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  1. Article ; Online: Giving birth and dying alone in hospital during the COVID-19 pandemic - a time for shifting paradigm toward continuity of care.

    Morano, Sandra / Calleja-Agius, Jean

    Journal of perinatal medicine

    2020  Volume 48, Issue 6, Page(s) 551–552

    MeSH term(s) Betacoronavirus ; COVID-19 ; Continuity of Patient Care/trends ; Coronavirus Infections/epidemiology ; Death ; Female ; Hospitalization ; Humans ; Italy/epidemiology ; Pandemics ; Parturition/psychology ; Pneumonia, Viral/epidemiology ; Pregnancy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country Germany
    Document type Letter
    ZDB-ID 123512-6
    ISSN 1619-3997 ; 0300-5577 ; 0936-174X
    ISSN (online) 1619-3997
    ISSN 0300-5577 ; 0936-174X
    DOI 10.1515/jpm-2020-0220
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  2. Article: Giving birth and dying alone in hospital during the COVID-19 pandemic - a time for shifting paradigm toward continuity of care

    Morano, Sandra / Calleja-Agius, Jean

    J Perinat Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #633403
    Database COVID19

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  3. Article ; Online: Giving birth and dying alone in hospital during the COVID-19 pandemic – a time for shifting paradigm toward continuity of care

    Morano, Sandra / Calleja-Agius, Jean

    Journal of Perinatal Medicine

    2020  Volume 48, Issue 6, Page(s) 551–552

    Keywords Obstetrics and Gynaecology ; Pediatrics, Perinatology, and Child Health ; covid19
    Publisher Walter de Gruyter GmbH
    Publishing country de
    Document type Article ; Online
    ZDB-ID 123512-6
    ISSN 1619-3997 ; 0300-5577 ; 0936-174X
    ISSN (online) 1619-3997
    ISSN 0300-5577 ; 0936-174X
    DOI 10.1515/jpm-2020-0220
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  4. Article ; Online: Giving birth and dying alone in hospital during the COVID-19 pandemic – a time for shifting paradigm toward continuity of care

    Morano, Sandra / Calleja-Agius, Jean

    2020  

    Abstract: We read with interest the article by Grünebaum et al. Professionally Responsible Counseling About Birth Location During the COVID-19 Pandemic (2020) and we would like to share with you our experience in North Italy. In the current war against the COVID- ... ...

    Abstract We read with interest the article by Grünebaum et al. Professionally Responsible Counseling About Birth Location During the COVID-19 Pandemic (2020) and we would like to share with you our experience in North Italy. In the current war against the COVID-19 pandemic, the healthcare professionals have become the frontliners in the defense against the enemy’s attacks, and the victims are “exposed” with photos of defenseless bodies lying in agony in hospital beds. As Italy is overcoming the first wave of the infection peak, it’s time for reflection. There is still a long way to go, and we are yet unable to imagine an end.

    peer-reviewed
    Keywords COVID-19 (Disease) ; Epidemics ; Childbirth ; Labor (Obstetrics) ; Continuum of care ; covid19
    Language English
    Publisher Walter de Gruyter GmbH
    Publishing country mt
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Cultural perspectives on vaginal birth after previous caesarean section in countries with high and low rates - A hermeneutic study.

    Lundgren, Ingela / Morano, Sandra / Nilsson, Christina / Sinclair, Marlene / Begley, Cecily

    Women and birth : journal of the Australian College of Midwives

    2019  Volume 33, Issue 4, Page(s) e339–e347

    Abstract: Background: Caesarean section (CS) rates are increasing worldwide, an increase that is multifactorial and not well understood. There is considerable variation in the rates of vaginal birth after previous Caesarean section (VBAC). Cultural differences ... ...

