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Article ; Online: A flavonoid metabolon: cytochrome b

Ruan, Haixiang / Gao, Liping / Fang, Zhou / Lei, Ting / Xing, Dawei / Ding, Yan / Rashid, Arif / Zhuang, Juhua / Zhang, Qiang / Gu, Chunyang / Qian, Wei / Zhang, Niuniu / Qian, Tao / Li, Kongqing / Xia, Tao / Wang, Yunsheng

The Plant journal : for cell and molecular biology

2024

Abstract: ... on epigallocatechin gallate. Our analysis involving the DESI-MSI method to reveal a distinct distribution pattern of B ... CsF3'5'H, the enzyme for B-ring trihydroxylation, did not directly interact with other enzymes ... We identified cytochrome b ...

Abstract	Flavan-3-ols are prominent phenolic compounds found abundantly in the young leaves of tea plants. The enzymes involved in flavan-3-ol biosynthesis in tea plants have been extensively investigated. However, the localization and associations of these numerous functional enzymes within cells have been largely neglected. In this study, we aimed to investigate the synthesis of flavan-3-ols in tea plants, particularly focusing on epigallocatechin gallate. Our analysis involving the DESI-MSI method to reveal a distinct distribution pattern of B-ring trihydroxylated flavonoids, primarily concentrated in the outer layer of buds. Subcellular localization showed that CsC4H, CsF3'H, and CsF3'5'H localizes endoplasmic reticulum. Protein-protein interaction studies demonstrated direct associations between CsC4H, CsF3'H, and cytoplasmic enzymes (CHS, CHI, F3H, DFR, FLS, and ANR), highlighting their interactions within the biosynthetic pathway. Notably, CsF3'5'H, the enzyme for B-ring trihydroxylation, did not directly interact with other enzymes. We identified cytochrome b
Language	English
Publishing date	2024-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.16710
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Article ; Online: Improving B

Yao, Jingwen / Ruan, Dan / Raymond, Catalina / Liau, Linda M / Salamon, Noriko / Pope, Whitney B / Nghiemphu, Phioanh L / Lai, Albert / Cloughesy, Timothy F / Ellingson, Benjamin M

Tomography (Ann Arbor, Mich.)

2018 Volume 4, Issue 3, Page(s) 123–137

Abstract: ... diseases. However, CEST contrast is sensitive to static magnetic field (B ...

Abstract	Amine chemical exchange saturation transfer (CEST) echoplanar imaging (EPI) provides unique pH and amino acid MRI contrast, enabling sensitive detection of altered microenvironment properties in various diseases. However, CEST contrast is sensitive to static magnetic field (B
Language	English
Publishing date	2018-02-01
Publishing country	United States
Document type	Journal Article
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.18383/j.tom.2018.00017
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Article ; Online: Mitigating the adverse effects of Aflatoxin B

Mo, Yi-Xin / Ruan, Meng-Ling / Wang, Jie / Liu, Ying / Wu, Yuan-Yuan / Wang, Guan-Lin / Han, Yan-Ming / Wan, Hai-Feng / Lamesgen, Dessalegn / Kuča, Kamil / Deng, Jiang / Sun, Lv-Hui

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2023 Volume 178, Page(s) 113907

Abstract: ... on aflatoxin B ...

Abstract	This study was to evaluate the efficacy of TOXO-XL (XL), an integrated mycotoxin-mitigating agent, on aflatoxin B
MeSH term(s)	Male ; Swine ; Animals ; Reactive Oxygen Species/metabolism ; Aflatoxin B1/toxicity ; Aflatoxin B1/metabolism ; Carcinoma, Hepatocellular/metabolism ; Chickens/metabolism ; Interleukin-6/metabolism ; Epithelial Cells ; Apoptosis ; Liver Neoplasms/metabolism
Chemical Substances	Reactive Oxygen Species ; Aflatoxin B1 (9N2N2Y55MH) ; Interleukin-6
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.113907
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Article ; Online: Cathepsin B-Responsive Programmed Brain Targeted Delivery System for Chemo-Immunotherapy Combination Therapy of Glioblastoma.

Jiang, Shaoping / Li, Wenpei / Yang, Jun / Zhang, Tian / Zhang, Yuquan / Xu, Lin / Hu, Bo / Li, Zhi / Gao, Huile / Huang, Yuanyu / Ruan, Shaobo

ACS nano

2024 Volume 18, Issue 8, Page(s) 6445–6462

Abstract: ... we propose a cathepsin B (CTSB)-responsive programmed brain-targeted delivery system (D&R-HM-MCA ...

