during the COVID-19 pandemic, hRSV rapidly re-emerged at a high intensity in 2022-2023. The G gene was sequenced for genotyping and analysis of deduced amino acids. A total of 128 hRSV-A and 179 hRSV-B G gene sequences were obtained. The phylogenetic analysis revealed that the GA2.3.5a (ON1) and GB5.0.5a (BA9) genotypes were responsible for the hRSV epidemics in Sicily.; only one strain belonged to the genotype GB5.0.4a. No differences were observed in the circulating genotypes during pre- and post-pandemic years. Amino acid sequence alignment revealed the continuous evolution of the G gene, with a combination of amino acid changes specifically appearing in 2022-2023. The predicted N-glycosylation sites were relatively conserved in ON1 and BA9 genotype strains. Our findings augment the understanding and prediction of the seasonal evolution of hRSV at the local level and its implication in the monitoring of novel variants worth considering in better design of candidate vaccines.
    Language English
    Publishing date 2023-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12091099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Outbreak of Novel Coronavirus (SARS-Cov-2): First Evidences From International Scientific Literature and Pending Questions.

    Amodio, Emanuele / Vitale, Francesco / Cimino, Livia / Casuccio, Alessandra / Tramuto, Fabio

    Healthcare (Basel, Switzerland)

    2020  Volume 8, Issue 1

    Abstract: On 31 December, 2019, a cluster of 27 pneumonia cases of unknown etiology was reported by Chinese health authorities in Wuhan City (China) [ ... ]. ...

    Abstract On 31 December, 2019, a cluster of 27 pneumonia cases of unknown etiology was reported by Chinese health authorities in Wuhan City (China) [...].
    Keywords covid19
    Language English
    Publishing date 2020-02-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare8010051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Real-life experience on COVID-19 and seasonal influenza vaccines co-administration in the vaccination hub of the University Hospital of Palermo, Italy.

    Costantino, Claudio / Mazzucco, Walter / Conforto, Arianna / Cimino, Livia / Pieri, Alessia / Rusignolo, Sara / Bonaccorso, Nicole / Bravatà, Floriana / Pipitone, Laura / Sciortino, Martina / Tocco, Marcello / Zarcone, Elena / Graziano, Giorgio / Tramuto, Fabio / Maida, Carmelo Massimo / Casuccio, Alessandra / Vitale, Francesco

    Human vaccines & immunotherapeutics

    2024  Volume 20, Issue 1, Page(s) 2327229

    Abstract: With the pandemic, there has been a global reduction in influenza virus circulation, with WHO reporting, during 2021/22 season, laboratory testing positivity rate for influenza of less than 3%. Influenza surveillance systems anticipated a peak of ... ...

    Abstract With the pandemic, there has been a global reduction in influenza virus circulation, with WHO reporting, during 2021/22 season, laboratory testing positivity rate for influenza of less than 3%. Influenza surveillance systems anticipated a peak of influenza cases in the Northern Hemisphere during 2022/2023 season and the Italian Ministry of Health recommended the routinary co-administration of influenza with bivalent COVID-19 vaccines for the 2022/2023 season. At the Vaccination Hub of the University Hospital (UH) of Palermo, more than 700 subjects received influenza and COVID-19 booster doses in co-administration, during the 2021/2022 season. A cross-sectional study analyzing attitudes and factors associated with adherence to influenza and COVID-19 seasonal vaccines co-administration was conducted at the Vaccination Hub of the UH of Palermo, from October to December 2022. Among the 1,263 respondents, 74.7% (
    MeSH term(s) Humans ; Male ; Influenza Vaccines ; Influenza, Human/prevention & control ; Influenza, Human/epidemiology ; Seasons ; COVID-19 Vaccines ; Cross-Sectional Studies ; COVID-19/prevention & control ; Vaccination ; Italy/epidemiology ; Hospitals, University
    Chemical Substances Influenza Vaccines ; COVID-19 Vaccines
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2024.2327229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Sero-Epidemiological Study of Varicella in the Italian General Population.

