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Article ; Online: Maternal anti-Toxoplasma gondii antibodies IgG2, IgG3 and IgG1 are markers of vertical transmission and clinical evolution of toxoplasmosis in the offspring.

Cañedo-Solares, Irma / Correa, Dolores / Luna-Pastén, Hector / Ortiz-Alegría, Luz Belinda / Gómez-Chávez, Fernando / Xicoténcatl-García, Lizbeth / Díaz-García, Luisa / Canfield-Rivera, Carlos E

Acta tropica

2023 Volume 243, Page(s) 106943

Abstract: Toxoplasma gondii can be transmitted vertically during pregnancy and may cause neurological, ocular, and even systemic damage to the offspring. Congenital toxoplasmosis (CT) can be diagnosed during gestation and/or after birth in the postnatal period. ... ...

Abstract	Toxoplasma gondii can be transmitted vertically during pregnancy and may cause neurological, ocular, and even systemic damage to the offspring. Congenital toxoplasmosis (CT) can be diagnosed during gestation and/or after birth in the postnatal period. The timely diagnosis is highly relevant for efficient clinical management. The most common laboratory methods for diagnosing CT are based on Toxoplasma-specific humoral immune responses. However, these methods are of low sensitivity or specificity. In a previous study with a small number of cases, the comparison of anti-T. gondii IgG subclasses between mothers and their offspring showed promising results for CT diagnosis and prognosis. Thus, in this work, we analyzed specific IgG subclasses and IgA in 40 T. gondii-infected mothers and their children, of which 27 were congenitally infected and 13 uninfected. A higher frequency of anti-Toxoplasma IgG2, IgG3, IgG4, and IgA antibodies was observed in mothers and congenitally infected offspring. Of these, IgG2 or IgG3 were statistically the most conspicuous. In the CT group, maternal IgG3 antibodies were significantly associated with severe disease of the infants and IgG1 and IgG3 with disseminated disease. The results support that maternal anti-T. gondii IgG3, IgG2 and IgG1 are markers of congenital transmission and severity/spread of disease in the offspring.
MeSH term(s)	Infant ; Female ; Child ; Pregnancy ; Humans ; Toxoplasma ; Immunoglobulin G ; Toxoplasmosis/diagnosis ; Toxoplasmosis, Congenital/diagnosis ; Immunoglobulin A ; Antibodies, Protozoan
Chemical Substances	Immunoglobulin G ; Immunoglobulin A ; Antibodies, Protozoan
Language	English
Publishing date	2023-05-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2023.106943
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Article ; Online: Maternal anti-Toxoplasma gondii antibodies IgG2, IgG3 and IgG1 are markers of vertical transmission and clinical evolution of toxoplasmosis in the offspring

Acta Tropica. 2023 July, v. 243 p.106943-

2023

Abstract	Toxoplasma gondii can be transmitted vertically during pregnancy and may cause neurological, ocular, and even systemic damage to the offspring. Congenital toxoplasmosis (CT) can be diagnosed during gestation and/or after birth in the postnatal period. The timely diagnosis is highly relevant for efficient clinical management. The most common laboratory methods for diagnosing CT are based on Toxoplasma-specific humoral immune responses. However, these methods are of low sensitivity or specificity. In a previous study with a small number of cases, the comparison of anti-T. gondii IgG subclasses between mothers and their offspring showed promising results for CT diagnosis and prognosis. Thus, in this work, we analyzed specific IgG subclasses and IgA in 40 T. gondii-infected mothers and their children, of which 27 were congenitally infected and 13 uninfected. A higher frequency of anti-Toxoplasma IgG2, IgG3, IgG4, and IgA antibodies was observed in mothers and congenitally infected offspring. Of these, IgG2 or IgG3 were statistically the most conspicuous. In the CT group, maternal IgG3 antibodies were significantly associated with severe disease of the infants and IgG1 and IgG3 with disseminated disease. The results support that maternal anti-T. gondii IgG3, IgG2 and IgG1 are markers of congenital transmission and severity/spread of disease in the offspring.
Keywords	Toxoplasma gondii ; disease course ; disease severity ; disease transmission ; immunoglobulin G ; postpartum period ; pregnancy ; progeny ; prognosis ; toxoplasmosis ; Congenital toxoplasmosis ; Laboratory diagnosis ; Maternal IgG subclasses ; Vertical transmission ; Disease outcome
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2023.106943
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Article: Genetic analysis and QTL mapping of domestication-related traits in chili pepper (