Abstract	Tumor-associated macrophages (TAMs) are closely related to the progression of glioblastoma multiform (GBM) and its development of therapeutic resistance to conventional chemotherapy. TAM-targeted therapy combined with conventional chemotherapy has emerged as a promising strategy to combat GBM. However, the presence of the blood-brain barrier (BBB) severely limits the therapeutic efficacy. Meanwhile, the lack of ability to distinguish different targeted cells also poses a challenge for precise therapy. Herein, we propose a cathepsin B (CTSB)-responsive programmed brain-targeted delivery system (D&R-HM-MCA) for simultaneous TAM-targeted and GBM-targeted delivery. D&R-HM-MCA could cross the BBB via low density lipoprotein receptor-associated protein 1 (LRP1)-mediated transcytosis. Upon reaching the GBM site, the outer angiopep-2 modification could be detached from D&R-HM-MCA via cleavage of the CTSB-responsive peptide, which could circumvent abluminal LRP1-mediated efflux. The exposed
MeSH term(s)	Humans ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Cathepsin B/metabolism ; Brain Neoplasms/drug therapy ; Brain/metabolism ; Immunotherapy ; Cell Line, Tumor ; Tumor Microenvironment
Chemical Substances	Cathepsin B (EC 3.4.22.1)
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c11958
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Article ; Online: CRISPR/Cas12a-Assisted Chemiluminescence Sensor for Aflatoxin B

Wang, Zhilong / Wei, Luyu / Ruan, Shilong / Chen, Yiping

Journal of agricultural and food chemistry

2023 Volume 71, Issue 10, Page(s) 4417–4425

Abstract: Herein, we report a CRISPR/Cas12a-assisted chemiluminescence sensor for aflatoxin B ...

Abstract	Herein, we report a CRISPR/Cas12a-assisted chemiluminescence sensor for aflatoxin B
MeSH term(s)	Nucleic Acids ; Edible Grain/chemistry ; Aflatoxin B1/analysis ; Luminescence ; CRISPR-Cas Systems ; Aptamers, Nucleotide ; Limit of Detection ; Horseradish Peroxidase ; Biosensing Techniques/methods
Chemical Substances	Nucleic Acids ; Aflatoxin B1 (9N2N2Y55MH) ; Aptamers, Nucleotide ; Horseradish Peroxidase (EC 1.11.1.-)
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c00341
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Article ; Online: Spliceosome component PHD finger 5A is essential for early B lymphopoiesis.

Zhang, Rui / Wang, Daoqin / Ruan, Gui-Xin / Wang, Ruisi / Li, Yuxing / Chen, Wenjing / Huang, Hengjun / Wang, Jing / Meng, Limin / Zhu, Zhijian / Lei, Dengfeng / Xu, Shengli / Ou, Xijun

Development (Cambridge, England)

2024 Volume 151, Issue 2

Abstract: ... The specific role of the spliceosome in B cell development is poorly understood. Here, we reveal ... that the spliceosomal U2 snRNP component PHD finger protein 5A (Phf5a) is vital for early B cell development. Loss ... of Phf5a results in pronounced defects in B cell development, causing an arrest at the transition from pre ...

Abstract	The spliceosome, a multi-megadalton ribonucleoprotein complex, is essential for pre-mRNA splicing in the nucleus and ensuring genomic stability. Its precise and dynamic assembly is pivotal for its function. Spliceosome malfunctions can lead to developmental abnormalities and potentially contribute to tumorigenesis. The specific role of the spliceosome in B cell development is poorly understood. Here, we reveal that the spliceosomal U2 snRNP component PHD finger protein 5A (Phf5a) is vital for early B cell development. Loss of Phf5a results in pronounced defects in B cell development, causing an arrest at the transition from pre-pro-B to early pro-B cell stage in the bone marrow of mutant mice. Phf5a-deficient B cells exhibit impaired immunoglobulin heavy (IgH) chain expression due to defective V-to-DJ gene rearrangement. Mechanistically, our findings suggest that Phf5a facilitates IgH gene rearrangement by regulating the activity of recombination-activating gene endonuclease and influencing chromatin interactions at the Igh locus.
MeSH term(s)	Animals ; Mice ; Spliceosomes/metabolism ; Trans-Activators/genetics ; RNA-Binding Proteins/metabolism ; PHD Zinc Fingers ; Lymphopoiesis/genetics
Chemical Substances	Trans-Activators ; RNA-Binding Proteins
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.202247
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Article ; Online: HCC prediction models in chronic hepatitis B patients receiving entecavir or tenofovir: a systematic review and meta-analysis.

