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Article ; Online: Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains.

Kanemura, Yonehiro / Yamamoto, Atsuyo / Katsuma, Asako / Fukusumi, Hayato / Shofuda, Tomoko / Kanematsu, Daisuke / Handa, Yukako / Sumida, Miho / Yoshioka, Ema / Mine, Yutaka / Yamaguchi, Ryo / Okada, Masayasu / Igarashi, Michihiro / Sekino, Yuko / Shirao, Tomoaki / Nakamura, Masaya / Okano, Hideyuki

Cells

2024 Volume 13, Issue 8

Abstract: Ischemic stroke is a major cerebrovascular disease with high morbidity and mortality rates; however, effective treatments for ischemic stroke-related neurological dysfunction have yet to be developed. In this study, we generated neural progenitor cells ... ...

Abstract	Ischemic stroke is a major cerebrovascular disease with high morbidity and mortality rates; however, effective treatments for ischemic stroke-related neurological dysfunction have yet to be developed. In this study, we generated neural progenitor cells from human leukocyte antigen major loci gene-homozygous-induced pluripotent stem cells (hiPSC-NPCs) and evaluated their therapeutic effects against ischemic stroke. hiPSC-NPCs were intracerebrally transplanted into rat ischemic brains produced by transient middle cerebral artery occlusion at either the subacute or acute stage, and their in vivo survival, differentiation, and efficacy for functional improvement in neurological dysfunction were evaluated. hiPSC-NPCs were histologically identified in host brain tissues and showed neuronal differentiation into vGLUT-positive glutamatergic neurons, extended neurites into both the ipsilateral infarct and contralateral healthy hemispheres, and synaptic structures formed 12 weeks after both acute and subacute stage transplantation. They also improved neurological function when transplanted at the subacute stage with γ-secretase inhibitor pretreatment. However, their effects were modest and not significant and showed a possible risk of cells remaining in their undifferentiated and immature status in acute-stage transplantation. These results suggest that hiPSC-NPCs show cell replacement effects in ischemic stroke-damaged neural tissues, but their efficacy is insufficient for neurological functional improvement after acute or subacute transplantation. Further optimization of cell preparation methods and the timing of transplantation is required to balance the efficacy and safety of hiPSC-NPC transplantation.
MeSH term(s)	Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology ; Humans ; Animals ; Neural Stem Cells/metabolism ; Neural Stem Cells/transplantation ; Neural Stem Cells/cytology ; Cell Differentiation ; Ischemic Stroke/pathology ; Ischemic Stroke/therapy ; Rats ; Synapses/metabolism ; Male ; Neurites/metabolism ; Brain/pathology ; Brain Ischemia/therapy ; Brain Ischemia/pathology ; Neurons/metabolism ; Neurons/pathology ; Rats, Sprague-Dawley ; Stroke/therapy ; Stroke/pathology
Language	English
Publishing date	2024-04-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13080671
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Article ; Online: Mitochondrial Transfer Induced by Adipose-Derived Mesenchymal Stem Cell Transplantation Improves Cardiac Function in Rat Models of Ischemic Cardiomyopathy.

Mori, Daisuke / Miyagawa, Shigeru / Kawamura, Takuji / Yoshioka, Daisuke / Hata, Hiroki / Ueno, Takayoshi / Toda, Koichi / Kuratani, Toru / Oota, Miwa / Kawai, Kotoe / Kurata, Hayato / Nishida, Hiroyuki / Harada, Akima / Toyofuku, Toshihiko / Sawa, Yoshiki

Cell transplantation

2023 Volume 32, Page(s) 9636897221148457

Abstract: Although mesenchymal stem cell transplantation has been successful in the treatment of ischemic cardiomyopathy, the underlying mechanisms remain unclear. Herein, we investigated whether mitochondrial transfer could explain the success of cell therapy in ... ...

