LIVIVO - Search results -

Search results

Result 1 - 10 of total 48

Search options

Article: Influence of fumed silicon dioxide on the stabilization of Eudragit RS/RL 30 D film-coated theophylline pellets.

Kucera, Shawn A / Stimpel, Doreen / Shah, Navnit H / Malick, A Waseem / Infeld, Martin H / McGinity, James W

Pharmaceutical development and technology

2008 Volume 13, Issue 3, Page(s) 245–253

Abstract: ... silicon dioxide on the drug release rate and physical aging of theophylline pellets coated with Eudragit RS 30 D ... and RL 30 D. Free films were assessed for both physicomechanical properties and water vapor ... containing Eudragit RS 30 D, 15% triethyl citrate (TEC), and 30% Aeroperl 300 was attributed ...

Abstract	The objective of this study was to investigate the influence of various grades of fumed silicon dioxide on the drug release rate and physical aging of theophylline pellets coated with Eudragit RS 30 D and RL 30 D. Free films were assessed for both physicomechanical properties and water vapor permeability with respect to time and storage conditions. The release rate of theophylline was influenced by the physical properties of the silicon dioxide employed. As the particle size of the silica dioxide decreased, there was an increase in dispersion viscosity, as well as a decrease in the theophylline release rate from the coated pellets. Films prepared from formulas containing Aeroperl 300 had twice the water vapor transmission rate of films prepared from formulas containing Aerosil 200 VV and Cab-O-Sil M-5P and showed consistent moisture permeability values during storage for up to 1 month at 25 degrees C/0% relative humidity (RH). Scanning electron microscopy (SEM) imaging of pellets coated with a formulation containing Aerosil 200 VV or Cab-O-Sil M-5P demonstrated film structures that were homogenous, while those coated with a formulation containing Aeroperl 300 produced heterogeneous films with large particles of the excipient present within the polymeric matrix of the film. Stability in the drug release rate exhibited by pellets coated with a formulation containing Eudragit RS 30 D, 15% triethyl citrate (TEC), and 30% Aeroperl 300 was attributed to the stabilization of the moisture vapor transmission rate of the acrylic films. Increasing the concentration of Aeroperl 300 in the coating formulation increased the theophylline release rate from coated pellets.
MeSH term(s)	Acrylates ; Chemical Phenomena ; Chemistry, Physical ; Drug Stability ; Excipients ; Latex ; Microscopy, Electron, Scanning ; Particle Size ; Permeability ; Polymethacrylic Acids/chemistry ; Powders ; Silicon Dioxide/chemistry ; Tablets, Enteric-Coated ; Tensile Strength ; Theophylline/administration & dosage ; Theophylline/chemistry ; Viscosity ; Water/chemistry
Chemical Substances	Acrylates ; Excipients ; Latex ; Polymethacrylic Acids ; Powders ; Tablets, Enteric-Coated ; Water (059QF0KO0R) ; methylmethacrylate-methacrylic acid copolymer (25086-15-1) ; Silicon Dioxide (7631-86-9) ; Theophylline (C137DTR5RG)
Language	English
Publishing date	2008-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1331774-x
ISSN	1097-9867 ; 1083-7450
ISSN (online)	1097-9867
ISSN	1083-7450
DOI	10.1080/10837450801949665
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5043: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Lower heart rates and beta-blockers are associated with new-onset atrial fibrillation.

Habel, Nicole / du Fay de Lavallaz, Jeanne / Infeld, Margaret / Koehler, Jodi L / Ziegler, Paul D / Lustgarten, Daniel L / Meyer, Markus

International journal of cardiology. Cardiovascular risk and prevention

2023 Volume 17, Page(s) 200182

Abstract: Background: Lower heart rates (HRs) prolong diastole, which increases filling pressures and wall stress. As a result, lower HRs may be associated with higher brain natriuretic peptide (BNP) levels and incident atrial fibrillation (AF). Beta-blockers may ...

