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Article ; Online: 3D Graphene Foam by Chemical Vapor Deposition: Synthesis, Properties, and Energy-Related Applications.

Banciu, Cristina Antonela / Nastase, Florin / Istrate, Anca-Ionela / Veca, Lucia Monica

2022 Volume 27, Issue 11

Abstract: In this review, we highlight recent advancements in 3D graphene foam synthesis by template-assisted chemical vapor deposition, as well as their potential energy storage and conversion applications. This method offers good control of the number of ... ...

Abstract	In this review, we highlight recent advancements in 3D graphene foam synthesis by template-assisted chemical vapor deposition, as well as their potential energy storage and conversion applications. This method offers good control of the number of graphene layers and porosity, as well as continuous connection of the graphene sheets. The review covers all the substrate types, catalysts, and precursors used to synthesize 3D graphene by the CVD method, as well as their most viable energy-related applications.
Language	English
Publishing date	2022-06-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27113634
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Article ; Online: 3D Graphene Foam by Chemical Vapor Deposition

Cristina Antonela Banciu / Florin Nastase / Anca-Ionela Istrate / Lucia Monica Veca

Molecules, Vol 27, Iss 3634, p

Synthesis, Properties, and Energy-Related Applications

2022 Volume 3634

Abstract	In this review, we highlight recent advancements in 3D graphene foam synthesis by template-assisted chemical vapor deposition, as well as their potential energy storage and conversion applications. This method offers good control of the number of graphene layers and porosity, as well as continuous connection of the graphene sheets. The review covers all the substrate types, catalysts, and precursors used to synthesize 3D graphene by the CVD method, as well as their most viable energy-related applications.
Keywords	3D graphene foam ; template-assisted chemical vapor deposition ; supercapacitors ; batteries ; dye-sensitized solar cells ; photodetectors ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Green Economy—Green Jobs in the Context of Sustainable Development

Anca Vasilica Tănasie / Luiza Loredana Năstase / Luminița Lucia Vochița / Andra Maria Manda / Geanina Iulia Boțoteanu / Cătălina Soriana Sitnikov

Sustainability, Vol 14, Iss 8, p

2022 Volume 4796

Abstract: Europe is in the middle of an energy crisis, exacerbated in large part by skyrocketing gas costs. Renewable energy is critical in this environment for decreasing Europe’s reliance on imported energy; boosting renewables in Europe requires a ‘New Energy ... ...

Abstract	Europe is in the middle of an energy crisis, exacerbated in large part by skyrocketing gas costs. Renewable energy is critical in this environment for decreasing Europe’s reliance on imported energy; boosting renewables in Europe requires a ‘New Energy Compact’—a coordinated effort throughout Europe to build more renewable energy capacity. The purpose of this research is to examine the structure of renewable energy production in Romania between 2010 and 2020, as well as the green employment produced by the renewable energy sector in Romania between 2010 and 2019. Using the Markov chain approach, it was predicted that in 2025, the hydropower industry’s employees would account for the biggest proportion of the overall average number of workers engaged in the renewable energy production sector in Romania (74.68%). Solar energy production employees will account for 14.31% of the average number of workers in the renewable energy production sector, biomass energy production employees will account for 5.8%, and wind energy production employees will account for 5.2% of the average number of workers in the green energy sector.
Keywords	green growth ; green jobs ; energy production ; renewable sources ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk of hepatitis B reactivation: From biologic therapies for psoriasis to immunosuppressive therapies for COVID-19 (Review).

Baroiu, Liliana / Anghel, Lucreția / Laurențiu Tatu, Alin / Iancu, Alina Viorica / Dumitru, Caterina / Leșe, Ana-Cristina / Drăgănescu, Miruna / Năstase, Florentina / Niculeț, Elena / Fotea, Silvia / Nechita, Aurel / Voinescu, Doina Carina / Stefanopol, Anca Ioana

Experimental and therapeutic medicine

2022 Volume 23, Issue 6, Page(s) 385

Abstract: The cytokine storm from the evolution of severe cases of COVID-19, requiring strong immunosuppressive therapies, has raised the issue of reactivation of hepatitis B virus (HBV) infections in these patients. An analysis of the first observational studies ... ...

