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Book ; Online: T cells and protective immunity to Plasmodium berghei in the rat / by K. N. Brown, W. Jarra, L. A. Hills

Brown, K. N / Jarra, W / Hills, L. A / World Health Organization

1976

Abstract: Documents : WHO/MAL/74.822-74.824, WHO/MAL/74.825 (WHO/VBC/74.475), WHO/MAL/74.826 (WHO/VBC/74.478), WHO/MAL/74.827 (WHO/VBC/74.486), WHO/MAL/74.828-74.829, WHO/MAL/74.830 (WHO/VBC/74.488), WHO/MAL/74.831-74.838, WHO/MAL/74.839 (WHO/VBC/74.505), WHO/MAL/ ... ...

Abstract	Documents : WHO/MAL/74.822-74.824, WHO/MAL/74.825 (WHO/VBC/74.475), WHO/MAL/74.826 (WHO/VBC/74.478), WHO/MAL/74.827 (WHO/VBC/74.486), WHO/MAL/74.828-74.829, WHO/MAL/74.830 (WHO/VBC/74.488), WHO/MAL/74.831-74.838, WHO/MAL/74.839 (WHO/VBC/74.505), WHO/MAL/74.840, WHO/MAL/75.841-75.846, WHO/MAL/75.847 (WHO/VBC/75.515), WHO/MAL/75.848, WHO/MAL/75.849 (WHO/VBC/75.538), WHO/MAL/75.850, WHO/MAL/75.851 (WHO/VBC/75.541), WHO/MAL/75.852-75.853, WHO/MAL/75.854 (WHO/VBC/75.547), WHO/MAL/75.855 (WHO/VBC/75.569), WHO/MAL/75.856 (WHO/VBC/75.571), WHO/MAL/75.857 (WHO/VBC/75.545), WHO/MAL/75.858-75.863, WHO/MAL/76.864-76.867, WHO/MAL/76.868 (WHO/VBC/76.624), WHO/MAL/76.869-76.873, WHO/MAL/76.874 (WHO/VBC/76.633), WHO/MAL/76.875-76.882, WHO/MAL/76.883 (WHO/VBC/76.634), bound in 1 vol Summary in French p. 11 WHO/MAL/76.878 21 p. (ill., graphs).
Keywords	Malaria ; Plasmodium berghei ; Rats ; T-Lymphocytes ; Parasitic Diseases and their Control ; prevention and control ; immunology ; parasitology
Language	English
Publisher	Geneva : World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: T cells and protective immunity to Plasmodium berghei in the rat / by K. N. Brown, W. Jarra, L. A. Hills

Brown, K. N / Jarra, W / Hills, L. A / World Health Organization

1976

Abstract	Documents : WHO/MAL/74.822-74.824, WHO/MAL/74.825 (WHO/VBC/74.475), WHO/MAL/74.826 (WHO/VBC/74.478), WHO/MAL/74.827 (WHO/VBC/74.486), WHO/MAL/74.828-74.829, WHO/MAL/74.830 (WHO/VBC/74.488), WHO/MAL/74.831-74.838, WHO/MAL/74.839 (WHO/VBC/74.505), WHO/MAL/74.840, WHO/MAL/75.841-75.846, WHO/MAL/75.847 (WHO/VBC/75.515), WHO/MAL/75.848, WHO/MAL/75.849 (WHO/VBC/75.538), WHO/MAL/75.850, WHO/MAL/75.851 (WHO/VBC/75.541), WHO/MAL/75.852-75.853, WHO/MAL/75.854 (WHO/VBC/75.547), WHO/MAL/75.855 (WHO/VBC/75.569), WHO/MAL/75.856 (WHO/VBC/75.571), WHO/MAL/75.857 (WHO/VBC/75.545), WHO/MAL/75.858-75.863, WHO/MAL/76.864-76.867, WHO/MAL/76.868 (WHO/VBC/76.624), WHO/MAL/76.869-76.873, WHO/MAL/76.874 (WHO/VBC/76.633), WHO/MAL/76.875-76.882, WHO/MAL/76.883 (WHO/VBC/76.634), bound in 1 vol Summary in French p. 11 WHO/MAL/76.878 21 p. (ill., graphs).
Keywords	Malaria ; Plasmodium berghei ; Rats ; T-Lymphocytes ; Parasitic Diseases and their Control ; prevention and control ; immunology ; parasitology
Language	English
Publisher	World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: 3'-sulfated Lewis

Das, Koushik K / Brown, Jeffrey W

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1089028

Abstract: Metaplasia, dysplasia, and cancer arise from normal ... ...