Abstract	Although mesenchymal stem cell transplantation has been successful in the treatment of ischemic cardiomyopathy, the underlying mechanisms remain unclear. Herein, we investigated whether mitochondrial transfer could explain the success of cell therapy in ischemic cardiomyopathy. Mitochondrial transfer in co-cultures of human adipose-derived mesenchymal stem cells and rat cardiomyocytes maintained under hypoxic conditions was examined. Functional recovery was monitored in a rat model of myocardial infarction following human adipose-derived mesenchymal stem cell transplantation. We observed mitochondrial transfer
MeSH term(s)	Rats ; Humans ; Animals ; Myocardium/metabolism ; Myocardial Infarction/therapy ; Myocardial Infarction/genetics ; Myocytes, Cardiac/metabolism ; Mesenchymal Stem Cells ; Mesenchymal Stem Cell Transplantation ; Cardiomyopathies/therapy ; Stem Cell Transplantation
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1135816-6
ISSN	1555-3892 ; 0963-6897
ISSN (online)	1555-3892
ISSN	0963-6897
DOI	10.1177/09636897221148457
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Article: Real-Time Monitoring of Key Gene Products Involved in Rice Photoperiodic Flowering.

Yoshioka, Hayato / Kimura, Keiko / Ogo, Yuko / Ohtsuki, Namie / Nishizawa-Yokoi, Ayako / Itoh, Hironori / Toki, Seiichi / Izawa, Takeshi

Frontiers in plant science

2021 Volume 12, Page(s) 766450

Abstract: Flowering is an important biological process through which plants determine the timing of reproduction. In rice, florigen mRNA is induced more strongly when the day length is shorter than the critical day length through recognition of 30-min differences ... ...

Abstract	Flowering is an important biological process through which plants determine the timing of reproduction. In rice, florigen mRNA is induced more strongly when the day length is shorter than the critical day length through recognition of 30-min differences in the photoperiod.
Language	English
Publishing date	2021-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2021.766450
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Article ; Online: Titanium Nanosurface with a Biomimetic Physical Microenvironment to Induce Endogenous Regeneration of the Periodontium.

Yamada, Masahiro / Kimura, Tsuyoshi / Nakamura, Naoko / Watanabe, Jun / Kartikasari, Nadia / He, Xindie / Tiskratok, Watcharaphol / Yoshioka, Hayato / Shinno, Hidenori / Egusa, Hiroshi

ACS applied materials & interfaces

2022 Volume 14, Issue 24, Page(s) 27703–27719

Abstract: The periodontium supports the teeth by dentoalveolar fibrous joints that serve unique oral functions. Endogenous regeneration of the periodontium around artificial teeth (dental implants) provides a cost-effective solution for the extension of healthy ... ...

Abstract	The periodontium supports the teeth by dentoalveolar fibrous joints that serve unique oral functions. Endogenous regeneration of the periodontium around artificial teeth (dental implants) provides a cost-effective solution for the extension of healthy life expectancy but remains a challenge in regenerative medicine. Biomimetics can create smart biomaterials that tune endogenous cells at a tissue-material interface. Here, we created a smart titanium nanosurface mimicking the surface nanotopography and micromechanical properties of the tooth root cementum (TRC), which is essential for the induction of dentoalveolar fibrous joints to regenerate the periodontium. After transplantation into the rat renal capsule, only the titanium artificial tooth with the TRC-mimetic nanosurface formed a complex dentoalveolar fibrous joint structure, with bone tissue, periodontal ligament (PDL), and TRC, in the decellularized jawbone matrix. TRC-mimetic titanium implants induce the formation of functional periodontium, even in a jawbone implantation model, which generally causes osseointegration (ankyloses). In human PDL cells, TRC analogousness in the surface mechanical microenvironment regulates matrix mineralization through bone sialoprotein expression and phosphorus metabolism, which are critical for cementogenesis. Therefore, the titanium nanosurfaces with nanotopographical and mechanical microenvironments mimicking the TRC surface induce dentoalveolar fibrous joints for periodontal regeneration by interfacial tuning of endogenous cells.
MeSH term(s)	Animals ; Biomimetics ; Osseointegration ; Periodontal Ligament ; Periodontium/physiology ; Rats ; Titanium/pharmacology
Chemical Substances	Titanium (D1JT611TNE)
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c06679
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Article ; Online: Involvement of Bmal1 and Clock in Bromobenzene Metabolite-Induced Diurnal Renal Toxicity.

