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  1. Article ; Online: Protective Mechanisms of Juncus effusus and Carbonized Juncus effusus against D-Galactosamine-Induced Acute Liver Injury in Mice.

    Wang, Xiangming / Zhao, Menghui / Ju, Chengguo / Gao, Hui / Wang, Wei

    Chemical & pharmaceutical bulletin

    2024  Volume 72, Issue 3, Page(s) 280–285

    Abstract: This study investigated the hepatoprotective effects of Juncus effusus (J. effusus) and Carbonized J. effusus against liver injury caused by D-galactosamine (D-GalN) in mice. J. effusus and Carbonized J. effusus were administered by gavage once daily ... ...

    Abstract This study investigated the hepatoprotective effects of Juncus effusus (J. effusus) and Carbonized J. effusus against liver injury caused by D-galactosamine (D-GalN) in mice. J. effusus and Carbonized J. effusus were administered by gavage once daily starting seven days before the D-GalN treatment. The results of the study indicated that J. effusus and Carbonized J. effusus suppressed the D-GalN-induced generation of serum alanine transaminase (ALT), aspartate aminotransferase (AST), hepatic malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) was observed. The values of superoxide dismutase (SOD) exhibited an increase. In addition, J. effusus and Carbonized J. effusus promoted the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), NADPH quinone oxidoreductase-1 (NQO-1), heme oxygenase-1 (HO-1) as well as the mRNA expression of Nrf2, HO-1, NQO-1 and Glutamate cysteine ligase catalytic subunit (GCLC). The compressed Carbonized J. effusus demonstrated the optimum impact. These results suggest that J. effusus and Carbonized J. effusus protect against D-GalN-induced acute liver injury through the activation of the Nrf2 pathway.
    MeSH term(s) Animals ; Mice ; Alanine Transaminase/metabolism ; Alanine Transaminase/pharmacology ; Antioxidants/pharmacology ; Aspartate Aminotransferases/metabolism ; Aspartate Aminotransferases/pharmacology ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Galactosamine/toxicity ; Galactosamine/metabolism ; Lipopolysaccharides/pharmacology ; Liver ; NF-E2-Related Factor 2/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
    Chemical Substances Alanine Transaminase (EC 2.6.1.2) ; Antioxidants ; Aspartate Aminotransferases (EC 2.6.1.1) ; Galactosamine (7535-00-4) ; Lipopolysaccharides ; NF-E2-Related Factor 2 ; Tumor Necrosis Factor-alpha ; Plant Extracts
    Language English
    Publishing date 2024-02-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c23-00578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy.

    Liu, Yingying / Mou, Lingyun / Yi, Zhengzi / Lin, Qisheng / Banu, Khadija / Wei, Chengguo / Yu, Xiaoxia

    Journal of natural medicines

    2024  

    Abstract: We previously demonstrated that ginsenoside Re (G-Re) has protective effects on acute kidney injury. However, the underlying mechanism is still unclear. In this study, we conducted a meta-analysis and pathway enrichment analysis of all published ... ...

    Abstract We previously demonstrated that ginsenoside Re (G-Re) has protective effects on acute kidney injury. However, the underlying mechanism is still unclear. In this study, we conducted a meta-analysis and pathway enrichment analysis of all published transcriptome data to identify differentially expressed genes (DEGs) and pathways of G-Re treatment. We then performed in vitro studies to measure the identified autophagy and fibrosis markers in HK2 cells. In vivo studies were conducted using ureteric obstruction (UUO) and aristolochic acid nephropathy (AAN) models to evaluate the effects of G-Re on autophagy and kidney fibrosis. Our informatics analysis identified autophagy-related pathways enriched for G-Re treatment. Treatment with G-Re in HK2 cells reduced autophagy and mRNA levels of profibrosis markers with TGF-β stimulation. In addition, induction of autophagy with PP242 neutralized the anti-fibrotic effects of G-Re. In murine models with UUO and AAN, treatment with G-Re significantly improved renal function and reduced the upregulation of autophagy and profibrotic markers. A combination of informatics analysis and biological experiments confirmed that ginsenoside Re could improve renal fibrosis and kidney function through the regulation of autophagy. These findings provide important insights into the mechanisms of G-Re's protective effects in kidney injuries.
    Language English
    Publishing date 2024-04-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2227540-X
    ISSN 1861-0293 ; 1340-3443
    ISSN (online) 1861-0293
    ISSN 1340-3443
    DOI 10.1007/s11418-024-01800-7
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  3. Article: Association Between

