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  1. Book: Central nervous system malignancies

    Reardon, David A.

    (Hematology/oncology clinics of North America ; volume 36, number 1 (February 2022))

    2022  

    Author's details editor David A. Reardon
    Series title Hematology/oncology clinics of North America ; volume 36, number 1 (February 2022)
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size xvi, 282 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT021285231
    ISBN 978-0-323-81072-2 ; 0-323-81072-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  2. Book: Cancer immunology and immunotherapy for CNS tumors

    Reardon, David A.

    (Neuro-oncology ; volume 17, supplement 7, 2015)

    2015  

    Author's details edited by: David A. Reardon, MD and Michael Weller, MD
    Series title Neuro-oncology ; volume 17, supplement 7, 2015
    Neuro-Oncology
    Collection Neuro-Oncology
    Language English
    Size vii40 Seiten
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018871174
    Database Catalogue ZB MED Medicine, Health

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    Zs A 5307 -17,Suppl.7- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: [No title information]

    Reardon, David A

    Hematology/oncology clinics of North America

    2021  Volume 36, Issue 1, Page(s) xv–xvi

    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2021.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A new era for glioma therapy - targeting mutant IDH.

    Reardon, David A / Cahill, Daniel P

    Nature reviews. Clinical oncology

    2023  Volume 20, Issue 11, Page(s) 737–738

    MeSH term(s) Humans ; Glioma/drug therapy ; Glioma/genetics ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Isocitrate Dehydrogenase/genetics ; Mutation
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-023-00804-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Postpartum psychiatric episodes study missed effects of prior pregnancy losses.

    Reardon, David C

    Acta psychiatrica Scandinavica

    2023  

    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Letter
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Oncology of CNS tumors

    Tonn, Jörg-Christian / Reardon, David A. / Rutka, James T.

    2019  

    Author's details Jörg-Christian Tonn, David A. Reardon, James T. Rutka, Manfred Westphal editors
    Keywords Central Nervous System Neoplasms ; Hirntumor ; Zentralnervensystem ; Tumor ; Kind
    Subject Blastom ; Geschwulst ; Neoplasma ; Neoplasie ; Zentrales Nervensystem ; ZNS ; Systema nervosum centrale ; Central nervous system ; CNS ; Kindheit ; Kindesalter ; Kindschaft ; Kinder ; Gehirngeschwulst ; Gehirntumor ; Hirngeschwulst ; Tumor cerebri
    Subject code 616.9948 ; 618.929948
    Language English
    Size x, 794 Seiten, Illustrationen, 27 cm
    Edition Third edition
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT020068963
    ISBN 978-3-030-04151-9 ; 9783030041526 ; 3-030-04151-4 ; 3030041522
    Database Catalogue ZB MED Medicine, Health

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    2019 A 767 available for loan (reading room) Lesesaal EG

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  7. Article ; Online: Immunotherapy approaches for adult glioma: knowledge gained from recent clinical trials.

    Andersen, Brian M / Reardon, David A

    Current opinion in neurology

    2022  Volume 35, Issue 6, Page(s) 803–813

    Abstract: Purpose of review: Summarize principles behind various immunotherapy approaches for high and low-grade glioma in the context of recently completed clinical trials and the new insights they provide.: Recent findings: Despite the widespread success of ... ...

    Abstract Purpose of review: Summarize principles behind various immunotherapy approaches for high and low-grade glioma in the context of recently completed clinical trials and the new insights they provide.
    Recent findings: Despite the widespread success of therapies targeting the T-cell checkpoints programmed-death 1 and cytotoxic T lymphocyte antigen 4 in other malignancies, recent phase III trials in glioblastoma confirm the lack of efficacy of anti-programmed-death 1 monotherapy in more than 90% of patients. Vaccination approaches remain under investigation for high-grade glioma and have shown activity in some low-grade glioma patients. Chimeric antigen receptor T cells now feature a new generation of products engineered to potentially withstand glucocorticoid therapy. Oncolytic viral therapies have similarly advanced in sophistication, with drug-sensitive gene expression and tumor-selective modifications. Combinations of therapies hold promise for overcoming the numerous mechanisms of immune suppression in glioma.
    Summary: Although immunotherapies have yet to show rates of efficacy compared with other malignancies, new knowledge of immunology and combination therapies brings hope for improved efficacy in the future.
    MeSH term(s) Humans ; Glioma/drug therapy ; Immunotherapy ; Glioblastoma/therapy ; Combined Modality Therapy ; Immunologic Factors/therapeutic use
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2022-10-21
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Effects of Abortion Decision Rightness and Decision Type on Women's Satisfaction and Mental Health.

