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  1. Article: A Case of Diabetic Ketoacidosis Complicated With Necrotizing Esophagitis.

    Kawashima, Shumei / Abe, Hironori / Shimizu, Norihiro / Shikuma, Junpei / Suzuki, Ryo

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52871

    Abstract: Acute necrotizing esophagitis (ANE) is known as the "black esophagus." We present a case of ANE in a patient with slowly progressive type 1 diabetes mellitus. A 49-year-old man presented with vomiting, characterized by coffee residue-like emesis, and was ...

    Abstract Acute necrotizing esophagitis (ANE) is known as the "black esophagus." We present a case of ANE in a patient with slowly progressive type 1 diabetes mellitus. A 49-year-old man presented with vomiting, characterized by coffee residue-like emesis, and was diagnosed with diabetic ketoacidosis. Upper gastrointestinal endoscopy revealed black mucosa extending from the middle of the esophagus to the gastric junction, leading to a diagnosis of ANE. The patient was treated with proton pump inhibitors and showed marked improvement. The patient was discharged on the 20th day of illness.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52871
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  2. Article ; Online: Distribution of Signal Peptides in Microvesicles from Activated Macrophage Cells.

    Ono, Kenji / Sato, Junpei / Suzuki, Hiromi / Sawada, Makoto

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Extracellular vesicles, such as microvesicles (LEV) and exosomes (SEV), play an important role in intercellular signaling by encapsulating functional molecules and delivering them to specific cells. Recent studies showed that signal peptides (SPs), which ...

    Abstract Extracellular vesicles, such as microvesicles (LEV) and exosomes (SEV), play an important role in intercellular signaling by encapsulating functional molecules and delivering them to specific cells. Recent studies showed that signal peptides (SPs), which are derived from sequences at the N-terminal of newly synthesized proteins, exhibited biological activity in the extracellular fluid. We previously reported that SPs were secreted into the extracellular fluid via SEV; however, it remains unclear whether the release of SPs occurs via LEV. In the present study, we demonstrated that SP fragments from human placental secreted alkaline phosphatase (SEAP) were present in LEV as well as SEV released from RAW-Blue cells, which stably express an NF-κB-inducible SEAP reporter. When RAW-Blue cells were treated with LPS at 0-10,000 ng/mL, SEAP SP fragments per particle were more abundant in LEV than in SEV, with fragments in LEV and SEV reaching a maximum at 1000 and 100 ng/mL, respectively. The content of SEAP SP fragments in LEV from IFNγ-stimulated RAW-Blue cells was higher than those from TNFα-stimulated cells, whereas that in SEV from TNFα-stimulated RAW-Blue cells was higher than those from IFNγ-stimulated cells. Moreover, the content of SEAP SP fragments in LEV and SEV decreased in the presence of W13, a calmodulin inhibitor. Collectively, these results indicate that the transportation of SP fragments to extracellular vesicles was changed by cellular activation, and calmodulin was involved in their transportation to LEV and SEV.
    MeSH term(s) Female ; Pregnancy ; Humans ; Tumor Necrosis Factor-alpha ; Protein Sorting Signals ; Calmodulin ; Placenta ; Macrophages ; Extracellular Vesicles
    Chemical Substances Tumor Necrosis Factor-alpha ; Protein Sorting Signals ; Calmodulin
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512131
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  3. Article ; Online: Contribution of prophylactic administration of flurbiprofen for mesenteric traction syndrome to postoperative leakage or bleeding in gastrointestinal surgery: a retrospective observational study.

    Suzuki, Manzo / Shibata, Junpei / Mochizuki, Toshiaki / Bito, Hiroyasu

    Langenbeck's archives of surgery

    2023  Volume 408, Issue 1, Page(s) 337

    Abstract: Purpose: Mesenteric traction syndrome (MTS) sometimes occurs during abdominal surgery. Prophylactic administration of flurbiprofen, a non-steroidal anti-inflammatory drug, prevents the development of MTS. However, administration of non-steroidal anti- ... ...

