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  1. Article ; Online: Reconstructed Jing River streamflow from western China: A 399-year perspective for hydrological changes in the Loess Plateau

    Zhao, Xiaoen / Fang, Keyan / Chen, Feng / Martín, Hadad / Roig, Fidel A.

    Journal of Hydrology. 2023 June, v. 621 p.129573-

    2023  

    Abstract: The Jing River is a secondary tributary of the Yellow River, which flows through the middle ... machine learning models and simple linear regression to reconstruct the January-June streamflow of the Jing River ... information than with a single model. Over the past nearly four centuries, the Jing River has experienced ...

    Abstract The Jing River is a secondary tributary of the Yellow River, which flows through the middle of the Loess Plateau in China. Severe water scarcity and soil erosion in the basin have threatened sustainable social and economic development. To assess and solve the region’s water resource problems, it is important to understand its historical hydrological climate change. Accordingly, we used five machine learning models and simple linear regression to reconstruct the January-June streamflow of the Jing River based on the tree ring width of Pinus tabulaeformis and Pinus armandii. By combining six models into an ensemble streamflow reconstruction, we obtained a more accurate reconstruction and streamflow variability information than with a single model. Over the past nearly four centuries, the Jing River has experienced seven high streamflow periods and ten low streamflow periods. The main atmospheric forcing factors driving the streamflow variability are the Pacific Decadal Oscillation and the El Niño-Southern Oscillation, which regulate the climate and hydrology of the region by affecting water vapor fluxes and the Asian monsoon. The different climate scenarios revealed the continued reduction in the future Jing River streamflow and a worsening water resource situation. This new streamflow reconstruction can serve as a valuable reference for analyzing regional hydrology and informing water resource management and policy formulations.
    Keywords Pinus armandii ; Pinus tabuliformis ; basins ; climate ; climate change ; economic development ; growth rings ; issues and policy ; models ; monsoon season ; regression analysis ; rivers ; soil erosion ; stream flow ; water management ; water shortages ; water vapor ; China ; Yellow River ; Tree rings ; Machine learning ; Streamflow reconstruction ; Jing River
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1473173-3
    ISSN 1879-2707 ; 0022-1694
    ISSN (online) 1879-2707
    ISSN 0022-1694
    DOI 10.1016/j.jhydrol.2023.129573
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  2. Article: Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model.

    Yan, Guang / Tian, Fang / Liu, Peng / Sun, Jianming / Mao, Jianmin / Han, Wenjun / Mo, Ran / Guo, Shishuai / Yu, Quanyao

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 3686494

    Abstract: Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used ...

    Abstract Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the functions of SJD on spermatogenesis and sperm motility and explored the potential mechanisms involved. Here, we demonstrated that high, medium, and low doses of SJD are effective in restoring the impairments of the whole body and testicular tissue by cyclophosphamide inducing and to rescue the damage of testicular tissue cells including Sertoli cells and germ cells. SJD can partly restore the decrease in sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate in oligozoospermic mouse models. Ki67 staining analyses confirm SJD can promote testicular tissue cell proliferation. Real-time RT-PCR analyses also reveal that SJD can upregulate the expression of proliferation-associated gene
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/3686494
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    Zs.A 5995: Show issues Location:
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  3. Article ; Online: Epidemiological characteristics and disease burden of senile dementia death in Jing’an District， Shanghai from 2016 to 2020

    WAN Qiuping / YANG Xiaoming / CHU Xiaoting / YIN Xiaolie / ZHANG Guohui / WANG Yunhui / XIONG Jianjing / FANG Jialie

    Shanghai yufang yixue, Vol 34, Iss 8, Pp 736-

    2022  Volume 742

    Abstract: ObjectiveTo analyze the epidemiological characteristics of senile dementia death in Jing ... in the senile dementia death cases from 2016 to 2020 in Jing’an District. The YLL， YLD， DALY and their rates ... of the residents of Jing’an District from 2016 to 2020 were calculated by using Global Burden of Disease （GBD 2019 ...

    Abstract ObjectiveTo analyze the epidemiological characteristics of senile dementia death in Jing’an District from 2016 to 2020， as well as the trends of mortality， standardized mortality， years of life lost （YLL） due to early death， years lived with disability （YLD）， and disability-adjusted life year （DALY）， and to provide scientific basis for the prevention and control of senile dementia.MethodsThe distribution of senile dementia in terms of gender， age， marital status and education level was investigated in the senile dementia death cases from 2016 to 2020 in Jing’an District. The YLL， YLD， DALY and their rates of the residents of Jing’an District from 2016 to 2020 were calculated by using Global Burden of Disease （GBD 2019） research method and results in combination with the corresponding population data.ResultsCompared to those without dementia， deaths with dementia were more likely to be female， more likely to be over 80 years old， less likely to be married， and more likely to have education level under middle school. Among the deaths with dementia， only 27.70% of the primary cause of death was dementia， and the other main causes were cerebrovascular disease， coronary heart disease and diabetes mellitus， which accounted for 25.54%， 17.81% and 7.28%， respectively. There was a significant gender difference in the burden of disease on senile dementia in Jing’an District. Mortality， standardized mortality， YLL， YLD and DALY rates of females were higher than those of males. The burden of disease on senile dementia increased with age. The change trend of mortality and YLL rate from 2016 to 2020 was not statistically significant， while the YLD rate and DALY rate showed an upward trend， which was statistically significant.ConclusionAs the life span of residents in Jing’an District increases and the population aging deepens， the burden of disease on senile dementia is still heavy. This requires extensive attention of the whole society， and active exploration of prevention and control strategies and measures for senile ...
    Keywords senile dementia ; mortality ; disability adjusted life year ; burden of disease ; annual percentage change ; Medicine ; R
    Subject code 360
    Language Chinese
    Publishing date 2022-08-01T00:00:00Z
    Publisher Shanghai Preventive Medicine Association
    Document type Article ; Online
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  4. Article ; Online: Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model

    Guang Yan / Fang Tian / Peng Liu / Jianming Sun / Jianmin Mao / Wenjun Han / Ran Mo / Shishuai Guo / Quanyao Yu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2021  Volume 2021

    Abstract: Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used ...

    Abstract Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the functions of SJD on spermatogenesis and sperm motility and explored the potential mechanisms involved. Here, we demonstrated that high, medium, and low doses of SJD are effective in restoring the impairments of the whole body and testicular tissue by cyclophosphamide inducing and to rescue the damage of testicular tissue cells including Sertoli cells and germ cells. SJD can partly restore the decrease in sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate in oligozoospermic mouse models. Ki67 staining analyses confirm SJD can promote testicular tissue cell proliferation. Real-time RT-PCR analyses also reveal that SJD can upregulate the expression of proliferation-associated gene Lin28a and differentiation-associated genes Kit, Sohlh2, and Stra8. SJD can also reduce the impairment of mitochondrial membrane potential (MMP) and sperm plasma membrane integrity by cyclophosphamide inducing. Our results reveal that SJD is effective in improving both sperm quantity and quality by increasing the sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate. SJD can promote spermatogenesis by upregulating the expression of the proliferation-associated gene Lin28a and the differentiation-associated genes (Kit, Sohlh2, and Stra8). SJD can sustain MMP and sperm plasma membrane integrity to increase sperm motility.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 572
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
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  5. Article ; Online: Exploring potential biomarkers of coronary heart disease treated by Jing Zhi Guan Xin Pian using high-throughput metabolomics.

    Sun, Hui / Li, Xue-Na / Zhang, Ai-Hua / Zhang, Kun-Ming / Yan, Guang-Li / Han, Ying / Wu, Fang-Fang / Wang, Xi-Jun

    RSC advances

    2019  Volume 9, Issue 20, Page(s) 11420–11432

    Abstract: ... prevention method. Jing Zhi Guan Xin Pian (JZGXP) is a new preparation prepared from the effective extract ...

    Abstract Coronary heart disease (CHD) is a relatively complex disease characterized by narrowing of the arterial lumen and reduction of blood flow to the heart. There is no effective early diagnosis and prevention method. Jing Zhi Guan Xin Pian (JZGXP) is a new preparation prepared from the effective extract of Guanxin II. It is made of five components of traditional Chinese medicine and functions by promoting blood circulation and removing blood stasis and is used for the treatment of CHD and angina pectoris. In our study, a CHD rat model was prepared using a high-fat diet combined with intraperitoneal injection of vitamin D3. Clinical biochemical indexes (TG, CHO and HDL-C), histopathology (coronary and myocardial tissue), electrocardiogram and cardiac indexes were used to evaluate the efficacy of JZGXP in the treatment of CHD model rats. UPLC-HDMS-based metabolomics techniques were used to find metabolic profiles, biomarkers and related metabolic pathways in CHD models and to evaluate the effects of JZGXP on them. At the same time, the targets of JZGXP for the treatment of CHD were analyzed. Our study ultimately identified 25 biomarkers associated with CHD models. Further studies found that these 25 biomarkers involved 9 metabolic pathways in the body and found that JZGXP can recall 21 biomarkers in the urine of model rats and these biomarkers involve nine metabolic pathways. Finally, the targets of JZGXP for the treatment of CHD were β-alanine metabolism and tyrosine metabolism,
    Language English
    Publishing date 2019-04-11
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c8ra10557j
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  6. Book: Jing shan

    Shen, Fang / Zhang, Fuqiang

    2008  

    Institution Bei jing shi jing shan gong yuan guan li chu
    北京市景山公园管理处
    Author's details Zhang fu qiang zhuan wen; shen fang, zhang fu qiang zhu bian; bei jing shi jing shan gong yuan guan li chu bian ji
    Keywords Royal gardens/History ; Jingshan Gongyuan (Beijing, China)
    Language Chinese ; English
    Size 316 p., [8] p. of plates, col. ill, 30 cm
    Edition Di 1 ban
    Publisher Wen wu chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 7501022534 ; 9787501022533
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article: Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients: A Multi-center Randomized Controlled Trial.

    Yu, Nan-Nan / Xu, Zhi-Fang / Gao, Yang / Zhou, Zhi-Liang / Zhao, Xue / Zhou, Dan / Wang, Zhen-Guo / Chen, Ze-Lin / Pan, Xing-Fang / Guo, Yi

    Chinese journal of integrative medicine

    2020  Volume 27, Issue 8, Page(s) 570–577

    Abstract: Objective: To assess the effect and safety of bloodletting puncture at hand twelve Jing-Well ...

    Abstract Objective: To assess the effect and safety of bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance.
    Methods: In this multi-center and randomized controlled trial, 360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine, and patients in the bloodletting group received additional bloodletting puncture at HTWPs on admission immediately before conventional treatment. The primary outcome measure was Glasgow Coma Scale (GCS) score and the secondary outcomes included blood pressure, respiratory rate and pulse rate. All variables were evaluated at baseline (before bloodletting), 0 (after bloodletting immediately), 15, 30, 50 and 80 min post bloodletting.
    Results: At 80 min post bloodletting, the proportion of patients with improved consciousness in the bloodletting group was greater than the control group (P<0.05). In the separate analysis of moderate consciousness disturbance subgroup, bloodletting therapy benefited ischemic patients, and improved the eye and language response of GCS score at 15, 30, 50, 80 min post bloodletting (P<0.05 or P<0.01). No significant differences were observed regarding the secondary outcomes between two groups (P>0.05).
    Conclusion: The bloodletting puncture at HTWPs was safe and could improve conscious levels of ischemic stroke patients, highlighting a first-aid intervention for acute stroke. (Registration No. ChiCTR-INR-16009530).
    MeSH term(s) Acupuncture Points ; Bloodletting ; Consciousness ; Humans ; Random Allocation ; Stroke/therapy ; Treatment Outcome
    Language English
    Publishing date 2020-09-11
    Publishing country China
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-020-3093-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5823: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Bloodletting Puncture at Hand Twelve Jing-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway.

    Liu, Bao-Hu / Zhou, Dan / Guo, Yi / Zhang, Sai / Guo, Yong-Ming / Guo, Tong-Tong / Chen, Xu-Yi / Gong, Yi-Nan / Tang, Hui-Ling / Xu, Zhi-Fang

    Chinese journal of integrative medicine

    2021  Volume 27, Issue 4, Page(s) 291–299

    Abstract: ... effect of bloodletting puncture at hand twelve Jing-well points (HTWP) in traumatic brain injury (TBI ...

    Abstract Objective: To investigate whether blood-brain barrier (BBB) served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points (HTWP) in traumatic brain injury (TBI) and the potential molecular signaling pathways.
    Methods: Adult male Sprague-Dawley rats were assigned to the sham-operated (sham), TBI, and bloodletting puncture (bloodletting) groups (n=24 per group) using a randomized number table. The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days. The neurological function and cerebral edema were evaluated by modified neurological severity score (mNSS), cerebral water content, magnetic resonance imaging and hematoxylin and eosin staining. Cerebral blood flow was measured by laser speckles. The protein levels of aquaporin 4 (AQP4), matrix metalloproteinases 9 (MMP9) and mitogen-activated protein kinase pathway (MAPK) signaling were detected by immunofluorescence staining and Western blot.
    Results: Compared with TBI group, bloodletting puncture improved neurological function at 24 and 48 h, alleviated cerebral edema at 48 h, and reduced the permeability of BBB induced by TBI (all P<0.05). The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by bloodletting puncture (P<0.05 or P<0.01). In addition, the extracellular signal-regulated kinase (ERK) and p38 signaling pathways were inhibited by bloodletting puncture (P<0.05).
    Conclusions: Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling pathways. Therefore, bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema.
    MeSH term(s) Animals ; Bloodletting ; Brain Edema/therapy ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/therapy ; MAP Kinase Signaling System ; Male ; Mitogen-Activated Protein Kinases ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2021-01-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-021-3326-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5823: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Health-related benefits of air quality improvement from coal control in China: Evidence from the Jing-Jin-Ji region

    Sun, Dong / Jing Fang / Jingqi Sun

    Resources, Conservation & Recycling. 2016,

    2016  

    Abstract: The excessive coal consumption plays an important role in the city haze in the Jing-Jin-Ji region ... In this study, we evaluate health benefits resulting from coal control and air pollutants abatement in the Jing ...

    Abstract The excessive coal consumption plays an important role in the city haze in the Jing-Jin-Ji region. In this study, we evaluate health benefits resulting from coal control and air pollutants abatement in the Jing-Jin-Ji region employing the dose-response function. The estimation of total valuation has a range of 366.64–810.48 billion RMB for the whole region from 2015 to 2025 and the coal contribution to the economic benefits of air pollution mitigation is more than 50%. The considerable economic value of benefits makes it more attractive for the government to set stringent pollutants reduction target and the results are strong enough to provide air pollution control policy guidance.
    Keywords air ; air pollution ; air quality ; coal ; economic valuation ; issues and policy ; pollutants ; pollution control ; China
    Language English
    Size p. .
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 1498716-8
    ISSN 0921-3449
    ISSN 0921-3449
    DOI 10.1016/j.resconrec.2016.09.021
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  10. Article: Exploring potential biomarkers of coronary heart disease treated by Jing Zhi Guan Xin Pian using high-throughput metabolomics

    Sun, Hui / Xue-na Li / Ai-hua Zhang / Kun-ming Zhang / Guang-li Yan / Ying Han / Fang-fang Wu / Xi-jun Wang

    RSC advances. 2019 Apr. 11, v. 9, no. 20

    2019  

    Abstract: ... prevention method. Jing Zhi Guan Xin Pian (JZGXP) is a new preparation prepared from the effective extract ...

    Abstract Coronary heart disease (CHD) is a relatively complex disease characterized by narrowing of the arterial lumen and reduction of blood flow to the heart. There is no effective early diagnosis and prevention method. Jing Zhi Guan Xin Pian (JZGXP) is a new preparation prepared from the effective extract of Guanxin II. It is made of five components of traditional Chinese medicine and functions by promoting blood circulation and removing blood stasis and is used for the treatment of CHD and angina pectoris. In our study, a CHD rat model was prepared using a high-fat diet combined with intraperitoneal injection of vitamin D3. Clinical biochemical indexes (TG, CHO and HDL-C), histopathology (coronary and myocardial tissue), electrocardiogram and cardiac indexes were used to evaluate the efficacy of JZGXP in the treatment of CHD model rats. UPLC-HDMS-based metabolomics techniques were used to find metabolic profiles, biomarkers and related metabolic pathways in CHD models and to evaluate the effects of JZGXP on them. At the same time, the targets of JZGXP for the treatment of CHD were analyzed. Our study ultimately identified 25 biomarkers associated with CHD models. Further studies found that these 25 biomarkers involved 9 metabolic pathways in the body and found that JZGXP can recall 21 biomarkers in the urine of model rats and these biomarkers involve nine metabolic pathways. Finally, the targets of JZGXP for the treatment of CHD were β-alanine metabolism and tyrosine metabolism, i.e. amino acids metabolism. This study showed that metabolomics technology is effective for exploring potential biomarkers associated with syndromes or diseases and the therapeutic mechanisms of a traditional Chinese medicine formulation.
    Keywords Oriental traditional medicine ; animal models ; biochemical pathways ; biomarkers ; blood flow ; blood stasis ; cholecalciferol ; coronary disease ; drug therapy ; early diagnosis ; electrocardiography ; heart ; herbaceous plants ; herbal medicines ; high fat diet ; histopathology ; intraperitoneal injection ; metabolism ; metabolomics ; tyrosine ; urine
    Language English
    Dates of publication 2019-0411
    Size p. 11420-11432.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c8ra10557j
    Database NAL-Catalogue (AGRICOLA)

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