Abstract	Metaplasia, dysplasia, and cancer arise from normal epithelia
Language	English
Publishing date	2023-02-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1089028
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sub-optimal temperatures lead to altered expression of stress-related genes and increased 'C

Fisher, Tonja W / Munyaneza, Joseph E / Brown, Judith K

Frontiers in insect science

2024 Volume 3, Page(s) 1279365

Abstract: Introduction: The potato psyllid : Methods: ': Results: Relative gene expression profiles varied in psyllids reared at the three experimental temperatures. Psyllids reared at 18°C and 30°C exhibited greater fold-change increased expression of ... ...

Abstract	Introduction: The potato psyllid Methods: ' Results: Relative gene expression profiles varied in psyllids reared at the three experimental temperatures. Psyllids reared at 18°C and 30°C exhibited greater fold-change increased expression of stress- and ' Discussion: Temperature is a key factor in the life history of potato psyllid and multiplication/accumulation of '
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	3123819-1
ISSN	2673-8600 ; 2673-8600
ISSN (online)	2673-8600
ISSN	2673-8600
DOI	10.3389/finsc.2023.1279365
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Book ; Online: Preliminary studies on artificial immunization against Plasmodium berghei and adoptive transfer of this immunity by splenic T and T + B cells / by K. N. Brown, L. A. Hills, W. Jarra

Brown, K. N / Hills, L. A / Jarra, W / World Health Organization

1976

Abstract	Documents : WHO/MAL/74.822-74.824, WHO/MAL/74.825 (WHO/VBC/74.475), WHO/MAL/74.826 (WHO/VBC/74.478), WHO/MAL/74.827 (WHO/VBC/74.486), WHO/MAL/74.828-74.829, WHO/MAL/74.830 (WHO/VBC/74.488), WHO/MAL/74.831-74.838, WHO/MAL/74.839 (WHO/VBC/74.505), WHO/MAL/74.840, WHO/MAL/75.841-75.846, WHO/MAL/75.847 (WHO/VBC/75.515), WHO/MAL/75.848, WHO/MAL/75.849 (WHO/VBC/75.538), WHO/MAL/75.850, WHO/MAL/75.851 (WHO/VBC/75.541), WHO/MAL/75.852-75.853, WHO/MAL/75.854 (WHO/VBC/75.547), WHO/MAL/75.855 (WHO/VBC/75.569), WHO/MAL/75.856 (WHO/VBC/75.571), WHO/MAL/75.857 (WHO/VBC/75.545), WHO/MAL/75.858-75.863, WHO/MAL/76.864-76.867, WHO/MAL/76.868 (WHO/VBC/76.624), WHO/MAL/76.869-76.873, WHO/MAL/76.874 (WHO/VBC/76.633), WHO/MAL/76.875-76.882, WHO/MAL/76.883 (WHO/VBC/76.634), bound in 1 vol Summary in French p. 4 WHO/MAL/76.867 8 p. (ill., graphs).
Keywords	Malaria ; Plasmodium berghei ; Allergy and immunology ; B-Lymphocytes ; T-Lymphocytes ; Spleen ; Parasitic Diseases and their Control ; prevention and control
Language	English
Publisher	Geneva : World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

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Book ; Online: Preliminary studies on artificial immunization against Plasmodium berghei and adoptive transfer of this immunity by splenic T and T + B cells / by K. N. Brown, L. A. Hills, W. Jarra

