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Article ; Online: Sensing its own permeant ion: KCNQ1 channel inhibition by external K.

Barro-Soria, Rene

2023 Volume 155, Issue 5

MeSH term(s)	KCNQ1 Potassium Channel/genetics ; Potassium Channels/physiology ; Potassium Channels, Voltage-Gated
Chemical Substances	KCNQ1 Potassium Channel ; Potassium Channels ; Potassium Channels, Voltage-Gated
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.202313337
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Article ; Online: Hématome spontané du méso de l'angle colique droit et du colon transverse compliquant un traitement par anti vitamine K: à propos d'un cas et revue de la littérature.

Traoré, Ibrahim Alain / Zaré, Cyprien / Barro, Sié Drissa / Guibla, Ismaël

The Pan African medical journal

2016 Volume 23, Page(s) 52

Abstract: ... with vitamin K. We report the case of spontaneous hematoma of right angle of the transverse mesocolon ...

Title translation	Spontaneous hematoma of right angle of the transverse mesocolon: exceptional complication of anticoagulant therapy with vitamin K.
Abstract	Spontaneous hematoma of transverse mesocolon is a rare complication of anticoagulant treatment with vitamin K. We report the case of spontaneous hematoma of right angle of the transverse mesocolon associated with a hemoperitoneum in a 32-year-old patient treated by fluindione for pulmonary embolism. The diagnosis must be made urgently. The abdominal ultrasound and the scanning confirm the diagnosis. It is important to note that surgery is indicated only in the case of complications such as the risk of rupture of the hematoma.
MeSH term(s)	Adult ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Female ; Hematoma/chemically induced ; Hematoma/diagnostic imaging ; Hemoperitoneum/chemically induced ; Hemoperitoneum/diagnostic imaging ; Humans ; Mesocolon/diagnostic imaging ; Mesocolon/pathology ; Phenindione/administration & dosage ; Phenindione/adverse effects ; Phenindione/analogs & derivatives ; Pulmonary Embolism/drug therapy ; Vitamin K/antagonists & inhibitors
Chemical Substances	Anticoagulants ; Vitamin K (12001-79-5) ; Phenindione (5M7Y6274ZE) ; fluindione (EQ35YMS20Q)
Language	French
Publishing date	2016
Publishing country	Uganda
Document type	Case Reports ; Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2016.23.52.8231
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Article ; Online: Hématome spontané du méso de l'angle colique droit et du colon transverse compliquant un traitement par anti vitamine K

Ibrahim Alain Traoré / Cyprien Zaré / Sié Drissa Barro / Ismaél

The Pan African Medical Journal, Vol 23, Iss

à propos d'un cas et revue de la littérature

2016 Volume 52

Abstract: ... du traitement anticoagulant par antivitamine K. Nous rapportons un cas d'hématome spontané du méso de l'angle ... par antivitamine K pour embolie pulmonaire consécutive à une fracture des plateaux tibiaux droits. Le diagnostic ...

Abstract	L'hématome spontané du méso de l'angle colique droit et du transverse est une complication rare du traitement anticoagulant par antivitamine K. Nous rapportons un cas d'hématome spontané du méso de l'angle colique droit et du transverse associé à un hémopéritoine de grande abondance chez un patient traité par antivitamine K pour embolie pulmonaire consécutive à une fracture des plateaux tibiaux droits. Le diagnostic doit être fait en urgence. L'échographie abdominale et la tomodensitométrie confirment le diagnostic. Le traitement non opératoire est la règle. Le traitement chirurgical est indiqué en cas de complications telles que la rupture de l'hématome.
Keywords	hématome ; anticoagulant ; hémopéritoine ; Medicine ; R
Language	English
Publishing date	2016-02-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Antiplasmodial activity of alkaloid extracts from Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC), two plants used in traditional medicine in Burkina Faso.

Sanon, S / Azas, N / Gasquet, M / Ollivier, E / Mahiou, V / Barro, N / Cuzin-Ouattara, N / Traore, A S / Esposito, F / Balansard, G / Timon-David, P

Parasitology research

2003 Volume 90, Issue 4, Page(s) 314–317

Abstract: ... study: Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC). Alkaloid extracts of these plants ...