    Abstract Purpose: Mesenteric traction syndrome (MTS) sometimes occurs during abdominal surgery. Prophylactic administration of flurbiprofen, a non-steroidal anti-inflammatory drug, prevents the development of MTS. However, administration of non-steroidal anti-inflammatory drugs for postoperative pain increases the incidence of postoperative bleeding. Our aim was to examine the effect of prophylactic flurbiprofen administration on postoperative leakage or bleeding after gastrointestinal surgery.
    Methods: A retrospective observational study on patients who underwent open or laparoscopic abdominal surgery was conducted. Perioperative, anesthesia and medical records were reviewed. Patients who did (Flurbio-Group) or did not receive (Control-Group) prophylactic flurbiprofen administration were compared. Then, the Flurbio-Group and Control-Group were each divided into two groups according to whether the patients did or did not develop MTS (Flurbio-MTS-Group and Flurbio-no-MTS-Group, respectively, Control-MTS-Group and Control-no-MTS-Group, respectively).
    Results: This study included 188 patients (Flurbio-MTS-Group, 1 patient; Flurbio-no-MTS-Group, 31 patients; Control-MTS-Group, 59 patients; Control-no-MTS-Group, 97 patients). Seventeen patients developed postoperative leakage or bleeding. Eleven Flurbio-MTS-Group patients (18.6%), 4 Flurbio-no-MTS-Group patients (12.9%, 4/31), and only 2 Control-no-MTS-Group patients (2%, 2/97) developed postoperative leakage or bleeding. Multivariate logistic regression analysis demonstrated that there was a qualitative interaction effect between prophylactic administration of flurbiprofen and the development of MTS on postoperative leakage or bleeding.
    Conclusion: Prophylactic flurbiprofen administration increased the risk of postoperative leakage or bleeding among patients who did not develop MTS.
    MeSH term(s) Humans ; Flurbiprofen/administration & dosage ; Flurbiprofen/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Pain, Postoperative/drug therapy ; Retrospective Studies ; Postoperative Hemorrhage/chemically induced ; Incidence ; Postoperative Complications ; Abdomen/surgery ; Laparoscopy
    Chemical Substances Flurbiprofen (5GRO578KLP) ; Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2023-08-26
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-023-03077-y
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Successful introduction of sensor-augmented pump therapy in a patient with diabetes and needle phobia: A case report.

    Sugai, Keiji / Shikuma, Junpei / Hiroike, Satoshi / Abe, Hironori / Suzuki, Ryo

    Journal of diabetes investigation

    2023  Volume 14, Issue 11, Page(s) 1318–1320

    Abstract: Needle phobia is a specific phobia classified as an anxiety disorder in the Diagnostic and Statistical Manual of Mental Disorders-5, and can be a serious problem for patients requiring insulin injections. However, there have been few reports to date on ... ...

    Abstract Needle phobia is a specific phobia classified as an anxiety disorder in the Diagnostic and Statistical Manual of Mental Disorders-5, and can be a serious problem for patients requiring insulin injections. However, there have been few reports to date on the management of adults with diabetes and needle phobia. We here report a case of a woman with pancreatic diabetes who developed needle phobia and could no longer perform self-injections. She started to use a sensor-augmented pump (SAP), and was able to perform a puncture for the insulin pump and the continuous glucose monitoring sensor by herself. The SAP treatment achieved self-management, better glycemic control, and high treatment satisfaction quantified using the Diabetes Treatment Satisfaction Questionnaire in this patient. Our case suggests the therapeutic potential of SAP in adults with needle phobia and diabetes requiring insulin therapy.
    MeSH term(s) Adult ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 1/drug therapy ; Blood Glucose ; Blood Glucose Self-Monitoring ; Insulin/therapeutic use ; Phobic Disorders/drug therapy
    Chemical Substances Hypoglycemic Agents ; Blood Glucose ; Insulin
    Language English
    Publishing date 2023-07-26
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14061
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: A new hexactinellid-sponge-associated zoantharian (Porifera, Hexasterophora) from the northwestern Pacific Ocean.

    Kise, Hiroki / Nishijima, Miyuki / Iguchi, Akira / Minatoya, Junpei / Yokooka, Hiroyuki / Ise, Yuji / Suzuki, Atsushi

    ZooKeys

    2023  Volume 1156, Page(s) 71–85

    Abstract: Symbiotic associations between zoantharians and sponges can be divided into two groups: those that associate with Demospongiae and those that associate with Hexactinellida. ...

    Abstract Symbiotic associations between zoantharians and sponges can be divided into two groups: those that associate with Demospongiae and those that associate with Hexactinellida.
    Language English
    Publishing date 2023-03-24
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2445640-8
    ISSN 1313-2970 ; 1313-2989
    ISSN (online) 1313-2970
    ISSN 1313-2989
    DOI 10.3897/zookeys.1156.96698
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  6. Article ; Online: Senescent CD8

    Kakuda, Toshio / Suzuki, Junpei / Matsuoka, Yuko / Kikugawa, Tadahiko / Saika, Takashi / Yamashita, Masakatsu

    Cancer science

    2023  Volume 114, Issue 7, Page(s) 2810–2820

    Abstract: It has been suggested that aging of the immune system (immunosenescence) results in a decline in the acquired immune response, which is associated with an increase in age-related tumorigenesis. T-cell senescence plays a critical role in immunosenescence ... ...

    Abstract It has been suggested that aging of the immune system (immunosenescence) results in a decline in the acquired immune response, which is associated with an increase in age-related tumorigenesis. T-cell senescence plays a critical role in immunosenescence and is involved in the age-related decline of the immune function, which increases susceptibility to certain cancers. However, it has been shown that CD8
    MeSH term(s) Mice ; Animals ; CD8-Positive T-Lymphocytes ; Killer Cells, Natural ; Adaptive Immunity ; Melanoma, Experimental/metabolism ; Aging
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.15824
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  7. Article ; Online: Relationship between salivary alpha-amylase activity and pain relief scale score after low level laser therapy: a prospective interventional pilot study.

