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  1. Article ; Online: Zipper Method of Hacettepe: A Promising Method of Immunomodulation.

    Bayrakci, Benan / Kesici, Selman

    Journal of child neurology

    2020  Volume 35, Issue 5, Page(s) 344–345

    MeSH term(s) Humans ; Immunomodulation
    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639288-x
    ISSN 1708-8283 ; 0883-0738
    ISSN (online) 1708-8283
    ISSN 0883-0738
    DOI 10.1177/0883073819900718
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    Zs.A 2301: Show issues Location:
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  2. Article ; Online: Intravenous Lipid Emulsion Treatment for Calcium-Channel Blocker Intoxication: Pediatric Case Series and Review of the Literature.

    Katlan, Banu / Kesici, Selman / Bayrakci, Benan

    Pediatric emergency care

    2022  Volume 39, Issue 3, Page(s) 120–124

    Abstract: Background: Calcium-channel blocker (CCBs) intoxication remains the most lethal among all other drug overdoses (Arroyo and Kao. Pediatr Emerg Care 2009;25:533-538). This study aimed to describe the use and efficacy of intravenous lipid emulsion ... ...

    Abstract Background: Calcium-channel blocker (CCBs) intoxication remains the most lethal among all other drug overdoses (Arroyo and Kao. Pediatr Emerg Care 2009;25:533-538). This study aimed to describe the use and efficacy of intravenous lipid emulsion treatment in our CCB overdose patients in tandem with a comprehensive literature investigation.
    Case reports: Hereby we report 4 adolescent patients who arrived to the pediatric emergency department after intentional CCB ingestions. All patients were hospitalized in pediatric intensive care unit because of hypotension, and they were initially treated with fluid boluses, glucagon, calcium infusion, vasopressors, inotropes and insulin. Intravenous lipid emulsion (dose: 20% lipid emulsion given as a 1.5-mL/kg bolus followed by 0.25-0.5 mL/kg/min for 30-60 minutes) treatment was given to all patients unresponsive to initial treatments. Hemodynamic instability improved immediately after intravenous lipid emulsion treatment. All patients were discharged with complete recovery at the sixth day of pediatric intensive care unit admission.
    Conclusions: Intravenous lipid emulsion therapy stands as a salvage treatment for CCB intoxications with cardiovascular failure unresponsive to standard supportive treatments.
    MeSH term(s) Adolescent ; Humans ; Child ; Calcium Channel Blockers ; Fat Emulsions, Intravenous/therapeutic use ; Calcium ; Drug Overdose/drug therapy ; Insulin/therapeutic use
    Chemical Substances Calcium Channel Blockers ; Fat Emulsions, Intravenous ; Calcium (SY7Q814VUP) ; Insulin
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000002703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2083: Show issues Location:
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  3. Article ; Online: Zipper method is the emerging treatment option for severe Guillain-Barre syndrome related COVID-19.

    Saritas Nakip, Ozlem / Kesici, Selman / Bayrakci, Benan

    Autoimmunity reviews

    2021  Volume 20, Issue 7, Page(s) 102841

    MeSH term(s) COVID-19 ; Cytokine Release Syndrome ; Guillain-Barre Syndrome/therapy ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-05-08
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2021.102841
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    Zs.A 5913: Show issues Location:
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  4. Article ; Online: Impact of Leadership of Trained Intensivist in Pediatric Intensive Care Unit in a Middle Income Country: An Uncontrolled Before-After Study.

    Kesici, Selman / Bayrakci, Benan

    Indian journal of pediatrics

    2020  Volume 87, Issue 4, Page(s) 262–267

    Abstract: Objective: To evaluate the effects generated by an intensivist in pediatric intensive care unit (PICU) on the process of care and patient outcomes.: Methods: This study was a retrospective observational study conducted in the 16-bedded PICU of a ... ...

    Abstract Objective: To evaluate the effects generated by an intensivist in pediatric intensive care unit (PICU) on the process of care and patient outcomes.
    Methods: This study was a retrospective observational study conducted in the 16-bedded PICU of a tertiary referral center. Two years (2013-2015) period of the PICU without an intensivist and the following two years (2015-2017) when it was attended by an intensivist who was also the first ever graduate of the fellowship program in Turkey were compared.
    Results: Number of patients followed in PICU increased more than 2-fold. Number of mechanically ventilated patients increased more than 2-folds and presence of intensivist reduced the mechanical ventilation duration by 59%. Presence of intensivist reduced the mortality rates by 2.18 times. It was shown that management of PICU beds by an intensivist resulted in increased number of patients per year per PICU bed, increased care of true critical care patients who are in need of more intensive therapies and invasive procedures including extracorporeal treatment options, decreased length of stay, decreased number and rate of nosocomial infections, and decreased mortality rate.
    Conclusions: What transforms a unit full of critically ill patients to an intensive care unit is a dedicated intensivist. The current study demonstrated that intensivist is the crucial component of the PICUs.
    MeSH term(s) Child ; Controlled Before-After Studies ; Humans ; Intensive Care Units, Pediatric ; Leadership ; Length of Stay ; Retrospective Studies ; Turkey
    Keywords covid19
    Language English
    Publishing date 2020-01-10
    Publishing country India
    Document type Journal Article ; Observational Study
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-019-03154-5
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    Zs.A 826: Show issues Location:
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  5. Article ; Online: Concomitant use of surfactant and extra-corporeal membrane oxygenation for COVID-19 in an 8-year-old boy.

