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  1. Article: Mercury toxicity causes iron and sulfur deficiencies along with oxidative injuries in alfalfa (Medicago sativa)

    El-Shehawi, Ahmed M. / Rahman, Md Atikur / Elseehy, Mona M. / Kabir, Ahmad Humayan

    Plant biosystems. 2022 Jan. 2, v. 156, no. 1

    2022  

    Abstract: Mercury (Hg) toxicity impairs plant growth and yield. Thus, a better understanding of Hg-induced impairment is needed. In alfalfa, Hg toxicity caused a significant decrease in morphological parameters, as well as increased electrolyte leakage and cell ... ...

    Abstract Mercury (Hg) toxicity impairs plant growth and yield. Thus, a better understanding of Hg-induced impairment is needed. In alfalfa, Hg toxicity caused a significant decrease in morphological parameters, as well as increased electrolyte leakage and cell death. The Hg toxicity also adversely affected chlorophyll score and Fv/Fm (maximal quantum yield of PSII) in leaves. This was linked to lower MsIRT1 (Fe-regulated transporter) expression in roots, implying that Hg hinders Fe acquisition in alfalfa. Further, MsSULTR1;2 (sulfate transporter 1.2) and MsSULTR1;3 (sulfate transporter 1.3) were downregulated accompanied by the lower S status in root and shoot, indicating disturbance in S uptake in Hg-treated alfalfa. In silico analysis demonstrated that MsIRT1, MsSULTR1;2 and MsSULTR1;3 proteins are localized in the plasma membrane and showed close partnerships with several Arabidopsis genes, such as FRO2 (ferric reduction oxidase 2), FRU (FER-like regulator of Fe), bHLH39 (stress-responsive bHLH transcription factor) and protein domains (sulfate anion transporter, SLC26A/SuIP transporter) mainly linked to Fe and S uptake, respectively. Finally, photosynthetic disturbance induced by low Fe and S levels along with oxidative stress in cells is related to growth retardation in Hg-exposed alfalfa. These results could be used to develop Hg-tolerant alfalfa plants through breeding or transgenic programs. Supplemental data for this article is available online at https://doi.org/10.1080/11263504.2021.1985005 .
    Keywords Arabidopsis ; Medicago sativa ; alfalfa ; cell death ; chlorophyll ; computer simulation ; electrolyte leakage ; genetically modified organisms ; growth retardation ; iron ; mercury ; oxidative stress ; oxidoreductases ; photosystem II ; plant growth ; plasma membrane ; sulfates ; sulfur ; transcription factors
    Language English
    Dates of publication 2022-0102
    Size p. 284-291.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2146652-X
    ISSN 1724-5575 ; 1126-3504
    ISSN (online) 1724-5575
    ISSN 1126-3504
    DOI 10.1080/11263504.2021.1985005
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Genomic Study of COVID-19 Corona Virus Excludes Its Origin from Recombination or Characterized Biological Sources and Suggests a Role for HERVS in Its Wide Range Symptoms.

    El-Shehawi, Ahmed M / Alotaibi, Saqer S / Elseehy, Mona M

    Cytology and genetics

    2021  Volume 54, Issue 6, Page(s) 588–604

    Abstract: ... infection and severity. All isolates had the main five orfs (1ab, S, M, N, E), whereas they differed ...