Xu, Xiaolan / Jiang, Lushun / Zeng, Yifan / Pan, Liya / Lou, Zhuoqi / Ruan, Bing

Virology journal

2023 Volume 20, Issue 1, Page(s) 180

Abstract: ... hepatocellular carcinoma (HCC) prediction models in chronic hepatitis B patients receiving entecavir or tenofovir ... 76 to 0.86, respectively. REAL-B, AASL-HCC, and HCC-RESCUE achieved the best discrimination. HCC ... RESCUE, PAGE-B, and mPAGE-B overestimated HCC development, whereas mREACH-B, AASL-HCC, REAL-B, CAMD, CAGE ...

Abstract	Background: Our study aimed to compare the predictive performance of different hepatocellular carcinoma (HCC) prediction models in chronic hepatitis B patients receiving entecavir or tenofovir, including discrimination, calibration, negative predictive value (NPV) in low-risk, and proportion of low-risk. Methods: We conducted a systematic literature research in PubMed, EMbase, the Cochrane Library, and Web of Science before January 13, 2022. The predictive performance was assessed by area under receiver operating characteristic curve (AUROC), calibration index, negative predictive value, and the proportion in low-risk. Subgroup and meta-regression analyses of discrimination and calibration were conducted. Sensitivity analysis was conducted to validate the stability of the results. Results: We identified ten prediction models in 23 studies. The pooled 3-, 5-, and 10-year AUROC varied from 0.72 to 0.84, 0.74 to 0.83, and 0.76 to 0.86, respectively. REAL-B, AASL-HCC, and HCC-RESCUE achieved the best discrimination. HCC-RESCUE, PAGE-B, and mPAGE-B overestimated HCC development, whereas mREACH-B, AASL-HCC, REAL-B, CAMD, CAGE-B, SAGE-B, and aMAP underestimated it. All models were able to identify people with a low risk of HCC accurately. HCC-RESCUE and aMAP recognized over half of the population as low-risk. Subgroup analysis and sensitivity analysis showed similar results. Conclusion: Considering the predictive performance of all four aspects, we suggest that HCC-RESCUE was the best model to utilize in clinical practice, especially in primary care and low-income areas. To confirm our findings, further validation studies with the above four components were required.
MeSH term(s)	Humans ; Tenofovir/therapeutic use ; Carcinoma, Hepatocellular/epidemiology ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/epidemiology ; Liver Neoplasms/epidemiology ; Antiviral Agents/therapeutic use
Chemical Substances	Tenofovir (99YXE507IL) ; entecavir (5968Y6H45M) ; Antiviral Agents
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-023-02145-5
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Article ; Online: Optimization of the Biosynthesis of B-Ring

Wang, Longji / Ma, Xiubing / Ruan, Haixiang / Chen, Yang / Gao, Liping / Lei, Ting / Li, Yan / Gui, Lin / Guo, Lina / Xia, Tao / Wang, Yunsheng

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 10

Abstract: Flavonoids are important plant metabolites that exhibit a wide range of physiological and pharmaceutical functions. Because of their wide biological activities, such as anti-inflammatory, antioxidant, antiaging and anticancer, they have been widely used ... ...

Abstract	Flavonoids are important plant metabolites that exhibit a wide range of physiological and pharmaceutical functions. Because of their wide biological activities, such as anti-inflammatory, antioxidant, antiaging and anticancer, they have been widely used in foods, nutraceutical and pharmaceuticals industries. Here, the hydroxylase complex
MeSH term(s)	Biocatalysis ; Chromatography, High Pressure Liquid ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Flavonoids/biosynthesis ; Genetic Engineering ; Hydroxylation ; Mixed Function Oxygenases/metabolism ; Substrate Specificity ; Temperature ; Time Factors
Chemical Substances	Escherichia coli Proteins ; Flavonoids ; Mixed Function Oxygenases (EC 1.-)
Language	English
Publishing date	2021-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26102919
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Article ; Online: Changing incidence of hepatitis B and persistent infection risk in adults: a population-based follow-up study from 2011 in China.