    Abstract Background: Caesarean section (CS) rates are increasing worldwide, an increase that is multifactorial and not well understood. There is considerable variation in the rates of vaginal birth after previous Caesarean section (VBAC). Cultural differences could be one explanation of the varying rates.
    Objective: To interpret cultural perspectives on VBAC.
    Methods: A hermeneutic approach for analysing findings from four published qualitative studies that were part of the OptiBIRTH study, focusing on clinicians and women's views of important factors for improving the rate of VBAC. 115 clinicians and 73 women participated in individual interviews and focus group interviews in countries with low rates (Germany, Italy and Ireland) and countries with high rates (Sweden, Finland and the Netherlands), in the original studies.
    Results: Three themes demonstrated how the culture differs between the high and low VBAC rate countries; from being an obvious first alternative to an issue dependent on many factors; from something included in the ordinary care to something special; and from obstetrician making the final decision to a choice by the woman. The fourth theme, preparing for a new birth by early follow-up and leaving the last birth behind, reflects coherence between the cultures.
    Discussion: The findings deepen our understanding of why the VBAC rates vary across countries and healthcare settings, and can be used for improving the care for women.
    Conclusion: In order to improve VBAC rates both maternity care settings and individual professionals need to reflect on their VBAC culture, and make make changes to develop a 'pro-VBAC culture'.
    MeSH term(s) Adult ; Cesarean Section/psychology ; Cesarean Section/statistics & numerical data ; Cesarean Section, Repeat/psychology ; Cesarean Section, Repeat/statistics & numerical data ; Decision Making ; Female ; Focus Groups ; Hermeneutics ; Humans ; Interviews as Topic ; Maternal Health Services ; Obstetrics ; Parturition ; Pregnancy ; Qualitative Research ; Vaginal Birth after Cesarean/psychology ; Vaginal Birth after Cesarean/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2019-08-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2235085-8
    ISSN 1878-1799 ; 1871-5192
    ISSN (online) 1878-1799
    ISSN 1871-5192
    DOI 10.1016/j.wombi.2019.07.300
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  6. Article ; Online: Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?

    Gabbianelli, Rosita / Bordoni, Laura / Morano, Sandra / Calleja-Agius, Jean / Lalor, Joan G

    International journal of molecular sciences

    2020  Volume 21, Issue 14

    Abstract: Maternal lifestyle is an important factor in the programming of an infant's epigenome, in particular when considered alongside the mode of birth and choice of feeding method (i.e., breastfeeding or formula feeding). Beginning in utero, and during the ... ...

    Abstract Maternal lifestyle is an important factor in the programming of an infant's epigenome, in particular when considered alongside the mode of birth and choice of feeding method (i.e., breastfeeding or formula feeding). Beginning in utero, and during the first two years of an infant's life, cells acquire an epigenetic memory of the neonatal exposome which can be influential across the entire lifespan. Parental lifestyle (e.g., malnutrition, alcohol intake, smoke, stress, exposure to xenobiotics and/or drugs) can modify both the maternal and paternal epigenome, leading to epigenetic inheritance in their offspring. This review aims to outline the origin of early life modulation of the epigenome, and to share this fundamental concept with all the health care professionals involved in the development and provision of care during childbirth in order to inform future parents and clinicians of the importance of the this process and the key role it plays in the programming of a child's health.
    MeSH term(s) Breast Feeding ; Child Health ; Epigenesis, Genetic ; Gastrointestinal Microbiome ; Humans ; Infant ; Infant, Newborn ; Life Style ; Parent-Child Relations ; Parents
    Language English
    Publishing date 2020-07-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21145032
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  7. Article ; Online: Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum - a systematic review with implications for the function of the oxytocinergic system.

    Buckley, Sarah / Uvnäs-Moberg, Kerstin / Pajalic, Zada / Luegmair, Karolina / Ekström-Bergström, Anette / Dencker, Anna / Massarotti, Claudia / Kotlowska, Alicja / Callaway, Leonie / Morano, Sandra / Olza, Ibone / Magistretti, Claudia Meier

    BMC pregnancy and childbirth

    2023  Volume 23, Issue 1, Page(s) 137

    Abstract: Background: The reproductive hormone oxytocin facilitates labour, birth and postpartum adaptations for women and newborns. Synthetic oxytocin is commonly given to induce or augment labour and to decrease postpartum bleeding.: Aim: To systematically ... ...

