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  1. Book: Tata Memorial Center Textbook of Oncology

    Badwe, Rajendra A / Gupta, Sudeep / Shrikhande, Shailesh V / Laskar, Siddhartha

    2024  

    Author's details Prof. Rajendra A Badwe completed his MBBS from the King Edward Memorial Hospital, Mumbai in 1978 followed by MS in General Surgery from the same institution. Subsequently he trained at Tata Memorial Hospital, Mumbai, Toronomon Hospital, Tokyo, and the Royal Marsden Hospital, London. He joined Tata Memorial Centre in the Department of Surgical Oncology (Breast Cancer Unit) as a faculty member in 1992 and has been the Director of TMC since 2008. He is an internationally renowned breast cancer surgeon and researcher with seminal contributions in several themes including use of peri-operative interventions to improve long-term outcomes. He has received numerous national and international awards, including the Padma Shri by the Government of India in 2013. Prof. Sudeep Gupta completed his MBBS, MD and DM (Medical Oncology) from the All India Institute of Medical Sciences, New Delhi in 2000 and has been a faculty member in the Department ofMedical Oncology, Tata Memorial Centre since 2001
    Keywords Cancer Screening ; Cancer Staging ; Lymphoid Malignancies ; Oncological Emergencies ; Intensive Care in Onclogy
    Language English
    Size 1061 p.
    Edition 2024
    Publisher Palgrave MacMillan UK
    Document type Book
    Note PDA Manuell_20
    Format 210 x 279
    ISBN 9789819933778 ; 9819933773
    Database PDA

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  2. Article: Tata Memorial Hospital: a Peerless Icon.

    Badwe, Rajendra A / Goel, Nishu Singh

    Indian journal of surgical oncology

    2022  Volume 13, Issue Suppl 1, Page(s) 27–29

    Abstract: Few institutes last long and fewer maintain their pre-eminent position throughout their life. They are called temples of their silo. Tata Memorial Hospital and Centre (TMC) is one such temple of healing. The contribution of TMC in patient care, education ...

    Abstract Few institutes last long and fewer maintain their pre-eminent position throughout their life. They are called temples of their silo. Tata Memorial Hospital and Centre (TMC) is one such temple of healing. The contribution of TMC in patient care, education and research is unique and reasons for its success are varied. It is probably the best  expression of Tata culture, Government's commitment, dedication and autonomy of people who ran it. A glimpse into the journey with its changing vision towards a pointed mission of conquest of cancer in India is captured in words.
    Language English
    Publishing date 2022-07-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-022-01588-6
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  3. Article ; Online: Cancer Management in India during Covid-19.

    Pramesh, C S / Badwe, Rajendra A

    The New England journal of medicine

    2020  Volume 382, Issue 20, Page(s) e61

    MeSH term(s) Betacoronavirus ; COVID-19 ; Cancer Care Facilities/organization & administration ; Coronavirus Infections/complications ; Humans ; India ; Neoplasms/complications ; Neoplasms/therapy ; Pandemics ; Patient Care Management/methods ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Triage
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2011595
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  4. Article ; Online: Deciphering the mechanisms of action of progesterone in breast cancer.

    Chakravorty, Gaurav / Ahmad, Suhail / Godbole, Mukul S / Gupta, Sudeep / Badwe, Rajendra A / Dutt, Amit

    Oncotarget

    2023  Volume 14, Page(s) 660–667

    Abstract: A practice-changing, randomized, controlled clinical study established that preoperative hydroxyprogesterone administration improves disease-free and overall survival in patients with node-positive breast cancer. This research perspective summarizes ... ...

    Abstract A practice-changing, randomized, controlled clinical study established that preoperative hydroxyprogesterone administration improves disease-free and overall survival in patients with node-positive breast cancer. This research perspective summarizes evidences from our studies that preoperative hydroxyprogesterone administration may improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation. Non-coding RNAs, particularly
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Progesterone/pharmacology ; Progesterone/therapeutic use ; Receptors, Progesterone/metabolism ; Signal Transduction ; Hydroxyprogesterones/therapeutic use
    Chemical Substances Progesterone (4G7DS2Q64Y) ; Receptors, Progesterone ; Hydroxyprogesterones
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28455
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  5. Article ; Online: A prospective health economic evaluation to determine the productivity loss due to premature mortality from oral cancer in India.

    Singh, Arjun / Sullivan, Richard / Bavaskar, Manasi / Shetty, Rathan / Joshi, Poonam / Nair, Sudhir / Gupta, Sudeep / Chaturvedi, Pankaj / Badwe, Rajendra

    Head & neck

    2024  

    Abstract: Introduction: India contributes two-thirds of the global mortality due to oral cancer and has a younger population at risk. The societal costs of this premature mortality are barely discussed.: Methods: Using the human capital approach, we aimed to ... ...

    Abstract Introduction: India contributes two-thirds of the global mortality due to oral cancer and has a younger population at risk. The societal costs of this premature mortality are barely discussed.
    Methods: Using the human capital approach, we aimed to estimate the productivity lost due to premature mortality, valued using individual socioeconomic data, related to oral cancer in India. A bottom-up approach was used to prospectively collect data of 100 consecutive patients with oral cancer treated between 2019 and 2020, with a follow-up of 36 months.
    Results: The disease-specific survival for early and advanced stage was 85% and 70%, with a median age of 47 years. With 671 years lost prematurely, the loss of productivity was $41 900/early and $96 044/advanced stage. Based on population level rates, the total cost of premature mortality was $5.6 billion, representing 0.18% of GDP.
    Conclusion: India needs to implement tailored strategies to reduce the economic burden from premature mortality.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27776
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  7. Article ; Online: Intent of surgery of the primary tumor in metastatic breast cancer remains palliative.