    Iida, Ryoji / Konishi, Junpei / Suzuki, Takahiro

    Lasers in medical science

    2021  Volume 37, Issue 1, Page(s) 681–686

    MeSH term(s) Humans ; Low-Level Light Therapy ; Pain/radiotherapy ; Pilot Projects ; Prospective Studies ; Saliva ; Salivary alpha-Amylases
    Chemical Substances Salivary alpha-Amylases (EC 3.2.1.1)
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-020-03217-6
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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Interstitial lung disease with prolonged fever that occurred during long-term administration of olaparib in a 74-year-old ovarian cancer patient: Radiological features and considerations for preventing delayed diagnosis.

    Saito, Yoshinobu / Yamaguchi, Rei / Suzuki, Takahiro / Sato, Junpei / Nishijima, Nobuhiko / Saito, Sho / Aoyama, Junichi / Taniuchi, Namiko / Seike, Masahiro / Katsumata, Noriyuki

    Radiology case reports

    2024  Volume 19, Issue 6, Page(s) 2100–2105

    Abstract: A 74-year-old woman, who had been receiving olaparib for the treatment of ovarian cancer for more than a year, visited the emergency department complaining of a fever that had lasted for 1 month. She had been taking antipyretics and antibiotics for her ... ...

    Abstract A 74-year-old woman, who had been receiving olaparib for the treatment of ovarian cancer for more than a year, visited the emergency department complaining of a fever that had lasted for 1 month. She had been taking antipyretics and antibiotics for her fever, but without any effect. Although she had no symptoms other than fever, she had stopped taking olaparib for 1 week before her visit because she had developed anemia caused by myelosuppression from olaparib. After discontinuing olaparib, her maximum body temperature decreased. On admission, chest X-ray revealed no abnormalities, but chest CT showed diffuse ground-glass opacities. Chest CT taken 5 days later showed partial improvement; therefore, we diagnosed her with interstitial lung disease (ILD) associated with olaparib. After short-term steroid treatment, the ground-glass opacities disappeared, and the patient became afebrile. The CT scan taken for tumor evaluation 2 days before the onset of fever showed a few centrilobular nodular opacities and small patchy ground-glass opacities. These findings could indicate early lesions of ILD, but they seemed inconspicuous and nonspecific, and it might have been difficult to diagnose ILD then. To date, few cases of ILD associated with olaparib have been reported. However, based on previous reports, fever is often seen, and CT findings mainly comprise diffuse ground-glass opacities, and in some cases, centrilobular nodular shadows. Thus, in conjunction with the findings of the present case, these characteristics may be representative of olaparib-induced ILD.
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2024.02.064
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  9. Article ; Online: A new hexactinellid-sponge-associated zoantharian (Porifera, Hexasterophora) from the northwestern Pacific Ocean

    Hiroki Kise / Miyuki Nishijima / Akira Iguchi / Junpei Minatoya / Hiroyuki Yokooka / Yuji Ise / Atsushi Suzuki

    ZooKeys, Vol 1156, Iss , Pp 71-

    2023  Volume 85

    Abstract: Symbiotic associations between zoantharians and sponges can be divided into two groups: those that associate with Demospongiae and those that associate with Hexactinellida. Parachurabana shinseimaruae Kise, gen. nov. et sp. nov., a new genus and a new ... ...

    Abstract Symbiotic associations between zoantharians and sponges can be divided into two groups: those that associate with Demospongiae and those that associate with Hexactinellida. Parachurabana shinseimaruae Kise, gen. nov. et sp. nov., a new genus and a new species of Hexactinellida-associated zoantharian from Japanese waters, is described. It is characterized by a combination of the following: i) its host hexactinellid sponge, ii) very flat polyps, iii) cteniform endodermal marginal muscles, and iv) characteristic mutations in three mitochondrial regions (including a unique 26-bp deletion in 16S ribosomal DNA) and three nuclear regions. Parachurabana shinseimaruae Kise, gen. nov. et sp. nov. is the third genus in the family Parazoanthidae that is reported to be associated with Hexasterophora sponges. Although specimens have so far only been collected on Takuyo-Daigo Seamount off Minami-Torishima Island in Japan, unidentified zoantharians of similar description have been reported from the waters around Australia, indicating that the species might be widespread across the Pacific.
    Keywords Zoology ; QL1-991
    Subject code 590
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The histone demethylase Utx controls CD8

    Noda, Haruna / Suzuki, Junpei / Matsuoka, Yuko / Matsumoto, Akira / Kuwahara, Makoto / Kamei, Yoshiaki / Takada, Yasutsugu / Yamashita, Masakatsu

    Cancer science

    2023  Volume 114, Issue 7, Page(s) 2787–2797

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Mice ; Animals ; CD8-Positive T-Lymphocytes/metabolism ; Epigenesis, Genetic ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Gene Expression Regulation ; Histones/metabolism
    Chemical Substances Histone Demethylases (EC 1.14.11.-) ; Histones ; Utx protein, mouse (EC 1.14.11.-)
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.15814
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