Lopez-Moreno, Hector / Basurto-Garduño, Ana Celia / Torres-Meraz, Maria Alejandra / Diaz-Valenzuela, Eric / Arellano-Arciniega, Sergio / Zalapa, Juan / Sawers, Ruairidh J H / Cibrián-Jaramillo, Angelica / Diaz-Garcia, Luis

Frontiers in genetics

2023 Volume 14, Page(s) 1101401

Abstract: Chili pepper ( ...

Abstract	Chili pepper (
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1101401
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Article ; Online: Opitz GBBB syndrome with total anomalous pulmonary venous connection: A new MID1 gene variant.

Perea-Cabrera, Maryangel / Granados-Riveron, Javier T / Segura-Stanford, Begoña / Moreno-Vargas, Liliana M / Prada-Gracia, Diego / Moran-Espinosa, Mari C / Erdmenger, Julio / Diaz-Garcia, Hector / Sánchez-Urbina, Rocío

Molecular genetics & genomic medicine

2023 Volume 11, Issue 9, Page(s) e2234

Abstract: Background: Opitz GBBB syndrome (GBBB) is an X-linked disease characterized by midline defects, including congenital heart defects. We present our diagnostic approach to the identification of GBBB in a consanguineous family in which two males siblings ... ...

Abstract	Background: Opitz GBBB syndrome (GBBB) is an X-linked disease characterized by midline defects, including congenital heart defects. We present our diagnostic approach to the identification of GBBB in a consanguineous family in which two males siblings were concordant for a total anomalous connection of pulmonary veins and minor facial dysmorphias. Methods: Targeted exome sequencing analysis of a 380-gene panel associated with cardiovascular disease was performed on the propositus. Interpretative analysis of the exome results was conducted, and 3D models of the protein changes were generated. Results: We identified a NM_000381.4:c.608G>A;p.(Arg203Gln) change in MID1, affecting the conformation of the B-box 2 domain of the protein, with a zinc finger structure and associated protein interactions. This clinical phenotype is consistent with GBBB; however, the type of congenital heart disease observed in this case has not been previously reported. Conclusion: A new likely pathogenic variant on MID1 c.608G>A was found to be associated with Opitz GBBB syndrome.
MeSH term(s)	Humans ; Male ; Genetic Diseases, X-Linked/genetics ; Hypertelorism/genetics ; Hypospadias/genetics
Chemical Substances	MID1 protein, human (EC 2.3.2.27)
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.2234
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Article ; Online: Association between maternal diet, smoking, and the placenta MTHFR 677C/T genotype and global placental DNA methylation.

Diaz-Garcia, Hector / Vilchis-Gil, Jenny / Castro-Cerritos, Karla V / Rivera-Susunaga, Luis E / Klünder-Klünder, Miguel / Granados-Riveron, Javier T / Gómez-López, Jaqueline / López-Torres, Adolfo / Sánchez-Urbina, Rocío

Placenta

2023 Volume 146, Page(s) 17–24

Abstract: Introduction: The placenta provides nutrients to the fetus, and it has protective effects against harmful substances. Unhealthy maternal diets and toxic agents might increase free radical (FR) production. Elevated FR levels are associated with a high ... ...

