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  1. Article ; Online: Right ventricular function in dilated cardiomyopathies with chagasic and idiopathic etiologies.

    Miranda, Carla

    Revista da Associacao Medica Brasileira (1992)

    2019  Volume 65, Issue 11, Page(s) 1327–1328

    MeSH term(s) Cardiomyopathy, Dilated/parasitology ; Cardiomyopathy, Dilated/physiopathology ; Chagas Cardiomyopathy/physiopathology ; Humans ; Ventricular Function, Right/physiology
    Language English
    Publishing date 2019-11-28
    Publishing country Brazil
    Document type Comparative Study ; Editorial
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.65.11.1327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Right ventricular function in dilated cardiomyopathies with chagasic and idiopathic etiologies

    Carla Miranda

    Revista da Associação Médica Brasileira, Vol 65, Iss 11, Pp 1327-

    2019  Volume 1328

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Agronomic, Nutritional Traits, and Alkaloids of

    Valente, Inês M / Monteiro, André / Sousa, Carla / Miranda, Carla / Maia, Margarida R G / Castro, Carlos / Cabrita, Ana R J / Trindade, Henrique / Fonseca, António J M

    ACS agricultural science & technology

    2024  Volume 4, Issue 4, Page(s) 450–462

    Abstract: Lupins ( ...

    Abstract Lupins (
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ISSN 2692-1952
    ISSN (online) 2692-1952
    DOI 10.1021/acsagscitech.3c00581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Bovine Colostrum: Human and Animal Health Benefits or Route Transmission of Antibiotic Resistance-One Health Perspective.

    Miranda, Carla / Igrejas, Gilberto / Poeta, Patrícia

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: After calving, bovine colostrum is obtained from the mammary gland of the dam in the first days and fed to newborn ruminant to prevent microbial infections. Each bovine colostrum has a unique biochemical composition with high nutraceutical value compared ...

    Abstract After calving, bovine colostrum is obtained from the mammary gland of the dam in the first days and fed to newborn ruminant to prevent microbial infections. Each bovine colostrum has a unique biochemical composition with high nutraceutical value compared to milk. However, bovine colostrum is influenced by various factors, such as environmental, individual, and genetic factors, as well as processing methods. Proper colostrum management is crucial for obtaining high-quality colostrum and mitigating bacterial contamination. This is important not only for the health and survival of calves but also for the health of humans who consume colostrum and its co-products. It is essential to ensure that the consumed colostrum is free of pathogens to reap its benefits. Health-promoting products based on colostrum have gained significant interest. However, colostrum can contain pathogens that, if not eliminated, can contribute to their transmission and spread, as well as antibiotic resistance. The aim of this review was to promote the animal and human health benefits of bovine colostrum by improving its microbial quality and highlighting potential routes of dissemination of antibiotic-resistant pathogens. Implementing hygienic measures is one of the key factors in mitigating colostrum bacterial contamination and obtaining safe and high-quality colostrum. This helps reduce the exposure of pathogens to newborn calves, other animals, and humans, in a One Health analysis.
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12071156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ocular Tuberculosis in Pediatrics: A Case Report.

    Vieira, Paula Manuel / Zilhão, Carla / Miranda, Vasco

    Acta medica portuguesa

    2023  Volume 36, Issue 10, Page(s) 683–686

    Abstract: A 17-year-old male was taken to the emergency department for decreased left visual acuity and floaters beginning that same day. There was a history of exposure to pulmonary tuberculosis five years before (mother as index case) followed by a four-month ... ...

