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  1. Article ; Online: A case of hypopigmented mycosis fungoides with granulomatous slack skin.

    Cui, Wenjuan / Wang, Su / Xu, Junzhu

    International journal of dermatology

    2024  Volume 63, Issue 5, Page(s) 690–691

    MeSH term(s) Humans ; Mycosis Fungoides/pathology ; Mycosis Fungoides/diagnosis ; Mycosis Fungoides/complications ; Skin Neoplasms/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/complications ; Hypopigmentation/pathology ; Hypopigmentation/diagnosis ; Male ; Skin/pathology ; Female
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Case Reports ; Letter ; Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Research progress on genetic control of host susceptibility to tuberculosis.

    Hu, Wenjuan / Xu, Kaijin

    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

    2023  Volume 51, Issue 6, Page(s) 679–690

    Abstract: The "Lübeck disaster", twins studies, adoptees studies, and other epidemiological observational studies have shown that host genetic factors play a significant role in determining the host susceptibility ... ...

    Abstract The "Lübeck disaster", twins studies, adoptees studies, and other epidemiological observational studies have shown that host genetic factors play a significant role in determining the host susceptibility to
    MeSH term(s) Humans ; Genome-Wide Association Study ; Tuberculosis/genetics ; Gene Expression Regulation ; Cytokines/genetics ; Autoimmune Diseases ; Mycobacterium tuberculosis/genetics ; Genetic Predisposition to Disease
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-03-09
    Publishing country China
    Document type Review ; Journal Article
    ISSN 1008-9292
    ISSN 1008-9292
    DOI 10.3724/zdxbyxb-2022-0484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Case Report: A rare case of intramedullary spinal cord abscess with brain abscess caused by Klebsiella pneumoniae underwent surgical intervention.

    Zhang, Wenjuan / Guo, Xiangyu / Xu, Xuejun / Deng, Bing

    Frontiers in surgery

    2024  Volume 11, Page(s) 1338719

    Abstract: Background: Intramedullary Spinal Cord Abscess (ISCA) is an uncommon infectious disease of the central nervous system. Since its first report in 1830, there have been very few documented cases associated with it. Here, we present a case of ISCA with ... ...

    Abstract Background: Intramedullary Spinal Cord Abscess (ISCA) is an uncommon infectious disease of the central nervous system. Since its first report in 1830, there have been very few documented cases associated with it. Here, we present a case of ISCA with cerebral abscess caused by Klebsiella pneumoniae.
    Case presentation: A 55-year-old male patient presented with head and neck pain, fever, and left limb weakness for 5 days. The diagnosis of ISCA with brain abscess caused by Klebsiella pneumoniae was confirmed through sputum culture, cerebrospinal fluid gene test, pus culture, and magnetic resonance imaging (MRI) as well as computerized tomography (CT) scan. The patient had a history of pulmonary tuberculosis and old tuberculous foci were observed in the lung. Initially considering tuberculosis as the cause due to unclear etiology at that time, anti-tuberculosis treatment was administered. However, due to rapid deterioration in the patient's condition and severe neurological dysfunction within a short period of time after admission, surgical intervention including incision and drainage for intramedullary abscess along with removal of brain abscess was performed. Subsequent postoperative follow-up showed improvement in both symptoms and imaging findings.
    Conclusion: Early diagnosis of central nervous system (CNS) abscess coupled with prompt surgical intervention and administration of appropriate antibiotics are crucial factors in preventing disease progression and reducing mortality rates.
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2024.1338719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Aabrm1

    Li, Rong / Li, Yongcai / Xu, Wenyi / Liu, Wenjuan / Xu, Xiaobin / Bi, Yang / Prusky, Dov

    Frontiers in microbiology

    2024  Volume 14, Page(s) 1327765

    Abstract: Scytalone dehydratase (brm1) is one of the key enzymes in 1, 8-dihydroxynaphthalene (DHN) melanin synthesis, which mediates melanin biosythesis and regulates cell biological process of plant fungi, but its function ... ...

    Abstract Scytalone dehydratase (brm1) is one of the key enzymes in 1, 8-dihydroxynaphthalene (DHN) melanin synthesis, which mediates melanin biosythesis and regulates cell biological process of plant fungi, but its function in
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1327765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Gene polymorphisms of

    Zhang, Siyi / Liu, Shanshan / Chen, Wenchu / Yan, Yaping / Cai, Mansi / Liu, Xiaoping / Luo, Ailing / Li, Wenjuan / Yi, Lisha / Xu, Yingyi

    Journal of Cancer

    2024  Volume 15, Issue 6, Page(s) 1762–1769

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.90379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Research advances in intestinal diseases and related diarrhea in animal production.

    Du, Wenjuan / Wang, Xianghuang / Xu, Le / Zhou, Xihong / Song, Deguang / Xu, Qingbiao

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1201231

    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1201231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of flavor substances of rice bran kvass based on electronic nose and gas chromatography-mass spectrometry.

    Yu, Xiaochen / Zhang, Wenjuan / Xin, Liying / Xu, Su / Cheng, Jianjun

    Food chemistry: X

    2024  Volume 21, Page(s) 101161

    Abstract: In this paper, the electronic nose (E-nose) and headspace-solid phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC-MS) were used to analyze the volatiles of rice bran kvass (RBK) with the reference of Qiulin kvass (QLK) ...

