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Article ; Online: Doctor shopping for methylphenidate as a proxy for misuse and potential abuse in the 67 million inhabitants in France.

Rolland, Benjamin

2021 Volume 35, Issue 4, Page(s) 749–750

MeSH term(s)	France ; Humans ; Methylphenidate ; Opioid-Related Disorders ; Physicians ; Prescription Drug Misuse
Chemical Substances	Methylphenidate (207ZZ9QZ49)
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12675
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Article ; Online: Reply to "Alcohol-related liver disease treatment and EBM".

Louvet, Alexandre / Rolland, Benjamin

Liver international : official journal of the International Association for the Study of the Liver

2022 Volume 42, Issue 10, Page(s) 2346

MeSH term(s)	Humans ; Liver Diseases/therapy ; Surveys and Questionnaires
Language	English
Publishing date	2022-06-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15342
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Article: Baclofen in alcohol use disorder: An analysis of the data provided by the French "Temporary Recommendation for Use" 2014-2017 cohort.

de Beaurepaire, Renaud / Rolland, Benjamin

Frontiers in psychiatry

2022 Volume 13, Page(s) 949750

Abstract: Alcohol use disorder (AUD) is a devastating illness for which effective treatments are lacking. Studies over the last two decades have shown that baclofen, a GABA-B agonist, could be a promising treatment for AUD. However, the efficacy of baclofen is ... ...

Abstract	Alcohol use disorder (AUD) is a devastating illness for which effective treatments are lacking. Studies over the last two decades have shown that baclofen, a GABA-B agonist, could be a promising treatment for AUD. However, the efficacy of baclofen is still controversial, and studies have shown that it may be associated with an excess of hospitalizations and deaths. In March 2014, the French Health Safety Agency granted a "Temporary Recommendation for Use" (TRU) regulating the prescription of baclofen in subjects with AUD. The TRU allowed physicians to prescribe high-dose baclofen (up to 300 mg/d). The doses were adjusted, and tailored to the needs of each patient. Between March 2014 and March 2017, TRU clinical data were collected for a total of 6,939 subjects. The recorded data included information on alcohol consumption, the intensity of alcohol cravings, and adverse events. The present article proposes an analysis of the data provided by the TRU. Subjects for which data were missing regarding baclofen daily dosage, alcohol consumption or craving scores were discarded from the analyses. A cohort of two groups of subjects was analyzed. The first group included all TRU subjects suitable for analyses (5,550 subjects), and the second group included subjects followed for at least 365 days (169 subjects). Comparisons were made between baseline and endpoint of the follow-up period. The results show that a majority of subjects in the whole cohort had received doses of over 80 mg/d. The mean dose of baclofen at the endpoint was >110 mg/d in the second group of subjects. Doses of >80 mg/d were not associated with an increase in adverse events after adjustment for the follow-up duration. In terms of efficacy, comparisons between baseline and endpoint show that baclofen treatment significantly decreased alcohol consumption and alcohol cravings, and significantly increased the number of subjects with null or low-risk alcohol consumption according to WHO criteria.
Language	English
Publishing date	2022-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.949750
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Article: La réhabilitation psychosociale en addictologie.

Peyron, Eric / Franck, Nicolas / Labaume, Laura / Rolland, Benjamin

L'Encephale

2023 Volume 50, Issue 1, Page(s) 91–98

Abstract: Objectives: Addictive behaviors constitute complex behaviors that are usually related to social habits, such as substance use, gambling or gaming activities, or sexual or physical activity. They progressively overrun and stifle the routine habits of the ...