Brown, K. N / Hills, L. A / Jarra, W / World Health Organization

1976

Abstract	Documents : WHO/MAL/74.822-74.824, WHO/MAL/74.825 (WHO/VBC/74.475), WHO/MAL/74.826 (WHO/VBC/74.478), WHO/MAL/74.827 (WHO/VBC/74.486), WHO/MAL/74.828-74.829, WHO/MAL/74.830 (WHO/VBC/74.488), WHO/MAL/74.831-74.838, WHO/MAL/74.839 (WHO/VBC/74.505), WHO/MAL/74.840, WHO/MAL/75.841-75.846, WHO/MAL/75.847 (WHO/VBC/75.515), WHO/MAL/75.848, WHO/MAL/75.849 (WHO/VBC/75.538), WHO/MAL/75.850, WHO/MAL/75.851 (WHO/VBC/75.541), WHO/MAL/75.852-75.853, WHO/MAL/75.854 (WHO/VBC/75.547), WHO/MAL/75.855 (WHO/VBC/75.569), WHO/MAL/75.856 (WHO/VBC/75.571), WHO/MAL/75.857 (WHO/VBC/75.545), WHO/MAL/75.858-75.863, WHO/MAL/76.864-76.867, WHO/MAL/76.868 (WHO/VBC/76.624), WHO/MAL/76.869-76.873, WHO/MAL/76.874 (WHO/VBC/76.633), WHO/MAL/76.875-76.882, WHO/MAL/76.883 (WHO/VBC/76.634), bound in 1 vol Summary in French p. 4 WHO/MAL/76.867 8 p. (ill., graphs).
Keywords	Malaria ; Plasmodium berghei ; Allergy and Immunology ; B-Lymphocytes ; T-Lymphocytes ; Spleen ; Parasitic Diseases and their Control ; prevention and control
Language	English
Publisher	World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multicellularity: Amoebae follow the leader to food.

Tice, Alexander K / Brown, Matthew W

Current biology : CB

2022 Volume 32, Issue 9, Page(s) R418–R420

Abstract: Multicellular fruiting body formation through aggregation of individual cells has been known in Fonticla alba since the original description of the organism. A new study reveals the existence of a second transient collective cellular behavior separate ... ...

Abstract	Multicellular fruiting body formation through aggregation of individual cells has been known in Fonticla alba since the original description of the organism. A new study reveals the existence of a second transient collective cellular behavior separate from fruiting body formation.
MeSH term(s)	Amoeba
Language	English
Publishing date	2022-04-22
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2022.03.067
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Article ; Online: Phylogenetic placement of the protosteloid amoeba Microglomus paxillus identifies another case of sporocarpic fruiting in Discosea (Amoebozoa).

Tice, Alexander K / Spiegel, Frederick W / Brown, Matthew W

The Journal of eukaryotic microbiology

2023 Volume 70, Issue 4, Page(s) e12971

Abstract: Protosteloid amoebae are a paraphyletic assemblage of amoeboid protists found exclusively in the eukaryotic assemblage Amoebozoa. These amoebae can facultatively form a dispersal structure known as a fruiting body, or more specifically, a sporocarp, from ...

Abstract	Protosteloid amoebae are a paraphyletic assemblage of amoeboid protists found exclusively in the eukaryotic assemblage Amoebozoa. These amoebae can facultatively form a dispersal structure known as a fruiting body, or more specifically, a sporocarp, from a single amoeboid cell. Sporocarps consist of one to a few spores atop a noncellular stalk. Protosteloid amoebae are known in two out of three well-established major assemblages of Amoebozoa. Amoebae with a protosteloid life cycle are known in the major Amoebozoa lineages Discosea and Evosea but not in Tubulinea. To date, only one genus, which is monotypic, lacks sequence data and, therefore, remains phylogenetically homeless. To further clarify the evolutionary milieu of sporocarpic fruiting we used single-cell transcriptomics to obtain data from individual sporocarps of isolates of the protosteloid amoeba Microglomus paxillus. Our phylogenomic analyses using 229 protein coding markers suggest that M. paxillus is a member of the Discosea lineage of Amoebozoa most closely related to Mycamoeba gemmipara. Due to the hypervariable nature of the SSU rRNA sequence we were unable to further resolve the phylogenetic position of M. paxillus in taxon rich datasets using only this marker. Regardless, our results widen the known distribution of sporocarpy in Discosea and stimulate the debate between a single or multiple origins of sporocarpic fruiting in Amoebozoa.
MeSH term(s)	Phylogeny ; Amoeba/genetics ; Amoebozoa/genetics ; Biological Evolution ; Eukaryota
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1147218-2
ISSN	1550-7408 ; 1066-5234
ISSN (online)	1550-7408
ISSN	1066-5234
DOI	10.1111/jeu.12971
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Article: Monkey Prefrontal Cortex Learns to Minimize Sequence Prediction Error.