    Abstract A 17-year-old male was taken to the emergency department for decreased left visual acuity and floaters beginning that same day. There was a history of exposure to pulmonary tuberculosis five years before (mother as index case) followed by a four-month period of isoniazid prophylaxis. The ophthalmic examination showed posterior and intermediate uveitis in the left eye. Laboratory tests were normal; IgG for herpes simplex 1 was positive and both the varicella-zoster virus and remaining serologic tests were negative. Chest radiography was normal. Two weeks later, an epiretinal membrane with risk of tractional retinal detachment was observed. The Mantoux tuberculin skin test showed an induration of 15 mm and the IGRA test was positive. Sputum and vitreous humor samples were collected. Quadruple therapy and prednisolone were started. Ten days later, a posterior vitreous detachment with underlying vitreous hematoma was observed. Posterior vitrectomy and peripheral endolaser were performed without complications. One month later, the microbiological results became available, with the identification of Mycobacterium tuberculosis. Corticosteroids were weaned progressively. Antituberculous drugs were maintained for six months. The patient made a full recovery.
    MeSH term(s) Male ; Humans ; Child ; Adolescent ; Tuberculosis, Ocular/diagnosis ; Tuberculosis, Ocular/drug therapy ; Tuberculosis, Ocular/surgery ; Vitreous Body/microbiology ; Vitreous Body/surgery ; Vitrectomy ; Eye Diseases/surgery ; Mycobacterium tuberculosis
    Language English
    Publishing date 2023-04-19
    Publishing country Portugal
    Document type Case Reports ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.19245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Rheology of Complex Topical Formulations: An Analytical Quality by Design Approach to Method Optimization and Validation.

    Chiarentin, Lucas / Cardoso, Catarina / Miranda, Margarida / Vitorino, Carla

    Pharmaceutics

    2023  Volume 15, Issue 7

    Abstract: Analytical method validation ensures that a method provides trustworthy information about a particular sample when applied in accordance with the predefined protocol. According to regulatory standards, the rheological characteristics of topically applied ...

    Abstract Analytical method validation ensures that a method provides trustworthy information about a particular sample when applied in accordance with the predefined protocol. According to regulatory standards, the rheological characteristics of topically applied semisolid formulations are one of the key elements involved in microstructure equivalence documentation. Therefore, for generic drug product manufacturers, it is a dire need to take a step forward in rheology method development and validation procedures. This paper aims to apply Analytical Quality by Design (AQbD) principles towards the development and validation of rheology methods for topical creams, as complex semisolid formulations. Risk assessment was carried out through an Ishikawa diagram and an estimate failure mode, effects, and criticality analysis (FMECA). Sample application, peltier temperature control, and sample rest time were identified as critical method variables (CMVs), and a 2
    Language English
    Publishing date 2023-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15071810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ocular Tuberculosis in Pediatrics

    Paula Manuel Vieira / Carla Zilhão / Vasco Miranda

    Acta Médica Portuguesa (2023)

    A Case Report

    2023  

    Abstract: A 17-year-old male was taken to the emergency department for decreased left visual acuity and floaters beginning that same day. There was a history of exposure to pulmonary tuberculosis five years before (mother as index case) followed by a four-month ... ...

    Abstract A 17-year-old male was taken to the emergency department for decreased left visual acuity and floaters beginning that same day. There was a history of exposure to pulmonary tuberculosis five years before (mother as index case) followed by a four-month period of isoniazid prophylaxis. The ophthalmic examination showed posterior and intermediate uveitis in the left eye. Laboratory tests were normal; IgG for herpes simplex 1 was positive and both the varicella-zoster virus and remaining serologic tests were negative. Chest radiography was normal. Two weeks later, an epiretinal membrane with risk of tractional retinal detachment was observed. The Mantoux tuberculin skin test showed an induration of 15 mm and the IGRA test was positive. Sputum and vitreous humor samples were collected. Quadruple therapy and prednisolone were started. Ten days later, a posterior vitreous detachment with underlying vitreous hematoma was observed. Posterior vitrectomy and peripheral endolaser were performed without complications. One month later, the microbiological results became available, with the identification of Mycobacterium tuberculosis. Corticosteroids were weaned progressively. Antituberculous drugs were maintained for six months. The patient made a full recovery.
    Keywords Adolescent ; Tuberculosis ; Ocular/diagnosis ; Uveitis/diagnosis ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Ordem dos Médicos
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Antibiotic Resistance of

    Soares, Rúben / Miranda, Carla / Cunha, Sandra / Ferreira, Luís / Martins, Ângela / Igrejas, Gilberto / Poeta, Patrícia

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 11

    Abstract: ... ...

