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Article ; Online: Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes.

MacLeod, Daniel T / Nakatsuji, Teruaki / Wang, Zhenping / di Nardo, Anna / Gallo, Richard L

The Journal of investigative dermatology

2014 Volume 135, Issue 1, Page(s) 142–150

Abstract: ... with keratinocytes. The class A scavenger receptor known as MARCO (macrophage receptor with collagenous structure) is ... with AD. VV bound directly to MARCO, and overexpression of MARCO increased susceptibility to VV infection ... Furthermore, ligands with affinity for MARCO, or excess soluble MARCO, competitively inhibited VV infection ...

Abstract	Patients with altered skin immunity, such as individuals with atopic dermatitis (AD), can have a life-threatening disruption of the epidermis known as eczema vaccinatum after vaccinia virus (VV) infection of the skin. Here, we sought to better understand the mechanism(s) by which VV associates with keratinocytes. The class A scavenger receptor known as MARCO (macrophage receptor with collagenous structure) is expressed on human and mouse keratinocytes and found to be abundantly expressed in the skin of patients with AD. VV bound directly to MARCO, and overexpression of MARCO increased susceptibility to VV infection. Furthermore, ligands with affinity for MARCO, or excess soluble MARCO, competitively inhibited VV infection. These findings indicate that MARCO promotes VV infection and highlights potential new therapeutic strategies for prevention of VV infection in the skin.
MeSH term(s)	Animals ; Cells, Cultured ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/metabolism ; Humans ; Keratinocytes/cytology ; Keratinocytes/immunology ; Keratinocytes/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Binding/immunology ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; Receptors, Scavenger/antagonists & inhibitors ; Receptors, Scavenger/metabolism ; Smallpox Vaccine/adverse effects ; Smallpox Vaccine/immunology ; Vaccinia/immunology ; Vaccinia/metabolism ; Vaccinia/prevention & control ; Vaccinia virus/immunology ; Vaccinia virus/metabolism ; Viral Vaccines
Chemical Substances	MARCO protein, human ; Marco protein, mouse ; Receptors, Immunologic ; Receptors, Scavenger ; Smallpox Vaccine ; Viral Vaccines
Language	English
Publishing date	2014-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1038/jid.2014.330
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Article ; Online: HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection.

MacLeod, Daniel T / Nakatsuji, Teruaki / Yamasaki, Kenshi / Kobzik, Lester / Gallo, Richard L

Nature communications

2013 Volume 4, Page(s) 1963

Abstract: ... receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid ... with heparan sulphate proteoglycans to mediate adsorption to epithelial cells. Ligands of MARCO dramatically inhibit ... Herpes simplex virus type 1 glycoprotein C closely co-localizes with MARCO at the cell surface, and glycoprotein C ...

Abstract	Herpes simplex virus type 1 is an important epithelial pathogen and has the potential for significant morbidity in humans. Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition, is usurped by herpes simplex virus type 1 and functions together with heparan sulphate proteoglycans to mediate adsorption to epithelial cells. Ligands of MARCO dramatically inhibit herpes simplex virus type 1 adsorption and infection of human keratinocytes and protect mice against infection. Herpes simplex virus type 1 glycoprotein C closely co-localizes with MARCO at the cell surface, and glycoprotein C binds directly to purified MARCO with high affinity. Increasing MARCO expression enhances herpes simplex virus type 1 infection while MARCO(-/-) mice have reduced susceptibility to infection by herpes simplex virus type 1. These findings demonstrate that herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease, and suggests a new therapeutic target to alter pathogenicity of herpes simplex virus type 1 in skin infection.
MeSH term(s)	Adsorption ; Animals ; Cell Membrane/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Epithelial Cells/virology ; Herpes Simplex/metabolism ; Herpes Simplex/pathology ; Herpes Simplex/virology ; Herpesvirus 1, Human/physiology ; Humans ; Immunity, Innate/immunology ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Keratinocytes/virology ; Ligands ; Mice ; Protein Binding ; Protein Transport ; Receptors, Immunologic/metabolism ; Receptors, Scavenger/metabolism ; Viral Envelope Proteins/isolation & purification ; Viral Envelope Proteins/metabolism ; Virion/metabolism
Chemical Substances	Ligands ; MARCO protein, human ; Marco protein, mouse ; Receptors, Immunologic ; Receptors, Scavenger ; Viral Envelope Proteins ; glycoprotein gC, herpes simplex virus type 1
Language	English
Publishing date	2013-05-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/ncomms2963
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Article ; Online: La noción de marco y sistema de referencia para la enseñanza de la relatividad del movimiento en la física clásica

