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Article ; Online: Solitary pulmonary nodule in a renal transplant recipient.

Yang, Ya-Chen / Wu, Chi-Jung / Hsieh, Ming-I / Wu, Yi-Ju / Chen, Yi-Chun

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

2023 Volume 56, Issue 4, Page(s) 883–885

MeSH term(s)	Humans ; Kidney Transplantation/adverse effects ; Solitary Pulmonary Nodule/diagnostic imaging ; Solitary Pulmonary Nodule/drug therapy ; Mucormycosis/drug therapy ; Antifungal Agents/therapeutic use ; Kidney
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Letter
ZDB-ID	1497590-7
ISSN	1995-9133 ; 1684-1182 ; 0253-2662
ISSN (online)	1995-9133
ISSN	1684-1182 ; 0253-2662
DOI	10.1016/j.jmii.2023.02.002
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Article: Long-Term Survival and Cancer Risk in the Hepatitis C Virus-Infected Patients After Antiviral Treatment: A Nationwide Cohort Study.

Chen, Yi-Ju / Huang, Jing-Yang / Baskaran, Rathinasamy / Abomughaid, Mosleh Mohammad / Hsieh, Chang-Chi / Lin, Wan-Teng

Journal of Cancer

2024 Volume 15, Issue 1, Page(s) 113–125

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.87259
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Article: Clinical characteristics and outcomes of mixed virus or bacterial infection in children with laboratory-confirmed influenza infection.

Chien, Shao-Ju / Hsieh, Yun-Jung / Shih, Yu-Lien / Tseng, Yi-Ju

Journal of the Formosan Medical Association = Taiwan yi zhi

2022 Volume 121, Issue 10, Page(s) 2074–2084

Abstract: Background/purpose: This study investigated the demographic characteristics and influenza complications of paediatric patients and explored the association of different influenza virus types and viral and bacterial coinfections with disease severity.: ...

Abstract	Background/purpose: This study investigated the demographic characteristics and influenza complications of paediatric patients and explored the association of different influenza virus types and viral and bacterial coinfections with disease severity. Methods: This retrospective cohort study used data collected in 2010-2016 from the Chang Gung Research Database (CGRD), the largest collection of multi-institutional electronic medical records in Taiwan. Data were retrieved for children aged 0-18 years with laboratory-confirmed influenza. We extracted and analysed the demographic characteristics and the data on clinical features, complications, microbiological information, and advanced therapies of each case. Results: We identified 6193 children with laboratory-confirmed influenza, of whom 1964 (31.7%) were hospitalised. The age of patients with influenza A infection was lower than that of patients with influenza B (4.48 vs. 6.68, p < 0.001). Patients with influenza B infection had a higher incidence of myositis or rhabdomyolysis (4.4%, p < 0.001) and a higher need for advanced therapies (OR, 1.96; 95% CI, 1.32-2.9, p < 0.001). In addition to bacterial (OR, 9.07; 95% CI, 5.29-15.54, p < 0.001) and viral coinfection (OR, 7.73; 95% CI, 5.4-11.07, p < 0.001), dual influenza A and B infection was also a risk factor for influenza complications (OR, 2.13; 95% CI, 1.47-3.09, p < 0.001). Conclusion: Dual influenza A and B infection and bacterial coinfection can contribute to influenza complications. Early recognition of any influenza complication is critical for the timely initiation of organ-specific advanced therapies to improve influenza-associated outcomes.
MeSH term(s)	Bacterial Infections ; Child ; Coinfection ; Humans ; Influenza, Human/complications ; Influenza, Human/epidemiology ; Retrospective Studies ; Taiwan/epidemiology
Language	English
Publishing date	2022-03-21
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2022.03.002
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Article ; Online: Proteomic profiling of tumor microenvironment and prognosis risk prediction in stage I lung adenocarcinoma.

Lu, Yueh-Feng / Chang, Ya-Hsuan / Chen, Yi-Ju / Hsieh, Min-Shu / Lin, Mong-Wei / Hsu, Hsao-Hsun / Han, Chia-Li / Chen, Yu-Ju / Yu, Sung-Liang / Chen, Jin-Shing / Chen, Hsuan-Yu

Lung cancer (Amsterdam, Netherlands)

2024 Volume 191, Page(s) 107791

Abstract: Objectives: With the increasing popularity of CT screening, more cases of early-stage lung cancer are being diagnosed. However, 24.5% of stage I non-small-cell lung cancer (NSCLC) patients still experience treatment failure post-surgery. Biomarkers to ... ...