Abstract	In the course of the search for new antimalarial compounds, a study of plants traditionally used against malaria in Burkina Faso was made. An ethnobotanical study permitted the identification of plants currently used by the traditional healers and herbalists. Two plants among them were selected for further study: Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC). Alkaloid extracts of these plants were tested in vitro against two reference clones of Plasmodium falciparum: the W2 chloroquine-resistant and the D6 chloroquine-sensitive strains. Significant inhibitory activity was observed with Pavetta crassipes (IC(50)=1.23 microg/ml) and A. hispidum (IC(50)=5.02 microg/ml). Antiplasmodial activity was also evaluated against six Plasmodium falciparum isolates from children between 4 and 10 years old. The IC(50) values for the alkaloid extracts were in the range 25-670 ng/ml. These results indicated that P. falciparum wild strains were more sensitive to the alkaloid extracts than strains maintained in continuous culture. Moreover, the alkaloid extracts exhibit good in vitro antimalarial activity and weak cytotoxicity against three human cell lines (THP1, normal melanocytes, HTB-66). Isolation and structural determination are now necessary in order to precisely determine the active compounds.
MeSH term(s)	Alkaloids/pharmacology ; Animals ; Antimalarials/pharmacology ; Asteraceae/chemistry ; Burkina Faso ; Cell Line ; Child ; Child, Preschool ; Chloroquine/pharmacology ; Drug Resistance ; Humans ; Inhibitory Concentration 50 ; Malaria, Falciparum/parasitology ; Medicine, African Traditional ; Parasitic Sensitivity Tests ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/isolation & purification ; Rubiaceae/chemistry
Chemical Substances	Alkaloids ; Antimalarials ; Plant Extracts ; Chloroquine (886U3H6UFF)
Language	English
Publishing date	2003-07
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-003-0859-9
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Article: Fuzzy K-nearest neighbor classifiers for ventricular arrhythmia detection.

Cabello, D / Barro, S / Salceda, J M / Ruiz, R / Mira, J

International journal of bio-medical computing

1991 Volume 27, Issue 2, Page(s) 77–93

Abstract: We report a study of the efficiency of 4 classifiers (the K-nearest-neighbor and single-nearest ... were then applied to the test set. Optimal K for K-nearest-neighbor algorithms and optimal cluster ... performed correspondingly with an overall empirical error ratio of just 0.10 for the K-nearest-neighbor ...

Abstract	We report a study of the efficiency of 4 classifiers (the K-nearest-neighbor and single-nearest-prototype algorithms, each as parametrized by both Fuzzy C-Means and Fuzzy Covariance clustering) in the detection of ventricular arrhythmias in ECG traces characterized by 4 features derived from 7 spectral parameters. Principal components analysis was used in conjunction with a cardiologist's deterministic classification of 90 ECG traces to fix the number of trace classes to 5 (ventricular fibrillation/flutter, sinus rhythm, ventricular rhythms with aberrant complexes and 2 classes of artefact). Forty of the 90 traces were then defined as a test set; 5 different learning sets (numbering 25, 30, 35, 40 and 45 traces) were randomly selected from the remaining 50 traces; each learning set was used to parametrize both the classification algorithms using both fuzzy clustering algorithms and the parametrized classification algorithms were then applied to the test set. Optimal K for K-nearest-neighbor algorithms and optimal cluster volumes for Fuzzy Covariance algorithms were sought by trial and error to minimize classification differences with respect to the cardiologist's classification. Fuzzy Covariance clustering afforded significantly better perception of cluster structure than the Fuzzy C-Means algorithm, and the classifiers performed correspondingly with an overall empirical error ratio of just 0.10 for the K-nearest-neighbor algorithm parametrized by Fuzzy Covariance.
MeSH term(s)	Algorithms ; Arrhythmias, Cardiac/diagnosis ; Artificial Intelligence ; Diagnosis, Computer-Assisted ; Electrocardiography/methods ; Heart Ventricles ; Humans ; Reproducibility of Results ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted
Language	English
Publishing date	1991-02
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80151-3
ISSN	1878-366X ; 0020-7101
ISSN (online)	1878-366X
ISSN	0020-7101
DOI	10.1016/0020-7101(91)90089-w
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Article ; Online: Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls.

