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Article ; Online: Isolectin B4 (IB4)-conjugated streptavidin for the selective knockdown of proteins in IB4-positive (+) nociceptors.

Bogen, Oliver / Araldi, Dionéia / Sucher, Anatol / Kober, Kord / Ohara, Peter T / Levine, Jon D

2024 Volume 20, Page(s) 17448069241230419

Abstract: ... In ... ...

Abstract	In vivo
MeSH term(s)	Rats ; Animals ; Lectins/metabolism ; Nociceptors/metabolism ; Streptavidin/metabolism ; Rats, Sprague-Dawley ; Nerve Fibers, Unmyelinated/metabolism ; Oligonucleotides, Antisense/metabolism ; Ganglia, Spinal/metabolism
Chemical Substances	Lectins ; Streptavidin (9013-20-1) ; Oligonucleotides, Antisense
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/17448069241230419
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Psychiatry and neurodevelopmental disorders: experts by experience, clinical care and research.

Alexander, Regi T / Langdon, Peter E / O'Hara, Jean / Howell, Andreana / Lane, Tadhgh / Tharian, Reena / Shankar, Rohit

The British journal of psychiatry : the journal of mental science

2021 Volume 218, Issue 1, Page(s) 1–3

Abstract: People with neurodevelopmental disorders often present with challenging behaviours and psychiatric illnesses. Diagnosis and treatment require patients, families and healthcare professionals to work closely together in partnership, acknowledging their ... ...

Abstract	People with neurodevelopmental disorders often present with challenging behaviours and psychiatric illnesses. Diagnosis and treatment require patients, families and healthcare professionals to work closely together in partnership, acknowledging their respective areas of expertise. Good treatment outcomes should also be underpinned by robust research evidence. Key research priorities are highlighted.
MeSH term(s)	Attention Deficit Disorder with Hyperactivity ; Autism Spectrum Disorder ; Humans ; Neurodevelopmental Disorders/diagnosis ; Neurodevelopmental Disorders/therapy ; Psychiatry
Language	English
Publishing date	2021-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	218103-4
ISSN	1472-1465 ; 0007-1250
ISSN (online)	1472-1465
ISSN	0007-1250
DOI	10.1192/bjp.2020.237
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Article ; Online: Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats.

Gong, Kerui / Ohara, Peter T / Jasmin, Luc

Journal of visualized experiments : JoVE

2016 , Issue 115

Abstract: Patch clamp studies from dorsal root ganglia (DRGs) neurons have increased our understanding of the peripheral nervous system. Currently, the majority of recordings are conducted on dissociated DRG neurons, which is a standard preparation for most ... ...

Abstract	Patch clamp studies from dorsal root ganglia (DRGs) neurons have increased our understanding of the peripheral nervous system. Currently, the majority of recordings are conducted on dissociated DRG neurons, which is a standard preparation for most laboratories. Neuronal properties, however, can be altered by axonal injury resulting from enzyme digestion used in acquiring dissociated neurons. Further, dissociated neuron preparations cannot fully represent the microenvironment of the DRG since loss of contact with satellite glial cells that surround the primary sensory neurons is an unavoidable consequence of this method. To overcome the limitations in using conventional dissociated DRG neurons for patch clamp recordings, in this report we describe a method to prepare intact DRGs and conduct patch clamp recordings on individual primary sensory neurons ex vivo. This approach permits the fast and straightforward preparation of intact DRGs, mimicking in vivo conditions by keeping DRG neurons associated with their surrounding satellite glial cells and basement membrane. Furthermore, the method avoids axonal injury from manipulation and enzyme digestion such as when dissociating DRGs. This ex vivo preparation can additionally be used to study the interaction between primary sensory neurons and satellite glial cells.
MeSH term(s)	Animals ; Ganglia, Spinal/physiology ; Male ; Neuroglia/physiology ; Neurons/physiology ; Patch-Clamp Techniques/methods ; Rats ; Rats, Sprague-Dawley ; Receptors, Glutamate/physiology ; TRPA1 Cation Channel ; TRPC Cation Channels/physiology
Chemical Substances	Receptors, Glutamate ; TRPA1 Cation Channel ; TRPC Cation Channels ; Trpa1 protein, rat
Language	English
Publishing date	2016-09-29
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1940-087X
ISSN (online)	1940-087X
DOI	10.3791/54287
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Article ; Online: Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity.

Akai, Masaaki / Noma, Kazuhiro / Kato, Takuya / Nishimura, Seitaro / Matsumoto, Hijiri / Kawasaki, Kento / Kunitomo, Tomoyoshi / Kobayashi, Teruki / Nishiwaki, Noriyuki / Kashima, Hajime / Kikuchi, Satoru / Ohara, Toshiaki / Tazawa, Hiroshi / Choyke, Peter L / Kobayashi, Hisataka / Fujiwara, Toshiyoshi

British journal of cancer

2024

Abstract: Background: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a critical role in tumor immunosuppression. However, targeted depletion of CAFs is difficult due to their diverse cells of origin and the resulting lack of ... ...