Oscar Fernando Gallo Aconcha

Revista Científica, Vol 13, Iss

2011 Volume 1

Abstract: ... que tienen las nociones de marco y sistema de referencia en la relatividad clásica y de cómo influyen e la enseñanza ... están íntimamente ligadas a las nociones de marco y sistema de referencia y ...

Abstract	La introducción de la enseñanza de la física moderna y en particular de la relatividad del movimiento en la educación media se ha convertido en la última década en una preocupación para investigadores de la didáctica de la física y maestros. Con esta propuesta se pretende mostrar la importancia que tienen las nociones de marco y sistema de referencia en la relatividad clásica y de cómo influyen e la enseñanza de la relatividad del movimiento. En muchos casos la comprensión de algunos conceptos no ha sido lograda de la mejor manera, generando falencias a la hora de analizar fenómenos y enfrentar la validez de proposiciones teóricas que dan cuenta de los mismos; esto ocurre, en particular cuando se enseñan temas referentes a la relatividad del movimiento. El trabajo se limitara a mostrar como las nociones de movimiento, espacio y cuerpo están íntimamente ligadas a las nociones de marco y sistema de referencia y de cómo estos últimos están muy lejos de una simple definición.
Keywords	Marco de referencia ; Sistema de referencia ; Relatividad del movimiento ; movimiento ; espacio ; cuerpo ; Technology ; T ; Science ; Q
Language	English
Publishing date	2011-08-01T00:00:00Z
Publisher	Universidad Distrital Francisco José de Caldas
Document type	Article ; Online
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Article ; Online: Prognostic value of integrative genomic approaches for IDH-mutant gliomas.

Gallo, Marco

Neuro-oncology

2023 Volume 25, Issue 11, Page(s) 2042–2043

MeSH term(s)	Humans ; Prognosis ; Isocitrate Dehydrogenase/genetics ; Genes, Homeobox ; Glioma/genetics ; Brain Neoplasms/genetics ; Genomics
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noad151
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Article: Papel de los servicios de Atención Especializada del Sistema Nacional de Salud en el nuevo marco de la prevencion de riesgos laborales (y II).

Gallo-Fernández, M

Revista de neurologia

2000 Volume 31, Issue 9, Page(s) 876–879

Abstract: Introduction: Since 1986, the Government of Navarra has taken over the functions of security and health as part of the health 'area', with a broad conception of health, avoiding separating the citizen from the worker. In 1993, the Instituto Navarro de ... ...