Xu, Xiaolan / Wu, Chensi / Lou, Zhuoqi / Peng, Chunting / Jiang, Lushun / Wu, Tianxian / Zeng, Taiwen / Dong, Yin / Ruan, Bing

BMC public health

2023 Volume 23, Issue 1, Page(s) 256

Abstract: Background: This study aimed to estimate hepatitis B incidence and chronicity risk in rural adults ... in China under the background of eliminating viral hepatitis.: Methods: Hepatitis B surface antigen ... infection (> 6 months), chronic infection (> 12 months), and recovery with hepatitis B surface ...

Abstract	Background: This study aimed to estimate hepatitis B incidence and chronicity risk in rural adults in China under the background of eliminating viral hepatitis. Methods: Hepatitis B surface antigen (HBsAg) screening was conducted every 2 years in demonstration areas since 2011. Individuals with baseline HBsAg-negative were included. Incidence was calculated as the number of HBsAg-positive cases divided by the total person-times. HBsAg-positive individuals were followed up to study the persistent infection (> 6 months), chronic infection (> 12 months), and recovery with hepatitis B surface antibody (anti-HBs). The chi-square test and cox proportional regression analysis were performed. Results: There were 8,942 incident cases over 2,138,532 person-years, yielding an average incidence of 0.42 per 100 person-years. HBV incidence decreased rapidly in both genders and all age groups and then kept stable. Male gender, low population density, low gross domestic product per capita, and islanders were associated with higher incidence. Of the positive cases, 4,989 (55.8%) patients were followed up. The persistent infection, chronic infection, and recovery with anti-HBs rates were 32.3%, 31.0%, and 31.4%, respectively. Persistent or chronic infection was more common in younger adults and males, while seroconversion had no concern with gender or age. Conclusions: HBV incidence in adult rural residents was decreasing and stayed low. The chronicity rate was relatively high and protective antibodies were induced in only one third. The importance of population-based screening and vaccination for susceptible individuals should be addressed.
MeSH term(s)	Humans ; Adult ; Male ; Female ; Hepatitis B Surface Antigens ; Follow-Up Studies ; Persistent Infection ; Risk Factors ; Incidence ; Hepatitis B/epidemiology ; Hepatitis B/prevention & control ; Hepatitis B Antibodies ; China/epidemiology ; Hepatitis B virus
Chemical Substances	Hepatitis B Surface Antigens ; Hepatitis B Antibodies
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-15130-y
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Article ; Online: Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses.

Zeng, Qin / Wang, Shuyi / Li, Mengyuan / Wang, Shuang / Guo, Chaohuan / Ruan, Xinyuan / Watanabe, Ryu / Lai, Yimei / Huang, Yuefang / Yin, Xiaoyu / Zhang, Chuanzhao / Chen, Binfeng / Yang, Niansheng / Zhang, Hui

Cell metabolism

2023 Volume 35, Issue 5, Page(s) 837–854.e8

Abstract: Autoreactive B cell responses are essential for the development of systemic lupus erythematosus ... autoreactive B cell responses in SLE. In SLE, CD36-mediated lipid uptake leads to enhanced mitochondrial ... oxidative phosphorylation in B cells. Accordingly, the inhibition of fatty acid oxidation results in reduced autoreactive B ...

Abstract	Autoreactive B cell responses are essential for the development of systemic lupus erythematosus (SLE). Fibroblastic reticular cells (FRCs) are known to construct lymphoid compartments and regulate immune functions. Here, we identify spleen FRC-derived acetylcholine (ACh) as a key factor that controls autoreactive B cell responses in SLE. In SLE, CD36-mediated lipid uptake leads to enhanced mitochondrial oxidative phosphorylation in B cells. Accordingly, the inhibition of fatty acid oxidation results in reduced autoreactive B cell responses and ameliorated diseases in lupus mice. Ablation of CD36 in B cells impairs lipid uptake and differentiation of autoreactive B cells during autoimmune induction. Mechanistically, spleen FRC-derived ACh promotes lipid influx and generation of autoreactive B cells through CD36. Together, our data uncover a novel function of spleen FRCs in lipid metabolism and B cell differentiation, placing spleen FRC-derived ACh in a key position in promoting autoreactive B cells in SLE.
MeSH term(s)	Mice ; Animals ; Spleen ; Acetylcholine ; Lipid Metabolism ; Lupus Erythematosus, Systemic ; Lipids
Chemical Substances	Acetylcholine (N9YNS0M02X) ; Lipids
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2023.03.010
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