Abstract	Objectives: With the increasing popularity of CT screening, more cases of early-stage lung cancer are being diagnosed. However, 24.5% of stage I non-small-cell lung cancer (NSCLC) patients still experience treatment failure post-surgery. Biomarkers to predict lung cancer patients at high risk of recurrence are needed. Materials and methods: We collected protein mass spectrometry data from the Taiwan Lung Cancer Moonshot Project and performed bioinformatics analysis on proteins with differential expressions between tumor and adjacent normal tissues in 74 stage I lung adenocarcinoma (LUAD) cases, aiming to explore the tumor microenvironment related prognostic biomarkers. Findings were further validated in 6 external cohorts. Results: The analysis of differentially expressed proteins revealed that the most enriched categories of diseases and biological functions were cellular movement, immune cell trafficking, and cancer. Utilizing proteomic profiling of the tumor microenvironment, we identified five prognostic biomarkers (ADAM10, MIF, TEK, THBS2, MAOA). We then developed a risk score model, which independently predicted recurrence-free survival and overall survival in stage I LUAD. Patients with high risk scores experienced worse recurrence-free survival (adjusted hazard ratio = 8.28, p < 0.001) and overall survival (adjusted hazard ratio = 6.88, p = 0.013). Findings had been also validated in the external cohorts. Conclusion: The risk score model derived from proteomic profiling of tumor microenvironment can be used to predict recurrence risk and prognosis of stage I LUAD.
Language	English
Publishing date	2024-04-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2024.107791
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Article: Blockade of the SRC/STAT3/BCL-2 Signaling Axis Sustains the Cytotoxicity in Human Colorectal Cancer Cell Lines Induced by Dehydroxyhispolon Methyl Ether.

Hsieh, Ya-Chu / Dai, Yuan-Chang / Cheng, Kur-Ta / Yang, Wei-Ting / Ramani, Modukuri V / Subbaraju, Gottumukkala V / Chen, Yi-Ju / Chang, Chia-Che

Biomedicines

2023 Volume 11, Issue 9

Abstract: Colorectal cancer (CRC) is the third most prevalent human cancer globally. 5-Fluorouracil (5-FU)-based systemic chemotherapy is the primary strategy for advanced CRC treatment, yet is limited by poor response rate. Deregulated activation of signal ... ...

Abstract	Colorectal cancer (CRC) is the third most prevalent human cancer globally. 5-Fluorouracil (5-FU)-based systemic chemotherapy is the primary strategy for advanced CRC treatment, yet is limited by poor response rate. Deregulated activation of signal transducer and activator of transcription 3 (STAT3) is fundamental to driving CRC malignant transformation and a poor prognostic marker for CRC, underscoring STAT3 as a promising CRC drug target. Dehydroxyhispolon methyl ether (DHME) is an analog of Hispolon, an anticancer polyphenol abundant in the medicinal mushroom
Language	English
Publishing date	2023-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11092530
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Article ; Online: Human Umbilical Cord Mesenchymal-Stem-Cell-Derived Extracellular Vesicles Reduce Skin Inflammation In Vitro

Tzou-Yien Lin / Tsong-Min Chang / Wei-Cheng Tsai / Yi-Ju Hsieh / Li-Ting Wang / Huey-Chun Huang

International Journal of Molecular Sciences, Vol 24, Iss 23, p

2023 Volume 17109

Abstract: The protective roles of extracellular vesicles derived from human umbilical cord mesenchymal stem cells against oxazolone-induced damage in the immortalized human keratinocyte cell line HaCaT were investigated. The cells were pretreated with or without ... ...

