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  1. Article: Genomic instability and colorectal cancer.

    Cruz-Bustillo Clarens, D

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2005  Volume 97, Issue 10, Page(s) 683–687

    MeSH term(s) Colorectal Neoplasms/genetics ; Genes, APC ; Genomic Instability ; Humans
    Language Spanish
    Publishing date 2005-12-01
    Publishing country Spain
    Document type Comment ; Editorial
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.4321/s1130-01082005001000001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 199: Show issues Location:
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  2. Article: Molecular genetics of colorectal cancer.

    Cruz-Bustillo Clarens, D

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2004  Volume 96, Issue 1, Page(s) 48–59

    Abstract: Colorectal tumours constitute an excellent system to study carcinogenesis and the molecular events implicated in the development of cancer. Attending to the way it is transmitted, colorectal cancer may appear in one of three forms: sporadic, familial, ... ...

    Abstract Colorectal tumours constitute an excellent system to study carcinogenesis and the molecular events implicated in the development of cancer. Attending to the way it is transmitted, colorectal cancer may appear in one of three forms: sporadic, familial, and hereditary. The sporadic form is most common and has no familial or hereditary associated factor thus far, while familial and hereditary forms show the same inheritance pattern. Hereditary colorectal cancers develop by means of defined stages that go from lesions in the crypt of the colon through adenomas to manifest cancer. They are characterised by the accumulation of multiple mutations in tumour suppressor genes and oncogenes that affect the balance between cell proliferation and apoptosis. The colorectal carcinogenesis pathway is not unique and there are probably several ways for the initiation, development and progression of colorectal tumours.
    MeSH term(s) Clinical Trials as Topic ; Colorectal Neoplasms/classification ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/physiopathology ; Humans ; Molecular Biology
    Language Spanish
    Publishing date 2004-02-04
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.4321/s1130-01082004000100007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Genomic instability and colorectal cancer Inestabilidad genómica y cáncer colorrectal

    D. Cruz-Bustillo Clarens

    Revista Espanola de Enfermedades Digestivas, Vol 97, Iss 10, Pp 683-

    2005  Volume 687

    Keywords Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; DOAJ:Gastroenterology
    Language Spanish
    Publishing date 2005-10-01T00:00:00Z
    Publisher Sociedad Española de Patología Digestiva
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Molecular genetics of colorectal cancer Genética molecular del cáncer colorrectal

    D. Cruz-Bustillo Clarens

    Revista Espanola de Enfermedades Digestivas, Vol 96, Iss 1, Pp 48-

    2004  Volume 59

    Abstract: Colorectal tumours constitute an excellent system to study carcinogenesis and the molecular events implicated in the development of cancer. Attending to the way it is transmitted, colorectal cancer may appear in one of three forms: sporadic, familial, ... ...

    Abstract Colorectal tumours constitute an excellent system to study carcinogenesis and the molecular events implicated in the development of cancer. Attending to the way it is transmitted, colorectal cancer may appear in one of three forms: sporadic, familial, and hereditary. The sporadic form is most common and has no familial or hereditary associated factor thus far, while familial and hereditary forms show the same inheritance pattern. Hereditary colorectal cancers develop by means of defined stages that go from lesions in the crypt of the colon through adenomas to manifest cancer. They are characterised by the accumulation of multiple mutations in tumour suppressor genes and oncogenes that affect the balance between cell proliferation and apoptosis. The colorectal carcinogenesis pathway is not unique and there are probably several ways for the initiation, development and progression of colorectal tumours. Los tumores colorrectales constituyen un excelente sistema para estudiar la carcinogénesis y los eventos moleculares involucrados en el desarrollo de un tumor. El cáncer colorrectal puede presentarse en tres formas, según su forma de transmisión: esporádico, familiar y hereditario. La forma esporádica que es la mayoritaria, no tiene hasta el momento ningún factor familiar o hereditario asociado, mientras que las formas familiares y hereditarias siguen un patrón de herencia en la propensión familiar a padecerlo. Los cánceres colorrectales hereditarios se desarrollan mediante etapas definidas que van desde lesiones en la cripta del colon a través de adenomas hasta manifestar el cáncer y se caracterizan por la acumulación de múltiples mutaciones en genes supresores de tumor y oncogenes que afectan el balance entre la proliferación celular y la apoptosis. La vía de carcinogénesis colorrectal no es una sola y probablemente existan varios caminos para el inicio, desarrollo y progresión de un tumor colorrectal.
    Keywords Cáncer colorrectal ; Carcinogénesis colorrectal ; Genes supresores de tumor ; Genes porteros y genes guardianes ; Mutación germinal ; Mutación esporádica ; Inestabilidad en microsatélites ; Colorectal cancer ; Colorectal carcinogenesis ; Tumour suppressor genes ; Caretakers and gatekeepers ; Germinal mutation ; Sporadic mutation ; Microsatellite instability ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; DOAJ:Gastroenterology
    Language Spanish
    Publishing date 2004-01-01T00:00:00Z
    Publisher The Spanish Society of Digestive Pathology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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