    Zhang, Chengguo / Wei, Yinbin

    Clinical, cosmetic and investigational dermatology

    2021  Volume 14, Page(s) 1637–1643

    Abstract: Objective: The association between peptic ulcer disease (PUD) and chronic urticaria (CU) is rarely examined in individuals without : Methods: Patients without : Results: We included 40 patients with PUD as the PUD cohort and 80 patients without ... ...

    Abstract Objective: The association between peptic ulcer disease (PUD) and chronic urticaria (CU) is rarely examined in individuals without
    Methods: Patients without
    Results: We included 40 patients with PUD as the PUD cohort and 80 patients without PUD as the control cohort, between which there were no significant differences in patient characteristics, including age, sex, and several comorbidities (P all >0.05). Among the PUD cohort, 25.00% (10/40) of them were with CU, which was significantly higher than that in the control cohort 8.75% (7/80, P = 0.016). Results of logistic regression analyses showed PUD was significantly associated with increased risk of CU (odds ratio (OR) 3.48, 95% confidence interval (CI) 1.21-9.99, P = 0.021), which was consistent with that after adjusted for potential confounding factors (OR 3.77, 95% CI 1.24-11.45, P = 0.019).
    Conclusion: Helicobacter pylori
    Language English
    Publishing date 2021-11-10
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S336617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A new phosphate purification method for igneous weathering profiles.

    Guan, Chengguo / Peng, Yongbo / Wei, Ziran / Gong, Shanggui / Bao, Huiming

    Rapid communications in mass spectrometry : RCM

    2023  Volume 37, Issue 18, Page(s) e9601

    Abstract: Rationale: The oxygen isotope composition of phosphate (δ: Methods: Our phosphate purification method includes two steps of cation exchange resin treatment separated by a step of calcium phosphate precipitation (R-Ca-R method). In addition, the ... ...

    Abstract Rationale: The oxygen isotope composition of phosphate (δ
    Methods: Our phosphate purification method includes two steps of cation exchange resin treatment separated by a step of calcium phosphate precipitation (R-Ca-R method). In addition, the silver phosphate precipitation in our procedure is featured by slow evaporation to crystallization until the appearance of ammonium nitrate or silver nitrate crystals. We evaluated our methods on weathered and pristine igneous rocks, phosphorite rocks, KH
    Results: Our purification method converted over 99.9% phosphate in solution to calcium phosphate, which can be easily decalcified by cation resin. The improved silver phosphate precipitation method produced high phosphate yields (97.1%-99.5%) and retained original δ
    Conclusions: We developed a new phosphate purification method that is applicable to phosphate extraction in igneous rocks and IWPs. We also proposed a reliable indicator for the termination of silver phosphate precipitation. Our method can achieve high phosphate yield and reproducible δ
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 58731-x
    ISSN 1097-0231 ; 0951-4198
    ISSN (online) 1097-0231
    ISSN 0951-4198
    DOI 10.1002/rcm.9601
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    Zs.A 3461: Show issues Location:
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  5. Article ; Online: Simulation Study on the Optimisation of Replenishment of Landscape Water with Reclaimed Water Based on Transparency

    Dong Ao / Lijie Wei / Liang Pei / Chengguo Liu / Liming Wang

    International Journal of Environmental Research and Public Health, Vol 20, Iss 4141, p

    2023  Volume 4141

    Abstract: Water-scarce cities have fewer surface water (SW) resources available for ecological use, causing landscape water to deteriorate due to water shortage and fail to perform their intended landscape functions. As a result, many cities use reclaimed water ( ... ...

