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  1. Article: Analytical expression for the model that describes the heterogeneous reaction-diffusion process with immobilized enzyme (penicillin G acylase).

    Niyaz Ahmed, L / Thomas, Praveen

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21998

    Abstract: This research article examines the reaction-diffusion process in an immobilized enzyme batch reactor. The model incorporates strongly non-linear factors that are associated with standard Michaelis-Menten kinetics. The non-linear reaction-diffusion ... ...

    Abstract This research article examines the reaction-diffusion process in an immobilized enzyme batch reactor. The model incorporates strongly non-linear factors that are associated with standard Michaelis-Menten kinetics. The non-linear reaction-diffusion equations for substrate and product concentrations have been approximated analytically. Employing two different semi-analytical methods, Akbari-Ganji's method (AGM) and the modified Adomian decomposition method (MADM), to compute the dimensionless steady-state solutions to the system of non-linear differential equations for all values of reaction parameters. In addition, the dynamics of the mean integrated effectiveness factor of penicillin acylase in porous spherical particles have been presented for the determination of the local effectiveness factor. In order to gauge the potency of our proposed solution, we compare two semi-analytical results with a numerical result that are in good agreement across the whole concentration range. The proposed formulation aims to simulate the dynamic performance of the system utilizing the parameters and would enhance the determination of the optimum particle size for enzyme catalysts.
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Panomics to decode virulence and fitness in Gram-negative bacteria.

    Singh, Anuradha / Ambaru, Bindu / Bandsode, Viraj / Ahmed, Niyaz

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 1061596

    MeSH term(s) Virulence ; Gram-Negative Bacteria/genetics
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.1061596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genomic insights into virulence, antimicrobial resistance, and adaptation acumen of

    Saini, Poorvi / Bandsode, Viraj / Singh, Anuradha / Mendem, Suresh Kumar / Semmler, Torsten / Alam, Munirul / Ahmed, Niyaz

    mBio

    2024  Volume 15, Issue 3, Page(s) e0354523

    Abstract: Populations of common commensal bacteria such as : Importance: Evolutionary patterns ... ...

    Abstract Populations of common commensal bacteria such as
    Importance: Evolutionary patterns of
    MeSH term(s) Animals ; Humans ; Escherichia coli/genetics ; Virulence/genetics ; Anti-Bacterial Agents/pharmacology ; Escherichia coli Infections/microbiology ; Drug Resistance, Bacterial ; Genomics ; Soil ; Water
    Chemical Substances Anti-Bacterial Agents ; Soil ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03545-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genome Informatics and Machine Learning-Based Identification of Antimicrobial Resistance-Encoding Features and Virulence Attributes in Escherichia coli Genomes Representing Globally Prevalent Lineages, Including High-Risk Clonal Complexes.

    Shaik, Sabiha / Singh, Anuradha / Suresh, Arya / Ahmed, Niyaz

    mBio

    2022  Volume 13, Issue 1, Page(s) e0379621

    Abstract: Escherichia coli, a ubiquitous commensal/pathogenic member from ... ...

    Abstract Escherichia coli, a ubiquitous commensal/pathogenic member from the
    MeSH term(s) Humans ; Escherichia coli/genetics ; Virulence/genetics ; Anti-Bacterial Agents/pharmacology ; Escherichia coli Infections/epidemiology ; Virulence Factors/genetics ; Drug Resistance, Multiple, Bacterial/genetics ; Drug Resistance, Bacterial/genetics ; Informatics ; Machine Learning ; Phylogeny
    Chemical Substances Anti-Bacterial Agents ; Virulence Factors
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03796-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unraveling the evolutionary dynamics of toxin-antitoxin systems in diverse genetic lineages of

    Singh, Anuradha / Lankapalli, Aditya Kumar / Mendem, Suresh Kumar / Semmler, Torsten / Ahmed, Niyaz

    mBio

    2023  Volume 15, Issue 1, Page(s) e0302323

    Abstract: Importance: Large-scale genomic studies ... ...

    Abstract Importance: Large-scale genomic studies of
    MeSH term(s) Humans ; Escherichia coli/genetics ; Toxin-Antitoxin Systems/genetics ; Bacterial Toxins/genetics ; Escherichia coli Proteins/genetics ; Bacteria ; Bacterial Proteins/genetics ; Antitoxins/genetics
    Chemical Substances Bacterial Toxins ; Escherichia coli Proteins ; Bacterial Proteins ; Antitoxins
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03023-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Play the plug: How bacteria modify recognition by host receptors?

    Tiruvayipati, Suma / Hameed, Dharjath S / Ahmed, Niyaz

    Frontiers in microbiology

    2022  Volume 13, Page(s) 960326

    Abstract: The diverse microbial community that colonizes the gastrointestinal tract has remarkable effects on the host immune system and physiology resulting in homeostasis or disease. In both scenarios, the gut microbiota interacts with their host through ligand- ... ...