Abstract	Background: Lower heart rates (HRs) prolong diastole, which increases filling pressures and wall stress. As a result, lower HRs may be associated with higher brain natriuretic peptide (BNP) levels and incident atrial fibrillation (AF). Beta-blockers may increase the risk for AF due to suppression of resting HRs. Objective: Examine the relationships of HR, BNP, beta-blockers and new-onset AF in the REVEAL-AF and SPRINT cohort of subjects at risk for developing AF. Methods: In REVEAL-AF, 383 subjects without a history of AF and a mean CHA Results: The median daytime HR in the REVEAL-AF cohort was 75bpm [IQR 68-83]. Subjects with below-median HRs had 2.4-fold higher BNP levels compared to subjects with above-median HRs (median BNP [IQR]: 62 pg/dl [37-112] vs. 26 pg/dl [13-53], p < 0.001). HRs <75bpm were associated with a higher incidence of AF: 37% vs. 27%, p < 0.05. This was validated in the SPRINT cohort after adjusting for AF risk factors. Both a HR < 75bpm and beta-blocker use were associated with a higher rate of AF: 1.9 vs 0.7% (p < 0.001) and 2.5% vs. 0.6% (p < 0.001), respectively. The hazard ratio for patients on beta-blockers to develop AF was 3.72 [CI 2.32, 5.96], p < 0.001. Conclusions: Lower HRs are associated with higher BNP levels and incident AF, mimicking the hemodynamic effects of diastolic dysfunction. Suppression of resting HR by beta-blockers could explain their association with incident AF.
Language	English
Publishing date	2023-02-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-4875
ISSN (online)	2772-4875
DOI	10.1016/j.ijcrp.2023.200182
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Congenital left ventricular wall defects presenting with ventricular arrhythmias: A case series.

Infeld, Margaret / Nicoli, Charles D / Khadanga, Sherrie / VanBuren, Peter / Correa de Sa, Daniel D

HeartRhythm case reports

2020 Volume 6, Issue 10, Page(s) 715–719

Language	English
Publishing date	2020-07-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2020.06.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Platelet reactivity in response to aspirin and ticagrelor in African-Americans and European-Americans.

Infeld, Margaret / Friede, Kevin A / San, Tan Ru / Knickerbocker, Holly J / Ginsburg, Geoffrey S / Ortel, Thomas L / Voora, Deepak

Journal of thrombosis and thrombolysis

2020 Volume 51, Issue 2, Page(s) 249–259

Abstract: Platelet gene polymorphisms are associated with variable on-treatment platelet reactivity and vary by race. Whether differences in platelet reactivity and aspirin or ticagrelor exist between African-American and European-Americans remains poorly ... ...

Abstract	Platelet gene polymorphisms are associated with variable on-treatment platelet reactivity and vary by race. Whether differences in platelet reactivity and aspirin or ticagrelor exist between African-American and European-Americans remains poorly understood. Biological samples from three prior prospective antiplatelet challenge studies at the Duke Clinical Research Unit were used to compare platelet reactivity between African-American and European-American subjects. Platelet reactivity at baseline, on-aspirin, on-ticagrelor, and the treatment effect of aspirin or ticagrelor were compared between groups using an adjusted mixed effects model. Compared with European-Americans (n = 282; 50% female; mean ± standard deviation age, 50 ± 16), African-Americans (n = 209; 67% female; age 48 ± 12) had lower baseline platelet reactivity with platelet function analyzer-100 (PFA-100) (p < 0.01) and with light transmission aggregometry (LTA) in response to arachidonic acid (AA), adenosine diphosphate (ADP), and epinephrine agonists (p < 0.05). African-Americans had lower platelet reactivity on aspirin in response to ADP, epinephrine, and collagen (p < 0.05) and on ticagrelor in response to AA, ADP, and collagen (p < 0.05). The treatment effect of aspirin was greater in European-Americans with an AA agonist (p = 0.002). Between-race differences with in vitro aspirin mirrored those seen in vivo. The treatment effect of ticagrelor was greater in European-Americans in response to ADP (p < 0.05) but with collagen, the treatment effect was greater for African-Americans (p < 0.05). Platelet reactivity was overall lower in African-Americans off-treatment, on aspirin, and on ticagrelor. European-Americans experienced greater platelet suppression on aspirin and on ticagrelor. The aspirin response difference in vivo and in vitro suggests a mechanism intrinsic to the platelet. Whether the absolute level of platelet reactivity or the degree of platelet suppression after treatment is more important for clinical outcomes is uncertain.
MeSH term(s)	Adult ; Black or African American ; Aged ; Aspirin/pharmacology ; Blood Platelets/drug effects ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Middle Aged ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Function Tests ; Ticagrelor/pharmacology ; White People
Chemical Substances	Platelet Aggregation Inhibitors ; Ticagrelor (GLH0314RVC) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2020-11-06
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-020-02327-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4352: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Clinical impact of Bachmann's bundle pacing defined by electrocardiographic criteria on atrial arrhythmia outcomes.