Abstract	The cytokine storm from the evolution of severe cases of COVID-19, requiring strong immunosuppressive therapies, has raised the issue of reactivation of hepatitis B virus (HBV) infections in these patients. An analysis of the first observational studies in patients with COVID-19 and immunosuppressive therapy and HBV infection along with special clinical cases was presented, as well as personal experience on a series of cases (a group of 958 patients with COVID-19), compared with the analysis of studies performed on patients with HBV infection that underwent biological therapies for psoriasis and personal experience (a group of 81 psoriasis patients treated with biological therapies). Clinical studies have revealed that HBV reactivation in patients undergoing biological therapies for psoriasis, can be prevented with monitoring and treatment protocols and thus, these therapies have been demonstrated to be safe and effective. In COVID-19, immunosuppressive therapies are short-lived but in high doses, and the conclusions of clinical trials are contradictory, but there are published cases of HBV reactivation, which requires a unitary attitude in the prevention of HBV reactivation in these patients. An algorithm was presented for monitoring and treatment of HBV infection for patients with psoriasis treated with biological therapy and the conditions when this protocol can be used for patients with COVID-19 and immunosuppressive therapy.
Language	English
Publishing date	2022-04-12
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11312
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Article: Effects of a novel cytokine haemoadsorbtion system on inflammatory response in septic shock after cephalic pancreatectomy - a case report.

Tomescu, Dana / Dima, Simona O / Tănăsescu, Sabina / Tănase, Cristiana Pistol / Năstase, Anca / Popescu, Mihai

Romanian journal of anaesthesia and intensive care

2017 Volume 21, Issue 2, Page(s) 134–138

Abstract: Severe sepsis and septic shock are associated with an inflammatory cascade that is primarily responsible for multiple organ dysfunction. To date, there are no specific treatments designed to modulate and rebalance inflammatory cytokines levels. We ... ...

Abstract	Severe sepsis and septic shock are associated with an inflammatory cascade that is primarily responsible for multiple organ dysfunction. To date, there are no specific treatments designed to modulate and rebalance inflammatory cytokines levels. We present a case of a 50 years old man with postoperative septic shock after undergoing cephalic pancreatectomy for a pancreatic cystic tumor. The use of a haemoadsorbtion device (CytoSorb
Language	English
Publishing date	2017-09-06
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2977912-1
ISSN	2502-0307 ; 2392-7518
ISSN (online)	2502-0307
ISSN	2392-7518
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Article ; Online: Analysis of Practices to Increase the Workforce Agility and to Develop a Sustainable and Competitive Business

Anca-Ioana Munteanu / Nicolae Bibu / Marian Nastase / Nicoleta Cristache / Cosmin Matis

Sustainability, Vol 12, Iss 3545, p

2020 Volume 3545

Abstract: The current business environment is volatile and complex. Companies must constantly identify creative and environmentally friendly solutions. The emphasis on employees and workforce agility has become an attribute of sustainable and competitive ... ...

Abstract	The current business environment is volatile and complex. Companies must constantly identify creative and environmentally friendly solutions. The emphasis on employees and workforce agility has become an attribute of sustainable and competitive organizations simultaneously. The purpose of our study is to validate the hypothesis that there is a direct positive relationship between ranking as important top position of human resources in a company and the extent to which specific practices to increase workforce agility were adopted. Our survey is based on an original questionnaire, with a 92% response rate. We focused on large, independent decision-making companies from Western Romania, for which the implementation of sustainable principles is more difficult than for multinationals. The statistical analysis was performed using SPSS23 (Statistical Package for the Social Sciences). The results indicate an average extent of the adoption of management practices aiming to increase workforce agility (45%) and a ranking of human resources in first place as the most important resource (31.7%). Using the Pearson Chi-Square Test, the hypothesis was confirmed (significance = 0.026). Our main conclusion is that if managers intend to develop a sustainable and competitive business, they should attribute a strategic role to employees and adopt practices to increase their agility.
Keywords	agility ; organizational agility ; agile workforce ; agile practices ; human resources ; competitive advantage ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Analysis of Corporate Entrepreneurship in Public R&D Institutions

Alexandru Agapie / Cristian Vizitiu / Silvia Elena Cristache / Marian Năstase / Liliana Crăciun / Anca Gabriela Molănescu

Sustainability, Vol 10, Iss 7, p

2018 Volume 2297

Abstract: This paper aimed at establishing a Corporate Entrepreneurship diagnosis model within public R&D institutions. We based our analysis on empirical identification of a generalized set of organizational factors, perceived as intrapreneurship vectors. The ... ...

