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  1. Article ; Online: G

    Boyhus, Lotte-Emilie / Danielsen, Mia / Bengtson, Nina Smidt / Ben Achim Kunze, Micha / Kubiak, Xavier / Sminia, Tjerk J / Løper, Jacob Hartvig / Tran, Phuong Thu / Lindorff-Larsen, Kresten / Rasmussen, Søren G F / Mathiesen, Jesper Mosolff / Pedersen, Daniel Sejer

    RSC advances

    2018  Volume 8, Issue 4, Page(s) 2219–2228

    Abstract: A series of G ...

    Abstract A series of G
    Language English
    Publishing date 2018-01-09
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c7ra11713b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: G

    Chen, Min / Wilson, Eric A / Cui, Zhenzhong / Sun, Hui / Shrestha, Yogendra B / Podyma, Brandon / Le, Christina H / Naglieri, Benedetta / Pacak, Karel / Gavrilova, Oksana / Weinstein, Lee S

    Molecular metabolism

    2019  Volume 25, Page(s) 142–153

    Abstract: Objective: G: Methods: We created mice (DMHGsKO) with G: Results: DMHGsKO mice developed ... in the DMH suggest that defective DMH MC4R/G: Conclusions: DMH G ...

    Abstract Objective: G
    Methods: We created mice (DMHGsKO) with G
    Results: DMHGsKO mice developed severe, early-onset obesity associated with hyperphagia and reduced energy expenditure and locomotor activity, along with impaired brown adipose tissue thermogenesis. Studies in mice with loss of MC4R in the DMH suggest that defective DMH MC4R/G
    Conclusions: DMH G
    MeSH term(s) Adipose Tissue, Brown/metabolism ; Animals ; Energy Metabolism/physiology ; GTP-Binding Protein alpha Subunits, Gs/genetics ; GTP-Binding Protein alpha Subunits, Gs/metabolism ; Gene Expression Regulation ; Genetic Predisposition to Disease/genetics ; Glucose/metabolism ; Homeostasis/physiology ; Hyperphagia/metabolism ; Hypothalamus/metabolism ; Leptin/metabolism ; Male ; Mice ; Mice, Knockout ; Obesity/genetics ; Obesity/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Receptor, Melanocortin, Type 4/metabolism ; Signal Transduction/physiology ; Sympathetic Nervous System/metabolism ; Thermogenesis/physiology
    Chemical Substances Leptin ; MC4R protein, mouse ; Receptor, Melanocortin, Type 4 ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 (EC 3.1.3.48) ; Ptpn1 protein, mouse (EC 3.1.3.48) ; GTP-Binding Protein alpha Subunits, Gs (EC 3.6.5.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-04-12
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 2212-8778
    ISSN (online) 2212-8778
    DOI 10.1016/j.molmet.2019.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: g-C

    Chen, Chao / Zhou, Shilong / Xia, Jiawei / Li, Le / Qian, Xingyue / Yin, Fengxiang / He, Guangyu / Chen, Haiqun

    Journal of colloid and interface science

    2023  Volume 653, Issue Pt A, Page(s) 551–560

    Abstract: Exploring efficient, easy-to-manufacture, and inexpensive bifunctional electrocatalysts with abundant accessible active sites is crucial for rechargeable zinc-air batteries (ZABs). Herein, we report the strategy consisting of the space confinement and ... ...

    Abstract Exploring efficient, easy-to-manufacture, and inexpensive bifunctional electrocatalysts with abundant accessible active sites is crucial for rechargeable zinc-air batteries (ZABs). Herein, we report the strategy consisting of the space confinement and pore-making engineering to fabricate single-atom catalyst enriched with Fe-N
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.09.094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  4. Article ; Online: Phosphorous doped g-C

    Liu, Gang / Wang, Ya / Zhou, YuYi / Cao, JiaLe / Yuan, Ming / Lv, Hui

    Journal of colloid and interface science

    2021  Volume 594, Page(s) 658–668

    Abstract: The photoreduction of the green-house gas ... ...