Infeld, Margaret / Nicoli, Charles D / Meagher, Sean / Tompkins, Bradley J / Wayne, Shawn / Irvine, Benjamin / Betageri, Omkar / Habel, Nicole / Till, Sean / Lobel, Jennings / Meyer, Markus / Lustgarten, Daniel L

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2022 Volume 24, Issue 9, Page(s) 1460–1468

Abstract: Aims: Evaluate whether Bachmann's bundle pacing (BBp) defined by electrocardiographic (ECG) criteria is associated with less atrial fibrillation/tachycardia (AF/AT) compared with anatomically defined right atrial septal pacing (RASp) and right atrial ... ...

Abstract	Aims: Evaluate whether Bachmann's bundle pacing (BBp) defined by electrocardiographic (ECG) criteria is associated with less atrial fibrillation/tachycardia (AF/AT) compared with anatomically defined right atrial septal pacing (RASp) and right atrial appendage pacing (RAAp). Methods and results: This is a retrospective study comparing BBp with non-specific RASp and RAAp on new incidence, burden, and recurrence of AF/AT. We included patients who underwent atrial lead placement between 2006 and 2019 and received > 20% atrial pacing. BBp was defined by paced P-wave morphology and fluoroscopic lead position. Compared with RASp (n = 107) and RAAp (n = 108), AF/AT burden was lower in the BBp (n = 134) group by repeated measures ANOVA (P < 0.001). Over 2-year follow-up, AF/AT burden increased in the RASp (P < 0.01) and RAAp (P < 0.01) groups but did not significantly change in the BBp group (P = 0.91). Atrial arrhythmia burden was lower in the BBp group than the RASp and RAAp groups at 12-15, 18-21, and 24-27 months (P < 0.05) after pacemaker placement. Risk of AF/AT recurrence was lower in BBp than RASp (HR 0.43; P < 0.01) and RAAp patients (HR 0.29, P < 0.01). Risk of de novo AF/AT was also lower in BBp than in RASp (OR 0.12; P < 0.01) and RAAp patients (OR 0.20, P < 0.01). Conclusion: Bachmann's bundle pacing defined using P-wave criteria was associated with decreased atrial arrhythmia burden, recurrence, and de novo incidence compared with right atrial septal pacing and right atrial appendage pacing.
MeSH term(s)	Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/therapy ; Cardiac Pacing, Artificial/methods ; Electrocardiography ; Heart Septal Defects, Atrial ; Retrospective Studies ; Tachycardia
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euac029
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5434: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Diabetic retinopathy screening.

Infeld, D

Eye (London, England)

2001 Volume 15, Issue Pt 1, Page(s) 128

MeSH term(s)	Diabetic Retinopathy/diagnosis ; Fluorescein Angiography/adverse effects ; Humans ; Mass Screening/methods
Language	English
Publishing date	2001-02
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2001.40
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 3010: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 603: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Giant cell (temporal) arteritis and temporal artery biopsy.

Infeld, D

Postgraduate medical journal

2001 Volume 77, Issue 907, Page(s) 358–359

MeSH term(s)	Aged ; Biopsy ; Blood Sedimentation ; Giant Cell Arteritis/blood ; Giant Cell Arteritis/complications ; Giant Cell Arteritis/diagnosis ; Humans ; Middle Aged ; Predictive Value of Tests
Language	English
Publishing date	2001-02-06
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	80325-x
ISSN	1469-0756 ; 0032-5473
ISSN (online)	1469-0756
ISSN	0032-5473
DOI	10.1136/pmj.77.907.358b
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.340: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Analysis of methods of ocular examination in screening for diabetic retinopathy.

Infeld, D

Diabetic medicine : a journal of the British Diabetic Association

2001 Volume 18, Issue 2, Page(s) 166–167

MeSH term(s)	Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/prevention & control ; Humans ; Macular Edema/diagnosis ; Mass Screening/methods ; Ophthalmoscopy ; Photography
Language	English
Publishing date	2001-02
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1954: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Influence of Sex on Platelet Reactivity in Response to Aspirin.