    Abstract The diverse microbial community that colonizes the gastrointestinal tract has remarkable effects on the host immune system and physiology resulting in homeostasis or disease. In both scenarios, the gut microbiota interacts with their host through ligand-receptor binding whereby the downstream signaling processes determine the outcome of the interaction as disease or the counteractive immune responses of the host. Despite several studies on microbe-host interactions and the mechanisms by which this intricate process happens, a comprehensive and updated inventory of known ligand-receptor interactions and their roles in disease is paramount. The ligands which originate as a result of microbial responses to the host environment contribute to either symbiotic or parasitic relationships. On the other hand, the host receptors counteract the ligand actions by mounting a neutral or an innate response. The varying degrees of polymorphic changes in the host receptors contribute to specificity of interaction with the microbial ligands. Additionally, pathogenic microbes manipulate host receptors with endogenous enzymes belonging to the effector protein family. This review focuses on the diversity and similarity in the gut microbiome-host interactions both in health and disease conditions. It thus establishes an overview that can help identify potential therapeutic targets in response to critically soaring antimicrobial resistance as juxtaposed to tardy antibiotic development research.
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.960326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Functional molecular characterization and the assessment of the transmission route of multidrug-resistant Helicobacter pullorum isolates from free-range and broiler chickens.

    Qumar, Shamsul / Majid, Mohammad / Qaria, Majjid A / Mendem, Suresh Kumar / Ahmed, Niyaz

    Microbial pathogenesis

    2023  Volume 182, Page(s) 106253

    Abstract: Background: Some of the life-threatening, food-borne, and zoonotic infections are transmitted through poultry birds. Inappropriate and irrational use of antimicrobials in the livestock industry has resulted in an increased incidence of multi-drug ... ...

    Abstract Background: Some of the life-threatening, food-borne, and zoonotic infections are transmitted through poultry birds. Inappropriate and irrational use of antimicrobials in the livestock industry has resulted in an increased incidence of multi-drug resistant bacteria of epidemic potentials.
    Materials and methods: The adhesion and invasion properties of 11 free-range and broiler chicken derived Helicobacterpullorum isolates were evaluated. To examine the biofilm formation of H. pullorum isolates, crystal violet assay was performed. A quantitative assay of invasion-associated genes was carried out after infecting HepG2 cells with two different representative (broiler and free-range chicken) H. pullorum isolates, using RT-PCR assay. Furthermore, we investigated the prevalence of H. pullorum, Campylobacter jejuni and Salmonella spp. in chicken caeca and oviducts to determine the possibility of trans-ovarian transmission.
    Results: All H. pullorum isolates adhered to HepG2 cells significantly but a notable difference towards their invasion potential was observed between free-range and broiler chicken isolates wherein broiler isolates were found to be more invasive compared to free-range isolates. Furthermore, cdtB, flhA and flaB genes of H. pullorum were upregulated post infection of HepG2 cells, in broiler chicken isolates compared to free-range chicken isolates. Moreover, all isolates of H. pullorum were found to form biofilm on the liquid-air interface of the glass coverslips and sidewalls of the wells with similar propensities. Despite presence of H. pullorum and C. jejuni in high concentrations in the caecum, they were completely absent in oviduct samples, thus ruling out the possibility of vertical transmission of these bacterial species. In contrast, Salmonella spp. was found to be present in a significant proportion in the oviduct samples of egg-laying hens suggesting its vertical transmission.
    Conclusions: Our findings suggest that H. pullorum, an emerging multi-drug resistant (MDR) pathogen could be transmitted from poultry sources to humans. In addition to this, its strong functional similarity with C. jejuni provides a firm basis for H. pullorum to be an emerging food-associated, MDR pathogenic bacterium that could pose risk to public health.
    MeSH term(s) Animals ; Female ; Humans ; Chickens/microbiology ; Poultry/microbiology ; Helicobacter/genetics ; Campylobacter jejuni/genetics ; Poultry Diseases/microbiology ; Anti-Bacterial Agents/pharmacology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2023.106253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Genome Dynamics and Evolution of Multiple-Drug-Resistant Bacteria: Implications for Global Infection Control Priorities.

    Shaik, Sabiha / Suresh, Arya / Ahmed, Niyaz

    The Journal of infectious diseases

    2021  Volume 224, Issue 12 Suppl 2, Page(s) S876–S882

    Abstract: Genomics-driven molecular epidemiology of pathogenic bacteria has largely been carried out through functionally neutral/inert sequences, mostly entailing polymorphic gene loci or repetitive tracts. However, it is very important to harness phenotypically ... ...