    Abstract The photoreduction of the green-house gas CO
    Language English
    Publishing date 2021-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2021.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  5. Article ; Online: CdS Deposited In Situ on g-C

    Ma, Ligang / Jiang, Wenjun / Lin, Chao / Xu, Le / Zhu, Tianyu / Ai, Xiaoqian

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 23

    Abstract: ... applications. Herein, CdS nanorods are successfully grown in situ between a monolayer of g-C ...

    Abstract Ultra-thin two-dimensional materials are attracting widespread interest due to their excellent properties, and they are becoming ideal candidates for a variety of energy and environmental photocatalytic applications. Herein, CdS nanorods are successfully grown in situ between a monolayer of g-C
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28237846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Fabrication of binary g-C

    Nguyen, Trinh Duy / Nguyen, Vinh Huu / Le Hoang Pham, Ai / Van Nguyen, Tuyen / Lee, Taeyoon

    RSC advances

    2022  Volume 12, Issue 39, Page(s) 25377–25387

    Abstract: In this study, g-C ...

    Abstract In this study, g-C
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra04222c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: G-CSF reshapes the cytosolic PCNA scaffold and modulates glycolysis in neutrophils.

    Aymonnier, Karen / Bosetta, Enzo / Leborgne, Nathan G F / Ullmer, Audrey / Le Gall, Morgane / De Chiara, Alessia / Salnot, Virginie / Many, Souganya / Scapini, Patrizia / Wicks, Ian / Chatfield, Simon / Martin, Katherine R / Witko-Sarsat, Véronique

    Journal of leukocyte biology

    2023  Volume 115, Issue 2, Page(s) 205–221

    Abstract: ... Granulocyte colony-stimulating factor (G-CSF) is a cytokine produced in response to inflammatory stimuli that regulates many aspects ... of neutrophil biology. Here, we used isolated normal-density neutrophils from G-CSF-treated ... glycolysis in HDs but had no effect on GD neutrophils. These data demonstrate that G-CSF alters the PCNA ...

    Abstract Cytosolic proliferating cell nuclear antigen (PCNA) is involved in neutrophil survival and function, in which it acts as a scaffold and associates with proteins involved in apoptosis, NADPH oxidase activation, cytoskeletal dynamics, and metabolism. While the PCNA interactome has been characterized in neutrophils under homeostatic conditions, less is known about neutrophil PCNA in pathophysiological contexts. Granulocyte colony-stimulating factor (G-CSF) is a cytokine produced in response to inflammatory stimuli that regulates many aspects of neutrophil biology. Here, we used isolated normal-density neutrophils from G-CSF-treated haemopoietic stem cell donors (GDs) as a model to understand the role of PCNA during inflammation. Proteomic analysis of the neutrophil cytosol revealed significant differences between GDs and healthy donors (HDs). PCNA was one of the most upregulated proteins in GDs, and the PCNA interactome was significantly different in GDs compared with HDs. Importantly, while PCNA associated with almost all enzymes involved in glycolysis in HDs, these associations were decreased in GDs. Functionally, neutrophils from GDs had a significant increase in glycolysis compared with HDs. Using p21 competitor peptides, we showed that PCNA negatively regulates neutrophil glycolysis in HDs but had no effect on GD neutrophils. These data demonstrate that G-CSF alters the PCNA scaffold, affecting interactions with key glycolytic enzymes, and thus regulates glycolysis, the main energy pathway utilized by neutrophils. By this selective control of glycolysis, PCNA can organize neutrophils functionality in parallel with other PCNA mechanisms of prolonged survival. PCNA may therefore be instrumental in the reprogramming that neutrophils undergo in inflammatory or tumoral settings.
    MeSH term(s) Neutrophils/metabolism ; Granulocyte Colony-Stimulating Factor/metabolism ; Cytosol/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Proteomics ; Cytokines/metabolism
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7) ; Proliferating Cell Nuclear Antigen ; Cytokines
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Design and Preclinical Evaluation of a Nanoparticle Vaccine against Respiratory Syncytial Virus Based on the Attachment Protein G.