    Abstract Background: The reproductive hormone oxytocin facilitates labour, birth and postpartum adaptations for women and newborns. Synthetic oxytocin is commonly given to induce or augment labour and to decrease postpartum bleeding.
    Aim: To systematically review studies measuring plasma oxytocin levels in women and newborns following maternal administration of synthetic oxytocin during labour, birth and/or postpartum and to consider possible impacts on endogenous oxytocin and related systems.
    Methods: Systematic searches of PubMed, CINAHL, PsycInfo and Scopus databases followed PRISMA guidelines, including all peer-reviewed studies in languages understood by the authors. Thirty-five publications met inclusion criteria, including 1373 women and 148 newborns. Studies varied substantially in design and methodology, so classical meta-analysis was not possible. Therefore, results were categorized, analysed and summarised in text and tables.
    Results: Infusions of synthetic oxytocin increased maternal plasma oxytocin levels dose-dependently; doubling the infusion rate approximately doubled oxytocin levels. Infusions below 10 milliunits per minute (mU/min) did not raise maternal oxytocin above the range observed in physiological labour. At high intrapartum infusion rates (up to 32 mU/min) maternal plasma oxytocin reached 2-3 times physiological levels. Postpartum synthetic oxytocin regimens used comparatively higher doses with shorter duration compared to labour, giving greater but transient maternal oxytocin elevations. Total postpartum dose was comparable to total intrapartum dose following vaginal birth, but post-caesarean dosages were higher. Newborn oxytocin levels were higher in the umbilical artery vs. umbilical vein, and both were higher than maternal plasma levels, implying substantial fetal oxytocin production in labour. Newborn oxytocin levels were not further elevated following maternal intrapartum synthetic oxytocin, suggesting that synthetic oxytocin at clinical doses does not cross from mother to fetus.
    Conclusions: Synthetic oxytocin infusion during labour increased maternal plasma oxytocin levels 2-3-fold at the highest doses and was not associated with neonatal plasma oxytocin elevations. Therefore, direct effects from synthetic oxytocin transfer to maternal brain or fetus are unlikely. However, infusions of synthetic oxytocin in labour change uterine contraction patterns. This may influence uterine blood flow and maternal autonomic nervous system activity, potentially harming the fetus and increasing maternal pain and stress.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Humans ; Oxytocin ; Parturition ; Postpartum Period ; Labor, Obstetric ; Postpartum Hemorrhage
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-022-05221-w
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  8. Article ; Online: Plasma Biomarker Profile and Clinical Correlations in Adult Patients With Tuberous Sclerosis Complex.

    Orlando, Biagio / Morano, Alessandra / Manzini, Valeria / Cerulli Irelli, Emanuele / Borioni, Maria S / Veroni, Caterina / Salamone, Enrico Michele / D'Amelio, Chiara / Moliterni, Elisa / Giustini, Sandra / Ruffolo, Gabriele / Arisi, Ivan / D'Onofrio, Mara / Giallonardo, Anna T / Piscopo, Paola / Di Bonaventura, Carlo

    Neurology

    2023  Volume 101, Issue 19, Page(s) e1933–e1938

    Abstract: Objectives: Different pathophysiologic mechanisms, especially involving astrocytes, could contribute to tuberous sclerosis complex (TSC). We assessed neurodegeneration and astrocytopathy plasma biomarkers in adult patients with TSC to define TSC ... ...

    Abstract Objectives: Different pathophysiologic mechanisms, especially involving astrocytes, could contribute to tuberous sclerosis complex (TSC). We assessed neurodegeneration and astrocytopathy plasma biomarkers in adult patients with TSC to define TSC biomarker profile and investigate clinical-radiologic correlations.
    Methods: Patients with TSC aged 15 years or older followed at Policlinico "Umberto I" of Rome were consecutively enrolled (July 2021-June 2022). The plasma levels of the following biomarkers were compared between patients and age/sex-matched healthy controls (HCs): tTau, pTau181, Abeta
    Results: Thirty-one patients (20 females/11 males; median age 30 years, interquartile range 24-47) and 38 HCs were enrolled. Only GFAP was significantly higher in the whole TSC population than in HCs (132.71 [86.14-231.06] vs 44.80 [32.87-66.76] pg/mL,
    Discussion: Our exploratory study documented a significant increase of GFAP plasma concentration in adult patients with TSC, correlated with their neurologic severity, supporting the central role of astrocytopathy in TSC pathophysiology.
    MeSH term(s) Male ; Female ; Humans ; Adult ; Autism Spectrum Disorder/genetics ; Tuberous Sclerosis/genetics ; Biomarkers ; Astrocytes ; Genotype ; Glial Fibrillary Acidic Protein/genetics
    Chemical Substances Biomarkers ; Glial Fibrillary Acidic Protein
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207799
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  9. Article ; Online: Nutri-Epigenetics and Gut Microbiota