    Abstract Genomics-driven molecular epidemiology of pathogenic bacteria has largely been carried out through functionally neutral/inert sequences, mostly entailing polymorphic gene loci or repetitive tracts. However, it is very important to harness phenotypically relevant markers to assign a valid functional epidemiological context to tracking of pathogens. These should include microbial acumen to acquire multiple drug resistance (MDR), their physiological coordinates with reference to clinical or community-level dynamics of incidence/transmission, and their response or refractoriness to the activated immune system. We propose that multidimensional and multicentric approaches, based on diverse data integration coupled with comparative genomics and functional molecular infection epidemiology, would likely be successful in tracking the emergence and spread of MDR pathogens and thereby guiding the global infection control strategies in a highly informed manner.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/genetics ; Bacteria/isolation & purification ; Bangladesh ; Drug Resistance, Multiple, Bacterial/drug effects ; Drug Resistance, Multiple, Bacterial/genetics ; Evolution, Molecular ; Genetic Variation ; Genome, Bacterial ; Genomics/methods ; Genotype ; India ; Infection Control ; Microbial Sensitivity Tests ; Molecular Epidemiology ; Phylogeny ; Whole Genome Sequencing/methods
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 445: Show issues

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  9. Article: Massive Ovarian Edema: An Extremely Rare Cause of Ovarian Mass in a 7-Year-Old Girl.

    Mahajan, Nidhi / Khatri, Arti / Khan, Niyaz Ahmed / Gupta, Natasha

    Journal of Indian Association of Pediatric Surgeons

    2020  Volume 25, Issue 4, Page(s) 256–257

    Language English
    Publishing date 2020-06-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2164528-0
    ISSN 1998-3891 ; 0971-9261
    ISSN (online) 1998-3891
    ISSN 0971-9261
    DOI 10.4103/jiaps.JIAPS_111_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Functional molecular characterization and the assessment of the transmission route of multidrug-resistant Helicobacter pullorum isolates from free-range and broiler chickens

    Qumar, Shamsul / Majid, Mohammad / Qaria, Majjid A. / Mendem, Suresh Kumar / Ahmed, Niyaz

    Microbial Pathogenesis. 2023 Sept., v. 182 p.106253-

    2023  

    Abstract: Some of the life-threatening, food-borne, and zoonotic infections are transmitted through poultry birds. Inappropriate and irrational use of antimicrobials in the livestock industry has resulted in an increased incidence of multi-drug resistant bacteria ... ...

    Abstract Some of the life-threatening, food-borne, and zoonotic infections are transmitted through poultry birds. Inappropriate and irrational use of antimicrobials in the livestock industry has resulted in an increased incidence of multi-drug resistant bacteria of epidemic potentials. The adhesion and invasion properties of 11 free-range and broiler chicken derived Helicobacterpullorum isolates were evaluated. To examine the biofilm formation of H. pullorum isolates, crystal violet assay was performed. A quantitative assay of invasion-associated genes was carried out after infecting HepG2 cells with two different representative (broiler and free-range chicken) H. pullorum isolates, using RT-PCR assay. Furthermore, we investigated the prevalence of H. pullorum, Campylobacter jejuni and Salmonella spp. in chicken caeca and oviducts to determine the possibility of trans-ovarian transmission. All H. pullorum isolates adhered to HepG2 cells significantly but a notable difference towards their invasion potential was observed between free-range and broiler chicken isolates wherein broiler isolates were found to be more invasive compared to free-range isolates. Furthermore, cdtB, flhA and flaB genes of H. pullorum were upregulated post infection of HepG2 cells, in broiler chicken isolates compared to free-range chicken isolates. Moreover, all isolates of H. pullorum were found to form biofilm on the liquid-air interface of the glass coverslips and sidewalls of the wells with similar propensities. Despite presence of H. pullorum and C. jejuni in high concentrations in the caecum, they were completely absent in oviduct samples, thus ruling out the possibility of vertical transmission of these bacterial species. In contrast, Salmonella spp. was found to be present in a significant proportion in the oviduct samples of egg-laying hens suggesting its vertical transmission. Our findings suggest that H. pullorum, an emerging multi-drug resistant (MDR) pathogen could be transmitted from poultry sources to humans. In addition to this, its strong functional similarity with C. jejuni provides a firm basis for H. pullorum to be an emerging food-associated, MDR pathogenic bacterium that could pose risk to public health.
    Keywords Campylobacter jejuni ; Helicobacter pullorum ; Salmonella ; adhesion ; anti-infective agents ; bacteria ; biofilm ; broiler chickens ; cecum ; gentian violet ; glass ; liquid-air interface ; livestock and meat industry ; multiple drug resistance ; oviducts ; oviposition ; pathogenesis ; pathogens ; public health ; risk ; Poultry ; antimicrobial resistance ; Biofilms ; Caecum ; transmission, ; Prevalence
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2023.106253
    Database NAL-Catalogue (AGRICOLA)

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