Yoshioka, Hiroki / Yokota, Satoshi / Tominaga, Sarah / Tsukiboshi, Yosuke / Suzui, Masumi / Shinohara, Yasuro / Yoshikawa, Masae / Sasaki, Hayato / Sasaki, Nobuya / Maeda, Tohru / Miura, Nobuhiko

Biological & pharmaceutical bulletin

2023 Volume 46, Issue 6, Page(s) 824–829

Abstract: Circadian rhythms are endogenous oscillators that regulate 24 h behavioral and physiological processes. Our previous investigation demonstrated that bromobenzene metabolite (4-bromocatechol: 4-BrCA) exhibited chronotoxicity (i.e., the nephrotoxicity ... ...

Abstract	Circadian rhythms are endogenous oscillators that regulate 24 h behavioral and physiological processes. Our previous investigation demonstrated that bromobenzene metabolite (4-bromocatechol: 4-BrCA) exhibited chronotoxicity (i.e., the nephrotoxicity induced by 4-BrCA was observed during the dark phase, while not observed at light phase in mice). However, the molecular mechanism is still unknown. The aim of the present study is to investigate the cellular molecule(s) involved in the 4-BrCA-induced nephrotoxicity using mouse renal cortex tubular cell lines (MuRTE61 cells). We found that 4-BrCA showed dose dependent (0.01-1 mM) cell proliferation defect in MuRTE61 cells. By treating with 0.03 mM 4-BrCA, we demonstrated that major clock genes (Bmal1, Clock, Cry1, Cry2, Per1, and Per2) were significantly downregulated. Interestingly, the expression levels of two genes, Bmal1 and Clock, continued to decrease after 3 h of treatment with 4-BrCA, while Cry1, Per1, and Per2 were unchanged until 24 h of treatment. Moreover, BMAL1 and CLOCK levels are higher at light phase. We speculated that BMAL1 and CLOCK might function defensively against 4-BrCA-induced nephrotoxicity since the expression levels of Bmal1 and Clock were rapidly decreased. Finally, overexpression of Bmal1 and Clock restored 4-BrCA-induced cell proliferation defect in MuRTE61 cells. Taken together, our results suggest that Bmal1 and Clock have protective roles against 4-BrCA-induced nephrotoxicity.
MeSH term(s)	Mice ; Animals ; ARNTL Transcription Factors/genetics ; ARNTL Transcription Factors/metabolism ; Bromobenzenes ; Circadian Rhythm/genetics ; Gene Expression Regulation
Chemical Substances	ARNTL Transcription Factors ; bromobenzene (CO4D5J547L) ; Bromobenzenes
Language	English
Publishing date	2023-05-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b23-00072
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Zs.A 1474: Show issues

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Article ; Online: Humoral and cellular responses after COVID-19 booster vaccination in patients recently treated with anti-CD20 antibodies.

Blood cancer journal

2023 Volume 13, Issue 1, Page(s) 17

MeSH term(s)	Humans ; COVID-19
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2600560-8
ISSN	2044-5385 ; 2044-5385
ISSN (online)	2044-5385
ISSN	2044-5385
DOI	10.1038/s41408-023-00792-z
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Article: Genetic Alteration May Proceed with a Histological Change in Glioblastoma: A Report from Initially Diagnosed as Nontumor Lesion Cases.

Takeuchi, Hayato / Takahashi, Yoshinobu / Tanigawa, Seisuke / Okamoto, Takanari / Kodama, Yoshinori / Shishido-Hara, Yukiko / Yoshioka, Ema / Shofuda, Tomoko / Kanemura, Yonehiro / Konishi, Eiichi / Hashimoto, Naoya

NMC case report journal

2022 Volume 9, Page(s) 199–208

Abstract: Despite recent signs of progress in diagnostic radiology, it is quite rare that a glioblastoma (GBM) is detected asymptomatically. We describe two patients with asymptomatic nonenhancing GBMs that were not diagnosed with neoplasia at first. The patients ... ...