Title translation	The psychosocial rehabilitation in addiction medicine.
Abstract	Objectives: Addictive behaviors constitute complex behaviors that are usually related to social habits, such as substance use, gambling or gaming activities, or sexual or physical activity. They progressively overrun and stifle the routine habits of the concerned individuals, for example within their occupational or family spheres of life, as well as in their hobbies or in their main physiological functions, such as sleep or eating cycles. The rehabilitation approach of care integrates the objective of restoring the altered habits and functional rhythms, to optimize the clinical outcomes and improve quality of life of the concerned persons. Methods: Using a focused and narrative literature review, we aimed to explain what psychosocial rehabilitation consists in, and why this approach is particularly relevant for the addiction care, although to date it has remained insufficiently developed in the routine practice of many facilities. Results: The "rehab" approach, is first based on a structured and comprehensive assessment of the clinical and functional aspects of the patient, which secondarily allows to frame an individualized project of care that is closely built together with the patient. This project of care can integrate classical pharmacotherapeutic and psychotherapeutic tools, but it also emphasizes wider approaches for restoring some basic social and physiological functions of the concerned person, such as sleep, eating, social functioning, physical activity, or spiritual needs. Priorities among these different dimensions have to be defined by the concerned person. Conclusions: The "rehab" approach is particularly relevant in addiction medicine. It represents a more global conception of care that conceives the recovery of social and physiological functioning as a core treatment objective for the concerned persons. The consequences for care organization are that many additional professionals should be integrated into the treatment schemes for addiction, including peer counselors, occupational therapists, physical activity coaches, or dieticians.
MeSH term(s)	Humans ; Quality of Life ; Psychiatric Rehabilitation ; Addiction Medicine ; Substance-Related Disorders/psychology ; Behavior, Addictive
Language	French
Publishing date	2023-09-16
Publishing country	France
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	214431-1
ISSN	0013-7006
ISSN	0013-7006
DOI	10.1016/j.encep.2023.07.001
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Article: Opinions of French psychiatrists on the regulatory status of cannabis: Results from the "PsyCan - Encéphale" national online survey.

Leclerc, Léa / Fakra, Eric / Pignon, Baptiste / Benyamina, Amine / Gaillard, Raphaël / Rolland, Benjamin

L'Encephale

2024

Abstract: Objective: To explore the opinions of French psychiatrists toward the legalization of medical or recreational use of cannabis in France.: Methods: Psycan was an anonymous Internet survey conducted between September 28, 2021 and March 29, 2022, among ... ...

Abstract	Objective: To explore the opinions of French psychiatrists toward the legalization of medical or recreational use of cannabis in France. Methods: Psycan was an anonymous Internet survey conducted between September 28, 2021 and March 29, 2022, among subscribers of the Encéphale Online community, i.e., approximately 4000 French psychiatrists. Participants were asked to complete a structured questionnaire, collecting their socio-demographic features, clinical experience, opinions toward cannabis legalization, and perceived impact of cannabis derivatives for psychiatric disorders. Logistic regression models were used to identify factors associated with being for or against cannabis legalization. Results: In total, 413 psychiatrists answered the survey, of whom 253 (61.3%) declared being in favour of recreational cannabis, and 349 (84.4%) of medical cannabis. Being in favour of legalization of recreational cannabis was negatively associated with being female (odd ratio [OR]=0.61; 95% confidence interval [CI]=0.41-0.93), and with the frequency of meeting patients with cannabis use disorder (OR=0.60; 95%CI=0.43-0.83). Most respondents were concerned about the development of psychotic disorders. The most frequent pro-legalization arguments were improved prevention, better control of product content, and better protection of youth, respectively. Arguments against legalization were increased societal damages, increased impact on health, including mental health. Conclusions: A majority of French psychiatrists were in favour of the marketing of medical cannabis, and, to a lesser extent, the legalization of recreational cannabis. For recreational cannabis, the proportion of pro-legalization psychiatrists was slightly more elevated than that found in the French general population.
Language	English
Publishing date	2024-02-03
Publishing country	France
Document type	Journal Article
ZDB-ID	214431-1
ISSN	0013-7006
ISSN	0013-7006
DOI	10.1016/j.encep.2023.11.008
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Article ; Online: Compared Profile of Late-Onset Versus Childhood-Onset ADHD: A Case-Control Study Among Treatment-Seeking Adult Patients.

