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Book ; Online: Dylan's autobiography of a vocation

Renza, Louis A.

a reading of the lyrics 1965-1967

2017

Abstract: Many critics have interpreted Bob Dylan's lyrics, especially those composed during the middle ...

Author's details	Louis A. Renza
Abstract	Many critics have interpreted Bob Dylan's lyrics, especially those composed during the middle to late 1960s, in the contexts of their relation to American folk, blues, and rock 'n' roll precedents; their discographical details and concert performances; their social, political and cultural relevance; and/or their status for discussion as "poems." Dylans Autobiography of a Vocation instead focuses on how all of Dylan's 1965-1967 songs manifest traces of his ongoing, internal "autobiography" in which he continually declares and questions his relation to a self-determined existential summons
Keywords	Music ; Dylan, Bob ; Lyrik
Subject	Gedicht ; Poem ; Dichtung ; Poesie ; Lyrisches Werk ; Lyrikwerk ; Gedichtwerk
Language	English
Size	1 Online-Ressource (xviii, 200 Seiten)
Publisher	Bloomsbury Academic ; Knowledge Unlatched
Publishing place	New York ; London ; Oxford ; New Delhi ; Sydney ; Berlin
Publishing country	United States ; Great Britain ; India ; Australia
Document type	Book ; Online
Note	Open Access
HBZ-ID	HT020102340
ISBN	978-1-5013-2852-7 ; 978-1-5013-2854-1 ; 978-1-5013-2853-4 ; 1-5013-2852-2 ; 1-5013-2854-9 ; 1-5013-2853-0
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator.

Knabl, Paul / Schauer, Alexandra / Pomreinke, Autumn P / Zimmermann, Bob / Rogers, Katherine W / Čapek, Daniel / Müller, Patrick / Genikhovich, Grigory

eLife

2024 Volume 13

Abstract: BMP signaling has a conserved function in patterning the dorsal-ventral body axis in Bilateria and the directive axis in anthozoan cnidarians. So far, cnidarian studies have focused on the role of different BMP signaling network components in regulating ... ...

Abstract	BMP signaling has a conserved function in patterning the dorsal-ventral body axis in Bilateria and the directive axis in anthozoan cnidarians. So far, cnidarian studies have focused on the role of different BMP signaling network components in regulating pSMAD1/5 gradient formation. Much less is known about the target genes downstream of BMP signaling. To address this, we generated a genome-wide list of direct pSMAD1/5 target genes in the anthozoan
MeSH term(s)	Animals ; Sea Anemones/genetics ; Gene Expression Regulation, Developmental ; Signal Transduction ; Genome ; Gene Expression ; Body Patterning/genetics
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.80803
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions.

Robert, Nicolas S M / Sarigol, Fatih / Zimmermann, Bob / Meyer, Axel / Voolstra, Christian R / Simakov, Oleg

BMC genomics

2022 Volume 23, Issue 1, Page(s) 143

Abstract: Background: Animal genomes are strikingly conserved in terms of local gene order (microsynteny). While some of these microsyntenies have been shown to be coregulated or to form gene regulatory blocks, the diversity of their genomic and regulatory ... ...

Abstract	Background: Animal genomes are strikingly conserved in terms of local gene order (microsynteny). While some of these microsyntenies have been shown to be coregulated or to form gene regulatory blocks, the diversity of their genomic and regulatory properties across the metazoan tree of life remains largely unknown. Results: Our comparative analyses of 49 animal genomes reveal that the largest gains of synteny occurred in the last common ancestor of bilaterians and cnidarians and in that of bilaterians. Depending on their node of emergence, we further show that novel syntenic blocks are characterized by distinct functional compositions (Gene Ontology terms enrichment) and gene density properties, such as high, average and low gene density regimes. This is particularly pronounced among bilaterian novel microsyntenies, most of which fall into high gene density regime associated with higher gene coexpression levels. Conversely, a majority of vertebrate novel microsyntenies display a low gene density regime associated with lower gene coexpression levels. Conclusions: Our study provides first evidence for evolutionary transitions between different modes of microsyntenic block regulation that coincide with key events of metazoan evolution. Moreover, the microsyntenic profiling strategy and interactive online application (Syntenic Density Browser, available at: http://synteny.csb.univie.ac.at/ ) we present here can be used to explore regulatory properties of microsyntenic blocks and predict their coexpression in a wide-range of animal genomes.
MeSH term(s)	Animals ; Evolution, Molecular ; Gene Order ; Genome ; Genomics ; Synteny
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-022-08304-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ancient animal genome architecture reflects cell type identities.

Zimmermann, Bob / Robert, Nicolas S M / Technau, Ulrich / Simakov, Oleg

Nature ecology & evolution

2019 Volume 3, Issue 9, Page(s) 1289–1293

Abstract: The level of conservation of ancient metazoan gene order (synteny) is remarkable. Despite this, the functionality of the vast majority of such regions in metazoan genomes remains elusive. Utilizing recently published single-cell expression data from ... ...

