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Article ; Online: A novel treatment of clavicular nonunion: Combination with PRP, autologous bone grafting, and internal plate fixation.

Jiang, Ye / Ju, Weina / Gai, Ning / Qi, Baochang

Technology and health care : official journal of the European Society for Engineering and Medicine

2023 Volume 32, Issue 2, Page(s) 545–550

Abstract: Background: Nonunion is a major concern for orthopedic surgeons, particularly nonunion of the clavicle, which can cause severe pain, loss of full range of motion, poor sleep quality, and loss of strength in the affected individuals. Platelet-rich plasma ...

Abstract	Background: Nonunion is a major concern for orthopedic surgeons, particularly nonunion of the clavicle, which can cause severe pain, loss of full range of motion, poor sleep quality, and loss of strength in the affected individuals. Platelet-rich plasma (PRP), an important biological agent, is widely used in orthopedics. Objective: We used a combination of three techniques - the PRP technique, autologous bone grafting technique, and internal plate fixation technique - to ensure adequate internal fixation and enable a bone growth-supportive environment at the fracture site. Methods: The surgical approach was applied to a patient with clavicle nonunion. Results: Based on postoperative follow-up findings and intraoperative findings at the time of re-removal of the patient's implant, the prognosis at the fracture site was considered satisfactory. Conclusion: We observed that the patient treated with this method had favorable clinical outcomes, and we recommend that this technique be used in patients with long-bone nonunion.
MeSH term(s)	Humans ; Fractures, Ununited/surgery ; Treatment Outcome ; Bone Transplantation/methods ; Clavicle/surgery ; Fracture Healing ; Fracture Fixation, Internal/methods ; Bone Plates ; Fractures, Bone/surgery ; Retrospective Studies
Language	English
Publishing date	2023-08-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1159961-3
ISSN	1878-7401 ; 0928-7329
ISSN (online)	1878-7401
ISSN	0928-7329
DOI	10.3233/THC-230336
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3846: Show issues

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Article: Comparison of plate fixation vs. intramedullary fixation for the management of mid-shaft clavicle fractures: A systematic review and meta-analysis of randomised controlled trials.

Ju, Weina / Mohamed, Sayid Omar / Qi, Baochang

Experimental and therapeutic medicine

2020 Volume 20, Issue 3, Page(s) 2783–2793

Abstract: A number of meta-analyses have compared clinical outcomes following plate vs. intramedullary fixation for midshaft clavicle fractures (MSCF), but with conflicting results. There is a requirement for updated level-1 evidence to guide clinicians managing ... ...

Abstract	A number of meta-analyses have compared clinical outcomes following plate vs. intramedullary fixation for midshaft clavicle fractures (MSCF), but with conflicting results. There is a requirement for updated level-1 evidence to guide clinicians managing MSCF. The aim of the present systematic review and meta-analysis was to compare clinical outcomes following plate vs. intramedullary fixation of MSCF. The PubMed, Scopus, BioMed Central, Cochrane Central Register of Controlled Trials and Google Scholar databases were searched for records added until 1st July 2019. A total of 10 randomised controlled trials (RCTs) were included. Shoulder function was assessed using the Constant-Murley Shoulder Outcome questionnaire and the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH). There was no statistically significant difference in Constant-Murley scores between plate and intramedullary fixation [Mean difference (MD)=0.75; 95% CI: -2.49 to 3.99; P=0.65; I
Language	English
Publishing date	2020-07-13
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2020.9002
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Article: Therapeutic effects of statins drugs use and continuous nursing on patients with chronic obstructive pulmonary disease and the influence of life quality.

Weina, Ju / Yanhua, Liu / Jian, Wang / Yan, Shao

Pakistan journal of pharmaceutical sciences

2018 Volume 31, Issue 3(Special), Page(s) 11794–11184

Abstract: Chronic obstructive pulmonary disease (COPD) is able to be treated and delayed. Many interventions include smoking cessation and daily maintenance of drug therapy. In clinical practice, although respiratory physicians have given optimal drug treatment to ...