Abstract	This paper aimed at establishing a Corporate Entrepreneurship diagnosis model within public R&D institutions. We based our analysis on empirical identification of a generalized set of organizational factors, perceived as intrapreneurship vectors. The quantitative research targeted 50 experienced public entities and was based on validating one of the most popular psychometric instruments in the entrepreneurial literature: the Corporate Entrepreneurship Assessment Instrument (CEAI)—originally intended for the North American economic environment. As recent literature questioned the cross-cultural portability of psychometric instruments, this study intended to validate the five-factor intrinsic structure of CEAI. The five factors deduced by our statistical analysis were: support for opportunity investigations and reinforcement; dynamic environment and recognition; decreased formalization; knowledge sharing; time availability and strategic awareness. Next, the factor scores were used as input variables for a logistic regression procedure, with the output variable being the intrapreneurial value of the respondents’ institutions. Two factors contribute considerably to the predicted intrapreneurial value: support for opportunity investigations and reinforcement and decreased formalization. The validity of the whole approach is supported by the relevance of the original CEAI questionnaire, able to reveal intrapreneurial characteristics, and by the prediction power of the logistic regression model over the intrapreneurial propensity of public institutions.
Keywords	corporate entrepreneurship ; intrapreneurship ; psychometric instrument ; cross-cultural portability ; personnel management ; factor analysis ; logistic regression ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	330
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Correlation between BAP1 Localization, Driver Mutations, and Patient Survival in Uveal Melanoma.

Cole, Yasemin C / Zhang, Yu-Zhi / Gallo, Beatrice / Januszewski, Adam P / Nastase, Anca / Essex, David J / Thaung, Caroline M H / Cohen, Victoria M L / Sagoo, Mandeep S / Bowcock, Anne M

Cancers

2022 Volume 14, Issue 17

Abstract: Uveal melanoma (UM) is an uncommon but highly aggressive ocular malignancy. Poor overall survival is associated with deleterious BAP1 alterations, which frequently occur with monosomy 3 (LOH3) and a characteristic gene expression profile. Tumor DNA from ... ...

Abstract	Uveal melanoma (UM) is an uncommon but highly aggressive ocular malignancy. Poor overall survival is associated with deleterious BAP1 alterations, which frequently occur with monosomy 3 (LOH3) and a characteristic gene expression profile. Tumor DNA from a cohort of 100 UM patients from Moorfields Biobank (UK) that had undergone enucleation were sequenced for known UM driver genes (BAP1, SF3B1, EIF1AX, GNAQ, and GNA11). Immunohistochemical staining of BAP1 and interphase FISH for chromosomes 3 and 8 was performed, and cellular localization of BAP1 was correlated with BAP1 mutations. Wildtype (WT) BAP1 staining was characterized by nBAP1 expression with <10% cytoplasmic BAP1 (cBAP1). Tumors exhibited heterogeneity with respect to BAP1 staining with different percentages of nBAP1 loss: ≥25% loss of nuclear BAP1 (nBAP1) was superior to chr8q and LOH3 as a prognostic indicator. Of the successfully sequenced UMs, 38% harbored oncogenic mutations in GNA11 and 48% harbored mutations in GNAQ at residues 209 or 183. Of the secondary drivers, 39% of mutations were in BAP1, 11% were in EIF1AX, and 20% were in the SF3B1 R625 hotspot. Most tumors with SF3B1 or EIF1AX mutations retained nuclear BAP1 (nBAP1). The majority of tumor samples with likely pathogenic BAP1 mutations, regardless of mutation class, displayed ≥25% loss of nBAP1. This included all tumors with truncating mutations and 80% of tumors with missense mutations. In addition, 60% of tumors with truncating mutations and 82% of tumors with missense mutations expressed >10% cBAP1.
Language	English
Publishing date	2022-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14174105
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Article ; Online: Comparative RNA-Sequencing Analysis Reveals High Complexity and Heterogeneity of Transcriptomic and Immune Profiles in Hepatocellular Carcinoma Tumors of Viral (HBV, HCV) and Non-Viral Etiology.