    Abstract The COVID-19 corona virus has become a world pandemic which started in December 2019 in Wuhan, China with no confirmed biological source. Various countries reported the genomic sequence of different isolates obtained from infected patients. This allowed us to obtain a number of 38 isolates of full genomic sequences. Alignment of nucleotide (nt) sequence was carried out using Clustal Omega multiple alignment service at the EBI website. Alignment of nt sequence and phylogenetic relationship revealed that the COVID-19 is a new viral strain and its biological source has not been yet detected. The expected orf pattern was different among isolates obtained from the same country or different countries as well as from SARS-CoV isolates or bats CoV suggesting different virus human interaction possibilities during infection and severity. All isolates had the main five orfs (1ab, S, M, N, E), whereas they differed in the expected accessory orfs. Being with the biological source of COVID-19 undetected, the role of human endogenous retrovirus (HERVs) in the regulation of the host cell gene expression or the encoding for products that could modulate COVID-19 infection and the spectrum of its symptoms is discussed.
    Language English
    Publishing date 2021-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390717-x
    ISSN 1934-9440 ; 0095-4527
    ISSN (online) 1934-9440
    ISSN 0095-4527
    DOI 10.3103/S0095452720060031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: A Genome-Wide Identification and Expression Pattern of

    Khan, Waqar / El-Shehawi, Ahmed M / Ali, Fayaz / Ali, Murad / Alqurashi, Mohammed / Althaqafi, Mohammed M / Alharthi, Siraj B

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Laccase-like multi-copper oxidases (LMCOs) are a group of enzymes involved in the oxidation of numerous substrates. Recently, these enzymes have become extremely popular due to their practical applications in various fields of biology. LMCOs generally ... ...

    Abstract Laccase-like multi-copper oxidases (LMCOs) are a group of enzymes involved in the oxidation of numerous substrates. Recently, these enzymes have become extremely popular due to their practical applications in various fields of biology. LMCOs generally oxidize various substrates by linking four-electron reduction of the final acceptor, molecular oxygen (O
    Language English
    Publishing date 2023-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12091904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Characterization of the Impacts of Living at High Altitude in Taif: Oxidative Stress Biomarker Alterations and Immunohistochemical Changes.

    Soliman, Mohamed Mohamed / Aldhahrani, Adil / Althobaiti, Fayez / Ahmed, Mohamed Mohamed / Sayed, Samy / Alotaibi, Saqer / Shukry, Mustafa / El-Shehawi, Ahmed M

    Current issues in molecular biology

    2022  Volume 44, Issue 4, Page(s) 1610–1625

    Abstract: ... at normal sea level in Jeddah, whereas rats in group B were maintained in an area in Taif 2600 m above ...

    Abstract At high elevations, the human body experiences a number of pathological, physiological, and biochemical changes, all of which have adverse impacts on human health and organ vitality. This study aimed to investigate the alterations in the liver and kidney biomarkers, oxidative stress markers, gene expression, and cellular histology of rats maintained at high altitudes and normal sea level. A total of twenty male Wistar rats at 2 months of age were randomly assigned to two groups. The rats in group A were maintained at normal sea level in Jeddah, whereas rats in group B were maintained in an area in Taif 2600 m above sea level. After 2 months of housing, orbital blood samples were collected for the analysis of significant biochemical indicators of oxidative stress biomarkers of the liver and kidneys. Liver and kidney tissues from both groups were taken to examine the hepatorenal changes occurring at the biochemical, histological, immunohistochemical, and genetic levels. The results revealed substantial increases in the serum levels of liver and kidney biomarkers (GPT, GOT, urea, and creatinine) and decreases in the serum levels of antioxidant biomarkers (
    Language English
    Publishing date 2022-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb44040110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Heat Shock Proteins Expression Is Regulated by Promoter CpG Methylation/demethylation under Heat Stress in Wheat Varieties.

    S Alotaibi, Saqer / El-Shehawi, Ahmed M / M Elseehy, Mona

    Pakistan journal of biological sciences : PJBS

    2020  Volume 23, Issue 10, Page(s) 1310–1320

    Abstract: Background and objective: Heat shock proteins are induced by high temperature and other environmental stimuli to protect cellular proteins. Despite extensive research on the molecular response to heat stress, the effect of high temperatures on genes and ...