Abstract	Introduction: The placenta provides nutrients to the fetus, and it has protective effects against harmful substances. Unhealthy maternal diets and toxic agents might increase free radical (FR) production. Elevated FR levels are associated with a high risk of oxidative stress, which may cause DNA damage. DNA might be oxidized in the placenta, occasionally affecting its methylation profile due to 8-hidroxy-2'-deoxyguanosine formation. Methods: This study assessed 130 mothers and their children. The maternal's nutritional patterns were determined using the Food Frequency Questionnaire. Information on smoking and alcohol consumption was collected during the medical examination. Data on placental DNA were obtained to determine the MTHFR 677C/T genotype and the proportion of placental DNA methylation (pDNAm). Results: Consumption of vitamins and folic acid was above 85%. The pDNAm was found to be correlated with gestational age and coffee intake. Mothers with a smoking history had a low pDNAm. Placentas with the TT genotype had a higher but not significant pDNAm. In the placentas with the CC/CT genotype, the pDNAm was positively associated with carbohydrate and biotin intake. However, the TT genotype was negatively associated with folate and vegetable intake. Discussion: The pDNAm was positively associated with coffee intake, but not with macro-, and micronutrient intake. However, it was negatively associated with cigarette smoking. The placentas with the CC/CT genotype had a lower pDNAm than those with the TT genotype. In the placentas with the CC/CT or TT genotype, methylation was positively, and negatively associated with micro- or macronutrients, respectively.
MeSH term(s)	Child ; Humans ; Female ; Pregnancy ; DNA Methylation ; Placenta ; Coffee ; Diet ; Genotype ; Folic Acid ; DNA ; Smoking/adverse effects ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics
Chemical Substances	Coffee ; Folic Acid (935E97BOY8) ; DNA (9007-49-2) ; MTHFR protein, human (EC 1.5.1.20) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20)
Language	English
Publishing date	2023-12-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	603951-0
ISSN	1532-3102 ; 0143-4004
ISSN (online)	1532-3102
ISSN	0143-4004
DOI	10.1016/j.placenta.2023.12.017
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Article ; Online: Diet and Maternal Obesity Are Associated with Increased Oxidative Stress in Newborns: A Cross-Sectional Study.

Lopez-Yañez Blanco, Arturo / Díaz-López, Keyla M / Vilchis-Gil, Jenny / Diaz-Garcia, Hector / Gomez-Lopez, Jacqueline / Medina-Bravo, Patricia / Granados-Riveron, Javier T / Gallardo, Juan M / Klünder-Klünder, Miguel / Sánchez-Urbina, Rocío

Nutrients

2022 Volume 14, Issue 4

Abstract: Overweight and obesity have become a world-health public problem, mainly for developing countries. Both health conditions have a higher prevalence among women of childbearing age. Physiopathology, overweight and obesity are characterized by a chronic ... ...

Abstract	Overweight and obesity have become a world-health public problem, mainly for developing countries. Both health conditions have a higher prevalence among women of childbearing age. Physiopathology, overweight and obesity are characterized by a chronic oxidative stress status, which has deleterious effects on mothers and children. Hence, we determine whether the qualities of diet during pregnancy and maternal pregestational body mass index (BMI) are associated with increased oxidative stress markers in mothers and newborns. Two hundred forty-two (242) mother-newborn pairs were classified according to their pregestational BMI. Information on food intake was collected using a food frequency questionnaire in the third trimester of pregnancy. Levels of Malondialdehyde (MDA) and Nitric Oxide (NO) were measured in plasma from mothers at the end of the third trimester of pregnancy and from cord blood at birth. MDA and NO levels in mother-newborn pairs with maternal pregestational overweight or obesity were higher than in mother-newborn pairs with pregestational normal weight. For women (and newborns) who had a higher intake of fruit and vegetables, the levels of NO and MDA were lower. Lastly, women with pregestational obesity had lower fruit and vegetable intake during pregnancy and higher levels of oxidative stress and in their newborns.
MeSH term(s)	Body Mass Index ; Child ; Cross-Sectional Studies ; Diet/adverse effects ; Female ; Humans ; Infant, Newborn ; Obesity, Maternal ; Oxidative Stress ; Pregnancy
Language	English
Publishing date	2022-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14040746
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Article: Dietary and Antioxidant Vitamins Limit the DNA Damage Mediated by Oxidative Stress in the Mother-Newborn Binomial.