Abstract	The level of conservation of ancient metazoan gene order (synteny) is remarkable. Despite this, the functionality of the vast majority of such regions in metazoan genomes remains elusive. Utilizing recently published single-cell expression data from several anciently diverging metazoan species, we reveal the level of correspondence between cell types and genomic synteny, identifying genomic regions conferring ancient cell type identity.
MeSH term(s)	Animals ; Genome ; Genomics ; Synteny
Language	English
Publishing date	2019-08-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2397-334X
ISSN (online)	2397-334X
DOI	10.1038/s41559-019-0946-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Muscle cell-type diversification is driven by bHLH transcription factor expansion and extensive effector gene duplications

Alison G. Cole / Stefan M. Jahnel / Sabrina Kaul / Julia Steger / Julia Hagauer / Andreas Denner / Patricio Ferrer Murguia / Elisabeth Taudes / Bob Zimmermann / Robert Reischl / Patrick R. H. Steinmetz / Ulrich Technau

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 11

Abstract: Different muscle cell types account for specific abilities in animals, yet how their diversification arose remains unclear. Here, the authors show that gene duplications of bHLH transcription factors and effector genes contributed to the diversification ... ...

Abstract	Different muscle cell types account for specific abilities in animals, yet how their diversification arose remains unclear. Here, the authors show that gene duplications of bHLH transcription factors and effector genes contributed to the diversification of muscle cell types in the sea anemone Nematostella.
Keywords	Science ; Q
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Muscle cell-type diversification is driven by bHLH transcription factor expansion and extensive effector gene duplications.

Cole, Alison G / Jahnel, Stefan M / Kaul, Sabrina / Steger, Julia / Hagauer, Julia / Denner, Andreas / Murguia, Patricio Ferrer / Taudes, Elisabeth / Zimmermann, Bob / Reischl, Robert / Steinmetz, Patrick R H / Technau, Ulrich

Nature communications

2023 Volume 14, Issue 1, Page(s) 1747

Abstract: Animals are typically composed of hundreds of different cell types, yet mechanisms underlying the emergence of new cell types remain unclear. Here we address the origin and diversification of muscle cells in the non-bilaterian, diploblastic sea anemone ... ...

Abstract	Animals are typically composed of hundreds of different cell types, yet mechanisms underlying the emergence of new cell types remain unclear. Here we address the origin and diversification of muscle cells in the non-bilaterian, diploblastic sea anemone Nematostella vectensis. We discern two fast and two slow-contracting muscle cell populations, which differ by extensive sets of paralogous structural protein genes. We find that the regulatory gene set of the slow cnidarian muscles is remarkably similar to the bilaterian cardiac muscle, while the two fast muscles differ substantially from each other in terms of transcription factor profiles, though driving the same set of structural protein genes and having similar physiological characteristics. We show that anthozoan-specific paralogs of Paraxis/Twist/Hand-related bHLH transcription factors are involved in the formation of fast and slow muscles. Our data suggest that the subsequent recruitment of an entire effector gene set from the inner cell layer into the neural ectoderm contributes to the evolution of a novel muscle cell type. Thus, we conclude that extensive transcription factor gene duplications and co-option of effector modules act as an evolutionary mechanism underlying cell type diversification during metazoan evolution.
MeSH term(s)	Animals ; Gene Duplication ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Sea Anemones/genetics ; Gene Expression Regulation ; Muscle Cells ; Phylogeny
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37220-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A cadherin switch marks germ layer formation in the diploblastic sea anemone

Pukhlyakova, Ekaterina A / Kirillova, Anastasia O / Kraus, Yulia A / Zimmermann, Bob / Technau, Ulrich

Development (Cambridge, England)

2019 Volume 146, Issue 20

Abstract: Morphogenesis is a shape-building process during development of multicellular organisms. During this process, the establishment and modulation of cell-cell contacts play an important role. Cadherins, the major cell adhesion molecules, form adherens ... ...

Abstract	Morphogenesis is a shape-building process during development of multicellular organisms. During this process, the establishment and modulation of cell-cell contacts play an important role. Cadherins, the major cell adhesion molecules, form adherens junctions connecting epithelial cells. Numerous studies of Bilateria have shown that cadherins are associated with the regulation of cell differentiation, cell shape changes, cell migration and tissue morphogenesis. To date, the role of cadherins in non-bilaterians is unknown. Here, we study the expression and function of two paralogous classical cadherins, Cadherin 1 and Cadherin 3, in a diploblastic animal, the sea anemone
MeSH term(s)	Animals ; Cadherins/metabolism ; Ectoderm/cytology ; Ectoderm/metabolism ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/metabolism ; Endoderm/cytology ; Endoderm/metabolism ; Germ Layers/cytology ; Germ Layers/metabolism ; Sea Anemones/embryology ; Sea Anemones/metabolism
Chemical Substances	Cadherins
Language	English
Publishing date	2019-10-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.174623
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes.