Abstract	Despite recent signs of progress in diagnostic radiology, it is quite rare that a glioblastoma (GBM) is detected asymptomatically. We describe two patients with asymptomatic nonenhancing GBMs that were not diagnosed with neoplasia at first. The patients had brain scans as medical checkups, and incidentally lesions were detected. In both cases, surgical specimens histopathologically showed no evidence of neoplasia, whereas molecular genetic findings were isocitrate dehydrogenase (IDH)-wildtype, O
Language	English
Publishing date	2022-07-08
Publishing country	Japan
Document type	Case Reports
ISSN	2188-4226
ISSN	2188-4226
DOI	10.2176/jns-nmc.2022-0038
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Article: Impact of the response to platinum-based chemotherapy on the second-line immune checkpoint inhibitor monotherapy in non-small cell lung cancer with PD-L1 expression ≤49%: a multicenter retrospective study.

Frontiers in oncology

2024 Volume 14, Page(s) 1303543

Abstract: Introduction: The efficacy of second-line immune checkpoint inhibitor (ICI) therapy is limited in non-small cell lung cancer (NSCLC) patients with ≤ 49% PD-L1 expression. Although chemoimmunotherapy is a promising strategy, platinum-based chemotherapy ... ...

Abstract	Introduction: The efficacy of second-line immune checkpoint inhibitor (ICI) therapy is limited in non-small cell lung cancer (NSCLC) patients with ≤ 49% PD-L1 expression. Although chemoimmunotherapy is a promising strategy, platinum-based chemotherapy followed by ICI monotherapy is often used to avoid synergistic adverse events. However, predictors of the efficacy of ICI monotherapy after platinum-based chemotherapy in NSCLC with ≤ 49% PD-L1 expression remain scarce. Methods: This multicenter retrospective study evaluated 54 advanced or recurrent NSCLC patients with ≤ 49% PD-L1 expression who were treated with second-line ICI monotherapy following disease progression on first-line platinum-based chemotherapy at nine hospitals in Japan. The impact of response to platinum-based chemotherapy on the efficacy of subsequent ICI monotherapy was investigated. Results: The response to first-line platinum-based chemotherapy was divided into two groups: the non-progressive disease (PD) group, which included patients who did not experience disease progression after four cycles of chemotherapy, and the PD group, which included patients who showed initial PD or could not maintain disease control during the four cycles of chemotherapy and switched to second-line ICI monotherapy. Among the 54 patients, 32 and 22 were classified into the non-PD and PD groups, respectively. The non-PD group showed better response rates (p = 0.038) and longer overall survival (OS) with ICI monotherapy (p = 0.023) than the PD group. Multivariate analysis identified that maintaining a non-PD status after four cycles of chemotherapy was an independent prognostic factor for ICI monotherapy (p = 0.046). Moreover, patients with a modified Glasgow Prognostic Score (mGPS) of 0 showed a tendency for longer OS with ICI monotherapy (p = 0.079), and there was a significant correlation between maintaining non-PD after four cycles of chemotherapy and an mGPS of 0 (p = 0.045). Conclusion: Maintaining a non-PD status after four cycles of platinum-based chemotherapy was a predictor of OS after second-line ICI monotherapy. These findings will help physicians select the most suitable treatment option for NSCLC patients who were treated with platinum-based chemotherapy and switched to second-line treatment. Those who experienced early PD during platinum-based chemotherapy should not be treated with ICI monotherapy in the second-line setting.
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1303543
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Article ; Online: Efficacy and associated factors of endoscopic transpapillary drainage for postoperative biliary leakage.

Murata, Jun / Shigekawa, Minoru / Ishii, Shuji / Suda, Takahiro / Ikezawa, Kenji / Hirao, Motohiro / Matsumoto, Kengo / Kegasawa, Tadashi / Iwahashi, Kiyoshi / Iio, Sadaharu / Nakanishi, Fumihiko / Nakazuru, Shoichi / Yoshida, Yuichi / Yamai, Takuo / Sato, Katsuhiko / Yoshioka, Teppei / Hikita, Hayato / Tatsumi, Tomohide / Takehara, Tetsuo

DEN open

2023 Volume 4, Issue 1, Page(s) e281

Abstract: Objective: Adequate biliary decompression is important in treating bile leaks, and endoscopic transpapillary drainage is widely used for this purpose. As an indicator to evaluate the usefulness of endoscopic drainage for postoperative biliary leakage, ... ...