    Katlan, Banu / Kesici, Selman / Bayrakci, Benan

    Minerva cardiology and angiology

    2021  Volume 69, Issue 5, Page(s) 620–621

    MeSH term(s) COVID-19 ; Child ; Extracorporeal Membrane Oxygenation ; Humans ; Male ; Pulmonary Surfactants ; SARS-CoV-2 ; Surface-Active Agents
    Chemical Substances Pulmonary Surfactants ; Surface-Active Agents
    Language English
    Publishing date 2021-04-07
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 3059238-0
    ISSN 2724-5772
    ISSN (online) 2724-5772
    DOI 10.23736/S2724-5683.21.05374-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 14: Show issues Location:
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  6. Article: Apnea Test on Extracorporeal Membrane Oxygenation: Step Forward with Carbon Dioxide.

    Nakip, Ozlem Saritas / Kesici, Selman / Terzi, Kivanc / Bayrakci, Benan

    The journal of extra-corporeal technology

    2022  Volume 54, Issue 1, Page(s) 83–87

    Abstract: Apnea test must be performed to confirm brain death in patients meet clinical criteria. But the increment of carbon dioxide is generally not achievable because of the diminished production of carbon dioxide and additional sweep in extra corporeal ... ...

    Abstract Apnea test must be performed to confirm brain death in patients meet clinical criteria. But the increment of carbon dioxide is generally not achievable because of the diminished production of carbon dioxide and additional sweep in extra corporeal membrane oxygenation (ECMO). We report three children with congenital heart disease treated with ECMO and had brain death during follow-up. All met clinical criteria but apnea test cannot be achieved in classical way because of prolonged duration and hemodynamic compromise. Therefore, we used external carbon dioxide to achieve desired levels of oxygen and carbon dioxide safely. Because of the lack of protocols for pediatric patients on ECMO, apnea test with exogenous carbon dioxide may be a reliable and rapid test in such patients. Especially cardiac patients, in whom classical apnea test can cause rapid deterioration, exogenous carbon dioxide may serve as an alternative.
    MeSH term(s) Humans ; Child ; Extracorporeal Membrane Oxygenation/methods ; Brain Death ; Carbon Dioxide ; Apnea/diagnosis ; Apnea/therapy ; Oxygen
    Chemical Substances Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 390977-3
    ISSN 0022-1058
    ISSN 0022-1058
    DOI 10.1182/ject-83-87
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    Zs.B 2148: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Fatal thrombotic microangiopathy in an infant with COVID-19: a case report.

    Nakip, Özlem Sarıtaş / Kesici, Selman / Terzi, Kıvanç / Orhan, Diclehan / Bayrakcı, Benan

    The Turkish journal of pediatrics

    2023  Volume 65, Issue 4, Page(s) 667–671

    Abstract: Background: While macrovascular thrombosis is common in adult COVID-19 patients, thrombotic microangiopathy as a part of endothelitis might play an important role in severe organ dysfunction. Thrombocytopenia-associated multiple organ failure (TAMOF) is ...

    Abstract Background: While macrovascular thrombosis is common in adult COVID-19 patients, thrombotic microangiopathy as a part of endothelitis might play an important role in severe organ dysfunction. Thrombocytopenia-associated multiple organ failure (TAMOF) is a thrombotic microangiopathy syndrome that is associated with endothelial damage. Herein, we aim to report a pediatric TAMOF case related to SARS-CoV-2 infection which has been scarcely reported to date.
    Case: A 7-month-old boy who became severely ill after being infected with SARS-CoV-2 required advanced critical care treatments such as continuous renal replacement therapy, therapeutic plasma exchange, and extracorporeal membrane oxygenation. A heart and lung biopsy obtained during sternotomy showed thrombotic microangiopathy. Despite early plasma exchange, mortality was inevitable because of severe liver failure.
    Conclusions: This case report implies that SARS-CoV-2 infection could cause TAMOF in children. To the best of our knowledge, this is the second SARS-CoV-2-induced pediatric TAMOF case. More studies are needed to determine alternative treatments for patients with TAMOF who are resistant to conventional therapies.
    MeSH term(s) Adult ; Male ; Humans ; Infant ; Child ; COVID-19/complications ; SARS-CoV-2 ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/etiology ; Thrombotic Microangiopathies/therapy ; Multiple Organ Failure/etiology ; Multiple Organ Failure/therapy ; Plasma Exchange
    Language English
    Publishing date 2023-09-04
    Publishing country Turkey
    Document type Case Reports
    ZDB-ID 123487-0
    ISSN 2791-6421 ; 0041-4301
    ISSN (online) 2791-6421
    ISSN 0041-4301
    DOI 10.24953/turkjped.2022.1150
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    Zs.B 988: Show issues Location:
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  8. Article ; Online: Physiological advantages of children against COVID-19.

