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  1. Book: Glial cells in health and disease of the CNS

    Bernhardi, Rommy von

    (Advances in experimental medicine and biology ; 949 ; Biomedicine)

    2016  

    Author's details Rommy von Bernhardi, editor
    Series title Advances in experimental medicine and biology ; 949
    Biomedicine
    Collection
    Keywords aging ; cytotoxicity ; disease mechanisms ; glial cells ; neurodegenerative disease ; neuroinflammation
    Language English
    Size xi, 348 Seiten, Illustrationen, Diagramme, 23.5 cm x 15.5 cm, 0 g
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019116337
    ISBN 978-3-319-40762-3 ; 9783319407647 ; 3-319-40762-7 ; 3319407643
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -949- not available for loan Zeitschriften-Lesesaal

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  2. Book ; Online ; E-Book: Glial cells in health and disease of the CNS

    von Bernhardi, Rommy

    (Advances in experimental medicine and biology ; volume 949)

    2016  

    Author's details Rommy von Bernhardi editor
    Series title Advances in experimental medicine and biology ; volume 949
    Collection
    Keywords aging ; cytotoxicity ; disease mechanisms ; glial cells ; neurodegenerative disease ; neuroinflammation
    Language English
    Size 1 Online-Ressource (XI, 348 Seiten)
    Publisher Springer
    Publishing place Cham
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Note Lizenzpflichtig
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019116367
    ISBN 978-3-319-40764-7 ; 9783319407623 ; 3-319-40764-3 ; 3319407627
    DOI 10.1007/978-3-319-40764-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Book ; Online ; E-Book: The plastic brain

    von Bernhardi, Rommy / Eugenín, Jaime / Muller, Kenneth J.

    (Advances in experimental medicine and biology ; 1015)

    2017  

    Author's details Rommy von Bernhardi, Jaime Eugenín, Kenneth J. Muller editors
    Series title Advances in experimental medicine and biology ; 1015
    Collection
    Keywords Medicine ; Neurosciences
    Subject code 612.8
    Language English
    Size 1 Online-Ressource (IX, 284 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019506281
    ISBN 978-3-319-62817-2 ; 9783319628158 ; 3-319-62817-8 ; 3319628151
    DOI 10.1007/978-3-319-62817-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Article: Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases.

    Eugenín, Jaime / Eugenín-von Bernhardi, Laura / von Bernhardi, Rommy

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1249320

    Abstract: The chemokine fractalkine (FKN, ... ...

    Abstract The chemokine fractalkine (FKN, CX
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1249320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: The plastic brain

    von Bernhardi, Rommy / Eugenín, Jaime / Muller, Kenneth J.

    (Advances in experimental medicine and biology ; 1015)

    2017  

    Author's details Rommy von Bernhardi, Jaime Eugenin, Kenneth J. Muller editor
    Series title Advances in experimental medicine and biology ; 1015
    Collection
    Keywords brain plasticity ; functional-state plasticity ; injury-induced plasticity ; perinatal plasticity ; stressor-induced plasticity
    Subject code 610
    Language English
    Size ix, 284 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019506299
    ISBN 978-3-319-62815-8 ; 3-319-62815-1 ; 9783319628172 ; 3319628178
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1015- not available for loan Zeitschriften-Lesesaal

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  6. Book: Neurodegenerative diseases

    Bernhardi, Rommy von

    from molecular concepts to therapeutic targets

    2008  

    Author's details Rommy von Bernhardi ... ed
    Keywords Neurodegenerative Diseases ; Alzheimer Disease
    Language English
    Size VI, 219 S. : Ill., graph. Darst., 26 cm
    Publisher Nova Biomed. Books
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT015971534
    ISBN 978-1-60456-167-8 ; 1-60456-167-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4304 order for loan Magazin

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  7. Article: Microglial reactivity in brainstem chemosensory nuclei in response to hypercapnia.

    Eugenín, Jaime / Beltrán-Castillo, Sebastián / Irribarra, Estefanía / Pulgar-Sepúlveda, Raúl / Abarca, Nicolás / von Bernhardi, Rommy

    Frontiers in physiology

    2024  Volume 15, Page(s) 1332355

    Abstract: Microglia, the resident immune cells of the CNS, surveil, detect, and respond to various extracellular signals. Depending on the nature of these signals, an integrative microglial response can be triggered, resulting in a phenotypic transformation. Here, ...