    Abstract Background and objective: Heat shock proteins are induced by high temperature and other environmental stimuli to protect cellular proteins. Despite extensive research on the molecular response to heat stress, the effect of high temperatures on genes and pathways remains unclear. This study investigated the expression of the HSP17 gene in nine Egyptian wheat varieties and the role of HSP17 promoter CpG methylation in the regulation of HSP17 under high temperature.
    Materials and methods: The HSP17 expression was investigated by using semi-quantitative PCR analysis. Methylation at the HSP17 promoter proximal region was analyzed using bisulphite sequencing and CpG viewer software.
    Results: Under normal conditions, HSP17 and methyltransferase 3 (MET3) exhibited similar expression levels in the 9 studied varieties. After exposure to high temperature, the expression level of HSP17 in Giza155 was barely detected. Among the nine varieties, the expression level of HSP17 was highest in Giza168 (11.3 folds of Giza155). Analysis of methylation of 14 CpG islands at the HSP17 proximal promoter sequence showed that methylation of 10 CpG islands differed only by 10-20%, whereas methylation at the other 4 CpGs differed by 56.7-60%. The high expression of HSP17 in Giza168 in response to high temperature was associated with low methylation of four CpGs and low MET3 expression, whereas low expression of HSP17 in Giza155 was associated with high methylation and high MET3 expression.
    Conclusion: The results can aid the development of next-generation approaches to the evaluation of commercial wheat varieties and the development of next-generation approaches to plant breeding employing epiallele integration.
    MeSH term(s) Cloning, Molecular ; CpG Islands ; DNA Primers/genetics ; DNA, Complementary/metabolism ; Egypt ; Gene Expression Regulation, Plant ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Heat-Shock Response ; Methylation ; Methyltransferases/metabolism ; Plant Proteins/metabolism ; Promoter Regions, Genetic ; Seeds/metabolism ; Temperature ; Triticum/genetics ; Triticum/physiology
    Chemical Substances DNA Primers ; DNA, Complementary ; Heat-Shock Proteins ; Plant Proteins ; heat-shock protein, 17-kDa ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2020-09-27
    Publishing country Pakistan
    Document type Journal Article
    ISSN 1812-5735
    ISSN (online) 1812-5735
    DOI 10.3923/pjbs.2020.1310.1320
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  6. Article: Serotyping and Antimicrobial Resistance Profile of Enteric Nontyphoidal

    Youssef, Reem A / Abbas, Ahmad M / El-Shehawi, Ahmed M / Mabrouk, Mona I / Aboshanab, Khaled M

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 5

    Abstract: A total of 300 human fecal samples were collected from febrile neutropenic patients suffering from severe gastroenteritis, followed by identification and serological characterization of recovered isolates. Fifty ... ...

    Abstract A total of 300 human fecal samples were collected from febrile neutropenic patients suffering from severe gastroenteritis, followed by identification and serological characterization of recovered isolates. Fifty nontyphoidal
    Language English
    Publishing date 2021-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10050493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Early-stage iron deficiency alters physiological processes and iron transporter expression, along with photosynthetic and oxidative damage to sorghum.

    Prity, Sadia Akter / El-Shehawi, Ahmed M / Elseehy, Mona M / Tahura, Sharaban / Kabir, Ahmad Humayan

    Saudi journal of biological sciences

    2021  Volume 28, Issue 8, Page(s) 4770–4777

    Abstract: Iron (Fe) starvation in Strategy II plants is a major nutritional problem causing severe visual symptoms and yield reductions. This prompted us to investigate the physiological and molecular consequences of Fe deficiency responses at an early stage in ... ...

    Abstract Iron (Fe) starvation in Strategy II plants is a major nutritional problem causing severe visual symptoms and yield reductions. This prompted us to investigate the physiological and molecular consequences of Fe deficiency responses at an early stage in sorghum plants. The Fe-starved sorghum did not show shoot biomass reduction, but the root length, biomass, and chlorophyll synthesis were severely affected. The chlorophyll
    Language English
    Publishing date 2021-05-06
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2021.04.092
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  8. Article: The Protective Impact of

    Soliman, Mohamed Mohamed / Alotaibi, Saqer S / Sayed, Samy / Hassan, Mohamed M / Althobaiti, Fayez / Aldhahrani, Adil / Youssef, Gehan B A / El-Shehawi, Ahmed M

    Frontiers in veterinary science

    2022  Volume 8, Page(s) 817183

    Abstract: ... Salsola ... ...