    Gabutti, Giovanni / Grassi, Tiziana / Bagordo, Francesco / Savio, Marta / Rota, Maria Cristina / Castiglia, Paolo / Baldovin, Tatjana / Napolitano, Francesco / Panico, Alessandra / Ogliastro, Matilde / Trombetta, Claudia Maria / Ditommaso, Savina / Tramuto, Fabio / Sero-Epidemiological Study Group

    Vaccines

    2023  Volume 11, Issue 2

    Abstract: The aim of this study was to analyze the seroprevalence of varicella in Italy and to evaluate the impact of varicella vaccination, which has been mandatory for newborns since 2017. The levels of VZV-specific IgG antibodies were determined by the ELISA ... ...

    Abstract The aim of this study was to analyze the seroprevalence of varicella in Italy and to evaluate the impact of varicella vaccination, which has been mandatory for newborns since 2017. The levels of VZV-specific IgG antibodies were determined by the ELISA method in residual serum samples obtained from subjects aged between 6 and 64 years and residing in 13 Italian regions. Overall, 3746 serum samples were collected in the years 2019 and 2020. The overall seroprevalence was 91.6% (89.9% in males and 93.3% in females;
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11020306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Outbreak of Novel Coronavirus (SARS-Cov-2)

    Emanuele Amodio / Francesco Vitale / Livia Cimino / Alessandra Casuccio / Fabio Tramuto

    Healthcare, Vol 8, Iss 1, p

    First Evidences From International Scientific Literature and Pending Questions

    2020  Volume 51

    Abstract: On 31 December, 2019, a cluster of 27 pneumonia cases of unknown etiology was reported by Chinese health authorities in Wuhan City (China) [.] ...

    Abstract On 31 December, 2019, a cluster of 27 pneumonia cases of unknown etiology was reported by Chinese health authorities in Wuhan City (China) [.]
    Keywords sars-cov-2 ; outbreak ; covid-19 ; public health ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Influenza vaccination of healthcare workers in Italy: could mandatory vaccination be a solution to protect patients?

    Costantino, Claudio / Restivo, Vincenzo / Tramuto, Fabio / Casuccio, Alessandra / Vitale, Francesco

    Future microbiology

    2019  Volume 14, Page(s) 45–49

    Abstract: Several studies have reported that influenza infections in healthcare workers (HCWs) can lead to nosocomial outbreaks. HCWs can potentially be infected with influenza every year, and may continue to work, encouraging the spread of the virus. Different ... ...

    Abstract Several studies have reported that influenza infections in healthcare workers (HCWs) can lead to nosocomial outbreaks. HCWs can potentially be infected with influenza every year, and may continue to work, encouraging the spread of the virus. Different strategies, such as informative interventions on influenza and influenza vaccination, 'onsite' vaccination weeks, communicative strategies through dedicated web and social media pages, and mandatory informed dissent form, were organized for HCWs working at the University Hospital of Palermo, during previous influenza seasons. However, the increased vaccination rates observed among HCWs still remain far from the 75% recommended by Public Health Authorities. The level of coverage observed in countries with mandatory vaccination policies for HCWs, could suggest the adoption of this strategy for increase influenza vaccination adherence in Italy.
    MeSH term(s) Attitude of Health Personnel ; Health Personnel/psychology ; Health Personnel/statistics & numerical data ; Hospitals, University ; Humans ; Infectious Disease Transmission, Professional-to-Patient/prevention & control ; Influenza Vaccines/standards ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Italy/epidemiology ; Mandatory Programs/statistics & numerical data ; Vaccination/legislation & jurisprudence ; Vaccination/psychology ; Vaccination/statistics & numerical data ; Vaccination Coverage
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2019-06-18
    Publishing country England
    Document type Journal Article
    ISSN 1746-0921
    ISSN (online) 1746-0921
    DOI 10.2217/fmb-2018-0238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hospitalization rates for intussusception in children aged 0-59 months from 2009 to 2014 in Italy.

    Restivo, Vincenzo / Costantino, Claudio / Tramuto, Fabio / Vitale, Francesco

    Human vaccines & immunotherapeutics

    2017  Volume 13, Issue 2, Page(s) 445–449

    Abstract: The real cause of intussusception is not fully understood and a variety of conditions have been associated with it (Meckel diverticulum, polyps, duplication cysts, parasites, Henoch-Schönlein purpura, cystic fibrosis, hemolytic-uremic syndrome and ... ...