Bavato, Francesco / Barro, Christian / Schnider, Laura K / Simrén, Joel / Zetterberg, Henrik / Seifritz, Erich / Quednow, Boris B

Molecular psychiatry

2024

Abstract: The recent introduction of new-generation immunoassay methods allows the reliable quantification of structural brain markers in peripheral matrices. Neurofilament light chain (NfL), a neuron-specific cytoskeletal component released in extracellular ... ...

Abstract	The recent introduction of new-generation immunoassay methods allows the reliable quantification of structural brain markers in peripheral matrices. Neurofilament light chain (NfL), a neuron-specific cytoskeletal component released in extracellular matrices after neuroaxonal impairment, is considered a promising blood marker of active brain pathology. Given its sensitivity to a wide range of neuropathological alterations, NfL has been suggested for the use in clinical practice as a highly sensitive, but unspecific tool to quantify active brain pathology. While large efforts have been put in characterizing its clinical profile in many neurological conditions, NfL has received far less attention as a potential biomarker in major psychiatric disorders. Therefore, we briefly introduce NfL as a marker of neuroaxonal injury, systematically review recent findings on cerebrospinal fluid and blood NfL levels in patients with primary psychiatric conditions and highlight the opportunities and pitfalls. Current evidence suggests an elevation of blood NfL levels in patients with major depression, bipolar disorder, psychotic disorders, anorexia nervosa, and substance use disorders compared to physiological states. However, blood NfL levels strongly vary across diagnostic entities, clinical stage, and patient subgroups, and are influenced by several demographic, clinical, and analytical factors, which require accurate characterization. Potential clinical applications of NfL measure in psychiatry are seen in diagnostic and prognostic algorithms, to exclude neurodegenerative disease, in the assessment of brain toxicity for different pharmacological compounds, and in the longitudinal monitoring of treatment response. The high inter-individual variability of NfL levels and the lack of neurobiological understanding of its release are some of the main current limitations. Overall, this primer aims to introduce researchers and clinicians to NfL measure in the psychiatric field and to provide a conceptual framework for future research directions.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-024-02524-6
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Article: Gestion de l’épidémie de la COVID-19 par les établissements publics de santé — analyse de la Fédération hospitalière de France.

Barro, K / Malone, A / Mokede, A / Chevance, C

Journal de chirurgie viscerale

2020 Volume 157, Issue 3, Page(s) S20–S24

Abstract: The objective of this article is to detail the measures taken in public institutions to cope with the COVID-19 epidemic. It details the initial strategy, organizational evolution towards "all-COVID", coordination between the various stakeholders and the ... ...

Title translation	Management of the COVID-19 epidemic by public health establishments - Analysis by the Fédération hospitalière de France.
Abstract	The objective of this article is to detail the measures taken in public institutions to cope with the COVID-19 epidemic. It details the initial strategy, organizational evolution towards "all-COVID", coordination between the various stakeholders and the strategy for maintaining continuity of care. The Quebec experience is also used as an example. Finally, an exit strategy must be anticipated at this phase of the epidemic.
Keywords	covid19
Language	French
Publishing date	2020-04-18
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2541648-0
ISSN	1878-786X ; 0021-7697
ISSN	1878-786X ; 0021-7697
DOI	10.1016/j.jchirv.2020.04.009
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Article ; Online: Management of the COVID-19 epidemic by public health establishments-Analysis by the Fédération Hospitalière de France.

Barro, K / Malone, A / Mokede, A / Chevance, C

Journal of visceral surgery

2020 Volume 157, Issue 3S1, Page(s) S19–S23

Abstract	The objective of this article is to detail the measures taken in public institutions to cope with the COVID-19 epidemic. It details the initial strategy, organizational evolution towards "all-COVID", coordination between the various stakeholders and the strategy for maintaining continuity of care. The Quebec experience is also used as an example. Finally, an exit strategy must be anticipated at this phase of the epidemic.
MeSH term(s)	COVID-19 ; Continuity of Patient Care ; Coronavirus Infections/therapy ; France ; Hospitals, Public/organization & administration ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; Public Health ; Quality of Health Care ; Quebec ; Societies, Hospital
Keywords	covid19
Language	English
Publishing date	2020-04-18
Publishing country	France
Document type	Journal Article
ISSN	1878-7886
ISSN (online)	1878-7886
DOI	10.1016/j.jviscsurg.2020.04.011
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Article ; Online: Total hip arthroplasty associated with transverse subtrochanteric shortening osteotomy and conical stem fixation in Crowe type IV hip dysplasia.