    Rosita Gabbianelli / Laura Bordoni / Sandra Morano / Jean Calleja-Agius / Joan G. Lalor

    International Journal of Molecular Sciences, Vol 21, Iss 5032, p

    How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?

    2020  Volume 5032

    Abstract: Maternal lifestyle is an important factor in the programming of an infant’s epigenome, in particular when considered alongside the mode of birth and choice of feeding method (i.e., breastfeeding or formula feeding). Beginning in utero, and during the ... ...

    Abstract Maternal lifestyle is an important factor in the programming of an infant’s epigenome, in particular when considered alongside the mode of birth and choice of feeding method (i.e., breastfeeding or formula feeding). Beginning in utero, and during the first two years of an infant’s life, cells acquire an epigenetic memory of the neonatal exposome which can be influential across the entire lifespan. Parental lifestyle (e.g., malnutrition, alcohol intake, smoke, stress, exposure to xenobiotics and/or drugs) can modify both the maternal and paternal epigenome, leading to epigenetic inheritance in their offspring. This review aims to outline the origin of early life modulation of the epigenome, and to share this fundamental concept with all the health care professionals involved in the development and provision of care during childbirth in order to inform future parents and clinicians of the importance of the this process and the key role it plays in the programming of a child’s health.
    Keywords nutri-epigenetics ; gut microbiota ; breastfeeding ; birth care ; best practice ; parent education ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 300
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Long or complicated mpox in patients with uncontrolled HIV infection.

    Corma-Gómez, Anaïs / Cabello, Alfonso / Orviz, Eva / Morante-Ruiz, Miguel / Ayerdi, Oskar / Al-Hayani, Aws / Muñoz-Gómez, Ana / Santos, Ignacio De Los / Gómez-Ayerbe, Cristina / Rodrigo, David / Riestra, Sandra De la Rosa / Reus-Bañuls, Sergio / Silva-Klug, Ana / Galindo, María José / Santos, Marta / Serrano-Fuentes, Miriam / Faro-Míguez, Naya / Pérez-Camacho, Inés / Corona-Mata, Diana /
    Morano, Luis / López-Ruz, Miguel Ángel / Montero, Marta / Anaya-Baz, Blanca / Merino, Dolores / Castillo-Navarro, Antonia / Pineda, Juan A / Macías, Juan

    Journal of medical virology

    2024  Volume 96, Issue 3, Page(s) e29511

    Abstract: To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, the aim of this study was to assess the impact of HIV on the clinical course of mpox, in a large population of patients from ... ...

    Abstract To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, the aim of this study was to assess the impact of HIV on the clinical course of mpox, in a large population of patients from Spain. Nationwide case-series study. Patients from 18 Spanish hospitals, with PCR-confirmed mpox from April 27, 2022 to June 30, 2023 were included in this study. The main outcome was the development of long or complicated (LC) mpox, defined as: (i) duration of the clinical course ≥ 28 days, or; (ii) disseminated disease, or: (iii) emergence of severe complications. One thousand eight hundred twenty-three individuals were included. Seven hundred eighty-six (43%) were people living with HIV (PLWH), of whom 11 (1%) had a CD4 cell count < 200 cells/mm
    MeSH term(s) Humans ; HIV Infections ; Mpox (monkeypox) ; CD4 Lymphocyte Count ; Disease Progression ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29511
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