    Reardon, David C / Rafferty, Katherine A / Longbons, Tessa

    Cureus

    2023  Volume 15, Issue 5, Page(s) e38882

    Abstract: Background A case series report based on the Turnaway Study has previously concluded that 99% of women with a history of abortion will continue to affirm satisfaction with their decisions to abort. Those findings have been called into question due to a ... ...

    Abstract Background A case series report based on the Turnaway Study has previously concluded that 99% of women with a history of abortion will continue to affirm satisfaction with their decisions to abort. Those findings have been called into question due to a low participation rate (31%) and reliance on a single yes/no assessment of decision satisfaction. Aim To utilize more sensitive scales in assessing decision satisfaction and the associated mental health outcomes women attribute to their abortions. Method  A retrospective survey was completed by 1,000 females, aged 41-45, living in the United States. The survey instrument included 11 visual analog scales for respondents to rate their personal preferences and outcomes they attributed to their abortion decisions. A categorical question allowed women to identify if their abortions were wanted and consistent with their own values and preferences, inconsistent with their values and preferences, unwanted, or coerced. Linear regression models were tested to identify which of three decision scales best predicted positive or negative emotions, effects on mental health, emotional attachment, personal preferences, moral conflict, and other factors relevant to an assessment of satisfaction with a decision to abort. Results Of 226 women reporting a history of abortion, 33% identified it as wanted, 43% as accepted but inconsistent with their values and preferences, and 24% as unwanted or coerced. Only wanted abortions were associated with positive emotions or mental health gains. All other groups attributed more negative emotions and mental health outcomes to their abortions. Sixty percent reported they would have preferred to give birth if they had received more support from others or had more financial security. Conclusions Perceived pressure to abort is strongly associated with women attributing more negative mental health outcomes to their abortions. The one-third of women for whom abortion is wanted and consistent with their values and preferences are most likely over-represented in studies initiated at abortion clinics. More research is needed to understand better the experience of the two-thirds of women for whom abortion is unwanted, coerced, or otherwise inconsistent with their own values and preferences.
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Vaccination for IDH-mutant tumors: A novel therapeutic approach applied to glioma.

    Reardon, David A / Weller, Michael

    Med (New York, N.Y.)

    2021  Volume 2, Issue 5, Page(s) 450–452

    Abstract: In a recent Nature publication, Platten et al. describe the feasibility, safety, immunogenicity, and encouraging efficacy of a vaccine targeting the IDH1 R132H protein among newly diagnosed patients with IDH1-mutant glioma. These findings raise promising ...

    Abstract In a recent Nature publication, Platten et al. describe the feasibility, safety, immunogenicity, and encouraging efficacy of a vaccine targeting the IDH1 R132H protein among newly diagnosed patients with IDH1-mutant glioma. These findings raise promising therapeutic ramifications for the spectrum of IDH1/2-driven tumors.
    MeSH term(s) Glioma/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Mutation ; Vaccination
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2021-04-27
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2021.04.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Current Landscape of Immune Checkpoint Blockade in Glioblastoma.

    Akintola, Oluwatosin O / Reardon, David A

    Neurosurgery clinics of North America

    2021  Volume 32, Issue 2, Page(s) 235–248

    Abstract: The glioblastoma tumor microenvironment is highly immunosuppressed. This immunosuppressive state is engineered by inhibitory molecules secreted by tumor cells that limit activation of immune effector cells, drive T-cell exhaustion, and enhance the ... ...

    Abstract The glioblastoma tumor microenvironment is highly immunosuppressed. This immunosuppressive state is engineered by inhibitory molecules secreted by tumor cells that limit activation of immune effector cells, drive T-cell exhaustion, and enhance the immunosuppressive action of tumor-associated myeloid cells. Immunotherapeutic approaches have sought to combat glioblastoma microenvironment immunosuppression with agents such as immune checkpoint inhibitors. Although immune checkpoint blockade in glioblastoma has yielded disappointing results thus far, there is significant interest in the combination of immune checkpoint blockade with other approaches to enhance response.
    MeSH term(s) Glioblastoma/drug therapy ; Humans ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor/therapeutic use ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2020.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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