Title translation	Role of specialized care services of the national health service in the framework for the prevention of occupational risks (II).
Abstract	Introduction: Since 1986, the Government of Navarra has taken over the functions of security and health as part of the health 'area', with a broad conception of health, avoiding separating the citizen from the worker. In 1993, the Instituto Navarro de Salud Laboral created, under the direction of the departments of Health and Labor, combined diverse functions and resources, integrating preexisting structures into a technical department to be responsible for the overall health care of workers. Development: The structure is based on two coordinated pillars, security and hygiene at work and occupational health. As more specifically to do with health, we describe the systems of epidemiological information and vigilance and programs for occupational disabilities, health activities in industry and investigation of diseases. The Unidades de Salud Laboral link the workplace with the public health service. The occupational health plan of Navarra will set out future strategies. Conclusions: It is necessary to involve neurologists in occupational health. Occupational risks and injury are everyone's problem. The neurologist's role in accidents is usually of health care; detection of illness is more difficult when an occupational relationship is not considered. Data from work should be included in the clinical history. The official figures for occupational neurological diseases are ridiculous and more cases should be detected. There should be a fluid relationship between neurologists, occupational doctors and experts in prevention.
MeSH term(s)	Humans ; National Health Programs/organization & administration ; Neurology/organization & administration ; Occupational Health ; Occupational Medicine/organization & administration ; Regional Health Planning ; Spain
Language	Spanish
Publishing date	2000-11
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
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Article ; Online: Current advancements in B-cell receptor sequencing fast-track the development of synthetic antibodies.

Gallo, Eugenio

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 134

Abstract: ... the ability to improve the design and engineering of synthetic Abs by offering an initial sequence framework ...

Abstract	Synthetic antibodies (Abs) are a class of engineered proteins designed to mimic the functions of natural Abs. These are produced entirely in vitro, eliminating the need for an immune response. As such, synthetic Abs have transformed the traditional methods of raising Abs. Likewise, deep sequencing technologies have revolutionized genomics and molecular biology. These enable the rapid and cost-effective sequencing of DNA and RNA molecules. They have allowed for accurate and inexpensive analysis of entire genomes and transcriptomes. Notably, via deep sequencing it is now possible to sequence a person's entire B-cell receptor immune repertoire, termed BCR sequencing. This procedure allows for big data explorations of natural Abs associated with an immune response. Importantly, the identified sequences have the ability to improve the design and engineering of synthetic Abs by offering an initial sequence framework for downstream optimizations. Additionally, machine learning algorithms can be introduced to leverage the vast amount of BCR sequencing datasets to rapidly identify patterns hidden in big data to effectively make in silico predictions of antigen selective synthetic Abs. Thus, the convergence of BCR sequencing, machine learning, and synthetic Ab development has effectively promoted a new era in Ab therapeutics. The combination of these technologies is driving rapid advances in precision medicine, diagnostics, and personalized treatments.
MeSH term(s)	Humans ; Receptors, Antigen, B-Cell/genetics ; Antibodies/genetics ; Algorithms ; Big Data ; Genomics
Chemical Substances	Receptors, Antigen, B-Cell ; Antibodies
Language	English
Publishing date	2024-01-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08941-0
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Article ; Online: The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design.

Gallo, Eugenio

Journal of biomedical science

2024 Volume 31, Issue 1, Page(s) 29

Abstract: ... Within this framework, deep sequencing has enabled the exploration of whole genomes and transcriptomes, including ...

Abstract	Synthetic antibodies (Abs) represent a category of artificial proteins capable of closely emulating the functions of natural Abs. Their in vitro production eliminates the need for an immunological response, streamlining the process of Ab discovery, engineering, and development. These artificially engineered Abs offer novel approaches to antigen recognition, paratope site manipulation, and biochemical/biophysical enhancements. As a result, synthetic Abs are fundamentally reshaping conventional methods of Ab production. This mirrors the revolution observed in molecular biology and genomics as a result of deep sequencing, which allows for the swift and cost-effective sequencing of DNA and RNA molecules at scale. Within this framework, deep sequencing has enabled the exploration of whole genomes and transcriptomes, including particular gene segments of interest. Notably, the fusion of synthetic Ab discovery with advanced deep sequencing technologies is redefining the current approaches to Ab design and development. Such combination offers opportunity to exhaustively explore Ab repertoires, fast-tracking the Ab discovery process, and enhancing synthetic Ab engineering. Moreover, advanced computational algorithms have the capacity to effectively mine big data, helping to identify Ab sequence patterns/features hidden within deep sequencing Ab datasets. In this context, these methods can be utilized to predict novel sequence features thereby enabling the successful generation of de novo Ab molecules. Hence, the merging of synthetic Ab design, deep sequencing technologies, and advanced computational models heralds a new chapter in Ab discovery, broadening our comprehension of immunology and streamlining the advancement of biological therapeutics.
MeSH term(s)	Genomics ; Binding Sites, Antibody ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-024-01018-5
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Article: Editorial: Management and Treatment of Pilonidal Disease: 189 Years After Mayo.