Friede, Kevin A / Infeld, Margaret M / Tan, Ru San / Knickerbocker, Holly J / Myers, Rachel A / Dubois, Laura G / Thompson, J Will / Kaddurah-Daouk, Rima / Ginsburg, Geoffrey S / Ortel, Thomas L / Voora, Deepak

Journal of the American Heart Association

2020 Volume 9, Issue 14, Page(s) e014726

Abstract: Background There are sex differences in the efficacy and safety of aspirin for the prevention of myocardial infarction and stroke. Whether this is explained by underlying differences in platelet reactivity and aspirin response remains poorly understood. ... ...

Abstract	Background There are sex differences in the efficacy and safety of aspirin for the prevention of myocardial infarction and stroke. Whether this is explained by underlying differences in platelet reactivity and aspirin response remains poorly understood. Methods and Results Healthy volunteers (n=378 208 women) and patients with coronary artery disease or coronary artery disease risk factors (n=217 112 women) took aspirin for 4 weeks. Light transmittance aggregometry using platelet-rich plasma was used to measure platelet reactivity in response to epinephrine, collagen, and ADP at baseline, 3 hours after the first aspirin dose, and after 4 weeks of daily aspirin therapy. A subset of patients underwent pharmacokinetic and pharmacodynamic assessment with levels of salicylate and cyclooxygenase-1-derived prostaglandin metabolites and light transmittance aggregometry in response to arachidonic acid and after ex vivo exposure to aspirin. At baseline, women had increased platelet aggregation in response to ADP and collagen. Innate platelet response to aspirin, assessed with ex vivo aspirin exposure of baseline platelets, did not differ by sex. Three hours after the first oral aspirin dose, platelet aggregation was inhibited in women to a greater degree in response to epinephrine and to a lesser degree with collagen. After 4 weeks of daily therapy, despite higher salicylate concentrations and greater cyclooxygenase-1 inhibition, women exhibited an attenuation of platelet inhibition in response to epinephrine and ADP. Conclusions We observed agonist-dependent sex differences in platelet responses to aspirin. Despite higher cyclooxygenase-1 inhibition, daily aspirin exposure resulted in a paradoxical attenuation of platelet inhibition in response to epinephrine and ADP over time in women but not in men.
MeSH term(s)	Adult ; Aged ; Aspirin/pharmacology ; Case-Control Studies ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Sex Characteristics ; Young Adult
Chemical Substances	Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2020-07-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.119.014726
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Cell-matrix interactions in gland development in the lung.

Infeld, M D

Experimental lung research

1997 Volume 23, Issue 2, Page(s) 161–169

Abstract: The tubulo-acinar glands of the conducting airways participate in lung host defense and the pathogenesis of chronic inflammatory airway disease. Models of gland development may provide clues to mechanisms that promote hypersecretion in diseases such as ... ...

Abstract	The tubulo-acinar glands of the conducting airways participate in lung host defense and the pathogenesis of chronic inflammatory airway disease. Models of gland development may provide clues to mechanisms that promote hypersecretion in diseases such as chronic bronchitis and cystic fibrosis. The developmental anatomy of airway glands was described 30 years ago, but the regulation of gland formation remains a mystery. During the pseudoglandular stage of lung development, poorly differentiated surface epithelial cells grow radially from the lumen and invade the airway submucosa. The basal lamina is remodeled during this process and animal studies indicate a correlation between the expression of the 72-kD gelatinase (MMP-2) and gland morphogenesis. Cell culture models with lung epithelial and mesenchymal elements mimic early gland morphogenesis. Studies using this model have corroborated the involvement of 72-kD gelatinase in the formation of gland-like structures. While the secretion and activation of 72-kD gelatinase is correlated with epithelial matrix invasion, the presence of activated 72-kD gelatinase is not by itself sufficient to permit epithelial matrix invasion. Whether the 72-kD gelatinase participates in a more complex proteolytic cascade or whether appropriate localization of the enzyme is critical to airway epithelial morphogenesis is the focus of ongoing investigation.
MeSH term(s)	Animals ; Bronchi/embryology ; Bronchi/enzymology ; Embryonic and Fetal Development ; Epithelial Cells ; Epithelium/embryology ; Epithelium/enzymology ; Extracellular Matrix/physiology ; Gelatinases/metabolism ; Humans ; Lung/cytology ; Lung/embryology ; Lung/enzymology ; Matrix Metalloproteinase 2 ; Metalloendopeptidases/metabolism ; Trachea/embryology ; Trachea/enzymology
Chemical Substances	Gelatinases (EC 3.4.24.-) ; Metalloendopeptidases (EC 3.4.24.-) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	1997-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.3109/01902149709074028
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1568: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito