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  1. Article: Update Prostatakarzinom und Nierenzellkarzinom. Jozefina Casuscelli berichtet über erfolgreiche und weniger erfolgreiche Ansätze in der immuntherapeutischen Behandlung urologischer Tumoren

    Casuscelli, Jozefina

    TZM-News

    2022  Volume 24, Issue 3, Page(s) 4

    Language German
    Document type Article
    ZDB-ID 1497189-6
    ISSN 1437-8019
    Database Current Contents Medicine

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    Zs.A 5602: Show issues Location:
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  2. Book ; Audio / Video ; Thesis: Analysis of the cytoplasmic interaction of polycystin-1 and polycystin-2

    Casuscelli, Jozefina

    2012  

    Author's details vorgelegt von: Jozefina Casuscelli
    Language English
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Witten, Herdecke, Univ., Diss., 2012
    HBZ-ID HT017777311
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 MO 290 order for loan Magazin

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  3. Book ; Online ; Thesis: Analysis of the cytoplasmic interaction of polycystin-1 and polycystin-2

    Casuscelli, Jozefina [Verfasser]

    2022  

    Author's details vorgelegt von: Jozefina Casuscelli
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Leipzig ; Deutsche Nationalbibliothek
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Book ; Online ; Thesis: Charakterisierung und klinische Implikationen der molekularen Hintergründe von Subtypen des Nierenzellkarzinoms

    Casuscelli, Jozefina [Verfasser]

    2021  

    Author's details Jozefina Casuscelli
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Aberrant Splice Variants: A Novel Characterization of Clear Cell Renal Cell Carcinoma.

    Casuscelli, Jozefina / Pal, Sumanta K

    European urology

    2022  Volume 82, Issue 4, Page(s) 363–364

    MeSH term(s) Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Mutation ; RNA Splicing
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Einfluss von PD-(L)1-Checkpoint-Inhibitoren auf die Lebensqualität von Patienten mit fortgeschrittenem oder metastasiertem Urothelkarzinom im Vergleich zur Chemotherapie

    Wietheger, Benjamin [Verfasser] / Casuscelli, Jozefina [Akademischer Betreuer]

    Evaluation im Rahmen einer prospektiven, unizentrischen klinischen Studie der Urologischen Klinik und Poliklinik der LMU Universitätsklinik München

    2023  

    Author's details Benjamin Wietheger ; Betreuer: Jozefina Casuscelli
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  7. Article: The Vanishing Clinical Value of PD-L1 Status as a Predictive Biomarker in the First-Line Treatment of Urothelial Carcinoma of the Bladder.

    Tamalunas, Alexander / Aydogdu, Can / Unterrainer, Lena M / Schott, Melanie / Rodler, Severin / Ledderose, Stephan / Schulz, Gerald B / Stief, Christian G / Casuscelli, Jozefina

    Cancers

    2024  Volume 16, Issue 8

    Abstract: Background: Our study endeavors to elucidate the clinical implications of PD-L1 positivity in individuals afflicted with advanced urothelial carcinoma of the bladder (UCB).: Methods: Patients with advanced UCB were prospectively enrolled following a ... ...

    Abstract Background: Our study endeavors to elucidate the clinical implications of PD-L1 positivity in individuals afflicted with advanced urothelial carcinoma of the bladder (UCB).
    Methods: Patients with advanced UCB were prospectively enrolled following a radical cystectomy (RC) performed within January 2017 to December 2022 at our tertiary referral center. The clinical outcome, defined as the progression-free survival (PFS) and overall survival (OS) on systemic treatment, was analyzed using an χ
    Results: A total of 648 patients were included following an RC performed within January 2017 to December 2022. Their PD-L1 status was analyzed with the primary PD-L1-specific antibody (clone SP263, Ventana) and defined both by the CPS and IC-score in 282 patients (43.5%) with a high risk (pT3-pT4 and/or lymph node involvement) or metastatic UCB. While the median PFS was significantly prolonged 5-fold in PD-L1+ patients, we found no difference in OS, regardless of PD-L1 status, or treatment regimen.
    Conclusions: While PD-L1 positivity indicates prolonged PFS, the presence of PD-L1 does not influence OS rates, suggesting its limited usefulness as a prognostic biomarker in bladder cancer. However, the positive correlation between an PD-L1 status and a sustained response to ICI treatments indicates its potential role as a predictive biomarker. Further research is required to understand how the predictive value of PD-L1 positivity may extend to the use of ICIs in combination with antibody-drug conjugates.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Systemtherapie des Nierenzellkarzinoms und Management von Nebenwirkungen.

    Berg, Elena K / Aydogdu, Can / Götz, Melanie / Rodler, Severin / Tamalunas, Alexander / Stief, Christian G / Casuscelli, Jozefina

    MMW Fortschritte der Medizin

    2023  Volume 165, Issue 13, Page(s) 39–41

    Title translation Systemic treatment of renal cancer and management of immunotherapy related toxicity.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/drug therapy ; Kidney Neoplasms/drug therapy ; Immunotherapy/adverse effects ; Retrospective Studies
    Language German
    Publishing date 2023-06-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-023-2751-0
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  9. Article ; Online: Are We Ready for Adjuvant Sunitinib in High-risk Renal Cell Carcinoma?

    Casuscelli, Jozefina / Hsieh, James J

    European urology

    2017  Volume 73, Issue 1, Page(s) 69–70

    MeSH term(s) Antineoplastic Agents ; Carcinoma, Renal Cell ; Humans ; Indoles ; Kidney Neoplasms ; Pyrroles ; Sunitinib
    Chemical Substances Antineoplastic Agents ; Indoles ; Pyrroles ; Sunitinib (V99T50803M)
    Language English
    Publishing date 2017-10-12
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2017.09.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Longer Telomere Length and Renal Cell Carcinoma.

    Casuscelli, Jozefina / Hakimi, A Ari

    European urology

    2017  Volume 72, Issue 5, Page(s) 755–756

    MeSH term(s) Biomarkers, Tumor ; Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; Telomerase ; Telomere
    Chemical Substances Biomarkers, Tumor ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2017.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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