    Nair, Nita S / Parmar, Vani / Badwe, Rajendra A

    The breast journal

    2019  Volume 25, Issue 2, Page(s) 353

    MeSH term(s) Breast Neoplasms ; Databases, Factual ; Humans ; Palliative Care
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/tbj.13224
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    Zs.A 4483: Show issues Location:
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  8. Article: Screening for breast cancer: Cost-effective solutions for low- & middle-income countries.

    Mishra, Gauravi A / Pimple, Sharmila A / Mittra, Indraneel / Badwe, Rajendra A

    The Indian journal of medical research

    2021  Volume 154, Issue 2, Page(s) 229–236

    Abstract: Low- and middle-income countries (LMICs) have limited financial resources and proportionately smaller portions allocated for health budget. With competing health priorities, treatment of the diagnosed cases and establishment of treatment facilities are ... ...

    Abstract Low- and middle-income countries (LMICs) have limited financial resources and proportionately smaller portions allocated for health budget. With competing health priorities, treatment of the diagnosed cases and establishment of treatment facilities are the main concerns in LMICs. Infectious diseases, reducing infant, child and maternal mortality may seem crucial as compared to early cancer detection. LMICs that are committed to providing comprehensive cancer care, will need to judiciously choose the screening tool depending on specifics of how the tool is expected to perform in the population and the cost-effectiveness with respect to the number of lives expected to be saved. Increasing awareness about breast health in general and common cancers and non communicable diseases (NCDs), in particular, may lead to symptomatic women approaching the healthcare facilities at an earlier stage. When the limited available resources are mobilized towards cancer screening, increasing awareness would lead to greater acceptability of the programme. The reach of the programme to achieve good population coverage, the establishment of the diagnostic referral linkages and the availability and accessibility of treatment facilities, will all decide the outcome of the screening programme.
    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Cost-Benefit Analysis ; Developing Countries ; Early Detection of Cancer ; Female ; Humans ; Mass Screening
    Language English
    Publishing date 2021-12-02
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2635_20
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  9. Article ; Online: Clinical Benefit of Circulating Tumor DNA Analysis in Early-Stage Breast Cancer.

    Chitkara, Garvit / Hawaldar, Rohini / Badwe, Rajendra A

    JAMA oncology

    2019  Volume 6, Issue 3, Page(s) 439

    MeSH term(s) Biomarkers, Tumor ; Breast Neoplasms ; Circulating Tumor DNA ; Humans ; Neoplasm Recurrence, Local
    Chemical Substances Biomarkers, Tumor ; Circulating Tumor DNA
    Language English
    Publishing date 2019-12-17
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.5677
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  10. Article ; Online: Performance of potentially inappropriate medications assessment tools in older Indian patients with cancer.

    Kumar, Sharath / Castelino, Renita / Rao, Abhijith / Gattani, Shreya / Kumar, Anita / Pillai, Anupa / Sehgal, Arshiya / Rane, Pallavi / Ramaswamy, Anant / Dhekale, Ratan / Krishnamurthy, Jyoti / Banavali, Shripad / Badwe, Rajendra / Prabhash, Kumar / Noronha, Vanita / Gota, Vikram

    Cancer medicine

    2024  

    Abstract: Background: Polypharmacy and potentially inappropriate medication (PIM) use are common problems in older adults. Safe prescription practices are a necessity. The tools employed for the identification of PIM sometimes do not concur with each other.: ... ...

    Abstract Background: Polypharmacy and potentially inappropriate medication (PIM) use are common problems in older adults. Safe prescription practices are a necessity. The tools employed for the identification of PIM sometimes do not concur with each other.
    Methods: A retrospective analysis of patients ≥60 years who visited the Geriatric Oncology Clinic of the Tata Memorial Hospital, Mumbai, India from 2018 to 2021 was performed. Beer's-2015, STOPP/START criteria v2, PRISCUS-2010, Fit fOR The Aged (FORTA)-2018, and the EU(7)-PIM list-2015 were the tools used to assess PIM. Every patient was assigned a standardized PIM value (SPV) for each scale, which represented the ratio of the number of PIMs identified by a given scale to the total number of medications taken. The median SPV of all five tools was considered the reference standard for each patient. Bland-Altman plots were utilized to determine agreement between each scale and the reference. Association between baseline variables and PIM use was determined using multiple logistic regression analysis.
    Results: Of the 467 patients included in this analysis, there were 372 (79.66%) males and 95 (20.34%) females with an average age of 70 ± 5.91 years. The EU(7)-PIM list was found to have the highest level of agreement given by a bias estimate of 0.010, the lowest compared to any other scale. The 95% CI of the bias was in the narrow range of -0.001 to 0.022, demonstrating the precision of the estimate. In comparison, the bias (95%) CI of Beer's criteria, STOPP/START criteria, PRISCUS list, and FORTA list were -0.039 (-0.053 to -0.025), 0.076 (0.060 to 0.092), 0.035 (0.021 to 0.049), and -0.148 (-0.165 to -0.130), respectively. Patients on polypharmacy had significantly higher PIM use compared to those without (OR = 1.47 (1.33-1.63), p = <0.001).
    Conclusions: The EU(7)-PIM list was found to have the least bias and hence can be considered the most reliable among all other tools studied.
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6797
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