Paslaru, Liliana / Bindea, Gabriela / Nastase, Anca / Sorop, Andrei / Zimbru, Cristian / Herlea, Vlad / Hrehoret, Doina / Brasoveanu, Vlad / Zamfir, Radu / Dima, Simona / Popescu, Irinel

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 12

Abstract: Background and Objectives: Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is the leading cause of cancer-related mortality. It arises and progresses against fibrotic or cirrhotic backgrounds mainly due to infection with ... ...

Abstract	Background and Objectives: Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is the leading cause of cancer-related mortality. It arises and progresses against fibrotic or cirrhotic backgrounds mainly due to infection with hepatitis viruses B (HBV) or C (HCV) or non-viral causes that lead to chronic inflammation and genomic changes. A better understanding of molecular and immune mechanisms in HCC subtypes is needed. Materials and Methods: To identify transcriptional changes in primary HCC tumors with or without hepatitis viral etiology, we analyzed the transcriptomes of 24 patients by next-generation sequencing. Results: We identified common and unique differentially expressed genes for each etiological tumor group and analyzed the expression of SLC, ATP binding cassette, cytochrome 450, cancer testis, and heat shock protein genes. Metascape functional enrichment analysis showed mainly upregulated cell-cycle pathways in HBV and HCV and upregulated cell response to stress in non-viral infection. GeneWalk analysis identified regulator, hub, and moonlighting genes and highlighted CCNB1, ACTN2, BRCA1, IGF1, CDK1, AURKA, AURKB, and TOP2A in the HCV group and HSF1, HSPA1A, HSP90AA1, HSPB1, HSPA5, PTK2, and AURKB in the group without viral infection as hub genes. Immune infiltrate analysis showed that T cell, cytotoxic, and natural killer cell markers were significantly more highly expressed in HCV than in non-viral tumors. Genes associated with monocyte activation had the highest expression levels in HBV, while high expression of genes involved in primary adaptive immune response and complement receptor activity characterized tumors without viral infection. Conclusions: Our comprehensive study underlines the high degree of complexity of immune profiles in the analyzed groups, which adds to the heterogeneous HCC genomic landscape. The biomarkers identified in each HCC group might serve as therapeutic targets.
MeSH term(s)	Male ; Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Transcriptome/genetics ; Hepatitis B virus/genetics ; Hepatitis C/complications ; Hepatitis C/genetics ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2022-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58121803
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Article ; Online: Molecular Biomarkers as Predictors for Biliary Complications Following Liver Transplantation. A Prospective Study.

Dorobantu, Bogdan / Popescu, Irinel / Dima, Simona / Nastase, Anca / Iacob, Speranta

Journal of gastrointestinal and liver diseases : JGLD

2017 Volume 26, Issue 3, Page(s) 253–259

Abstract: Background: The biliary complications (BC) have been always considered the "Achilles' heel" of liver transplantation (LT), being one of the leading causes of postoperative morbidity.: Aim: To analyse predictors of BC, by monitoring in the peripheral ... ...

Abstract	Background: The biliary complications (BC) have been always considered the "Achilles' heel" of liver transplantation (LT), being one of the leading causes of postoperative morbidity. Aim: To analyse predictors of BC, by monitoring in the peripheral blood the biomarkers involved in the inflammation and hepatic fibrosis, such as the matrix metalloproteinases (MMP 2, 9) and their tissue inhibitors (TIMP1), the interleukins (IL 2, 8), alfa-TNF, the endothelins and their receptors. Methods: Thirty LT patients were followed-up prospectively for 5 years. The mRNA for the following biomarkers was quantified in the peripheral blood by qRTPCR and protein expression investigated by ELISA: MMP 2, 9, TIMP1, IL 2, IL 8, TNF-alfa, and endothelins and their receptors. Results: Five patients developed anastomotic stenosis (AS). There was no difference regarding mRNA levels for all studied genes between AS and non-AS patients. Two cytokines were significantly different: pre-LT TNF alpha was higher in the non-AS group and post-LT endothelin-1 at day 7 and month 3 were higher in the AS group. There was a trend for lower levels of serum cytokines for patients without AS compared to patients with AS. Conclusion: BC play an important role in the patients' postoperative morbidity and molecular biomarkers prediction should improve their early recognition and treatment.
Language	English
Publishing date	2017-09
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2427021-0
ISSN	1842-1121 ; 1841-8724
ISSN (online)	1842-1121
ISSN	1841-8724
DOI	10.15403/jgld.2014.1121.263.dor
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