    Abstract In this paper, the electronic nose (E-nose) and headspace-solid phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC-MS) were used to analyze the volatiles of rice bran kvass (RBK) with the reference of Qiulin kvass (QLK). Meanwhile, the flavor amino acids of RBK before and after fermentation were determined. The results showed that the kinds of kvass remained consistent in terms of the overall category of volatiles while there were differences in content between them (p < 0.05). A total of 35 volatile compounds, mainly including esters, alcohols, phenols, aldehydes, and acids, were identified by GC-MS in the two kinds of kvass. In addition, the total essential amino acid content and the total sweet amino acid content of RBK increased significantly (
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1575
    ISSN (online) 2590-1575
    DOI 10.1016/j.fochx.2024.101161
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  8. Article ; Online: Macrophage: Hidden Criminal in Therapy Resistance.

    Ding, Yimin / Cao, Qian / Yang, Wenjuan / Xu, Junjie / Xiao, Peng

    Journal of innate immunity

    2024  Volume 16, Issue 1, Page(s) 188–202

    Abstract: Background: Although substantial efforts have been made by researchers to develop drugs, a disappointing reality is that the emergence of drug resistance is an unavoidable reality for the majority of patients. In recent years, emerging evidence suggests ...

    Abstract Background: Although substantial efforts have been made by researchers to develop drugs, a disappointing reality is that the emergence of drug resistance is an unavoidable reality for the majority of patients. In recent years, emerging evidence suggests a connection between drug resistance and immune dysregulation.
    Summary: As a ubiquitously distributed, versatile innate immune cell, macrophages play essential roles in maintaining tissue homeostasis in a steady state. Nevertheless, it is becoming aware that macrophages undermine the action of therapeutic drugs across various disease types. Reprogramming macrophage function has been proven to be effective in restoring patient responsiveness to treatment. Herein, we comprehensively reviewed how macrophages respond to drugs and the mechanisms by which they contribute to treatment unresponsiveness in cancer, inflammatory diseases, and metabolic diseases. In addition, future prospects in macrophage-based combination therapy were discussed.
    Key messages: Targeting macrophages is a promising strategy for overcoming drug resistance in immune disorders.
    MeSH term(s) Humans ; Macrophages/immunology ; Animals ; Immunity, Innate ; Neoplasms/immunology ; Neoplasms/therapy ; Neoplasms/drug therapy ; Drug Resistance ; Inflammation/immunology ; Homeostasis
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000538212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Application of Data Encryption Technology in Network Information Security Sharing

    Dongzhi Xu / Wenjuan Zheng

    Security and Communication Networks, Vol

    2022  Volume 2022

    Abstract: In order to solve the problem of user information insecurity in the process of network information security sharing, this study proposes a data encryption technology based on network information security sharing. This method applies the data encryption ... ...

    Abstract In order to solve the problem of user information insecurity in the process of network information security sharing, this study proposes a data encryption technology based on network information security sharing. This method applies the data encryption technology to the computer network security protection, which can not only improve the computer network security but also protect the user data information security and provide users with more efficient and high-quality computer network services. The experimental results show that it takes about 2.35 seconds to generate a 1024-bit key pair. It takes about 12.29 seconds to encrypt a 2.1 m text document with a 1024-bit public key and about 561 seconds to decrypt a 2.1 m text document. Conclusion. The data encryption technology based on network information security sharing can effectively solve the problem of user information insecurity in the process of network information security sharing.
    Keywords Technology (General) ; T1-995 ; Science (General) ; Q1-390
    Subject code 303
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi-Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Switching to the aflibercept (3 mg) therapy for treatment-resistant wet age-related macular degeneration: 1-year outcomes.

    Feng, Chengcheng / Chu, Wenjuan / Lin, Ping / Xu, Haifeng / Chen, Xiuli

    Medicine

    2024  Volume 103, Issue 16, Page(s) e37839

    Abstract: This study aimed to elucidate 1-year outcomes following switching to the aflibercept (3 mg) therapy for treatment-resistant wet age-related macular degeneration (wAMD). In this prospective, open-label, non-controlled clinical trial, 18 patients with wAMD ...

    Abstract This study aimed to elucidate 1-year outcomes following switching to the aflibercept (3 mg) therapy for treatment-resistant wet age-related macular degeneration (wAMD). In this prospective, open-label, non-controlled clinical trial, 18 patients with wAMD who had multiple recurrences or persistent exudation despite intravitreal injections of anti-vascular endothelial growth factor agents (except aflibercept) received a 3-mg intravitreal aflibercept injection every 4 weeks. Each patient received 3 to 8 injections. The central retinal thickness and fibrovascular pigment epithelial detachment height decreased significantly at 1 month after initiation of the aflibercept injection, and the values were 146 and 163.2 μm, respectively, at the final visit. The morphological improvement was sustained. The intraretinal and subretinal fluid was completely absorbed at the end of the follow-up. The logMAR vision increased from baseline 0.68 to 0.59 (P < .05). No ocular or systemic adverse events occurred. The intravitreal injection of 3-mg aflibercept seems to be feasible in the treatment of wAMD unresponsive to other anti-vascular endothelial growth factor agents.
    MeSH term(s) Humans ; Treatment Outcome ; Prospective Studies ; Endothelial Growth Factors/therapeutic use ; Wet Macular Degeneration/drug therapy ; Receptors, Vascular Endothelial Growth Factor/therapeutic use ; Recombinant Fusion Proteins/therapeutic use ; Retina ; Intravitreal Injections ; Angiogenesis Inhibitors/therapeutic use ; Tomography, Optical Coherence ; Ranibizumab/therapeutic use
    Chemical Substances aflibercept (15C2VL427D) ; Endothelial Growth Factors ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) ; Recombinant Fusion Proteins ; Angiogenesis Inhibitors ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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