Mimendia, I / Lakhani, K / Núñez, J H / Barro, V / Guerra-Farfán, E / Collado, D / Hernández, A

Musculoskeletal surgery

2023 Volume 107, Issue 3, Page(s) 367–372

Abstract: Purpose: Total hip arthroplasty (THA) in high-dislocated hip dysplasia is a surgical challenge, presenting difficulties in the biomechanical reconstruction of the hip. The purpose of the present study is to analyze clinical and radiological outcomes of ... ...

Abstract	Purpose: Total hip arthroplasty (THA) in high-dislocated hip dysplasia is a surgical challenge, presenting difficulties in the biomechanical reconstruction of the hip. The purpose of the present study is to analyze clinical and radiological outcomes of a series of patients with Crowe type IV hip dysplasia who underwent a THA with transverse subtrochanteric shortening osteotomy and conical stem fixation in our Hip surgery unit. Methods: This non-interventional retrospective study included all patients diagnosed with Crowe type IV hip dysplasia who underwent a THA using a subtrochanteric shortening osteotomy and uncemented conical stem fixation between January 1, 2008, and December 31, 2015. Demographic, clinical and radiologic data were analyzed, including Harris Hip Score and Oxford Hip Score. Results: Seventeen hips in 13 patients were included in the final analysis. All patients were women and mean age was 39 years (range 35-45). Mean follow-up was 5.6 years (range 1-8). Average length of the osteotomy was 3.4 cm (range 3-4.5) and mean lowering of the center of rotation was 5.67 cm (range 3.8-9.1). Mean time for bone union was 5.5 months. No nerve palsy or non-union was detected at the end of follow-up period. Conclusion: The use of cementless conical stem fixation associated with a transverse subtrochanteric shortening osteotomy for treating Crowe type IV hip dysplasia permits to correct the rotational alterations of the femur and provides good stability of the osteotomy, with very low risk of nerve palsy and non-union rates.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Male ; Arthroplasty, Replacement, Hip/adverse effects ; Hip Dislocation/surgery ; Retrospective Studies ; Hip Dislocation, Congenital/diagnostic imaging ; Hip Dislocation, Congenital/surgery ; Hip Dislocation, Congenital/etiology ; Femur/diagnostic imaging ; Femur/surgery ; Osteotomy ; Follow-Up Studies
Language	English
Publishing date	2023-03-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2495458-5
ISSN	2035-5114 ; 2035-5106
ISSN (online)	2035-5114
ISSN	2035-5106
DOI	10.1007/s12306-023-00779-w
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Article ; Online: Setting up a Video Transmission Tool for Teleconsultation and Tele-Expertise in an African Context: Case of Burkina Faso.

Barro, Seydou Golo / Kambire, Jonathan Gaius / Kantagba, Yves M K / Karambiri, Daniel / Ouattara, Thomas A / Ougda, Chams Nour / Staccini, Pascal

Studies in health technology and informatics

2023 Volume 309, Page(s) 194–198

Abstract: Since the COVID-19 health crisis, telemedicine has received a lot of attention around the world. Following attempts to set up a telemedicine system, in particular teleconsultation and teleexpertise, which proved inconclusive in Burkina, we have seen ... ...

Abstract	Since the COVID-19 health crisis, telemedicine has received a lot of attention around the world. Following attempts to set up a telemedicine system, in particular teleconsultation and teleexpertise, which proved inconclusive in Burkina, we have seen several technologies and tools that could enable the implementation of a telemedicine solution that meets the realities of Burkina Faso. The results of the study of the existing system and interviews with health professionals have made it possible to design a telemedicine platform combining a scalable video-transmission tool adapted to the country's health system.
MeSH term(s)	Humans ; Remote Consultation ; Burkina Faso ; Telemedicine ; Health Personnel ; Palliative Care
Language	English
Publishing date	2023-10-06
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230777
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