    Abstract Microglia, the resident immune cells of the CNS, surveil, detect, and respond to various extracellular signals. Depending on the nature of these signals, an integrative microglial response can be triggered, resulting in a phenotypic transformation. Here, we evaluate whether hypercapnia modifies microglia phenotype in brainstem respiratory-related nuclei. Adult C57BL/6 inbred mice were exposed to 10% CO
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1332355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases.

    Triviño, Juan José / von Bernhardi, Rommy

    Neurochemistry international

    2021  Volume 144, Page(s) 104982

    Abstract: Microglia serve key functions in the central nervous system (CNS), participating in the establishment and regulation of synapses and the neuronal network, and regulating activity-dependent plastic changes. As the neuroimmune system, they respond to ... ...

    Abstract Microglia serve key functions in the central nervous system (CNS), participating in the establishment and regulation of synapses and the neuronal network, and regulating activity-dependent plastic changes. As the neuroimmune system, they respond to endogenous and exogenous signals to protect the CNS. In aging, one of the main changes is the establishment of inflamm-aging, a mild chronic inflammation that reduces microglial response to stressors. Neuroinflammation depends mainly on the increased activation of microglia. Microglia over-activation may result in a reduced capacity for performing normal functions related to migration, clearance, and the adoption of an anti-inflammatory state, contributing to an increased susceptibility for neurodegeneration. Oxidative stress contributes both to aging and to the progression of neurodegenerative diseases. Increased production of reactive oxygen species (ROS) and neuroinflammation associated with age- and disease-dependent mechanisms affect synaptic activity and neurotransmission, leading to cognitive dysfunction. Astrocytes prevent microglial cell cytotoxicity by mechanisms mediated by transforming growth factor β1 (TGFβ1). However, TGFβ1-Smad3 pathway is impaired in aging, and the age-related impairment of TGFβ signaling can reduce protective activation while facilitating cytotoxic activation of microglia. A critical analysis on the effect of aging microglia on neuronal function is relevant for the understanding of age-related changes on neuronal function. Here, we present evidence in the context of the "microglial dysregulation hypothesis", which leads to the reduction of the protective functions and increased cytotoxicity of microglia, to discuss the mechanisms involved in neurodegenerative changes and Alzheimer's disease.
    MeSH term(s) Aging/metabolism ; Aging/pathology ; Animals ; Brain/metabolism ; Brain/pathology ; Cellular Senescence/physiology ; Humans ; Inflammation Mediators/metabolism ; Microglia/metabolism ; Microglia/pathology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Oxidative Stress/physiology ; Synapses/metabolism ; Synapses/pathology
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2021-02-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/j.neuint.2021.104982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1610: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: What Is Neural Plasticity?

    von Bernhardi, Rommy / Bernhardi, Laura Eugenín-von / Eugenín, Jaime

    Advances in experimental medicine and biology

    2017  Volume 1015, Page(s) 1–15

    Abstract: Neural plasticity" refers to the capacity of the nervous system to modify itself, functionally and structurally, in response to experience and injury. As the various chapters in this volume show, plasticity is a key component of neural development and ... ...

    Abstract "Neural plasticity" refers to the capacity of the nervous system to modify itself, functionally and structurally, in response to experience and injury. As the various chapters in this volume show, plasticity is a key component of neural development and normal functioning of the nervous system, as well as a response to the changing environment, aging, or pathological insult. This chapter discusses how plasticity is necessary not only for neural networks to acquire new functional properties, but also for them to remain robust and stable. The article also reviews the seminal proposals developed over the years that have driven experiments and strongly influenced concepts of neural plasticity.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-62817-2_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Glial cells in health and disease of the CNS

    Bernhardi, Rommy von

    (Advances in experimental medicine and biology, ; volume 949)

    2016  

    Author's details Rommy von Bernhardi, editor
    Series title Advances in experimental medicine and biology, ; volume 949
    MeSH term(s) Neuroglia/physiology ; Central Nervous System/physiology ; Neuroglia/pathology ; Central Nervous System/pathology
    Language English
    Size xi, 348 pages :, illustrations
    Document type Book
    ISBN 9783319407623 ; 3319407627 ; 9783319407647 ; 3319407643
    Database Catalogue of the US National Library of Medicine (NLM)

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