Abstract	The protective roles of extracellular vesicles derived from human umbilical cord mesenchymal stem cells against oxazolone-induced damage in the immortalized human keratinocyte cell line HaCaT were investigated. The cells were pretreated with or without UCMSC-derived extracellular vesicles 24 h before oxazolone exposure. The pretreated UVMSC-EVs showed protective activity, elevating cell viability, reducing intracellular ROS, and reducing the changes in the mitochondrial membrane potential compared to the cells with a direct oxazolone treatment alone. The UCMSC-EVs exhibited anti-inflammatory activity via reducing the inflammatory cytokines IL-1β and TNF-α. A mechanism study showed that the UCMSC-EVs increased the protein expression levels of SIRT1 and P53 and reduced P65 protein expression. It was concluded that UVMSC-EVs can induce the antioxidant defense systems of HaCaT cells and that they may have potential as functional ingredients in anti-aging cosmetics for skin care.
Keywords	extracellular vesicle ; umbilical-cord-derived mesenchymal stem cells ; SIRT1 ; p53 ; NF-κB ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Human Umbilical Cord Mesenchymal-Stem-Cell-Derived Extracellular Vesicles Reduce Skin Inflammation In Vitro.

Lin, Tzou-Yien / Chang, Tsong-Min / Tsai, Wei-Cheng / Hsieh, Yi-Ju / Wang, Li-Ting / Huang, Huey-Chun

International journal of molecular sciences

2023 Volume 24, Issue 23

Abstract	The protective roles of extracellular vesicles derived from human umbilical cord mesenchymal stem cells against oxazolone-induced damage in the immortalized human keratinocyte cell line HaCaT were investigated. The cells were pretreated with or without UCMSC-derived extracellular vesicles 24 h before oxazolone exposure. The pretreated UVMSC-EVs showed protective activity, elevating cell viability, reducing intracellular ROS, and reducing the changes in the mitochondrial membrane potential compared to the cells with a direct oxazolone treatment alone. The UCMSC-EVs exhibited anti-inflammatory activity via reducing the inflammatory cytokines IL-1β and TNF-α. A mechanism study showed that the UCMSC-EVs increased the protein expression levels of SIRT1 and P53 and reduced P65 protein expression. It was concluded that UVMSC-EVs can induce the antioxidant defense systems of HaCaT cells and that they may have potential as functional ingredients in anti-aging cosmetics for skin care.
MeSH term(s)	Humans ; Oxazolone ; Extracellular Vesicles/metabolism ; Inflammation/metabolism ; Mesenchymal Stem Cells/metabolism ; Umbilical Cord
Chemical Substances	Oxazolone (15646-46-5)
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242317109
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Article: Lactobacillus plantarum

Yeh, Wen-Ling / Hsu, Yi-Ju / Ho, Chin-Shen / Ho, Hsieh-Hsun / Kuo, Yi-Wei / Tsai, Shin-Yu / Huang, Chi-Chang / Lee, Mon-Chien

Frontiers in nutrition

2022 Volume 9, Page(s) 896503

Abstract: Increasing numbers of researchers are investigating the benefits of probiotics in enhancing exercise performance and verifying the role of the gut-muscle axis. In our previous study, ...

Abstract	Increasing numbers of researchers are investigating the benefits of probiotics in enhancing exercise performance and verifying the role of the gut-muscle axis. In our previous study,
Language	English
Publishing date	2022-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.896503
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Article ; Online: NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.

Chen, Chih-Wei / Su, Chi / Huang, Chang-Yu / Huang, Xuan-Rong / Cuili, Xiaojing / Chao, Tung / Fan, Chun-Hsiang / Ting, Cheng-Wei / Tsai, Yi-Wei / Yang, Kai-Chien / Yeh, Ti-Yen / Hsieh, Sung-Tsang / Chen, Yi-Ju / Feng, Yuxi / Hunter, Tony / Chang, Zee-Fen

Nature communications

2024 Volume 15, Issue 1, Page(s) 2264

Abstract: NME3 is a member of the nucleoside diphosphate kinase (NDPK) family localized on the mitochondrial outer membrane (MOM). Here, we report a role of NME3 in hypoxia-induced mitophagy dependent on its active site phosphohistidine but not the NDPK function. ... ...