    Abstract Water-scarce cities have fewer surface water (SW) resources available for ecological use, causing landscape water to deteriorate due to water shortage and fail to perform their intended landscape functions. As a result, many cities use reclaimed water (RW) to replenish them. However, this could cause concern among the people, as RW usually has higher nutrient concentrations, which may stimulate algae growth and deteriorate the aesthetic senses of the receiving water bodies. In order to assess the feasibility of using RW for this purpose, this study used Xingqing Lake in Northwest China as insight into the effect of RW replenishment on the visual landscape quality of urban landscape water. Water transparency (measured by SD) is used as an intuitive indicator to reflect the comprehensive influence of suspended solids and algae growth on the water’s aesthetic quality. Scenario analyses were carried out after calibrating and validating one-year data in MIKE 3 software with both SD and algae growth calculations, and the results showed that the low concentration of suspended matter in RW could compensate for the decrease in SD due to algal blooms caused by high concentrations of nitrogen and phosphorus, and the effect on SD is especially pronounced under conditions that are not conducive to algal growth, such as good flow conditions and low temperature. In addition, to meet a SD ≥ 70 mm, the total water inflow required can be significantly reduced with the optimal application of RW. It is also indicated that partial or complete utilization of RW to replace SW for replenishing the landscape water could be feasible from the viewpoint of landscape quality, at least for the landscape water investigated in this study. This can provide a method for the improvement to urban water management practices by using RW for replenishment in water-scarce cities.
    Keywords landscape urban water ; water transparency ; algae growth ; water replenishment ; reclaimed water ; Medicine ; R
    Subject code 710
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  6. Article ; Online: Simulation Study on the Optimisation of Replenishment of Landscape Water with Reclaimed Water Based on Transparency.

    Ao, Dong / Wei, Lijie / Pei, Liang / Liu, Chengguo / Wang, Liming

    International journal of environmental research and public health

    2023  Volume 20, Issue 5

    Abstract: Water-scarce cities have fewer surface water (SW) resources available for ecological use, causing landscape water to deteriorate due to water shortage and fail to perform their intended landscape functions. As a result, many cities use reclaimed water ( ... ...

    Abstract Water-scarce cities have fewer surface water (SW) resources available for ecological use, causing landscape water to deteriorate due to water shortage and fail to perform their intended landscape functions. As a result, many cities use reclaimed water (RW) to replenish them. However, this could cause concern among the people, as RW usually has higher nutrient concentrations, which may stimulate algae growth and deteriorate the aesthetic senses of the receiving water bodies. In order to assess the feasibility of using RW for this purpose, this study used Xingqing Lake in Northwest China as insight into the effect of RW replenishment on the visual landscape quality of urban landscape water. Water transparency (measured by SD) is used as an intuitive indicator to reflect the comprehensive influence of suspended solids and algae growth on the water's aesthetic quality. Scenario analyses were carried out after calibrating and validating one-year data in MIKE 3 software with both SD and algae growth calculations, and the results showed that the low concentration of suspended matter in RW could compensate for the decrease in SD due to algal blooms caused by high concentrations of nitrogen and phosphorus, and the effect on SD is especially pronounced under conditions that are not conducive to algal growth, such as good flow conditions and low temperature. In addition, to meet a SD ≥ 70 mm, the total water inflow required can be significantly reduced with the optimal application of RW. It is also indicated that partial or complete utilization of RW to replace SW for replenishing the landscape water could be feasible from the viewpoint of landscape quality, at least for the landscape water investigated in this study. This can provide a method for the improvement to urban water management practices by using RW for replenishment in water-scarce cities.
    MeSH term(s) Humans ; Water/analysis ; Cities ; China ; Eutrophication ; Nitrogen/analysis
    Chemical Substances Water (059QF0KO0R) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20054141
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  7. Article ; Online: An Investigation of the High-Speed Machinability of 7050 Aluminum Alloy Based on Different Prefabricated Crystal Orientations

    Chenbing Ni / Wei Lu / Youqiang Wang / Chengguo Zong / Dejian Liu / Guoliang Liu

    Lubricants, Vol 11, Iss 413, p

    2023  Volume 413

    Abstract: This study investigated the high-speed cutting performance of 7050 aluminum alloy with prefabricated crystal orientations under dry-cutting conditions. Three specimens with different crystal orientations were prefabricated using pre-deformations of 10, ... ...