Jurek, Lucie / Montègue, Solène / Larrieu, Agathe / Icard, Christophe / Rolland, Benjamin

Journal of attention disorders

2023 Volume 27, Issue 14, Page(s) 1630–1637

Abstract: Objective: To compare the characteristics of childhood-onset versus late-onset Attention Deficit Hyperactivity Disorder (ADHD) in a sample of treatment-seeking patients.: Method: Among total of 101 adult patients who were recently diagnosed for ADHD, ...

Abstract	Objective: To compare the characteristics of childhood-onset versus late-onset Attention Deficit Hyperactivity Disorder (ADHD) in a sample of treatment-seeking patients. Method: Among total of 101 adult patients who were recently diagnosed for ADHD, using the Diagnostic Interview for Adult ADHD (DIVA 2.0), 56 subjects exhibited childhood-onset ADHD, versus 45 displayed late-onset ADHD. Both groups were compared according to their sociodemographic, clinical, and neuropsychological features, providing crude ( Results: Compared to late-onset ADHD, patients with childhood-onset had a lower educational score, ( Conclusion: Childhood-onset adult ADHD displayed a more severe profile, relative to late-onset ADHD.
MeSH term(s)	Humans ; Adult ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Case-Control Studies ; Quality of Life ; Impulsive Behavior ; Substance-Related Disorders
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/10870547231191756
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Zs.A 5196: Show issues

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Article ; Online: Five Challenges in Implementing Cognitive Remediation for Patients with Substance Use Disorders in Clinical Settings.

Maurage, Pierre / Rolland, Benjamin / Pitel, Anne-Lise / D'Hondt, Fabien

Neuropsychology review

2023

Abstract: Many patients with substance use disorders (SUDs) present cognitive deficits, which are associated with clinical outcomes. Neuropsychological remediation might help rehabilitate cognitive functions in these populations, hence improving treatment ... ...

Abstract	Many patients with substance use disorders (SUDs) present cognitive deficits, which are associated with clinical outcomes. Neuropsychological remediation might help rehabilitate cognitive functions in these populations, hence improving treatment effectiveness. Nardo and colleagues (Neuropsychology Review, 32, 161-191, 2022) reviewed 32 studies applying cognitive remediation for patients with SUDs. They underlined the heterogeneity and lack of quality of studies in this research field but concluded that cognitive remediation remains a promising tool for addictive disorders. We capitalize on the insights of this review to identify the key barriers that currently hinder the practical implementation of cognitive remediation in clinical settings. We outline five issues to be addressed, namely, (1) the integration of cognitive remediation in clinical practices; (2) the selection criteria and individual factors to consider; (3) the timing to be followed; (4) the priority across trained cognitive functions; and (5) the generalization of the improvements obtained. We finally propose that cognitive remediation should not be limited to classical cognitive functions but should also be extended toward substance-related biases and social cognition, two categories of processes that are also involved in the emergence and persistence of SUDs.
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1062572-0
ISSN	1573-6660 ; 1040-7308
ISSN (online)	1573-6660
ISSN	1040-7308
DOI	10.1007/s11065-023-09623-1
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Article: Prise en charge des addictions en milieu carcéral.

Eck, Marion / Rolland, Benjamin / Icard, Christophe / Fovet, Thomas

Soins; la revue de reference infirmiere

2022 Volume 67, Issue 870-871, Page(s) 48–52

Abstract: High levels of substance-related disorders among incarcerated people have been documented and there is a lot of drug users in French prisons. Several health and social workers are involved in the management of people dealing with addictions in prison. ... ...