    Abstract Salsola imbricata
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.817183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Molecular characterization of Fe-acquisition genes causing decreased Fe uptake and photosynthetic inefficiency in Fe-deficient sunflower.

    Kabir, Ahmad Humayan / Tahura, Sharaban / Elseehy, Mona M / El-Shehawi, Ahmed M

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 5537

    Abstract: Iron (Fe) deficiency in plants hinders growth and yield. Thus, this study aims to elucidate the responses and molecular characterization of genes in Fe-deficient sunflower. The study was conducted on 14 days-old sunflower plants cultivated in hydroponic ... ...

    Abstract Iron (Fe) deficiency in plants hinders growth and yield. Thus, this study aims to elucidate the responses and molecular characterization of genes in Fe-deficient sunflower. The study was conducted on 14 days-old sunflower plants cultivated in hydroponic culture under Fe-sufficient and Fe-deficient conditions. The Fe-starved sunflower showed substantial decrease in plant biomass, SPAD score, quantum yield efficiency of PSII (Fv/Fm), photosynthetic performance index (Pi_ABS). Further, Fe shortage reduced Fe and Zn concentrations in roots and shoots, accompanied by a marked decrease of HaNramp1 and HaZIP1 expression in roots, suggesting the association of Zn status contributing to photosynthetic inefficiency in sunflower. The ferric chelate reductase (FCR) activity, along with HaFRO2 and HaIRT1 transcripts, were constitutively expressed, suggesting that sunflower plants can regulate FCR activity, although the lack of bioavailable Fe in the rhizosphere strongly corresponds to the limited Fe uptake in sunflower. The substantial increase of proton extrusion in roots and the localization of Fe-related genes in the plasma membrane are also evident in sunflower as common responses to Fe-deficiency by this Strategy I plant species. Analysis showed that three motifs of Fe-related proteins were linked to the ZIP zinc transporter. The interactome map revealed the close partnership of these Fe-related genes in addition to FRU gene encoding putative transcription factor linked to Fe uptake response. The cis-regulatory analysis of promoter suggested the involvement of auxin, salicylic acid, and methyl jasmonate-responsive elements in the regulatory process in response to Fe deficiency. These findings may be beneficial to develop Fe-efficient sunflower plants through breeding or genome editing approaches.
    MeSH term(s) Gene Expression Regulation, Plant ; Genes, Plant ; Helianthus/genetics ; Helianthus/metabolism ; Iron/metabolism ; Photosynthesis ; Plant Roots/metabolism
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-85147-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Anti-Inflammatory, Anti-Apoptotic, and Antioxidant Effects of a Pomegranate-Peel Extract against Acrylamide-Induced Hepatotoxicity in Rats.

    Sayed, Samy / Alotaibi, Saqer S / El-Shehawi, Ahmed M / Hassan, Mohamed M / Shukry, Mustafa / Alkafafy, Mohamed / Soliman, Mohamed Mohamed

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 2

    Abstract: The Acrylamide is a toxic compound generated under oxidative stress arising from intracellular ROS production and induced toxicity. It is frequently used in industry and generated through the heating of tobacco and foods high in carbohydrates. The exact ... ...

    Abstract The Acrylamide is a toxic compound generated under oxidative stress arising from intracellular ROS production and induced toxicity. It is frequently used in industry and generated through the heating of tobacco and foods high in carbohydrates. The exact mechanism of its toxicity is still unclear. In this study, an extract of the peels of pomegranate (
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12020224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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