Diaz-Garcia, Hector / Vilchis-Gil, Jenny / Garcia-Roca, Pilar / Klünder-Klünder, Miguel / Gomez-Lopez, Jacqueline / Granados-Riveron, Javier T / Sanchez-Urbina, Rocio

Life (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: During pregnancy, appropriate nutritional support is necessary for the development of the foetus. Maternal nutrition might protect the foetus from toxic agents such as free radicals due to its antioxidant content. In this study, 90 mothers and their ... ...

Abstract	During pregnancy, appropriate nutritional support is necessary for the development of the foetus. Maternal nutrition might protect the foetus from toxic agents such as free radicals due to its antioxidant content. In this study, 90 mothers and their children were recruited. DNA damage mediated by oxidative stress (OS) was determined by the levels of 8-hidroxy-2′-deoxyguanosine (8-OHdG) in the plasma of women and umbilical cord blood. The mothers and newborns were categorised into tertiles according to their 8-OHdG levels for further comparison. No relevant clinical differences were observed in each group. A strong correlation was observed in the mother−newborn binomial for 8-OHdG levels (Rho = 0.694, p < 0.001). In the binomial, a lower level of 8-OHdG was associated with higher consumption of calories, carbohydrates, lipids, and vitamin A (p < 0.05). In addition, the levels of 8-OHdG were only significantly lower in newborns from mothers with a higher consumption of vitamin A and E (p < 0.01). These findings were confirmed by a significant negative correlation between the 8-OHdG levels of newborns and the maternal consumption of vitamins A and E, but not C (Rho = −0.445 (p < 0.001), −0.281 (p = 0.007), and −0.120 (p = 0.257), respectively). Multiple regression analysis showed that the 8-OHdG levels in mothers and newborns inversely correlated with vitamin A (β = −1.26 (p = 0.016) and −2.17 (p < 0.001), respectively) and pregestational body mass index (β = −1.04 (p = 0.007) and −0.977 (p = 0.008), respectively). In conclusion, maternal consumption of vitamins A and E, but not C, might protect newborns from DNA damage mediated by OS.
Language	English
Publishing date	2022-07-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12071012
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Article ; Online: Targeted analysis of genomic regions enriched in African ancestry reveals novel classical HLA alleles associated with asthma in Southwestern Europeans.

Suarez-Pajes, Eva / Díaz-García, Claudio / Rodríguez-Pérez, Héctor / Lorenzo-Salazar, Jose M / Marcelino-Rodríguez, Itahisa / Corrales, Almudena / Zheng, Xiuwen / Callero, Ariel / Perez-Rodriguez, Eva / Garcia-Robaina, Jose C / González-Montelongo, Rafaela / Flores, Carlos / Guillen-Guio, Beatriz

Scientific reports

2021 Volume 11, Issue 1, Page(s) 23686

Abstract: Despite asthma has a considerable genetic component, an important proportion of genetic risks remain unknown, especially for non-European populations. Canary Islanders have the largest African genetic ancestry observed among Southwestern Europeans and ... ...

Abstract	Despite asthma has a considerable genetic component, an important proportion of genetic risks remain unknown, especially for non-European populations. Canary Islanders have the largest African genetic ancestry observed among Southwestern Europeans and the highest asthma prevalence in Spain. Here we examined broad chromosomal regions previously associated with an excess of African genetic ancestry in Canary Islanders, with the aim of identifying novel risk variants associated with asthma susceptibility. In a two-stage cases-control study, we revealed a variant within HLA-DQB1 significantly associated with asthma risk (rs1049213, meta-analysis p = 1.30 × 10
MeSH term(s)	Adult ; Alleles ; Asthma/epidemiology ; Asthma/etiology ; Blacks/genetics ; Case-Control Studies ; Disease Susceptibility ; Female ; Genetic Predisposition to Disease ; Genomics/methods ; HLA Antigens/genetics ; Haplotypes ; Humans ; Male ; Middle Aged ; Odds Ratio ; Population Surveillance ; Risk Assessment ; Risk Factors ; Spain/epidemiology ; Whites/genetics ; Young Adult
Chemical Substances	HLA Antigens
Language	English
Publishing date	2021-12-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-02893-w
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Article ; Online: Genotyping of the Major SARS-CoV-2 Clade by Short-Amplicon High-Resolution Melting (SA-HRM) Analysis.