Gallo, Gaetano / Milone, Marco / La Torre, Marco / Basso, Luigi

Frontiers in surgery

2022 Volume 9, Page(s) 950793

Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.950793
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Article ; Online: The local variation of the Gaussian modulus enables different pathways for fluid lipid vesicle fusion.

Bottacchiari, Matteo / Gallo, Mirko / Bussoletti, Marco / Casciola, Carlo Massimo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 23

Abstract: Viral infections, fertilization, neurotransmission, and many other fundamental biological processes rely on membrane fusion. Straightforward calculations based on the celebrated Canham-Helfrich elastic model predict a large topological energy barrier ... ...

Abstract	Viral infections, fertilization, neurotransmission, and many other fundamental biological processes rely on membrane fusion. Straightforward calculations based on the celebrated Canham-Helfrich elastic model predict a large topological energy barrier that prevents the fusion process from being thermally activated. While such high energy is in accordance with the physical barrier function of lipid membranes, it is difficult to reconcile with the biological mechanisms involved in fusion processes. In this work, we use a Ginzburg-Landau type of free energy that recovers the Canham-Helfrich model in the limit of small width-to-vesicle-extension ratio, with the additional ability to handle topological transitions. We show that a local modification of the Gaussian modulus in the merging region both dramatically lowers the elastic energy barrier and substantially changes the minimal energy pathway for fusion, in accordance with experimental evidence. Therefore, we discuss biological examples in which such a modification might play a crucial role.
MeSH term(s)	Membrane Fusion ; Entropy ; Membranes ; Biological Transport ; Lipids ; Lipid Bilayers
Chemical Substances	Lipids ; Lipid Bilayers
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50922-7
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Article ; Online: Design and Characterization of a Powered Wheelchair Autonomous Guidance System.

Gallo, Vincenzo / Shallari, Irida / Carratù, Marco / Laino, Valter / Liguori, Consolatina

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 5

Abstract: The current technological revolution driven by advances in machine learning has motivated a wide range of applications aiming to improve our quality of life. Representative of such applications are autonomous and semiautonomous Powered Wheelchairs (PWs), ...

Abstract	The current technological revolution driven by advances in machine learning has motivated a wide range of applications aiming to improve our quality of life. Representative of such applications are autonomous and semiautonomous Powered Wheelchairs (PWs), where the focus is on providing a degree of autonomy to the wheelchair user as a matter of guidance and interaction with the environment. Based on these perspectives, the focus of the current research has been on the design of lightweight systems that provide the necessary accuracy in the navigation system while enabling an embedded implementation. This motivated us to develop a real-time measurement methodology that relies on a monocular RGB camera to detect the caregiver's feet based on a deep learning method, followed by the distance measurement of the caregiver from the PW. An important contribution of this article is the metrological characterization of the proposed methodology in comparison with measurements made with dedicated depth cameras. Our results show that despite shifting from 3D imaging to 2D imaging, we can still obtain comparable metrological performances in distance estimation as compared with Light Detection and Ranging (LiDAR) or even improved compared with stereo cameras. In particular, we obtained comparable instrument classes with LiDAR and stereo cameras, with measurement uncertainties within a magnitude of 10 cm. This is further complemented by the significant reduction in data volume and object detection complexity, thus facilitating its deployment, primarily due to the reduced complexity of initial calibration, positioning, and deployment compared with three-dimensional segmentation algorithms.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24051581
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