    Abstract The real cause of intussusception is not fully understood and a variety of conditions have been associated with it (Meckel diverticulum, polyps, duplication cysts, parasites, Henoch-Schönlein purpura, cystic fibrosis, hemolytic-uremic syndrome and infectious gastroenteritis). Furthermore few European countries, following WHO recommendation to monitor baseline incidence of intussusception before implementation of immunization program for rotavirus, used intussusception rate as a baseline value to compare the same figures in the period before and after introduction of vaccination. In this study, data of intussusception hospitalizations occurred among Italian children aged 0 through 59 months from 2009 to 2014 were analyzed. A total amount of 3,088 children were included, accounting for a hospitalization rate of 20.2 per 100,000. Overall, the hospitalization rate for intussusception had a slight increase in trend from 2009 to 2014 (18%). In particular children 0-11 months had a hospitalization rate higher than 12-59 months with an aggregate value of 36 Vs. 16 per 100,000 respectively. Among all children hospitalized for intussusception a total of 239 (7.7%) had also a previous or concomitant hospitalization for gastroenteritis. This study demonstrates that Italian hospitalizations for intussusception are increasing by time and the role played by different risk factors, including acute gastroenteritis, have to be investigated in the future. These data could be useful to monitor intussusception hospitalization in the perspective of anti-rotavirus vaccination introduction in Italy.
    MeSH term(s) Child, Preschool ; Female ; Hospitalization ; Humans ; Incidence ; Infant ; Infant, Newborn ; Intussusception/epidemiology ; Italy/epidemiology ; Male
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2017.1264784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6967: Show issues Location:
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  9. Article: Outbreak of Novel Coronavirus (SARS-Cov-2): First Evidences From International Scientific Literature and Pending Questions

    Amodio, Emanuele / Vitale, Francesco / Cimino, Livia / Casuccio, Alessandra / Tramuto, Fabio

    Healthcare (Basel)

    Abstract: On 31 December, 2019, a cluster of 27 pneumonia cases of unknown etiology was reported by Chinese health authorities in Wuhan City (China) [ ] ...

    Abstract On 31 December, 2019, a cluster of 27 pneumonia cases of unknown etiology was reported by Chinese health authorities in Wuhan City (China) [ ]
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #3464
    Database COVID19

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  10. Article ; Online: Universal rotavirus vaccination program in Sicily: Reduction in health burden and cost despite low vaccination coverage.

    Costantino, Claudio / Restivo, Vincenzo / Tramuto, Fabio / Casuccio, Alessandra / Vitale, Francesco

    Human vaccines & immunotherapeutics

    2018  Volume 14, Issue 9, Page(s) 2297–2302

    Abstract: Rotavirus is considered the main cause of severe gastroenteritis and nosocomial infections in Pediatric units, especially during late winter and early spring season in temperate region. In 2013 Sicilian Region, for the first time in Italy, introduced ... ...

    Abstract Rotavirus is considered the main cause of severe gastroenteritis and nosocomial infections in Pediatric units, especially during late winter and early spring season in temperate region. In 2013 Sicilian Region, for the first time in Italy, introduced universal Rotavirus vaccination. This study aims to estimate health and economic impact on rotavirus Gastroenteritis (RVGE) among children aged 0-59 months in Sicily, after rotavirus vaccine introduction. We analyzed hospital discharge records including a diagnosis of RVGE occurred from 1
    MeSH term(s) Child, Preschool ; Female ; Health Care Costs/statistics & numerical data ; Hospitalization/economics ; Humans ; Immunization Programs/economics ; Infant ; Infant, Newborn ; Male ; Retrospective Studies ; Rotavirus Infections/economics ; Rotavirus Infections/epidemiology ; Rotavirus Infections/prevention & control ; Rotavirus Vaccines/administration & dosage ; Sicily/epidemiology ; Vaccination Coverage/statistics & numerical data
    Chemical Substances Rotavirus Vaccines
    Language English
    Publishing date 2018-06-22
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2018.1471306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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