Diaz-Garcia, Hector / Guzmán-Ortiz, Ana L / Angeles-Floriano, Tania / Parra-Ortega, Israel / López-Martínez, Briceida / Martínez-Saucedo, Mirna / Aquino-Jarquin, Guillermo / Sánchez-Urbina, Rocío / Quezada, Hector / Granados-Riveron, Javier T

Genes

2021 Volume 12, Issue 4

Abstract: The genome of the SARS-CoV-2 virus, the causal agent of the COVID-19 pandemic, has diverged due to multiple mutations since its emergence as a human pathogen in December 2019. Some mutations have defined several SARS-CoV-2 clades that seem to behave ... ...

Abstract	The genome of the SARS-CoV-2 virus, the causal agent of the COVID-19 pandemic, has diverged due to multiple mutations since its emergence as a human pathogen in December 2019. Some mutations have defined several SARS-CoV-2 clades that seem to behave differently in terms of regional distribution and other biological features. Next-generation sequencing (NGS) approaches are used to classify the sequence variants in viruses from individual human patients. However, the cost and relative scarcity of NGS equipment and expertise in developing countries prevent studies aimed to associate specific clades and variants to clinical features and outcomes in such territories. As of March 2021, the GR clade and its derivatives, including the B.1.1.7 and B.1.1.28 variants, predominate worldwide. We implemented the post-PCR small-amplicon high-resolution melting analysis to genotype SARS-CoV-2 viruses isolated from the saliva of individual patients. This procedure was able to clearly distinguish two groups of samples of SARS-CoV-2-positive samples predicted, according to their melting profiles, to contain GR and non-GR viruses. This grouping of the samples was validated by means of amplification-refractory mutation system (ARMS) assay as well as Sanger sequencing.
MeSH term(s)	COVID-19/virology ; Genotyping Techniques/methods ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation ; Nucleic Acid Denaturation ; RNA, Viral/isolation & purification ; SARS-CoV-2/genetics
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-04-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12040531
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Article: Genotyping of the Major SARS-CoV-2 Clade by Short-Amplicon High-Resolution Melting (SA-HRM) Analysis

Genes. 2021 Apr. 05, v. 12, no. 4

2021

Abstract	The genome of the SARS-CoV-2 virus, the causal agent of the COVID-19 pandemic, has diverged due to multiple mutations since its emergence as a human pathogen in December 2019. Some mutations have defined several SARS-CoV-2 clades that seem to behave differently in terms of regional distribution and other biological features. Next-generation sequencing (NGS) approaches are used to classify the sequence variants in viruses from individual human patients. However, the cost and relative scarcity of NGS equipment and expertise in developing countries prevent studies aimed to associate specific clades and variants to clinical features and outcomes in such territories. As of March 2021, the GR clade and its derivatives, including the B.1.1.7 and B.1.1.28 variants, predominate worldwide. We implemented the post-PCR small-amplicon high-resolution melting analysis to genotype SARS-CoV-2 viruses isolated from the saliva of individual patients. This procedure was able to clearly distinguish two groups of samples of SARS-CoV-2-positive samples predicted, according to their melting profiles, to contain GR and non-GR viruses. This grouping of the samples was validated by means of amplification-refractory mutation system (ARMS) assay as well as Sanger sequencing.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; animal pathogens ; equipment ; genotype ; genotyping ; humans ; mutation ; saliva ; viruses
Language	English
Dates of publication	2021-0405
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12040531
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