Abstract	Background: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a critical role in tumor immunosuppression. However, targeted depletion of CAFs is difficult due to their diverse cells of origin and the resulting lack of specific surface markers. Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer treatment that leads to rapid cell membrane damage. Methods: In this study, we used anti-mouse fibroblast activation protein (FAP) antibody to target FAP Results: FAP-targeted NIR-PIT induced specific cell death in CAFs without damaging adjacent normal cells. Furthermore, FAP-targeted NIR-PIT treated mice showed significant tumor regression in the CAF-rich tumor model accompanied by an increase in CD8 Conclusions: Cancers with FAP-positive CAFs in their TME grow rapidly and FAP-targeted NIR-PIT not only suppresses their growth but improves tumor immunosuppression. Thus, FAP-targeted NIR-PIT is a potential therapeutic strategy for selectively targeting the TME of CAF
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-024-02639-1
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Article ; Online: Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts using a Humanized anti-Fibroblast Activation Protein Antibody.

Kobayashi, Teruki / Noma, Kazuhiro / Nishimura, Seitaro / Kato, Takuya / Nishiwaki, Noriyuki / Ohara, Toshiaki / Kunitomo, Tomoyoshi / Kawasaki, Kento / Akai, Masaaki / Komoto, Satoshi / Kashima, Hajime / Kikuchi, Satoru / Tazawa, Hiroshi / Shirakawa, Yasuhiro / Choyke, Peter L / Kobayashi, Hisataka / Fujiwara, Toshiyoshi

Molecular cancer therapeutics

2024

Abstract: Esophageal cancer remains a highly aggressive malignancy with a poor prognosis, despite ongoing advancements in treatments such as immunotherapy. The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), plays a crucial role in ... ...

Abstract	Esophageal cancer remains a highly aggressive malignancy with a poor prognosis, despite ongoing advancements in treatments such as immunotherapy. The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), plays a crucial role in driving the aggressiveness of esophageal cancer. In a previous study utilizing human-derived xenograft models, we successfully developed a novel cancer treatment that targeted CAFs with near-infrared photoimmunotherapy (NIR-PIT), as an adjuvant therapy. In this study, we sought to translate our findings toward clinical practice by employing patient-derived xenograft (PDX) models and utilizing humanized monoclonal antibodies, specifically Sibrotuzumab, which is anti-human fibroblast activation protein (FAP) antibody and already being investigated in clinical trials as monotherapy. PDX models derived from esophageal cancer patients were effectively established, preserving the expression of key biomarkers such as EGFR and FAP, as observed in primary tumors. The application of FAP-targeted NIR-PIT using Sibrotuzumab, conjugated with the photosensitizer IR700DX, exhibited precise binding and selective elimination of FAP-expressing fibroblasts in vitro. Notably, in our in vivo investigations using both cell line-derived xenograft and PDX models, FAP-targeted NIR-PIT led to significant inhibition of tumor progression compared to control groups, all without inducing adverse events such as weight loss. Immunohistological assessments revealed a substantial reduction in CAFs exclusively within the tumor microenvironment of both models, further supporting the efficacy of our approach. Thus, our study demonstrates the potential of CAF-targeted NIR-PIT employing Sibrotuzumab as a promising therapeutic avenue for clinical treatment of esophageal cancer patients.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-23-0527
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Article ; Online: Close encounters of the third kind: evidence for contact with TNF-alpha.

Jasmin, Luc / Ohara, Peter T

Pain

2010 Volume 151, Issue 2, Page(s) 241–242

MeSH term(s)	Animals ; Microglia/drug effects ; Microglia/metabolism ; Models, Biological ; Peripheral Nervous System Diseases/immunology ; Peripheral Nervous System Diseases/pathology ; Substance P/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Tumor Necrosis Factor-alpha ; Substance P (33507-63-0)
Language	English
Publishing date	2010-08-23
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1016/j.pain.2010.07.025
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Article ; Online: Pain free and awake to enjoy it!

Jasmin, Luc / Ohara, Peter T

Pain

2009 Volume 141, Issue 3, Page(s) 187–188

MeSH term(s)	Animals ; Benzodiazepines/therapeutic use ; Humans ; Pain/drug therapy ; Pain/genetics ; Receptors, GABA-A/genetics ; Wakefulness
Chemical Substances	Receptors, GABA-A ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2009-01-06
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1016/j.pain.2008.12.014
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Article: Conversion of pilot plant derived 2G ethanol cellulosic stillage to value-added chemicals

Tana, Tana / Tran, Tuyen H.T. / Ramirez, Jerome / Strong, Peter James / O’Hara, Ian / Beltramini, Jorge / Doherty, William O.S. / Moghaddam, Lalehvash

Industrial crops and products. 2021 Nov. 01, v. 171

2021

Abstract: For second-generation (2 G) cellulosic ethanol production to be sustainable and viable, there is the need to value-add to the stillage. Here, pilot plant-derived 2G ethanol sugarcane bagasse stillage (BS) and eucalyptus stillage (ES) was transformed into ...