    Voorzaat, Richard / Cox, Freek / van Overveld, Daan / Le, Lam / Tettero, Lisanne / Vaneman, Joost / Bakkers, Mark J G / Langedijk, Johannes P M

    Vaccines

    2024  Volume 12, Issue 3

    Abstract: ... drift. The attachment protein G has long been ignored as a vaccine target due to perceived non ... essentiality and ineffective neutralization on immortalized cells. Here, we show strong G-based neutralization ... neutralization. Next, we designed an RSV vaccine component based on the central conserved domain (CCD) of G fused ...

    Abstract Human respiratory syncytial virus (RSV) poses a significant human health threat, particularly to infants and the elderly. While efficacious vaccines based on the F protein have recently received market authorization, uncertainties remain regarding the future need for vaccine updates to counteract potential viral drift. The attachment protein G has long been ignored as a vaccine target due to perceived non-essentiality and ineffective neutralization on immortalized cells. Here, we show strong G-based neutralization in fully differentiated human airway epithelial cell (hAEC) cultures that is comparable to F-based neutralization. Next, we designed an RSV vaccine component based on the central conserved domain (CCD) of G fused to self-assembling lumazine synthase (LS) nanoparticles from the thermophile
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12030294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Outcomes of Serum Food-Specific Immunoglobulin G 4 to Guide Elimination Diet in Patients With Eosinophilic Esophagitis.

    Lim, Amanda Huoy Wen / Ngoi, Benjamin / Perkins, Griffith B / Wong, Stephanie / Whitelock, Gail / Hurtado, Plinio / Ruszkiewicz, Andrew / Le, Thanh-Thao Adriana / Hissaria, Pravin / Nguyen, Nam Quoc

    The American journal of gastroenterology

    2024  

    Abstract: ... have identified an association with food-specific immunoglobulin G 4 (FS-IgG 4 ) rather ...

    Abstract Introduction: Eosinophilic esophagitis (EoE) is associated with atopy; however, recent studies have identified an association with food-specific immunoglobulin G 4 (FS-IgG 4 ) rather than immunoglobulin E antibodies. This study aimed to evaluate the role of serum FS-IgG 4 in guiding an elimination diet and its outcomes.
    Methods: Patients with and without EoE were enrolled in a prospective, controlled, single tertiary center trial. Serum FS-IgG 4 titers, esophageal eosinophil counts, and dysphagia symptom questionnaire scores were assessed, and participants with elevated FS-IgG 4 (ImmunoCAP, cutoff of 10 mgA/L) commenced 6-week targeted elimination diet. Repeat serum FS-IgG 4 and endoscopic and histologic examination were performed at 6-week follow-up.
    Results: Twenty-two patients with active EoE and 13 controls were recruited. Serum FS-IgG 4 to milk, wheat, soy, eggs, and nuts was significantly higher in EoE ( P = 0.0002, P = 0.002, P = 0.003, P = 0.012, and P < 0.001, respectively). Elevated serum FS-IgG 4 to 1 or more food groups (median 2) was identified in 21/22 (95.4%) patients with EoE; 20/21 underwent 6-week dietary elimination. Median reductions in dysphagia symptom questionnaire score and EoE endoscopic reference score after elimination were 8 ( P = 0.0007) and 1 ( P = 0.002), respectively. Nine (45%) patients had histological remission (<15 eosinophils per high-power field). Fall in median esophageal eosinophil count was not statistically significant (50 vs 23; P = 0.068). Serum FS-IgG 4 did not decline by 6-week follow-up.
    Discussion: Serum FS-IgG 4 to milk, wheat, soy, egg, and nuts was present at higher levels in EoE, with targeted elimination resulting in 45% histologic remission rate. Serum FS-IgG 4 has potential as a noninvasive biomarker in EoE. When successful, FS-IgG 4 -led elimination diet can negate need for medications and be viewed more favorably by patients because of its smaller endoscopic burden compared with empirical elimination diets.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: A Monstrosity of Sex-The Case of John G. Allen.

    Nagle, L E

    Buffalo medical and surgical journal

    2023  Volume 8, Issue 10, Page(s) 393–395

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 426472-1
    ISSN 1040-3825
    ISSN 1040-3825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    AMP -365/384-: Show issues

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