Abstract	Objective: Adequate biliary decompression is important in treating bile leaks, and endoscopic transpapillary drainage is widely used for this purpose. As an indicator to evaluate the usefulness of endoscopic drainage for postoperative biliary leakage, we focused on external drain removability, which affects quality of life, after endoscopic treatment. Our aim was to clarify the success rate of external tube removal after endoscopic drainage for postoperative biliary leakage and to examine associated factors. Methods: This was a multicenter retrospective study; 99 patients with biliary leakage at 13 institutions were enrolled between April 2014 and March 2019. Among these patients, 66 who were initially treated with endoscopic interventions for biliary leakage after cholecystectomy ( Results: In post-cholecystectomy biliary leakage, the external-drain-free rate at first endoscopic intervention was 100%, and the drains, including transpapillary stents, were successfully removed in almost all cases (16/17). In contrast, in post-hepatectomy biliary leakage, the external-drain-free rate was 44.9% (22/49), with all 22 of those patients eventually becoming entirely drain-free. A lower body mass index was the only significant factor associated with freedom from external drainage in post-hepatectomy biliary leakage (odds ratio 0.18, 95% confidence interval 0.05-0.65). Conclusions: Initial endoscopic treatment was effective for post-cholecystectomy biliary leakage, while approximately half of the patients with post-hepatectomy biliary leakage required multidisciplinary management. Achieving freedom from external drainage contributes to patients' quality of life and may be a predictor of treatment response after endoscopic therapy for postoperative biliary leakage.
Language	English
Publishing date	2023-08-17
Publishing country	Australia
Document type	Journal Article
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.281
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Article ; Online: Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity.

Okabe, Junya / Kodama, Takahiro / Sato, Yu / Shigeno, Satoshi / Matsumae, Takayuki / Daiku, Kazuma / Sato, Katsuhiko / Yoshioka, Teppei / Shigekawa, Minoru / Higashiguchi, Masaya / Kobayashi, Shogo / Hikita, Hayato / Tatsumi, Tomohide / Okamoto, Toru / Satoh, Takashi / Eguchi, Hidetoshi / Akira, Shizuo / Takehara, Tetsuo

Journal of experimental & clinical cancer research : CR

2023 Volume 42, Issue 1, Page(s) 262

Abstract: Background: Pancreatitis is known to be an important risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the exact molecular mechanisms of how inflammation promotes PDAC are still not fully understood. Regnase-1, an endoribonuclease, ... ...

Abstract	Background: Pancreatitis is known to be an important risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the exact molecular mechanisms of how inflammation promotes PDAC are still not fully understood. Regnase-1, an endoribonuclease, regulates immune responses by degrading mRNAs of inflammation-related genes. Herein, we investigated the role of Regnase-1 in PDAC. Methods: Clinical significance of intratumor Regnase-1 expression was evaluated by immunohistochemistry in 39 surgically-resected PDAC patients. The functional role of Regnase-1 was investigated by pancreas-specific Regnase-1 knockout mice and Kras-mutant Regnase-1 knockout mice. The mechanistic studies with gene silencing, RNA immunoprecipitation sequencing (RIP-seq) and immune cell reconstitution were performed in human/mouse PDAC cell lines and a syngeneic orthotopic tumor transplantation model of KrasG12D-mutant and Trp53-deficient PDAC cells. Results: Regnase-1 expression was negatively correlated with the clinical outcomes and an independent predictor of poor relapse-free and overall survival in PDAC patients. Pancreas-specific Regnase-1 deletion in mice promoteed pancreatic cancer with PMN-MDSC infiltration and shortened their survival. A syngeneic orthotopic PDAC model exhibited that Regnase-1 downregulation accelerated tumor progression via recruitment of intratumor CD11b Conclusions: IL-1b-mediated Regnase-1 downregulation induces MDSCs and promotes pancreatic cancer through the evasion of anticancer immunity.
MeSH term(s)	Animals ; Humans ; Mice ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Down-Regulation ; Inflammation/metabolism ; Mice, Knockout ; Myeloid-Derived Suppressor Cells ; Pancreatic Neoplasms/pathology ; Ribonucleases/genetics ; Pancreatic Neoplasms
Chemical Substances	ZC3H12A protein, human (EC 3.1.-) ; Ribonucleases (EC 3.1.-)
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-023-02831-w
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Zs.A 2065: Show issues

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