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  1. Article ; Online: Cellular resistance mechanisms in cancer and the new approaches to overcome resistance mechanisms chemotherapy.

    Al Saihati, Hajir A / Rabaan, Ali A

    Saudi medical journal

    2023  Volume 44, Issue 4, Page(s) 329–344

    Abstract: Despite major advancements in cancer healing approaches over the last few decades, chemotherapy remains the most popular malignancy treatment. Chemotherapeutic drugs are classified into many kinds based on their mechanism of action. Multidrug resistance ( ...

    Abstract Despite major advancements in cancer healing approaches over the last few decades, chemotherapy remains the most popular malignancy treatment. Chemotherapeutic drugs are classified into many kinds based on their mechanism of action. Multidrug resistance (MDR) is responsible for approximately 90% of fatalities in malignancy cases treated with standard chemotherapeutics or innovative targeted medicines. Many innovative prospective anti-cancer medicines displayed high anti-cancer efficacy in a single application. However, combining them with other medications improves cancer treatment efficacy. This supports the belief that a combination of drugs is significantly more effective than a single medicine. Due to the intricacy of MDR processes and the diversity of tumor illnesses, there will rarely be a single medicine that can be utilized to treat all types of cancer. Finding new medications that can reverse MDR in malignancy cells will augment efficacy of chemotherapeutic agents and allow us to treat cancers that are now incurable.
    MeSH term(s) Humans ; Antineoplastic Agents/therapeutic use ; Drug Resistance, Neoplasm ; Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-04-14
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
    DOI 10.15537/smj.2023.44.4.20220600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cholera: an overview with reference to the Yemen epidemic.

    Rabaan, Ali A

    Frontiers of medicine

    2018  Volume 13, Issue 2, Page(s) 213–228

    Abstract: Cholera is a secretory diarrhoeal disease caused by infection with Vibrio cholerae, primarily the V. cholerae O1 El Tor biotype. There are approximately 2.9 million cases in 69 endemic countries annually, resulting in 95 000 deaths. Cholera is associated ...

    Abstract Cholera is a secretory diarrhoeal disease caused by infection with Vibrio cholerae, primarily the V. cholerae O1 El Tor biotype. There are approximately 2.9 million cases in 69 endemic countries annually, resulting in 95 000 deaths. Cholera is associated with poor infrastructure and lack of access to sanitation and clean drinking water. The current cholera epidemic in Yemen, linked to spread of V. cholerae O1 (Ogawa serotype), is associated with the ongoing war. This has devastated infrastructure and health services. The World Health Organization had estimated that 172 286 suspected cases arose between 27th April and 19th June 2017, including 1170 deaths. While there are three oral cholera vaccines prequalified by the World Health Organization, there are issues surrounding vaccination campaigns in conflict situations, exacerbated by external factors such as a global vaccine shortage. Major movements of people complicates surveillance and administration of double doses of vaccines. Cholera therapy mainly depends on rehydration, with use of antibiotics in more severe infections. Concerns have arisen about the rise of antibiotic resistance in cholera, due to mobile genetic elements. In this review, we give an overview of cholera epidemiology, virulence, antibiotic resistance, therapy and vaccines, in the light of the ongoing epidemic in Yemen.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cholera/drug therapy ; Cholera/prevention & control ; Cholera Vaccines/therapeutic use ; DNA, Bacterial/genetics ; Disease Outbreaks ; Drug Resistance, Multiple, Bacterial ; Humans ; Microbial Sensitivity Tests ; Polymerase Chain Reaction ; Vibrio cholerae/drug effects ; Vibrio cholerae/isolation & purification ; Virulence Factors/genetics ; Yemen
    Chemical Substances Anti-Bacterial Agents ; Cholera Vaccines ; DNA, Bacterial ; Virulence Factors
    Language English
    Publishing date 2018-06-22
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-018-0631-2
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  3. Article ; Online: A rapid surge of the Omicron variant's sublineages BQ.1/BQ.1.1: A matter of worry amid the crucial trajectory of the COVID-19 pandemic.

    Dhawan, Manish / Sharma, Manish / Emran, Talha B / Rabaan, Ali A

    International journal of surgery (London, England)

    2023  Volume 109, Issue 3, Page(s) 504–506

    MeSH term(s) Humans ; COVID-19 ; Pandemics ; SARS-CoV-2 ; Anxiety
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Re-emergence of neglected tropical diseases amid the COVID-19 pandemic: epidemiology, transmission, mitigation strategies, and recent advances in chemotherapy and vaccines.

    Mohapatra, Ranjan K / Kandi, Venkataramana / Seidel, Veronique / Rabaan, Ali A

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1265803

    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1265803
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  5. Article ; Online: Middle East respiratory syndrome coronavirus: five years later.

    Rabaan, Ali A

    Expert review of respiratory medicine

    2017  Volume 11, Issue 11, Page(s) 901–912

    Abstract: Introduction: In the past five years, there have been 1,936 laboratory-confirmed cases of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in 27 countries, with a mortality rate of 35.6%. Most cases have arisen in the Middle East, particularly ... ...