    Yavuz, Sinan / Kesici, Selman / Bayrakci, Benan

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 109, Issue 8, Page(s) 1691

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country Norway
    Document type Letter ; Comment
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15410
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    Um IV Zs.95: Show issues Location:
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  9. Article ; Online: Optic nerve sheath diameter and pulsatility index for the diagnosis and follow-up in pediatric traumatic brain injury: a prospective observational cohort study.

    Saritas Nakip, Ozlem / Pektezel, Mehmet Yasir / Terzi, Kivanc / Kesici, Selman / Bayrakci, Benan

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Volume 39, Issue 9, Page(s) 2467–2477

    Abstract: Purpose: Invasive neuromonitoring could be difficult in children with traumatic brain injury (TBI). This study aimed to determine whether noninvasive intracranial pressure (nICP), calculated via pulsatility index (PI) and optic nerve sheath diameter ( ... ...

    Abstract Purpose: Invasive neuromonitoring could be difficult in children with traumatic brain injury (TBI). This study aimed to determine whether noninvasive intracranial pressure (nICP), calculated via pulsatility index (PI) and optic nerve sheath diameter (ONSD) had correlated with each other and patient outcome.
    Methods: All moderate-severe TBI patients were eligible. Patients with a diagnosis of intoxication that did not affect the mental status or cardiovascular system were enrolled as controls. The PI measurements were routinely performed bilaterally on the middle cerebral artery. A software (QLAB's Q-Apps) was used to calculate PI, which further placed the ICP equation of Bellner et al. Linear probe with a 10 MHz frequency transducer to measure ONSD, which further placed the ICP equation of Robba et al. All measurements were performed by a point-of-care ultrasound certified pediatric intensivist under the supervision of a neurocritical care specialist, before and 30 min after a hypertonic saline (HTS) infusion for every 6 h when the patient's mean arterial pressure, heart rate, body temperature, hemoglobin, and blood CO
    Results: Twenty-five TBI patients (200 measurements) and 19 controls (57 measurements) were included. Median nICP-PI and nICP-ONSD on admission were significantly higher in the TBI group (11.03 (9.98-12.63), p = 0.004, and 13.14 (12.27-14.64), p < 0.001, respectively). Median nICP-ONSD of severe TBI patients were higher than moderate TBI patients (13.58 (13.14-15.71) and 12.30 (9.83-13.14), respectively, p = 0.013). The median nICP-PI was the same across the type of injury (falls and motor vehicle accidents), while the median nICP-ONSD of the motor vehicle accident group was higher than falls. The first nICP-PI and nICP-ONSD measurements in PICU and admission pGCS were negatively correlated (r =  - 0.562, p = 0.003 and r =  - 0.582, p = 0.002, respectively). The mean nICP-ONSD during the study period and admission pGCS and GOS-E peds score significantly correlated. However, the Bland-Altman plots showed significant bias between the two methods of ICP except after 5th dose of HTS. All nICP values significantly decreased in time, and it was most obvious after the 5th dose of HTS. No significant correlations were found between delta sodium levels and nICP.
    Conclusion: Noninvasive estimation of ICP is helpful for the management of pediatric severe TBI patients. nICP driven by ONSD is more consistent with clinical findings of increased ICP but not useful as a follow-up tool in acute management because of slow circulation of CSF around the optic sheath. The correlation between admission GCS scores and GOS-E peds score favors ONSD as a good candidate for determining disease severity and predicting long-term outcomes.
    MeSH term(s) Humans ; Child ; Prospective Studies ; Follow-Up Studies ; Intracranial Hypertension/diagnosis ; Intracranial Hypertension/etiology ; Optic Nerve/diagnostic imaging ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/complications ; Ultrasonography/adverse effects ; Intracranial Pressure/physiology
    Language English
    Publishing date 2023-04-26
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-05959-4
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    Zs.A 2036: Show issues Location:
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  10. Article ; Online: Get rid of the bad first: Therapeutic plasma exchange with convalescent plasma for severe COVID-19.

    Kesici, Selman / Yavuz, Sinan / Bayrakci, Benan

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 23, Page(s) 12526–12527

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Immunization, Passive ; Pandemics ; Plasma Exchange ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2006691117
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