Abstract	Chronic obstructive pulmonary disease (COPD) is able to be treated and delayed. Many interventions include smoking cessation and daily maintenance of drug therapy. In clinical practice, although respiratory physicians have given optimal drug treatment to patients, there is no treatment for etiological factors in these treatments, and they have little effect on the long-term prognosis of COPD. Therefore, this paper puts forward a method of continuing care. Through Meta analysis of the therapeutic effects of statins, it is shown that statins have a positive impact on the treatment of chronic obstructive pulmonary disease. On the other hand, the study shows that continuing care can reduce the SGRQ (St George's respiratory questionnaire) score of the patient, thereby improving the patient's quality of life. Therefore, both drug therapy and continuing care are effective methods for the treatment of chronic obstructive pulmonary disease, which can be effectively combined.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/nursing ; Quality of Life
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2018-05-03
Publishing country	Pakistan
Document type	Journal Article ; Systematic Review
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Zs.A 6588: Show issues

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Article: Reduced expression in preterm birth of sFLT-1 and PlGF with a high sFLT-1/PlGF ratio in extracellular vesicles suggests a potential biomarker.

Hussein, Sama / Ju, Weina / Pizzella, Stephanie / Flory, Michael / Chu, Chu / Wang, Yong / Zhong, Nanbert

Frontiers in endocrinology

2022 Volume 13, Page(s) 1024587

Abstract: Preterm birth may have a pathological impact on intrauterine development of the fetal brain, resulting in developmental disabilities. In this study, we examine the expression of soluble Fms-like tyrosine kinase 1 (sFLT-1) and placental growth factor ( ... ...

Abstract	Preterm birth may have a pathological impact on intrauterine development of the fetal brain, resulting in developmental disabilities. In this study, we examine the expression of soluble Fms-like tyrosine kinase 1 (sFLT-1) and placental growth factor (PlGF), which is one of the vascular endothelial growth factors (VEGFs), as these play a key role in angiogenesis; in particular, we examine their effect on the sFLT-1/PlGF ratio in cases of preterm birth as compared to typical pregnancies. Enzyme-linked immunosorbent assay was performed on samples of maternal-derived plasma and extracellular vesicles-exosomes (EVs-EXs) isolated at the third trimester, consisting of 17 samples from cases of preterm birth and 38 control cases. Our results showed that both sFLT-1 (P=0.0014) and PlGF (P=0.0032) were significantly downregulated in cases of preterm birth compared to controls, while the sFLT-1/PIGF ratio was significantly (P=0.0008) increased in EVs-EXs, but not in maternal plasma. Our results suggest that this reduced expression of sFLT-1 and PlGF with an elevated sFLT-1/PlGF ratio in EVs-EXs may represent a potential biomarker for prediction of PTB.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; Placenta Growth Factor ; Premature Birth/diagnosis ; Vascular Endothelial Growth Factor Receptor-1 ; Pre-Eclampsia ; Vascular Endothelial Growth Factor A ; Receptor Protein-Tyrosine Kinases ; Biomarkers ; Exosomes
Chemical Substances	Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1) ; Vascular Endothelial Growth Factor A ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Biomarkers
Language	English
Publishing date	2022-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1024587
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Article: Genetic and Expression Analysis of COPI Genes and Alzheimer's Disease Susceptibility.

Yang, Yu / Wang, Xu / Ju, Weina / Sun, Li / Zhang, Haining

Frontiers in genetics

2019 Volume 10, Page(s) 866

Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly and the leading cause of dementia in humans. Evidence shows that cellular trafficking and recycling machineries are associated with AD risk. A recent study found that ... ...

Abstract	Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly and the leading cause of dementia in humans. Evidence shows that cellular trafficking and recycling machineries are associated with AD risk. A recent study found that the coat protein complex I (COPI)-dependent trafficking
Language	English
Publishing date	2019-09-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2019.00866
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Article ; Online: Diffuse large B-cell lymphoma involving peripheral nervous system with IgM antibodies against GM1 and GD1b: A case report.