Schwaiger, Michaela / Andrikou, Carmen / Dnyansagar, Rohit / Murguia, Patricio Ferrer / Paganos, Periklis / Voronov, Danila / Zimmermann, Bob / Lebedeva, Tatiana / Schmidt, Heiko A / Genikhovich, Grigory / Benvenuto, Giovanna / Arnone, Maria Ina / Technau, Ulrich

Nature ecology & evolution

2022 Volume 6, Issue 12, Page(s) 1921–1939

Abstract: Transcription factors are crucial drivers of cellular differentiation during animal development and often share ancient evolutionary origins. The T-box transcription factor Brachyury plays a pivotal role as an early mesoderm determinant and neural ... ...

Abstract	Transcription factors are crucial drivers of cellular differentiation during animal development and often share ancient evolutionary origins. The T-box transcription factor Brachyury plays a pivotal role as an early mesoderm determinant and neural repressor in vertebrates; yet, the ancestral function and key evolutionary transitions of the role of this transcription factor remain obscure. Here, we present a genome-wide target-gene screen using chromatin immunoprecipitation sequencing in the sea anemone Nematostella vectensis, an early branching non-bilaterian, and the sea urchin Strongylocentrotus purpuratus, a representative of the sister lineage of chordates. Our analysis reveals an ancestral gene regulatory feedback loop connecting Brachyury, FoxA and canonical Wnt signalling involved in axial patterning that predates the cnidarian-bilaterian split about 700 million years ago. Surprisingly, we also found that part of the gene regulatory network controlling the fate of neuromesodermal progenitors in vertebrates was already present in the common ancestor of cnidarians and bilaterians. However, while several endodermal and neuronal Brachyury target genes are ancestrally shared, hardly any of the key mesodermal downstream targets in vertebrates are found in the sea anemone or the sea urchin. Our study suggests that a limited number of target genes involved in mesoderm formation were newly acquired in the vertebrate lineage, leading to a dramatic shift in the function of this ancestral developmental regulator.
MeSH term(s)	Animals ; Feedback ; Mesoderm ; Transcription Factors ; Sea Anemones/genetics
Chemical Substances	Brachyury protein (EQ43SC3GDB) ; Transcription Factors
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2397-334X
ISSN (online)	2397-334X
DOI	10.1038/s41559-022-01905-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization.

Schmidbaur, Hannah / Kawaguchi, Akane / Clarence, Tereza / Fu, Xiao / Hoang, Oi Pui / Zimmermann, Bob / Ritschard, Elena A / Weissenbacher, Anton / Foster, Jamie S / Nyholm, Spencer V / Bates, Paul A / Albertin, Caroline B / Tanaka, Elly / Simakov, Oleg

Nature communications

2022 Volume 13, Issue 1, Page(s) 2172

Abstract: Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying these innovations remains unknown. ... ...

Abstract	Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying these innovations remains unknown. Using comparative and functional genomics in the model squid Euprymna scolopes, we reveal the unique genomic, topological, and regulatory organization of cephalopod genomes. We show that coleoid cephalopod genomes have been extensively restructured compared to other animals, leading to the emergence of hundreds of tightly linked and evolutionary unique gene clusters (microsyntenies). Such novel microsyntenies correspond to topological compartments with a distinct regulatory structure and contribute to complex expression patterns. In particular, we identify a set of microsyntenies associated with cephalopod innovations (MACIs) broadly enriched in cephalopod nervous system expression. We posit that the emergence of MACIs was instrumental to cephalopod nervous system evolution and propose that microsyntenic profiling will be central to understanding cephalopod innovations.
MeSH term(s)	Animals ; Cephalopoda/genetics ; Decapodiformes/genetics ; Genome/genetics ; Genomics ; Invertebrates/genetics
Language	English
Publishing date	2022-04-21
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-29694-7
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Article ; Online: Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning

Tatiana Lebedeva / Andrew J. Aman / Thomas Graf / Isabell Niedermoser / Bob Zimmermann / Yulia Kraus / Magdalena Schatka / Adrien Demilly / Ulrich Technau / Grigory Genikhovich

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 12

Abstract: The authors show in Nematostella that the more orally expressed β-catenin targets repress the more aborally expressed β-catenin targets, thus patterning the oral-aboral axis. This likely represents the common mechanism of β-catenin-dependent axial ... ...

Abstract	The authors show in Nematostella that the more orally expressed β-catenin targets repress the more aborally expressed β-catenin targets, thus patterning the oral-aboral axis. This likely represents the common mechanism of β-catenin-dependent axial patterning shared by Cnidaria and Bilateria.
Keywords	Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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