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  1. Article ; Online: High incidence of antiresorptive agent-related osteonecrosis of the jaw in patients with rheumatoid arthritis.

    Watanabe, Ryu

    Journal of bone and mineral metabolism

    2020  Volume 38, Issue 5, Page(s) 737–738

    MeSH term(s) Arthritis, Rheumatoid/drug therapy ; Autoimmune Diseases ; Bisphosphonate-Associated Osteonecrosis of the Jaw/epidemiology ; Humans ; Incidence ; Osteonecrosis/chemically induced ; Osteonecrosis/epidemiology ; Tooth Extraction
    Language English
    Publishing date 2020-04-09
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 1295123-7
    ISSN 1435-5604 ; 0914-8779
    ISSN (online) 1435-5604
    ISSN 0914-8779
    DOI 10.1007/s00774-020-01103-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4894: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: JAK inhibitors as promising agents for refractory Takayasu arteritis.

    Watanabe, Ryu

    Annals of the rheumatic diseases

    2020  Volume 81, Issue 4, Page(s) e67

    MeSH term(s) Colitis, Ulcerative ; Humans ; Janus Kinase Inhibitors/therapeutic use ; Piperidines ; Pyrimidines ; Takayasu Arteritis/complications ; Takayasu Arteritis/drug therapy
    Chemical Substances Janus Kinase Inhibitors ; Piperidines ; Pyrimidines ; tofacitinib (87LA6FU830)
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.114: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 167: Show issues

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  3. Article ; Online: Comment on: Long-term efficacy and safety of tocilizumab in refractory Takayasu arteritis: final results of the randomized controlled phase 3 TAKT study.

    Watanabe, Ryu

    Rheumatology (Oxford, England)

    2020  Volume 59, Issue 9, Page(s) e46–e47

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Humans ; Remission Induction ; Takayasu Arteritis/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2020-06-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  4. Article ; Online: CD4+ T Cells as Key Players in the Immunopathology of Takayasu Arteritis: Comment on the Article by.

    Watanabe, Ryu

    Arthritis & rheumatology (Hoboken, N.J.)

    2020  Volume 72, Issue 4, Page(s) 696–697

    MeSH term(s) CD4-Positive T-Lymphocytes ; Cell Differentiation ; Humans ; Lymphocyte Activation ; Mechanistic Target of Rapamycin Complex 1 ; Takayasu Arteritis
    Chemical Substances Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 24: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Eosinophilic Granulomatosis with Polyangiitis: Latest Findings and Updated Treatment Recommendations.

    Watanabe, Ryu / Hashimoto, Motomu

    Journal of clinical medicine

    2023  Volume 12, Issue 18

    Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) causes necrotizing vasculitis and eosinophil-rich granulomatous inflammation in small- to medium-sized vessels, resulting in multiple organ damage. EGPA is classified as an antineutrophil cytoplasmic ... ...

    Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) causes necrotizing vasculitis and eosinophil-rich granulomatous inflammation in small- to medium-sized vessels, resulting in multiple organ damage. EGPA is classified as an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, with myeloperoxidase-ANCA detected in approximately one-third of the patients. Conventional treatment of EGPA relies on systemic glucocorticoids (GCs) in combination with cyclophosphamide when poor prognostic factors are present; however, the dilemma between disease control and drug-related adverse effects has long been a challenge. Recent studies have revealed that the genetic background, pathophysiology, and clinical manifestations differ between ANCA-positive and ANCA-negative patients; however, mepolizumab, an interleukin (IL)-5 inhibitor, is effective in both groups, suggesting that the IL-5-eosinophil axis is deeply involved in the pathogenesis of both ANCA-positive and ANCA-negative EGPA. This review summarizes the latest knowledge on the pathophysiology of EGPA and focuses on the roles of eosinophils and ANCA. We then introduce the current treatment recommendations and accumulated evidence for mepolizumab on EGPA. Based on current unmet clinical needs, we discuss potential future therapeutic strategies for EGPA.
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12185996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Challenging therapeutic goal in large vessel vasculitis: Comment on "Statins reduce relapse rate in Takayasu arteritis" published in the journal.

    Watanabe, Ryu

    International journal of cardiology

    2019  Volume 287, Page(s) 120

    MeSH term(s) Arteritis ; Goals ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Recurrence ; Takayasu Arteritis
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2019-05-11
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2019.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Comment on: Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis.