Jiang, Zhaocai / Ju, Weina / Luo, Shen / Yang, Yu

Medicine

2019 Volume 98, Issue 15, Page(s) e15049

Abstract: Rationale: The occurrence of peripheral neuropathy associated with non-Hodgkin's lymphoma (NHL) is uncommon. And autoimmunity may play an important role. We report a case of the patient with NHL, has sensorimotor demyelinating polyneuropathy.: Patient ...

Abstract	Rationale: The occurrence of peripheral neuropathy associated with non-Hodgkin's lymphoma (NHL) is uncommon. And autoimmunity may play an important role. We report a case of the patient with NHL, has sensorimotor demyelinating polyneuropathy. Patient concerns: The patient presented with a 1-month history of progressive numbness at the distal extremities and motor weakness of the lower limbs. Meanwhile, patient also endorsed a painful lump on her right cheek. And then the enlarged cervical and supra clavicular lymph nodes were observed on admission. Biopsy of the lymph nodes showed NHL. Serum IgM antibodies against GM1 and GD1b were also positive. Diagnosis: Biopsy of the lymph nodes showed NHL. Serum IgM antibodies against GM1 and GD1b were also positive. Thus, the patience was diagnosed with lymphoma and sensorimotor polyneuropathy. Interventions: Patient refused the further treatment. Outcomes: After 11-month follow-up, the weakness of bilateral lower limbs worsens. Lessons: We have presented a case of NHL involving peripheral polyneuropathy with IgM antibodies against GM1 and GD1b. Patients may initially present with peripheral nerve complications or develop them during the course of lymphoma, even when in remission. This could complicate the diagnosis of peripheral polyneuropathy secondary to NHL.
MeSH term(s)	Diagnosis, Differential ; Disease Progression ; Female ; G(M1) Ganglioside/immunology ; Gangliosides/immunology ; Humans ; Immunoglobulin M/blood ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Polyradiculoneuropathy/diagnosis ; Polyradiculoneuropathy/etiology ; Polyradiculoneuropathy/immunology ; Polyradiculoneuropathy/pathology
Chemical Substances	Gangliosides ; Immunoglobulin M ; ganglioside, GD1b (19553-76-5) ; G(M1) Ganglioside (37758-47-7)
Language	English
Publishing date	2019-05-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000015049
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Article: Systematic review and meta-analysis: the effect of bronchopulmonary dysplasia on neurodevelopment in very low birth weight premature infants.

Gao, Shuqiang / Zhang, Xiaolong / Du, Weina / Zhou, Xiaofeng / Xi, Yufeng / Ju, Rong

Translational pediatrics

2021 Volume 10, Issue 11, Page(s) 3023–3033

Abstract: Background: A meta-analysis was performed to study the effect of steroid intervention on the neurodevelopment of extremely low birth weight preterm infants complicated with bronchopulmonary dysplasia, and to provide a theoretical basis for clinical ... ...