    Abstract Enterococcus
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13111761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Drilling into "Quality by Design" Approach for Analytical Methods.

    Chiarentin, Lucas / Gonçalves, Carla / Augusto, Cátia / Miranda, Margarida / Cardoso, Catarina / Vitorino, Carla

    Critical reviews in analytical chemistry

    2023  , Page(s) 1–42

    Abstract: The need for consistency in analytical method development reinforces the dependence of pharmaceutical product development and manufacturing on robust analytical data. The Analytical Quality by Design (AQbD), akin to the product Quality by Design (QbD) ... ...

    Abstract The need for consistency in analytical method development reinforces the dependence of pharmaceutical product development and manufacturing on robust analytical data. The Analytical Quality by Design (AQbD), akin to the product Quality by Design (QbD) endows a high degree of confidence to the method quality developed. AQbD involves the definition of the analytical target profile as starting point, followed by the identification of critical method variables and critical analytical attributes, supported on risk assessment and design of experiment tools for the establishment of a method operable design region and control strategy of the method. This systematic approach moves away from reactive troubleshooting to proactive failure reduction. The objective of this review is to highlight the elements of the AQbD framework and provide an overview of their implementation status in various analytical methods used in the pharmaceutical field. These methodologies include but are not limited to, high-performance liquid chromatography, UV-Vis spectrophotometry, capillary electrophoresis, supercritical fluid chromatography, and high-performance thin-layer chromatography. Finally, a critical appraisal is provided to highlight how regulators have encouraged AQbD principles application to boost the prevention of method failures and a better understanding of the method operable design region (MODR) and control strategy, ultimately resulting in cost-effectiveness and regulatory flexibility.
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2030019-0
    ISSN 1547-6510 ; 1040-8347
    ISSN (online) 1547-6510
    ISSN 1040-8347
    DOI 10.1080/10408347.2023.2253321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Targeting proto-oncogene B-MYB G-quadruplex with a nucleic acid-based fluorescent probe.

    Lourenço, Pedro / Miranda, André / Campello, Maria Paula Cabral / Paulo, António / Louis-Mergny, Jean / Cruz, Carla

    International journal of biological macromolecules

    2024  Volume 266, Issue Pt 1, Page(s) 131055

    Abstract: The B-MYB gene encodes a transcription factor (B-MYB) that regulates cell growth and survival. Abnormal expression of B-MYB is frequently observed in lung cancer and poses challenges for targeted drug therapy. Oncogenes often contain DNA structures ... ...

    Abstract The B-MYB gene encodes a transcription factor (B-MYB) that regulates cell growth and survival. Abnormal expression of B-MYB is frequently observed in lung cancer and poses challenges for targeted drug therapy. Oncogenes often contain DNA structures called G-quadruplexes (G4s) in their promoter regions, and B-MYB is no exception. These G4s play roles in genetic regulation and are potential cancer treatment targets. In this study, a probe was designed to specifically identify a G4 within the promoter region of the B-MYB gene. This probe combines an acridine derivative ligand with a DNA segment complementary to the target sequence, enabling it to hybridize with the adjacent sequence of the G4 being investigated. Biophysical studies demonstrated that the acridine derivative ligands C
    MeSH term(s) G-Quadruplexes ; Humans ; Fluorescent Dyes/chemistry ; Promoter Regions, Genetic ; Proto-Oncogene Mas ; Ligands ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Trans-Activators/chemistry ; Acridines/chemistry ; Acridines/pharmacology ; Cell Cycle Proteins
    Chemical Substances Fluorescent Dyes ; Proto-Oncogene Mas ; MYBL2 protein, human ; Ligands ; MAS1 protein, human ; Trans-Activators ; Acridines ; Cell Cycle Proteins
    Language English
    Publishing date 2024-03-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131055
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