    Abstract Introduction: In the past five years, there have been 1,936 laboratory-confirmed cases of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in 27 countries, with a mortality rate of 35.6%. Most cases have arisen in the Middle East, particularly the Kingdom of Saudi Arabia, however there was a large hospital-associated outbreak in the Republic of Korea in 2015. Exposure to dromedary camels has been recognized by the World Health Organization (WHO) as a risk factor in primary cases, but the exact mechanisms of transmission are not clear. Rigorous application of nationally defined infection prevention and control measures has reduced the levels of healthcare facility-associated outbreaks. There is currently no approved specific therapy or vaccine available. Areas covered: This review presents an overview of MERS-CoV within the last five years, with a particular emphasis on the key areas of transmission, infection control and prevention, and therapies and vaccines. Expert commentary: MERS-CoV remains a significant threat to public health as transmission mechanisms are still not completely understood. There is the potential for mutations that could increase viral transmission and/or virulence, and zoonotic host range. The high mortality rate highlights the need to expedite well-designed randomized clinical trials for direct, effective therapies and vaccines.
    MeSH term(s) Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Outbreaks ; Humans ; Infection Control ; Middle East/epidemiology ; Middle East Respiratory Syndrome Coronavirus/pathogenicity
    Keywords covid19
    Language English
    Publishing date 2017-08-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2017.1367288
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  6. Article: An evaluation of toxigenic

    Okeahialam, Christopher A / Rabaan, Ali A / Bolhuis, Albert

    Journal of infection prevention

    2021  Volume 22, Issue 5, Page(s) 231–236

    Abstract: Background: Antimicrobial stewardship has been associated with a reduction in the incidence of healthcare-associated : Aim/objective: To examine the impact of antimicrobial stewardship on the rate of toxigenic : Methods: A 12-year retrospective ... ...

    Abstract Background: Antimicrobial stewardship has been associated with a reduction in the incidence of healthcare-associated
    Aim/objective: To examine the impact of antimicrobial stewardship on the rate of toxigenic
    Methods: A 12-year retrospective review of laboratory data was conducted to compare the rates of toxigenic
    Result: There was a significant decline in the rate of toxigenic
    Discussion: The rate of toxigenic
    Language English
    Publishing date 2021-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2595000-9
    ISSN 1757-1782 ; 1757-1774
    ISSN (online) 1757-1782
    ISSN 1757-1774
    DOI 10.1177/17571774211012780
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  7. Article ; Online: Efficacy of empiric macrolides versus fluoroquinolones in community-acquired pneumonia associated with atypical bacteria: A meta-analysis.

    Basilim, Ahmed / Wali, Haytham / Rabaan, Ali A / Eljaaly, Khalid

    Respiratory medicine and research

    2022  Volume 82, Page(s) 100931

    Abstract: Introduction: It is unclear if one empiric regimen for community-acquired pneumonia (CAP) associated with atypical bacteria is superior to another. The objective of this meta-analysis was to compare fluoroquinolones to macrolides in the rates of ... ...

    Abstract Introduction: It is unclear if one empiric regimen for community-acquired pneumonia (CAP) associated with atypical bacteria is superior to another. The objective of this meta-analysis was to compare fluoroquinolones to macrolides in the rates of clinical failure in CAP associated with atypical pathogens.
    Methods: We searched PubMed and EMBASE databases for randomized controlled trials (RCTs) comparing the clinical efficacy of fluoroquinolones with macrolides for CAP associated with atypical bacteria. We estimated risk differences (RRs) with 95% confidence intervals (CIs) using random-effects models and assessed for heterogeneity (I
    Results: Five RCTs met the inclusion criteria. No significant differences between macrolides and fluoroquinolones and were identified in rates of clinical failure in CAP associated with any atypical bacteria (RR = 1.57 [95% CI 0.73 to 3.38]; p = 0.251; I
    Conclusions: This meta-analysis of RCTs found no significant differences between macrolides and fluoroquinolones in rates of clinical failure in CAP associated with atypical bacteria.
    MeSH term(s) Humans ; Fluoroquinolones/therapeutic use ; Macrolides/therapeutic use ; Pneumonia, Bacterial/drug therapy ; Pneumonia, Bacterial/epidemiology ; Pneumonia, Bacterial/microbiology ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/microbiology ; Anti-Bacterial Agents/therapeutic use ; Mycoplasma pneumoniae
    Chemical Substances Fluoroquinolones ; Macrolides ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-06-20
    Publishing country France
    Document type Meta-Analysis ; Journal Article
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2022.100931
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  8. Article: Human-transmissible sarbecovirus 'Khosta-2' similar to SARS-CoV-2: potential global threat?

    Mohapatra, Ranjan K / Mishra, Snehasish / Rabaan, Ali A / Mohanty, Aroop / Sah, Ranjit

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 4, Page(s) 1327–1328

    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000486
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  9. Article: The resurgence of Avian influenza and human infection: A brief outlook.

    Farahat, Ramadan Abdelmoez / Khan, Sheharyar Hassan / Rabaan, Ali A / Al-Tawfiq, Jaffar A

    New microbes and new infections

    2023  Volume 53, Page(s) 101122

    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2023.101122
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  10. Article ; Online: Possible threat of the Omicron subvariant BF.7 to FIH Hockey World Cup 2023 in particular and the South-East Asia Region in general.

    Mohapatra, Ranjan K / Mahal, Ahmed / Mishra, Snehasish / Rabaan, Ali A / Sah, Ranjit

    International journal of surgery (London, England)

    2023  Volume 109, Issue 3, Page(s) 646–647

    MeSH term(s) Humans ; Hockey ; Asia, Southeastern ; World Health Organization ; Asia, Eastern
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000241
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