Abstract	Background: A meta-analysis was performed to study the effect of steroid intervention on the neurodevelopment of extremely low birth weight preterm infants complicated with bronchopulmonary dysplasia, and to provide a theoretical basis for clinical treatment. Methods: The Wanfang database, Chinese Biomedical Literature database, VIP database, Baidu Academic, CNKI database, The Cochrane Library, Medline, Embase, and PubMed database were searched by computer from establishment to 2021. Randomized controlled trials on the effect of steroids on neurodevelopment in very low birth weight preterm infants with bronchial dysplasia published from January 10, 2007 were retrieved. The included literature was evaluated for bias risk, then analyzed using RevMan 5.3 software. Results: A total of 9 studies were included, with a total of 2,453 patients. The funnel plot showed that the circles and the midline of some studies were basically symmetrical, and there was no bias in the publications. The conclusions obtained were relatively reliable. Cerebral palsy, neurodevelopmental indicators, and MRI findings of preterm infants were analyzed. The cognitive impairment of very low birth weight preterm infants complicated with bronchial dysplasia (RR =0.83, 95% CI: 0.72-0.96, P=0.01) in the treatment group was significantly different from that in the control group, while cerebral palsy (RR =0.99, 95% CI: 0.75-1.29, P=0.93), speech impairment (RR =0.75, 95% CI: 0.46-1.21, P=0.24), hearing loss requiring amplification (RR =0.60, 95% CI: 0.35-1.03, P=0.06), bilateral blindness RR =0.81, 95% CI: 0.52-1.24, P=0.32), severe intraventricular hemorrhage (IVH) (RR =0.71, 95% CI: 0.33-1.50, P=0.37), and cystic periventricular leukomalacia (RR =0.82, 95% CI: 0.43-1.57, P=0.56) had no significant differences compared with the control group. Discussion: In this meta-analysis, we found that the use of steroids in very low birth weight preterm infants complicated with bronchial dysplasia had significant effects on cognition, but no significant effects on hearing, vision, or language function.
Language	English
Publishing date	2021-12-10
Publishing country	China
Document type	Journal Article
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp-21-449
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Article: Effect of Ketamine on LTP and NMDAR EPSC in Hippocampus of the Chronic Social Defeat Stress Mice Model of Depression.

Yang, Yu / Ju, Weina / Zhang, Haining / Sun, Li

Frontiers in behavioral neuroscience

2018 Volume 12, Page(s) 229

Abstract: Depression is a common mental disorder that is associated with memory dysfunction. Ketamine has recently been demonstrated to be a rapid antidepressant. The mechanisms underlying how depression induces memory dysfunction and how ketamine relieves ... ...

Abstract	Depression is a common mental disorder that is associated with memory dysfunction. Ketamine has recently been demonstrated to be a rapid antidepressant. The mechanisms underlying how depression induces memory dysfunction and how ketamine relieves depressive symptoms remain poorly understood. This work compared three groups of male C57BL/6J mice: mice exposed to chronic social defeat stress (CSDS) to induce a depression-like phenotype, depression-like mice treated with ketamine, and control mice that were not exposed to CSDS or treated with ketamine. Spatial working memory and long term memory were assessed by spontaneous alternation Y-maze and fear conditioning tests, respectively. We used western blot to analyze the density of
Language	English
Publishing date	2018-10-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2018.00229
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Article ; Online: Transcriptomics-determined chemokine-cytokine pathway presents a common pathogenic mechanism in pregnancy loss and spontaneous preterm birth.

Wang, Peirong / Pan, Jing / Tian, Xiujuan / Dong, Xiaoyan / Ju, Weina / Wang, Yong / Zhong, Nanbert

American journal of reproductive immunology (New York, N.Y. : 1989)

2021 Volume 86, Issue 1, Page(s) e13398

Abstract: Problem: Various etiological factors, such as infection and inflammation, may induce the adverse outcomes of pregnancy of miscarriage, stillbirth, or preterm birth. The pathogenic mechanisms associated with these adverse pregnancies are yet unclear. We ... ...