    Abstract This study investigated the high-speed cutting performance of 7050 aluminum alloy with prefabricated crystal orientations under dry-cutting conditions. Three specimens with different crystal orientations were prefabricated using pre-deformations of 10, 15, and 20%, and the effects of cutting parameters on cutting force, surface morphology, and tool wear were analyzed. The results showed that the three-dimensional cutting force initially increased and then decreased with the increase in cutting speed. In addition, the three-dimensional cutting force increased with the increase in cutting depth and feed rate. Under the same cutting parameters, the three-dimensional cutting force of 7050 aluminum alloy was in the following order: 20% pre-deformation > 10% pre-deformation > 15% pre-deformation. During high-speed cutting, different degrees of plowing, bulging, and sticky chips appeared on the machined surface, and the surface morphology of the 15% pre-deformed 7050 aluminum alloy was better than that of the other two pre-deformed 7050 aluminum alloys. During the high-speed cutting process, tool wear mainly occurred in the forms of collapse edge, adhesion, flaking, and breakage, and wear mechanisms were usually adhesive, diffusion, and oxidation wears. Under the same cutting parameters, the tool wear of the 15% pre-deformed 7050 aluminum alloy was lighter.
    Keywords aluminum alloy ; crystal orientation ; cutting parameters ; machinability ; tool wear ; Science ; Q
    Subject code 670
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Analysis of Primary Iris and Ciliary Body Cysts in Chinese Patients With Primary Angle Closure Disease.

    Wei, Kun / Zuo, Chengguo / Xu, Jinyi / Chen, Liming / Wang, Dingqiao / Tang, Zhongshu / Lin, Mingkai

    Frontiers in medicine

    2021  Volume 8, Page(s) 704200

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2021-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.704200
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  9. Article ; Online: A Lesion Microenvironment-Responsive Fungicide Nanoplatform for Crop Disease Prevention and Control.

    Wang, Chao-Yi / Jia, Chengguo / Zhang, Ming-Zhe / Yang, Song / Qin, Jian-Chun / Yang, Ying-Wei

    Advanced healthcare materials

    2022  Volume 11, Issue 10, Page(s) e2102617

    Abstract: Controlled fungicide delivery in response to the specific microenvironment produced by fungal pathogens is an advisable strategy to improve the efficacy of fungicides. Herein, the authors construct a smart fungicide nanoplatform, using mesoporous silica ... ...

    Abstract Controlled fungicide delivery in response to the specific microenvironment produced by fungal pathogens is an advisable strategy to improve the efficacy of fungicides. Herein, the authors construct a smart fungicide nanoplatform, using mesoporous silica nanoparticles (MSNs) as nanocarriers loaded with eugenol (EU) and Ag
    MeSH term(s) Botrytis/genetics ; Fungicides, Industrial/pharmacology ; Nanoparticles ; Silicon Dioxide/pharmacology
    Chemical Substances Fungicides, Industrial ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2022-01-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202102617
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    Zs.A 6966: Show issues Location:
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  10. Article ; Online: Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury.

    Feng, Ye / Sun, Zeguo / Fu, Jia / Zhong, Fang / Zhang, Weijia / Wei, Chengguo / Chen, Anqun / Liu, Bi-Cheng / He, John C / Lee, Kyung

    Kidney international

    2024  

    Abstract: Retinoic acid receptor responder protein-1 (RARRES1) is a podocyte-enriched transmembrane protein whose increased expression correlates with human glomerular disease progression. RARRES1 promotes podocytopenia and glomerulosclerosis via p53-mediated ... ...

    Abstract Retinoic acid receptor responder protein-1 (RARRES1) is a podocyte-enriched transmembrane protein whose increased expression correlates with human glomerular disease progression. RARRES1 promotes podocytopenia and glomerulosclerosis via p53-mediated podocyte apoptosis. Importantly, the cytopathic actions of RARRES1 are entirely dependent on its proteolytic cleavage into a soluble protein (sRARRES1) and subsequent podocyte uptake by endocytosis, as a cleavage mutant RARRES1 exerted no effects in vitro or in vivo. As RARRES1 expression is upregulated in human glomerular diseases, here we investigated the functional consequence of podocyte-specific overexpression of RARRES1 in mice in the experimental focal segmental glomerulosclerosis and diabetic kidney disease. We also examined the effects of long-term RARRES1 overexpression on slowly developing aging-induced kidney injury. As anticipated, the induction of podocyte overexpression of RARRES1 (Pod-RARRES1
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.04.011
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