    Watanabe, Ryu / Hashimoto, Motomu

    Rheumatology (Oxford, England)

    2022  Volume 61, Issue 7, Page(s) e183–e184

    MeSH term(s) Biomarkers ; Giant Cell Arteritis/diagnosis ; Humans ; Inflammation ; Pyruvate Kinase/blood
    Chemical Substances Biomarkers ; Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2022-02-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  8. Article ; Online: Vasculitogenic T Cells in Large Vessel Vasculitis.

    Watanabe, Ryu / Hashimoto, Motomu

    Frontiers in immunology

    2022  Volume 13, Page(s) 923582

    Abstract: Vasculitis is an autoimmune disease of unknown etiology that causes inflammation of the blood vessels. Large vessel vasculitis is classified as either giant cell arteritis (GCA), which occurs exclusively in the elderly, or Takayasu arteritis (TAK), which ...

    Abstract Vasculitis is an autoimmune disease of unknown etiology that causes inflammation of the blood vessels. Large vessel vasculitis is classified as either giant cell arteritis (GCA), which occurs exclusively in the elderly, or Takayasu arteritis (TAK), which mainly affects young women. Various cell types are involved in the pathogenesis of large vessel vasculitis. Among these, dendritic cells located between the adventitia and the media initiate the inflammatory cascade as antigen-presenting cells, followed by activation of macrophages and T cells contributing to vessel wall destruction. In both diseases, naive CD4
    MeSH term(s) Aged ; Female ; Giant Cell Arteritis/pathology ; Humans ; Inflammation/complications ; Janus Kinases ; Lymphocyte Count ; Takayasu Arteritis
    Chemical Substances Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2022-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.923582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Van der Waals Epitaxially Grown Molecular Crystal Dielectric Sb

    Ryu, Huije / Kim, Hyunjun / Jeong, Jae Hwan / Kim, Byeong Chan / Watanabe, Kenji / Taniguchi, Takashi / Lee, Gwan-Hyoung

    ACS nano

    2024  

    Abstract: Two-dimensional (2D) semiconducting materials have attracted significant interest as promising candidates for channel materials owing to their high mobility and gate tunability at atomic-layer thickness. However, the development of 2D electronics is ... ...

    Abstract Two-dimensional (2D) semiconducting materials have attracted significant interest as promising candidates for channel materials owing to their high mobility and gate tunability at atomic-layer thickness. However, the development of 2D electronics is impeded due to the difficulty in formation of high-quality dielectrics with a clean and nondestructive interface. Here, we report the direct van der Waals epitaxial growth of a molecular crystal dielectric, Sb
    Language English
    Publishing date 2024-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.4c01883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pathogenic role of monocytes/macrophages in large vessel vasculitis.

    Watanabe, Ryu / Hashimoto, Motomu

    Frontiers in immunology

    2022  Volume 13, Page(s) 859502

    Abstract: Vasculitis is an autoimmune vascular inflammation with an unknown etiology and causes vessel wall destruction. Depending on the size of the blood vessels, it is classified as large, medium, and small vessel vasculitis. A wide variety of immune cells are ... ...

    Abstract Vasculitis is an autoimmune vascular inflammation with an unknown etiology and causes vessel wall destruction. Depending on the size of the blood vessels, it is classified as large, medium, and small vessel vasculitis. A wide variety of immune cells are involved in the pathogenesis of vasculitis. Among these immune cells, monocytes and macrophages are functionally characterized by their capacity for phagocytosis, antigen presentation, and cytokine/chemokine production. After a long debate, recent technological advances have revealed the cellular origin of tissue macrophages in the vessel wall. Tissue macrophages are mainly derived from embryonic progenitor cells under homeostatic conditions, whereas bone marrow-derived circulating monocytes are recruited under inflammatory conditions, and then differentiate into macrophages in the arterial wall. Such macrophages infiltrate into an otherwise immunoprotected vascular site, digest tissue matrix with abundant proteolytic enzymes, and further recruit inflammatory cells through cytokine/chemokine production. In this way, macrophages amplify the inflammatory cascade and eventually cause tissue destruction. Recent studies have also demonstrated that monocytes/macrophages can be divided into several subpopulations based on the cell surface markers and gene expression. In this review, the subpopulations of circulating monocytes and the ontogeny of tissue macrophages in the artery are discussed. We also update the immunopathology of large vessel vasculitis, with a special focus on giant cell arteritis, and outline how monocytes/macrophages participate in the disease process of vascular inflammation. Finally, we discuss limitations of the current research and provide future research perspectives, particularly in humans. Through these processes, we explore the possibility of therapeutic strategies targeting monocytes/macrophages in vasculitis.
    MeSH term(s) Arteritis ; Cytokines/metabolism ; Giant Cell Arteritis ; Humans ; Inflammation ; Macrophages ; Monocytes
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.859502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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