Abstract	Problem: Various etiological factors, such as infection and inflammation, may induce the adverse outcomes of pregnancy of miscarriage, stillbirth, or preterm birth. The pathogenic mechanisms associated with these adverse pregnancies are yet unclear. We hypothesized that a common pathogenic mechanism may underlie variant adverse outcomes of pregnancy, which are induced by genetic-environmental factors. The specific objective of the current study is to uncover the common molecular mechanism(s) by identifying the specific transcripts that are present in variant subtypes of pregnancy loss and preterm birth. Method of study: Transcriptomic profiling was performed with RNA expression microarray or RNA sequencing of placentas derived from pregnancy loss (which includes spontaneous miscarriage, recurrent miscarriage, and stillbirth) and spontaneous preterm birth, followed by bioinformatic analysis of multi-omic integration to identify pathogenic molecules and pathways involved in pathological pregnancies. Results: The enrichment of common differentially expressed genes between full-term birth and preterm birth and pregnancy loss of miscarriage and stillbirth revealed different pathophysiological pathway(s), including cytokine signaling dysregulated in spontaneous preterm birth, defense response, graft-versus-host disease, antigen processing and presentation, and T help cell differentiation in spontaneous miscarriage. Thirty-three genes shared between spontaneous preterm birth and spontaneous miscarriage were engaged in pathways of interferon gamma-mediated signaling and of antigen processing and presentation. For spontaneous miscarriage, immune response was enriched in the fetal tissue of chorionic villi and in the maternal facet of the placental sac. The transcript of nerve growth factor receptor was identified as the common molecule that is differentially expressed in all adverse pregnancies: spontaneous preterm birth, stillbirth, spontaneous miscarriage, and recurrent miscarriage. Superoxide dismutase 2 was up-regulated in all adverse outcomes of pregnancy except for recurrent miscarriage. Cytokine-cytokine receptor interaction was the common pathway in spontaneous preterm birth and spontaneous miscarriage. Defense response was enriched in the fetal tissue of miscarriage and in the maternal tissue in spontaneous miscarriage. Conclusions: Our results indicated that the chemokine-cytokine pathway may play important roles in and function as a common pathogenic mechanism associated with, the different adverse outcomes of pregnancy, which demonstrated that differentially expressed transcripts could result from a common pathogenic mechanism associated with pregnancy loss and spontaneous preterm birth, although individual pregnancy outcomes may differ from each other phenotypically.
MeSH term(s)	Chemokines/metabolism ; Cytokines/metabolism ; Female ; Gene Expression Profiling ; Humans ; Pregnancy ; Pregnancy Outcome ; Premature Birth/immunology ; Receptors, CXCR4/genetics ; Receptors, Nerve Growth Factor/genetics ; Signal Transduction ; Superoxide Dismutase/genetics
Chemical Substances	CXCR4 protein, human ; Chemokines ; Cytokines ; Receptors, CXCR4 ; Receptors, Nerve Growth Factor ; Superoxide Dismutase (EC 1.15.1.1) ; superoxide dismutase 2 (EC 1.15.1.1)
Language	English
Publishing date	2021-02-10
Publishing country	Denmark
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604542-x
ISSN	1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
ISSN (online)	1600-0897
ISSN	0271-7352 ; 8755-8920 ; 1046-7408
DOI	10.1111/aji.13398
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1653: Show issues

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Article: Low-energy shock waves promote the cisplatin chemosensitivity of human osteosarcoma MNNG/HOS cells via the P2X7/Akt/mTOR pathway.

Gai, Ning / Ju, Wei-Na / Yu, Tie-Cheng / Qi, Bao-Chang

Annals of medicine and surgery (2012)

2024 Volume 86, Issue 5, Page(s) 2665–2670

Abstract: Background: The current dilemma of osteosarcoma treatment is the resistance of chemotherapeutic drugs after long-term usage, which also introduces life-threatening side effects.: Methods and results: To minimize chemoresistance in osteosarcoma ... ...

Abstract	Background: The current dilemma of osteosarcoma treatment is the resistance of chemotherapeutic drugs after long-term usage, which also introduces life-threatening side effects. Methods and results: To minimize chemoresistance in osteosarcoma patients, the authors applied shock waves (SWs) to human osteosarcoma MNNG/HOS cells, then evaluated the cell viability and extracellular ATP levels, and further investigated the effect of SWs on cisplatin (DDP) cytotoxicity in MNNG/HOS cells. The authors' results showed that 400 SW pulses at 0.21 mJ/mm Conclusions: For the first time, the authors found that SW therapy reduced the DDP resistance of MNNG/HOS osteosarcoma cells when the ATP receptor P2X7 was downregulated. SW therapy may provide a novel treatment strategy for chemoresistant human osteosarcoma.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001909
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