Abstract	For second-generation (2 G) cellulosic ethanol production to be sustainable and viable, there is the need to value-add to the stillage. Here, pilot plant-derived 2G ethanol sugarcane bagasse stillage (BS) and eucalyptus stillage (ES) was transformed into valuable products using hydrothermal liquefaction (HTL) at 300 °C and 20 bar with Pd/C and K₂CO₃. BS produced oil, phenolic monomers, and organic acid yields of 32 %, 49 % and 25 % respectively, while yields for ES were lower. Catechol constituted 43 % of the total phenolic content for BS. Recycling the aqueous phase (containing acetic, formic, lactic, and propionic acids) improved phenol, guaiacol and catechol yields. Oil stability tests indicated a significant drop in oil yield with aging, but there was no significant change in higher heating value. A preliminary techno-economic analysis suggests that the potential value of producing 2G ethanol and products (including fertilizer) from BS is three times that of depithed sugarcane bagasse. This study demonstrated a potential technology to convert 2 G cellulosic ethanol stillage to value-added chemicals, which not only improved the efficiency and profitability of 2G ethanol production but reduced organic contaminants synthesis.
Keywords	Eucalyptus ; bioethanol ; catechol ; ethanol ; ethanol production ; fertilizers ; guaiacol ; hydrothermal liquefaction ; oils ; phenol ; profitability ; sugarcane bagasse ; value added
Language	English
Dates of publication	2021-1101
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2021.113839
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Paclobutrazol elevates auxin and abscisic acid, reduces gibberellins and zeatin and modulates their transporter genes in Marubakaido apple (Malus prunifolia Borkh. var. ringo Asami) rootstocks.

Opio, Peter / Tomiyama, Hiroyuki / Saito, Takanori / Ohkawa, Katsuya / Ohara, Hitoshi / Kondo, Satoru

Plant physiology and biochemistry : PPB

2020 Volume 155, Page(s) 502–511

Abstract: To examine the dwarfing mechanism in apples, one-year-old Marubakaido (Malus prunifolia Borkh.) (invigorating) apple rootstock stools were foliar-sprayed with 860 mg ... ...

Abstract	To examine the dwarfing mechanism in apples, one-year-old Marubakaido (Malus prunifolia Borkh.) (invigorating) apple rootstock stools were foliar-sprayed with 860 mg L
MeSH term(s)	Abscisic Acid ; Gene Expression Regulation, Plant ; Genes, Plant ; Gibberellins ; Indoleacetic Acids ; Malus/drug effects ; Malus/genetics ; Plant Growth Regulators/metabolism ; Triazoles/pharmacology ; Zeatin
Chemical Substances	Gibberellins ; Indoleacetic Acids ; Plant Growth Regulators ; Triazoles ; paclobutrazol (6PLV42R3ZA) ; Abscisic Acid (72S9A8J5GW) ; Zeatin (7I6OOJ9GR6)
Language	English
Publishing date	2020-08-14
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2020.08.003
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Article ; Online: Skin cancer excisions and histopathology outcomes when following a contemporary population-based cohort longitudinally with 3D total-body photography.

Soyer, H Peter / O'Hara, Montana / V Silva, Carina / Horsham, Caitlin / Jayasinghe, Dilki / Sanjida, Saira / Schaider, Helmut / Aitken, Joanne / Sturm, Richard A / Prow, Tarl / Menzies, Scott W / Janda, Monika

Skin health and disease

2023 Volume 3, Issue 2, Page(s) e216

Abstract: Background: Skin cancer represents a significant health burden across the globe and early detection is critical to improve health outcomes. Three-dimensional (3D) total-body photography is a new and emerging technology which can support clinicians when ... ...

Abstract	Background: Skin cancer represents a significant health burden across the globe and early detection is critical to improve health outcomes. Three-dimensional (3D) total-body photography is a new and emerging technology which can support clinicians when they monitor people's skin over time. Objectives: The aim of this study was to improve our understanding of the epidemiology and natural history of melanocytic naevi in adults, and their relationship with melanoma and other skin cancers. Methods: Mind Your Moles was a 3-year prospective, population-based cohort study which ran from December 2016 to February 2020. Participants visited the Princess Alexandra Hospital every 6 months for 3 years to undergo both a clinical skin examination and 3D total-body photography. Results: A total of 1213 skin screening imaging sessions were completed. Fifty-six percent of participants ( Conclusions: 3D total-body imaging results in diagnosis of a high number of keratinocyte cancers (KCs) and their precursors in the general population.
Language	English
Publishing date	2023-01-22
Publishing country	England
Document type	Journal Article
ISSN	2690-442X
ISSN (online)	2690-442X
DOI	10.1002/ski2.216
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