Abstract	NME3 is a member of the nucleoside diphosphate kinase (NDPK) family localized on the mitochondrial outer membrane (MOM). Here, we report a role of NME3 in hypoxia-induced mitophagy dependent on its active site phosphohistidine but not the NDPK function. Mice carrying a knock-in mutation in the Nme3 gene disrupting NME3 active site histidine phosphorylation are vulnerable to ischemia/reperfusion-induced infarction and develop abnormalities in cerebellar function. Our mechanistic analysis reveals that hypoxia-induced phosphatidic acid (PA) on mitochondria is essential for mitophagy and the interaction of DRP1 with NME3. The PA binding function of MOM-localized NME3 is required for hypoxia-induced mitophagy. Further investigation demonstrates that the interaction with active NME3 prevents DRP1 susceptibility to MUL1-mediated ubiquitination, thereby allowing a sufficient amount of active DRP1 to mediate mitophagy. Furthermore, MUL1 overexpression suppresses hypoxia-induced mitophagy, which is reversed by co-expression of ubiquitin-resistant DRP1 mutant or histidine phosphorylatable NME3. Thus, the site-specific interaction with active NME3 provides DRP1 a microenvironment for stabilization to proceed the segregation process in mitophagy.
MeSH term(s)	Animals ; Mice ; Dynamins/genetics ; Dynamins/metabolism ; Histidine/metabolism ; Hypoxia ; Mitophagy/genetics ; Ubiquitination
Chemical Substances	Dynamins (EC 3.6.5.5) ; Histidine (4QD397987E) ; Nme3 protein, mouse (EC 2.7.4.6) ; Dnm1l protein, mouse (EC 3.6.5.5)
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46385-7
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Article: Case Report: Primary Aldosteronism Due to Bilateral Aldosterone-Producing Micronodules With HISTALDO Classical and Contralateral Non-Classical Pathology.

Chen, Yi-Ju / Peng, Kang-Yung / Chueh, Jeff S / Liao, Hung-Wei / Hsieh, Tsung-Yi / Wu, Vin-Cent / Wang, Shuo-Meng

Frontiers in endocrinology

2022 Volume 13, Page(s) 816754

Abstract: Background: Non-classical multiple aldosterone-producing micronodules/nodules (mAPM/mAPN) could be the pathogenesis of primary aldosteronism (PA). The co-existence of mAPM with adenomas harboring somatic mutations has not previously been reported.: ... ...

Abstract	Background: Non-classical multiple aldosterone-producing micronodules/nodules (mAPM/mAPN) could be the pathogenesis of primary aldosteronism (PA). The co-existence of mAPM with adenomas harboring somatic mutations has not previously been reported. Methods: We presented a PA patient with bilateral mAPM and concomitant autonomous cortisol secretion (ACS). Results: A 46-year-old Taiwanese woman presented with hypertension, hypokalemia, and bilateral adrenal adenomas. A 1 mg low-dose dexamethasone suppression test showed elevated morning serum cortisol. An adrenal vein sampling (AVS) suggested a left-sided lateralization of hyperaldosteronism. A right partial adrenalectomy and a left total adrenalectomy were performed. The patient showed biochemical and hypertension remission after the operation. This patient had bilateral mAPM with concomitant ACS, a right histopathologically classical PA adenoma, and a left non-classical PA adenoma. The right adrenal adenoma showed CYP11B1-negative and CYP11B2-positive staining and harbored the Conclusion: In a PA patient with concomitant ACS, bilateral APM could coexist with both histopathologically classical and non-classical PA adenomas, each with different somatic mutations. The presence of ACS could lead to the misinterpretation of AVS results.
MeSH term(s)	Adenoma/pathology ; Adrenocortical Adenoma/complications ; Adrenocortical Adenoma/genetics ; Adrenocortical Adenoma/surgery ; Aldosterone ; Cytochrome P-450 CYP11B2/metabolism ; Female ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/genetics ; Humans ; Hydrocortisone ; Hyperaldosteronism/complications ; Hyperaldosteronism/genetics ; Hyperaldosteronism/surgery ; Hypertension/complications ; Middle Aged ; Steroid 11-beta-Hydroxylase/genetics
Chemical Substances	G Protein-Coupled Inwardly-Rectifying Potassium Channels ; KCNJ5 protein, human ; Aldosterone (4964P6T9RB) ; Cytochrome P-450 CYP11B2 (EC 1.14.15.4) ; Steroid 11-beta-Hydroxylase (EC 1.14.15.4) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.816754
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