Cheng, Huzi / Chafee, Matthew V / Blackman, Rachael K / Brown, Joshua W

bioRxiv : the preprint server for biology

2024

Abstract: In this study, we develop a novel recurrent neural network (RNN) model of pre-frontal cortex that predicts sensory inputs, actions, and outcomes at the next time step. Synaptic weights in the model are adjusted to minimize sequence prediction error, ... ...

Abstract	In this study, we develop a novel recurrent neural network (RNN) model of pre-frontal cortex that predicts sensory inputs, actions, and outcomes at the next time step. Synaptic weights in the model are adjusted to minimize sequence prediction error, adapting a deep learning rule similar to those of large language models. The model, called Sequence Prediction Error Learning (SPEL), is a simple RNN that predicts world state at the next time step, but that differs from standard RNNs by using its own prediction errors from the previous state predictions as inputs to the hidden units of the network. We show that the time course of sequence prediction errors generated by the model closely matched the activity time courses of populations of neurons in macaque prefrontal cortex. Hidden units in the model responded to combinations of task variables and exhibited sensitivity to changing stimulus probability in ways that closely resembled monkey prefrontal neurons. Moreover, the model generated prolonged response times to infrequent, unexpected events as did monkeys. The results suggest that prefrontal cortex may generate internal models of the temporal structure of the world even during tasks that do not explicitly depend on temporal expectation, using a sequence prediction error minimization learning rule to do so. As such, the SPEL model provides a unified, general-purpose theoretical framework for modeling the lateral prefrontal cortex.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.28.582611
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Article ; Online: Postoperative Prescribing Practices Following Gynecologic Surgery.

Craven, Rachel J / Moureau, Madeline K / Brown, Heidi W / Buttigieg, Emily M

WMJ : official publication of the State Medical Society of Wisconsin

2024 Volume 123, Issue 1, Page(s) 24–28

Abstract: Background: Opioids prescribed for postoperative pain have exceeded patient need in the United States, playing a significant role in the opioid epidemic. In the preintervention phase of this project (September 2018 - March 2019), a chart review and ... ...

Abstract	Background: Opioids prescribed for postoperative pain have exceeded patient need in the United States, playing a significant role in the opioid epidemic. In the preintervention phase of this project (September 2018 - March 2019), a chart review and patient survey revealed that patients were prescribed double the number of opioids they consumed following gynecologic surgery. Objective: To ascertain whether an educational intervention recommending opiate prescriptions based on postoperative opioid use decreases gynecologic surgeons' opiate prescriptions. Methods: An educational intervention implemented in January 2021 communicated the discrepancy between patient need and medications prescribed and made prescribing recommendations for common gynecologic procedures. A postintervention (February 2021 - April 2021) retrospective chart review ascertained postoperative opioid prescribing practices. Residents were surveyed about their prescribing practices in June 2021. Descriptive statistics compared each phase. Results: For laparoscopic hysterectomy, the median morphine milligram equivalent (MME) was 150 (IQR 112.5-166.9) for preintervention and 150 (IQR 112.5-150) postintervention. For vaginal hysterectomy, median MME declined from 150 (IQR 112.5-225) to 112.5 (IQR 112.5-150). For laparoscopic surgery without hysterectomy, the median MME was 75 for both preintervention (IQR 75-120) and postintervention (IQR 60-80). For vaginal surgery without hysterectomy median MME went from 75 (IQR 75-142.5) to 54 (IQR 22.5-112.5). Median MME for hysteroscopy and dilation and curettage was 0 for both phases. When surveyed, residents reported prescribing lower amounts than actual prescribing practices. Conclusions: Despite education informing gynecologic surgeons that their opioid prescribing exceeded patient need, prescribing practices did not change. The difference between actual and resident-reported prescribing practices warrants further investigation.
MeSH term(s)	Humans ; Female ; Analgesics, Opioid/therapeutic use ; Retrospective Studies ; Practice Patterns, Physicians' ; Gynecologic Surgical Procedures ; Opiate Alkaloids ; Endrin/analogs & derivatives
Chemical Substances	Analgesics, Opioid ; MME (78185-58-7) ; Opiate Alkaloids ; Endrin (OB9NVE7YCL)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	441051-8
ISSN	2379-3961 ; 0043-6542 ; 1098-1861
ISSN (online)	2379-3961
ISSN	0043-6542 ; 1098-1861
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