Title translation	Addiction management in prisons.
Abstract	High levels of substance-related disorders among incarcerated people have been documented and there is a lot of drug users in French prisons. Several health and social workers are involved in the management of people dealing with addictions in prison. The coordination between substance use and mental health services in correctional settings and in the community is fundamental to ensure treatment continuity for these people.
MeSH term(s)	Humans ; Prisons ; Prisoners/psychology ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy ; Behavior, Addictive
Language	French
Publishing date	2022-11-10
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604655-1
ISSN	0038-0814
ISSN	0038-0814
DOI	10.1016/j.soin.2022.11.011
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Article ; Online: Alignment, calibration, and validation of an adaptive optics scanning laser ophthalmoscope for high-resolution human foveal imaging.

Moon, Benjamin / Poletti, Martina / Roorda, Austin / Tiruveedhula, Pavan / Liu, Soh Hang / Linebach, Glory / Rucci, Michele / Rolland, Jannick P

Applied optics

2024 Volume 63, Issue 3, Page(s) 730–742

Abstract: In prior art, advances in adaptive optics scanning laser ophthalmoscope (AOSLO) technology have enabled cones in the human fovea to be resolved in healthy eyes with normal vision and low to moderate refractive errors, providing new insight into human ... ...

Abstract	In prior art, advances in adaptive optics scanning laser ophthalmoscope (AOSLO) technology have enabled cones in the human fovea to be resolved in healthy eyes with normal vision and low to moderate refractive errors, providing new insight into human foveal anatomy, visual perception, and retinal degenerative diseases. These high-resolution ophthalmoscopes require careful alignment of each optical subsystem to ensure diffraction-limited imaging performance, which is necessary for resolving the smallest foveal cones. This paper presents a systematic and rigorous methodology for building, aligning, calibrating, and testing an AOSLO designed for imaging the cone mosaic of the central fovea in humans with cellular resolution. This methodology uses a two-stage alignment procedure and thorough system testing to achieve diffraction-limited performance. Results from retinal imaging of healthy human subjects under 30 years of age with refractive errors of less than 3.5 diopters using either 680 nm or 840 nm light show that the system can resolve cones at the very center of the fovea, the region where the cones are smallest and most densely packed.
MeSH term(s)	Humans ; Calibration ; Fovea Centralis/diagnostic imaging ; Lasers ; Ophthalmoscopes ; Refractive Errors ; Retinal Diseases/diagnostic imaging
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.504283
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Article ; Online: Faster evolution of a premating reproductive barrier is not associated with faster speciation rates in New World passerine birds.

Freeman, Benjamin G / Rolland, Jonathan / Montgomery, Graham A / Schluter, Dolph

Proceedings. Biological sciences

2022 Volume 289, Issue 1966, Page(s) 20211514

Abstract: Why are speciation rates so variable across the tree of life? One hypothesis is that this variation is explained by how rapidly reproductive barriers evolve. We tested this hypothesis by conducting a comparative study of the evolution of bird song, a ... ...

Abstract	Why are speciation rates so variable across the tree of life? One hypothesis is that this variation is explained by how rapidly reproductive barriers evolve. We tested this hypothesis by conducting a comparative study of the evolution of bird song, a premating barrier to reproduction. Speciation in birds is typically initiated when geographically isolated (allopatric) populations evolve reproductive barriers. We measured the strength of song as a premating barrier between closely related allopatric populations by conducting 2339 field experiments to measure song discrimination for 175 taxon pairs of allopatric or parapatric New World passerine birds, and estimated recent speciation rates from molecular phylogenies. We found evidence that song discrimination is indeed an important reproductive barrier: taxon pairs with high song discrimination in allopatry did not regularly interbreed in parapatry. However, evolutionary rates of song discrimination were not associated with recent speciation rates. Evolutionary rates of song discrimination were also unrelated to latitude or elevation, but species with innate song (suboscines) evolved song discrimination much faster than species with learned song (oscines). We conclude that song is a key premating reproductive barrier in birds, but faster evolution of this reproductive barrier between populations does not consistently result in faster diversification between species.
MeSH term(s)	Animals ; Biological Evolution ; Genetic Speciation ; Learning ; Phylogeny ; Reproduction ; Songbirds
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2021.1514
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